Clinical trials: Therapy Strategies
Multiple Sclerosis
Function Magnetic Resonance Imaging to Assess Two Therapeutic Strategies in Multiple Sclerosis (NeuroRehEM).
Multiple sclerosis (MS) is an autoimmune disease that causes cognitive and motor disabilities and contributes to decrease patients life quality.
- Trial name
- NeuroRehEM (NCT05270239)
- Testing
- N-back Cognitive Training, Virtual Reality Motor and Cognitive Training
- Where
- Spain
- Volunteers
- 94 people
- Sponsor
- Universitat Jaume I
Eye Trauma
Treatment of Corneal Wounds Emergencies During the COVID-19 Shutdown: Absorbable 10-0 Vicryl Sutures as a Valuable Strategy.
Vicryl (polyglactin) 10-0 resorbable suture is rarely used, little known to ophthalmologists but may offer therapeutic and practical advantages in eligible cases of corneal trauma, particularly during a COVID-19 pandemic.
- Trial name
- NCT04733846
- Testing
- data collection
- Where
- France
- Volunteers
- 10 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Chronic Kidney Disease
Study Evaluating the Benefit of Two Immunosuppressive Strategies on Renal Function
Prospective, multicenter, randomized and open label study evaluating the benefit on renal function at 12 months post-transplantation, with an immunosuppression without calcineurin inhibitor at 3 months and combining mycophenolate…
- Trial name
- NCT02334488
- Testing
- Everolimus, Tacrolimus, Mycophenolate sodium
- Where
- 14 sites in France
- Volunteers
- 329 people
- Sponsor
- Poitiers University Hospital
Psoriasis
Excimer Laser Phototherapy Outcomes in the Treatment of Psoriasis
The purpose of this study is to determine the best dosing strategy when using Excimer Laser to treat plaque-type psoriasis. In this study, half of the body's psoriasis will be treated with a new dosing strategy, and the other…
- Trial name
- Photos (NCT02294981)
- Testing
- Excimer laser phototherapy
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- University of California, San Francisco
Type 2 Diabetes, Diabetic Cardiomyopathy
NT-ProBNP-based Heart Failure Screening and Prevention Trial in Patients With Type 2 Diabetes: STRONG-DM Study
A pragmatic, randomized clinical trial to evaluate the effect of a heart failure (HF) risk assessment and prevention strategy incorporating HF clinical risk scores (WATCH-DM) with cardiac biomarker (NT-proBNP) paired with a…
- Conditions
- Type 2 Diabetes, Diabetic Cardiomyopathy, Heart Failure, Cardiometabolic Diseases
- Trial name
- STRONG-DM (NCT06593327)
- Testing
- Intensive Prevention Strategy
- Where
- 3 sites in United States
- Volunteers
- 300 people
- Sponsor
- University of Texas Southwestern Medical Center
Carcinoma, Squamous Cell of Head and Neck
Biomarker-based Study in R/M SCCHN
This is a biomarker-driven trial that will enroll patients with recurrent or metastatic squamous cell carcinoma of the head and neck progressing after first-line platinum-based chemotherapy.
- Trial name
- UPSTREAM (NCT03088059)
- Testing
- Afatinib, Palbociclib, standard of care
- Where
- 36 sites in Belgium, France and 3 more
- Volunteers
- 340 people
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
Acute Myeloid Leukemia, Childhood
A Prospective Multicenter Clinical Trial of MRD-based Treatment Strategy in Children and Young Adults With AML
Minimal-residual disease (MRD) will be measured either by flow cytometry, or polymerase chain reaction (PCR) methods, in 3 check-points and it will be one of the decision-making control parameter for the optimal therapy tactics.
- Trial name
- NCT03846362
- Testing
- HSCT
- Where
- 2 sites in Russia
- Volunteers
- 500 people
- Sponsor
- Federal Research Institute of Pediatric Hematology, Oncology and Immunology
Inflammatory Bowel Diseases, Ulcerative Colitis
Preemptive HLA Genotyping for the Safe Use of Infliximab-combination Therapy in Inflammatory Bowel Disease
Inflammatory bowel disease (IBD) is a common disease in Canada, leading to significant morbidity as a result of remitting and relapsing intestinal inflammation.
- Conditions
- Inflammatory Bowel Diseases, Ulcerative Colitis, Crohn Disease
- Trial name
- INHERIT (NCT04109300)
- Testing
- HLADQA1*05A>G screening, Standard of Care
- Where
- Canada
- Volunteers
- 162 people
- Sponsor
- Western University, Canada
Heroin Dependence
A Stepwise Strategy Utilizing Buprenorphine and Methadone
The objective of this study is to compare optimally given methadone maintenance treatment (MMT) for heroin dependence with a novel, sequential strategy, where patients are offered buprenorphine as first line treatment, allowed…
- Trial name
- NCT00310934
- Testing
- methadone, buprenorphine / methadone sequence, Relapse prevention
- Where
- Sweden
- Volunteers
- 96 people
- Sponsor
- Karolinska University Hospital
Metastatic Renal Cell Carcinoma, Stage IV Renal Cell Cancer AJCC v8
Stereotactic Body Radiation Therapy in Treating Patients With Oligometastatic Renal Cell Carcinoma
This phase II trial studies how well stereotactic body radiation therapy works in treating patients with kidney cancer that has spread to other places in the body (metastatic).
