Clinical trials: Therapy Strategies
Frailty, ACS (Acute Coronary Syndrome)
Prospective Observational Cohort Study on Impact of Frailty on Risk Prediction, Treatment Strategies, and Short-Term Outcomes in Patients With Acute Coronary Syndrome
we aim : To evaluate how frailty influences acute management decisions (invasive vs conservative strategy) in ACS patients and whether it independently affects short-term outcomes.
- Conditions
- Frailty, ACS (Acute Coronary Syndrome), MACE, GRACE Score
- Trial name
- NCT07190274
- Volunteers
- 645 people
- Sponsor
- Assiut University
Neuroblastoma
Ethanol-Lock Treatment in Preventing Central Venous Catheter Infections in Patients With High-Risk Neuroblastoma
RATIONALE: Ethanol-lock treatment may help prevent central venous catheter infections in patients with high-risk neuroblastoma. PURPOSE: This phase I trial is studying the side effects of ethanol-lock treatment in preventing…
- Trial name
- NCT00471679
- Testing
- ethanol
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
HIV
Thol'Impilo: Bringing People Into Care
The main objective of this study is to compare the effectiveness of combinations of three patient-oriented strategies, compared to the standard of care, to increase the proportion of patients who enter-into-care for HIV within 90…
- Trial name
- NCT02271074
- Testing
- Point of care CD4 testing, Care Facilitation, Transport support
- Where
- South Africa
- Volunteers
- 2,398 people, healthy volunteers welcome
- Sponsor
- The Aurum Institute NPC
HIV Infections
Monitoring Highly Active Antiretroviral Therapy in HIV-infected Parents in Thailand
The purpose of this study is to determine if a decision to switch to a subsequent antiretroviral regimen based upon the CD4 cell count rather than the standard switching strategy based on viral load could ensure the same…
- Trial name
- NCT00162682
- Testing
- Antiretroviral Drug Combination Switching Criteria
- Where
- 20 sites in Thailand
- Volunteers
- 716 people
- Sponsor
- Institut de Recherche pour le Developpement
HIV Infections
Simplification From Protease Inhibitors to Raltegravir
A switch from protease inhibitors (PIs) to raltegravir (RAL) will be effective virologically and immunologically. Moreover, it will be associated with significant improvements in the lipid profile in HIV patients with…
- Trial name
- ODIS (NCT00941083)
- Testing
- Raltegravir (Use RAL as a simplification strategy)
- Where
- Spain
- Volunteers
- 240 people
- Sponsor
- Hospital Carlos III, Madrid
ST Elevation Myocardial Infarction
STEMI Treated With a Polymer-free Sirolimus-coated Stent and P2Y12 Inhibitor-based SAPT Versus Conventional DAPT
Primary percutaneous coronary intervention (PCI) is the preferred revascularization strategy for patients with acute ST-segment elevation myocardial infarction (STEMI).
- Trial name
- STARS DAPT (NCT05785897)
- Testing
- Successful primary PCI, defined as primary PCI of the culprit lesion with ≥1 Abluminus NP polymer-free sirolimus-based nanocarrier eluting stent (Concept Medical Inc., India) implantation
- Where
- 2 sites in Switzerland
- Volunteers
- 350 people
- Sponsor
- IGLESIAS Juan Fernando
Hypomagnesemia
Dynamic Magnesium Replacement Strategies and 28-Day Mortality in Non-Cardiac Critically Ill Patients With Hypomagnesemia: A Target Trial Emulation
This study looks at how different ways of giving magnesium (a nutrient) affect the risk of death within 28 days for adults with low magnesium levels who are in the intensive care unit (ICU) for non-heart-related reasons.
- Trial name
- NCT07380542
- Where
- China
- Volunteers
- 12,887 people
- Sponsor
- Fujian Provincial Hospital
Prostate Cancer
18F-DCFPyL PET/CT Impact on Treatment Strategies for Patients With Prostate Cancer
The main purpose of this phase II trial study is to determine whether a positron emission tomography (PET)/computed tomography (CT) scan using 18F-DCFPyL affects the clinical management plan in Veterans.
- Trial name
- PROSPYL (NCT04390880)
- Testing
- 18F-DCFPyL
- Where
- United States
- Volunteers
- 239 people
- Sponsor
- VA Greater Los Angeles Healthcare System
Chronic Obstructive Pulmonary Disease
Different Positive Pressure Strategies in COPD Patients.
Chronic obstructive pulmonary disease (COPD) is characterized by a poorly reversible airway obstruction and consequent systemic manifestations.
- Trial name
- NCT03382197
- Testing
- Nebulization, Positive expiratory pressure valve, Nonivasive ventilation
- Where
- Brazil
- Volunteers
- 10 people
- Sponsor
- Universidade Federal de Pernambuco
Chagas Disease, Trypanosoma Cruzi Infection
University-Based Chagas Testing in Salta Province, Argentina
The goal of this observational study is to improve access to diagnosis and treatment for chronic Trypanosoma cruzi infection among university students of all ages and genders at the National University of Salta (UNSa), Argentina.
- Conditions
- Chagas Disease, Trypanosoma Cruzi Infection, Chronic Chagas Disease
- Trial name
- NCT07033325
- Testing
- Rapid diagnostic test (RDT) for Trypanosoma cruzi infection.
- Where
- 2 sites in Argentina
- Volunteers
- 2,568 people, healthy volunteers welcome
- Sponsor
- Mundo Sano Foundation
Triple-Negative Breast Cancer
A Trial Exploring the Opportune Administration of Nab-paclitaxel in the First Line Treatment, Camrelizumab Combined With Nab-paclitaxel and Famitinib, of TNBC.
