Clinical trials: Therapy Strategies
HIV Infections
Evaluation of a Lopinavir/Ritonavir Monotherapy vs a Triple Therapy as Maintenance Regimens in HIV-1 Infected Patients
A 2-year multicenter, phase II/III, randomized active-controlled trial to evaluate the efficacy and tolerance of two maintenance strategies in HIV-1 infected patients with HIV RNA below 50 copies/mL : a monotherapy with…
- Trial name
- ANRS 140 DREAM (NCT00946595)
- Testing
- efavirenz/emtricitabin/tenofovir, lopinavir/ritonavir
- Where
- France
- Volunteers
- 420 people
- Sponsor
- French National Agency for Research on AIDS and Viral Hepatitis
H Pylori Infection Eradication, Antibiotics Therapeutic Strategies
Therapeutic Trial Comparing Triple Therapy Guided by the PCR Detection of Clarithromycin Resistance vs Empiric Concomitant Quadruple Therapy for Helicobacter Pylori Infection
The H pylori infection remains a public health problem. The eradication rate with the first line triple therapy (PPI-amoxicillin-clarithromycin) is insufficient (estimated at 70%) due to the frequency of resistance to…
- Conditions
- H Pylori Infection Eradication, Antibiotics Therapeutic Strategies, H Pylori Eradication
- Trial name
- Hepysé (NCT02576236)
- Testing
- Quadruple concomitant therapy treatment, Triple therapy guided by the result of the molecular resistance test
- Where
- France
- Volunteers
- 2,500 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Therapy, Pleural Infections
Comparison of Early Pleural Irrigation Strategy With Saline to the Standard of Care for the Management of Complicated Pleural Infections.
Intrapleural enzyme therapy (IET) is regarded by recent guidelines as a "rescue" therapy for managing complicated pleural infections; however, it is associated with significant side effects, including pleural bleeding, pain, and…
- Trial name
- EPISSOC (NCT07666464)
- Testing
- intrapleural irrigation, Standard care
- Where
- France
- Volunteers
- 244 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Vaccination Refusal, COVID-19
COVID-19 Vaccine Uptake Trial
The goal of this study is to assess the best COVID-19 vaccine uptake strategy among students, staff and household members that have not been vaccinated.
- Trial name
- NCT05419232
- Testing
- Short Message Service (SMS) + Website Link Strategy, Phone Call with Peer Strategy
- Where
- 8 sites in United States
- Volunteers
- 262 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Atrial Fibrillation
Interventional Strategies in Treatment of Atrial Fibrillation: Percutaneous Closure of the Left Atrial Appendage Versus Catheter Ablation
Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia, associated with an increased risk of morbidity and mortality1.
- Trial name
- ISAR-AF (NCT01363895)
- Testing
- Percutaneous closure of LAA, Catheter ablation of AF
- Where
- Germany
- Volunteers
- 120 people
- Sponsor
- Deutsches Herzzentrum Muenchen
Acute Respiratory Distress Syndrome, Respiratory Distress Syndrome, Acute
Establishment and Evaluation of Prenatal Prevention and Treatment Strategy for NARDS
1. A predictive model for NARDS was established based on perinatal risk factors. Multivariate Logistic regression analysis was used to screen the independent prenatal risk factors for NARDS.
- Trial name
- NCT06188195
- Testing
- Dexamethasone
- Where
- China
- Volunteers
- 500 people
- Sponsor
- The Second Affiliated Hospital of Chongqing Medical University
Anemia, Neutropenia
Treatment of Anemia and Neutropenia in HIV/HCV Coinfected Patients Treated With Pegylated Interferon and Ribavirin
This study is designed to test two separate strategies for treatment of anemia (low hemoglobin) and neutropenia (low white blood cells) in HIV/HCV coinfected patients who are being treated with pegylated interferon and ribavirin.
- Conditions
- Anemia, Neutropenia, Hepatitis C Virus, HIV Infections
- Trial name
- NCT00194857
- Testing
- erythropoietin, GCSF
- Where
- United States
- Sponsor
- Weill Medical College of Cornell University
Large B-cell Lymphoma
A Trial of Polatuzumab Vedotin, Obinutuzumab and Glofitamab As a Peri-CAR-T Cell Treatment Strategy in Large B-cell Lymphoma
The PORTAL study will test a new combination of drugs (glofitamab, polatuzumab vedotin and obinutuzumab) in patients with large B-cell lymphoma (LBCL) that has come back (relapsed) or not responded to previous treatment.
- Trial name
- PORTAL (NCT06071871)
- Testing
- Glofitamab, Polatuzumab vedotin, Obinutuzumab
- Where
- 5 sites in United Kingdom
- Volunteers
- 99 people
- Sponsor
- University College, London
Unipolar Depression, Bipolar Depression
Ketamine as an Augmentation Strategy for Electroconvulsive Therapy (ECT) in Depression
The study aims to compare outcomes of Electroconvulsive Therapy (ECT) using ketamine versus methohexital anesthesia in depressed patients.
- Trial name
- NCT01881763
- Testing
- Ketamine, Methohexital
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Northwell Health
Inflammatory Bowel Diseases, Crohn Disease
Cost-effectiveness of TPMT Pharmacogenetics
The purpose of this study is to determine whether thiopurine S-methyltransferase (TPMT) genotyping prior to thiopurine use is cost-effective in patients with inflammatory bowel disease (IBD) in need of immune suppression.