- Trial name
- NCT03575611
- Testing
- Biopsy, Biospecimen Collection, Computed Tomography
- Where
- United States
- Volunteers
- 123 people
- Sponsor
- M.D. Anderson Cancer Center
Atrial Fibrillation (AF)
The Modified "Pills-in-the-Pocket" Strategy
This is a multicentre, prospective, randomised controlled study of 328 patients with non-paroxysmal AF (within 5 years of first diagnosis of AF) with recurrent atrial arrhythmias after first catheter ablation, randomly divided in…
- Trial name
- ABD-AF (NCT06657404)
- Testing
- use Amiodarone, Bisoprolol and Digoxin
- Where
- China
- Volunteers
- 328 people
- Sponsor
- Yumei Xue
AL Amyloidosis
Isatuximab as Upfront Therapy for the Treatment of High Risk AL Amyloidosis
This phase I trial studies the side effects of isatuximab and to see how well it works in treating patients with high risk immunoglobulin light chain amyloidosis (AL amyloidosis).
- Trial name
- NCT04754945
- Testing
- Bortezomib, Cyclophosphamide, Dexamethasone
- Where
- 6 sites in United States
- Volunteers
- 11 people
- Sponsor
- Emory University
Coronavirus Disease-2019
Sequential Oxygen Therapy Strategy for Patients With COVID-19
All patients with COVID-19 were divided into three groups according to their illness: mild patient who receive conventional oxygen therapy, severe patients who receive nasal high flow oxygen inhalation or non-invasive positive…
- Trial name
- SOTSPC (NCT04312100)
- Testing
- oxygen treatment
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Henan Provincial People's Hospital
Coronary Artery Disease
PREventive Invasive Strategy for Obstructive Coronary Artery Disease With Vulnerable Plaque Evaluated by CoroNary Computed Tomography Angiography-2
The PREVENT-2 trial is to determine whether an initial invasive strategy-consisting of early coronary angiography (CAG) with intent for preventive percutaneous coronary intervention (PCI) in addition to optimal medical therapy…
- Trial name
- PREVENT-2 (NCT07569692)
- Testing
- Initial Invasive Strategy, Initial Conservative Strategy
- Where
- South Korea
- Volunteers
- 2,500 people
- Sponsor
- Duk-Woo Park, MD
Cervical Cancer, Human Papillomavirus
Comparing Strategies for Implementing Primary HPV Screening
Cervical cancer screening is an important component of women's health care. Most adult women are familiar with the conventional screening modality, Pap test, which has successfully reduced the burden of cervical cancer in…
- Conditions
- Cervical Cancer, Human Papillomavirus, Health Knowledge, Attitudes, Practice, Health Care Utilization
- Trial name
- NCT04371887
- Testing
- Local Tailoring
- Where
- United States
- Volunteers
- 45,000 people
- Sponsor
- Chun Chao
Cancer
Prevention of Anthracycline-induced Cardiotoxicity
Anthracycline based anti-tumoral therapies are know to develop cardiac damage that could also lead to heart failure. Monocentric studies proved that a treatment with ACE inhibitors (ACEi) and betablockers (BB) during the first…
- Trial name
- ICOS-ONE (NCT01968200)
- Testing
- Enalapril
- Where
- Italy
- Volunteers
- 268 people
- Sponsor
- European Institute of Oncology
Dental Anxiety
Musical Intervention for Dental Anxiety
The goal of this clinical trial is to learn if listening to music during dental procedures lowers anxiety in adults. The main questions it aims to answer are: does music during the procedure lower dental anxiety, and does wearing…
- Trial name
- MI-DENT (NCT07240233)
- Testing
- Music via headphones, Headphones without audio
- Where
- Portugal
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Egas Moniz - Cooperativa de Ensino Superior, CRL
Non-Small-Cell Lung Cancer, Non-Small-Cell Lung Cancer Stage IV
Real-World Assessment of Therapeutic Strategies and Survival Outcomes Following First-Line Tislelizumab Therapy in Advanced Non-Small Cell Lung Cancer
This study is an observational study evaluating the treatment patterns and clinical outcomes after progression on first-line Tislelizumab treatment in advanced NSCLC.
- Trial name
- REALM-Post (NCT06962449)
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Shanghai Chest Hospital
Metastatic Breast Cancer, Drug Resistance
Real-World Study of Post-Resistance Treatment Strategies in Advanced Breast Cancer Following CDK4/6i, PIK3CA Inhibitors, or T-DXd
This is a real-world observational study aiming to evaluate the effectiveness of post-progression treatment strategies in patients with advanced breast cancer who have developed resistance to prior targeted therapies, including…
- Conditions
- Metastatic Breast Cancer, Drug Resistance, Hormone Receptor-Positive Breast Cancer, HER2-positive Breast Cancer
- Trial name
- NCT07073755
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Hunan Cancer Hospital
Chronic Hepatitis B
An Exploratory Study of RGT Strategy on Optimal NUC-experienced Patients
The aim of current study is to investigate whether the HBsAg clearance rate can be improved if applying RGT((Response-Guided Therapy) strategy in HBeAg positive CHB(chronic hepatitis B) patients treated by nucleoside…
- Trial name
- NCT02560649
- Testing
- Peginterferon alfa-2a plus Entecavir, Peginterferon alfa-2a plus Lamivudine, Peginterferon alfa-2a plus Adefovir
- Volunteers
- 324 people
- Sponsor
- Ruijin Hospital
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