The study is being conducted to evaluate the Opportune Administration of Nab-paclitaxel in the First Line Treatment Strategy, Camrelizumab and Famitinib with/without Nab-paclitaxel, of Patients with Unresectable Locally Advanced…
- Trial name
- NCT05670925
- Testing
- Camrelizumab plus Famitinib with/without nab-Palitaxel
- Where
- China
- Volunteers
- 46 people
- Sponsor
- Fudan University
Outpatients / Inpatients With Depression
Study on the Optimal Diagnosis and Treatment Strategy of Major Depressive Disorder Based on Anhedonia
This study is a multicenter clinical research and focuses on the exploring of optimal diagnosis and treatment strategies of MDD based on anhedonia.
- Trial name
- NCT05389046
- Testing
- Escitalopram, Escitalopram+Aripiprazole, Escitalopram+omega-3 PUFAs
- Where
- 3 sites in China
- Volunteers
- 252 people
- Sponsor
- Peking University
Triangular Fibrocartilage Complex Injury
Trial Comparing Treatment Strategies in Triangular Fibrocartilage Complex Ruptures
The trial is a multicentre, randomized, superiority, controlled, participant and outcome assessor (debridement versus placebo surgery randomization cohort) and trialist blinded (both arms) superiority, umbrella trial with two…
- Trial name
- REINFORCER (NCT04576169)
- Testing
- Arthroscopic Debridement, Arthroscopic or Open Repair, Physiotherapy
- Where
- 9 sites in Denmark, Finland and 1 more
- Volunteers
- 204 people
- Sponsor
- Tampere University Hospital
Critical Illness, Sepsis, Severe
Treatment Strategy of Human Gamma Globulin on the Therapy for Intensively Ill Children With Inflammatory Storm
The inflammatory storm in critically ill patients releases cytokines, causing systemic immune damage, which may be an important cause of multiple organ failure and even death.
- Trial name
- NCT04850456
- Where
- 2 sites in China
- Volunteers
- 200 people
- Sponsor
- Children's Hospital of Fudan University
Attention-deficit Hyperactivity Disorder
The Efficacy of Equine Assisted Occupational Therapy for Children With Attention Deficit Hyperactivity Disorder (ADHD) on Cognitive-emotional Aspects, Daily Function and Participation
The goal of this clinical trial is to develop and validate an Equine Assisted Occupational Therapy Intervention for children aged 6-12 with Attention Deficit Hyperactivity Disorder.
- Trial name
- NCT05869253
- Testing
- The efficacy of Equine Assisted Occupational Therapy, for children with Attention Deficit Hyperactivity Disorder (ADHD) on cognitive-emotional aspects, daily function and participation
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- Tel Aviv University
Chronic Pancreatitis
Treatment Strategy of Pancreatic Radiolucent Stone
Treatment strategy of chronic pancreatitis (CP) patients with large pancreatic radiolucent stone (≥ 5mm) has not been established.
- Trial name
- NCT04628273
- Testing
- encoscopic retrograde cholangio-pancreatography, extracorporeal shock wave lithotripsy
- Volunteers
- 52 people
- Sponsor
- Changhai Hospital
HFpEF - Heart Failure with Preserved Ejection Fraction, Atrial Fibrillation (AF)
Atrial Fibrillation with Heart Failure with Preserved Ejection Fraction: Treatment Strategies-Catheter Ablation Vs. Anti-Atrial Arrhythmia Drugs
A comparison of whether catheter ablation improves the prognosis (all-cause mortality and/or the composite endpoint of MACE) and reduces the recurrence rate of atrial fibrillation (AF) in patients with AF and heart failure with…
- Trial name
- NCT06740539
- Testing
- Catheter ablation of atrial fibrillation
- Where
- China
- Volunteers
- 304 people
- Sponsor
- Shanghai Chest Hospital
Diabetes Mellitus, Type 2, Integrated Traditional Chinese Medicine and Western Medicine
Integrated TCM - Western Medicine Strategy for Long - Distance Diabetes Management
The management of diabetes is of great value in reducing the risk of complications and alleviating the socioeconomic burden. Currently, the diabetes management models in China have not effectively integrated the advantages of…
- Conditions
- Diabetes Mellitus, Type 2, Integrated Traditional Chinese Medicine and Western Medicine, Telemedicine, Chronic Disease Management
- Trial name
- NCT07265037
- Testing
- Integrated TCM-Western Medicine Intelligent Diabetes Management Platform
- Where
- China
- Volunteers
- 10,000 people
- Sponsor
- Shanxi Bethune Hospital
Esophageal Cancer TNM Staging Primary Tumor (T) T4
Establishing Best Treatment Strategy for T4 Esophageal Cancer
The goal of this clinical trial is to investigate the safety and efficacy of a new treatment approach for T4-stage esophageal cancer, which involves chemoradiotherapy after induction chemotherapy.
- Trial name
- NCT06531434
- Testing
- "Docetaxel", "Cisplatin", "fluorouracil", "Radiation"
- Where
- Taiwan
- Volunteers
- 22 people
- Sponsor
- National Cheng-Kung University Hospital
Schizophrenia and Related Disorders, Immune Suppression
The Norwegian Prednisolone in Early Psychosis Study
Objective: The primary objective of this trial is to investigate whether prednisolone improves symptom severity as compared to placebo when given in addition to antipsychotic medication to patients with early-stage psychotic…
- Conditions
- Schizophrenia and Related Disorders, Immune Suppression, Psychosis, Cognitive Change
- Trial name
- NorPEPS (NCT03340909)
- Testing
- Prednisolone
- Where
- 3 sites in Norway
- Volunteers
- 12 people
- Sponsor
- Haukeland University Hospital
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.