- Conditions
- Inflammatory Bowel Diseases, Crohn Disease, Ulcerative Colitis
- Trial name
- TOPIC (NCT00521950)
- Testing
- TPMT genotyping; Drug: azathioprine or 6-mercaptopurine, azathioprine (AZA) or 6-mercaptopurine (6-MP)
- Where
- 3 sites in Netherlands
- Volunteers
- 853 people
- Sponsor
- ZonMw: The Netherlands Organisation for Health Research and Development
Cannabis Use Disorder
Vivitrol Treatment for Cannabis Use Disorder
The purpose of this study is to investigate the safety and effectiveness of 12 weeks treatment with an extended-release injectable form of naltrexone (Vivitrol) combined with a psychological intervention in 10 treatment-seeking…
- Trial name
- NCT04139668
- Testing
- Naltrexone 380 MG [Vivitrol], Motivational Enhancement Therapy and Cognitive Behavioral Therapy
- Where
- Canada
- Volunteers
- 1 people
- Sponsor
- Centre for Addiction and Mental Health
Coronary Artery Disease, Platelet Reactivity
Pharmacodynamic Outcomes in CCS Patients Treated With an Individualized Treatment Strategy
Patients with Chronic Coronary Syndrome (CCS) undergoing with elective percutaneous coronary intervention (PCI) are treated with dual antiplatelet therapy (DAPT), consisting of aspirin combined with clopidogrel for 6 months.
- Trial name
- NCT05773989
- Testing
- CYP2C19 genotype guided P2Y12 monotherapy, Clopidogrel
- Where
- Netherlands
- Volunteers
- 88 people
- Sponsor
- St. Antonius Hospital
Shock, Systemic Inflammatory Response Syndrome (SIRS)
Optimization of Therapeutic Human Serum Albumin Infusion in Selected Critically Ill Patients
Primary purpose : mortality at Day 28 Secondary purposes : Daily SOFA (Sequential Organ Failure Assessment) score lessening within Intensive Care Unit (ICU) Duration of increasing doses of norepinephrine infusion to maintain…
- Conditions
- Shock, Systemic Inflammatory Response Syndrome (SIRS), Hypoalbuminaemia
- Trial name
- AlbAlsace (NCT02755155)
- Testing
- Human serum albumin infusion 4%, Human serum albumin infusion 20%
- Where
- France
- Volunteers
- 138 people
- Sponsor
- University Hospital, Strasbourg, France
COVID-19 Pneumonia
Oral Prednisone Regimens to Optimize the Therapeutic Strategy in Patients With Organizing Pneumonia Post-COVID-19
Background: Based on data from the 2003 SARS-COVID pandemic, other serious lung infections, and patients with respiratory distress, it is estimated that 10-30% of patients with severe SARS-COVID-2 pneumonia may present as a…
- Trial name
- NORCOVID (NCT04534478)
- Testing
- Prednisone
- Volunteers
- 120 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Periodontal Disease
Randomized Controlled Trial of a Novel Laser-aided Orthodontic-periodontal Treatment Strategy
The aim of the study is to assess the effects of low-level laser therapy (LLLT) in patients with periodontitis during orthodontic-periodontal treatment for 12 months on the following aspects: (1) Effects on periodontal status…
- Trial name
- NCT02352038
- Testing
- low-level laser therapy, orthodontic treatment
- Where
- Hong Kong
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Bleeding Gastric Varices, Cirrhosis
"Early TIPS" Versus Glue Obliteration to Prevent Rebleeding From Gastric Varices
The primary objective of the study is to demonstrate the superiority of an "early tips" strategy over standard treatment by glue obliteration (G0) in preventing bleeding recurrence or death at one year after a non GOV1 gastric…
- Trial name
- GAVAPROSEC (NCT03705078)
- Testing
- Transjugular Portosytemic Shunt (TIPS), glue obliteration
- Where
- 20 sites in France
- Volunteers
- 104 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Health Care Utilization, Men
The Effect of the Program on the Health Perceptions and Responsibilities of Immigrant Men on Utiling Healthcare Services
Aims The study aims to examine the effect of "IHAPIM" program on health perceptions, health responsibilities, perceived stress level, attitudes towards utiling health care services and the types of coping strategies of immigrant…
- Trial name
- IHAP (NCT04831463)
- Testing
- Increasising Health Awareness Program for Immigrant Men
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Ondokuz Mayıs University
Metabolic Syndrome, Diet Modification
Diet for the Maintenance of Weight Loss and Metabolic Health in Obese Postmenopausal Women
The aim of the study will be comparing the effectiveness of two diets: moderate in fat with a high proportion of monounsaturated fatty acids (MUFAs) - the Mediterranean diet (MED) and 2) the low in fat and high in dietary fiber…
- Conditions
- Metabolic Syndrome, Diet Modification, Postmenopause
- Trial name
- WELCOME (NCT04136093)
- Testing
- the MED, the DASH, Control diet
- Where
- Poland
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Poznan University of Life Sciences
Chronic Heart Failure
Strategies to Improve Prescribing in Heart Failure Patients
The purpose of the study is to assess whether primary care physicians may uptitrate recommended drug therapies in stable heart failure patients if educational material and specialist support including phone or mail consultation…
- Trial name
- NCT01023438
- Testing
- Strategy for assisted uptitration, Usual care
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Niguarda Hospital
Sleep Disorder, Pre Diabetes
Recruitment Strategies Comparing Different Strategies in Sleep Apnea and Prediabetes
Recruitment strategies comparing different strategies.
- Conditions
- Sleep Disorder, Pre Diabetes, Obstructive Sleep Apnea
- Trial name
- NCT03984058
- Testing
- Lifestyle Intervention
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Johns Hopkins University
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