Clinical trials: Therapy Strategies
Chemotherapeutic Toxicity, Cardiotoxicity
Strategy Therapy on Cancer Therapy-Related Cardiac Dysfunction
The investigators use the cancer registration system of National Cheng Kung University Hospital to timely screen and evaluate those patients having breast cancer or lymphoma to enroll patients to participate in this clinical…
- Conditions
- Chemotherapeutic Toxicity, Cardiotoxicity, Heart Failure, Breast Cancer
- Trial name
- NCT05892146
- Testing
- Prevention therapy, Rescue therapy
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- National Cheng-Kung University Hospital
Hypertension, Blood Pressure
Implementation of Multifaceted Patient-Centered Treatment Strategies for Intensive Blood Pressure Control (IMPACTS)
The IMPACTS study utilizes an effectiveness-implementation hybrid type 2 design to achieve two primary goals simultaneously: 1).
- Trial name
- IMPACTS (NCT03483662)
- Testing
- Multicomponent Intervention, Enhanced Usual Care
- Where
- 2 sites in United States
- Volunteers
- 1,272 people
- Sponsor
- Tulane University
Osteoporosis
Comparison of Osteoporosis Disease Management Strategies (0000-039)
The purpose of this study is to assess the impact of disease management interventions on bone mineral density screening rates and osteoporosis treatment rates in women age 50-64 years at high risk for osteoporosis.
- Trial name
- NCT00145080
- Testing
- Disease Management Assessment
- Volunteers
- 4,685 people
- Sponsor
- Merck Sharp & Dohme LLC
Carotid Artery Aneurysm
Carotid Artery Aneurysm Treatment Using CGuard Divert-And-Heal Strategy
Non-randomized, single arm, open label, academic observational study of CGuard MicroNet covered stent system use to achieve endovascular lumen reconstruction in carotid artery aneurysms with indications for treatment (enlarging…
- Trial name
- C-HEAL (NCT04434456)
- Testing
- CGuard stent implantation
- Where
- Poland
- Volunteers
- 25 people
- Sponsor
- John Paul II Hospital, Krakow
Bronchoscopy, Sedation
Sedation Strategies for Therapeutic Bronchoscopy
Therapeutic bronchoscopy is a common procedure to treat respiratory diseases. The procedure includes stent implantation, bronchus dilation, electronic incision, laser therapy, and so on.
- Trial name
- NCT03406546
- Testing
- Dexmedetomidine, Remifentanil, Laryngeal mask
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Changhai Hospital
Schizophrenia, Schizoaffective Disorder
Open-label Study of Curcumin C-3 Complex in Schizophrenia
Current evidence suggests that schizophrenia as a serious and complex psychiatric disorder, continues to challenge mental health professionals in their search for better treatment options in the community.
- Conditions
- Schizophrenia, Schizoaffective Disorder, Depression
- Trial name
- NCT01875822
- Testing
- Super-Curcumin
- Where
- Puerto Rico
- Volunteers
- 17 people
- Sponsor
- Woodbury, Michel, M.D.
Crohn's Disease, Mucosal Inflammation
Assessment of Mucosal Activity to Improve the Prognosis of Patients With Crohn's Disease Treated With Immunosuppressants
This study will test that individualized treatment in patients with Crohn's Disease in remission or mild clinical activity under immunosuppressants may improve prognosis, rather than just treating flares.
- Trial name
- ADACAL (NCT01562951)
- Testing
- ADALIMUMAB
- Where
- 30 sites in Belgium, France and 1 more
- Volunteers
- 15 people
- Sponsor
- Grupo Espanol de Trabajo en Enfermedad de Crohn y Colitis Ulcerosa
HIV-1-infection
Reducing Antiretroviral Treatments
The purpose of this trial is to demonstrate at W48 the non-inferiority of a dual nucleoside analogues strategy with tenofovir (TDF) or tenofovir alafenamide (TAF) plus emtricitabine (FTC) or lamivudine (3TC) preceded by a 16 week…
- Trial name
- ALTAR (NCT04051970)
- Testing
- Antiretroviral
- Where
- France
- Volunteers
- 360 people
- Sponsor
- ANRS, Emerging Infectious Diseases
Chronic Coronary Syndrome, Coronary Artery Bypass Graft CABG
Antiplatelet Strategy for CCS Patients Undergoing CABG
To evaluate the long-term outcomes of different antiplatelet strategies, including DAPT, aspirin monotherapy, and clopidogrel monotherapy, in CCS patients undergoing CABG.
- Trial name
- CABG_DAPT_SAPT (NCT06881901)
- Volunteers
- 29,898 people
- Sponsor
- Samsung Medical Center
Heart Failure
A Strategy of Home Telehealth for Management of Congestive Heart Failure(STARTEL)
To demonstrate the safety, feasibility, quality of life, primary caregiver satisfaction, and cost effectiveness of integrated Home Telehealth care versus standard care in a heart failure clinic.
- Trial name
- NCT00247000
- Testing
- Routine Care in a HF clinic vs Home Telehealth Care for HF
- Where
- Canada
- Volunteers
- 150 people
- Sponsor
- Nova Scotia Health Authority
In-stent Restenosis Lesion
Comparison of the Efficacy of Paclitaxel-releasing Balloon Catheter System Versus the Everolimus-Eluting Stent System for Treatment of In-Stent Restenosis Lesions - Harmonizing Optimal Strategy for Treatment of In-Stent Restenosis Lesions (The HOST-ISR Trial) -
In-stent restenosis (ISR) lesions are considered one of the toughest lesions that interventional cardiologists encounter in the drug eluting stent (DES) era.
- Trial name
- NCT01093300
- Testing
- Paclitaxel-eluting balloon catheter, Everolimus-eluting stent
- Where
- South Korea
- Volunteers
- 264 people
- Sponsor
- Seoul National University Hospital
Shoulder Dislocation or Subluxation
Rotofunc - Non-traumatic Shoulder Instability and Total Rotator Cuff Function
The goal of this clinical trial is to test the effect of a novel assessment and treatment strategy for young adults with severely disabling non-traumatic shoulder instability.
- Trial name
- ROTOFUNC (NCT06261645)
- Testing
- Early Physiotherapist selected active exercises, Delayed Physiotherapist selected active exercises
- Where
- Sweden
- Volunteers
- 100 people
- Sponsor
- Sahlgrenska University Hospital
HIV
A Multicentre Trial of Second-line Antiretroviral Treatment Strategies in African Adults Using Atazanavir or Lopinavir/Ritonavir
In the well recognized context of HIV infection chronicity, it is now crucial to identify and evaluate effective, well tolerated and affordable second line regimen in resources limited countries where patients often change…
- Trial name
- ALISA (NCT01255371)
- Testing
- Lopinavir, Atazanavir
- Where
- 2 sites in South Africa, Tanzania
- Sponsor
- ANRS, Emerging Infectious Diseases
Congenital Mitral Insufficiency
Study of Innovative Drug Treatment Therapy for Pediatric Mitral Regurgitation
The goal of this observational study is to compare the safety and effectiveness of a modified drug therapy with traditional drug therapy in pediatric patients with mild to moderate mitral valve regurgitation.
- Trial name
- NCT06037434
- Testing
- Captopril Tablets, Metoprolol Oral Tablet, Spironolactone Tablets
- Where
- China
- Volunteers
- 122 people
- Sponsor
- China National Center for Cardiovascular Diseases
Cutaneous T-Cell Lymphoma/Mycosis Fungoides, Cutaneous T Cell Lymphoma
A Study of Molecular Subtyping-based Therapeutic Strategies for Cutaneous T-cell Lymphoma
Cutaneous T-cell lymphoma (CTCL) is a group of diseases resulting from clonal hyperplasia of memory T cells in the skin. The increasing incidence and high treatment costs have posed significant challenges to public health and the…
- Trial name
- AMITY (NCT06436677)
- Testing
- molecular subtype based treatment
- Where
- 3 sites in China
- Volunteers
- 100 people
- Sponsor
- Peking University First Hospital
Acute Myelogenous Leukemia
A Risk-Oriented Therapeutic Strategy for Adult Acute Myelogenous Leukemia
The study was set up to assess: 1. A two-step, increasing-intensity remission induction phase. A conventional chemotherapy course (ICE, plus G-CSF) was followed, in unresponsive patients, by sequential high-dose cytarabine (plus…
- Trial name
- NCT00400673
- Testing
- Two-step remission induction and risk-oriented consolidation
- Where
- 12 sites in Italy
- Volunteers
- 581 people
- Sponsor
- Northern Italy Leukemia Group
Persistent Ductus Arteriosus
The Best Treatment Strategy: Surgical vs Pharmacological to Close the Ductus Arteriosus Persistent in Preterm Infants
The decision to treat patent ductus arteriosus in preterm infants, varies from a conservative, medical or immediate surgical treatment; although, at present, there is some controversy about this decision.
- Trial name
- NCT02602054
- Testing
- Surgical treatment, Control group
- Where
- Mexico
- Volunteers
- 40 people
- Sponsor
- Hospital General Naval de Alta Especialidad - Escuela Medico Naval
Schizophrenia
New Antipsychotic Strategies: Quetiapine and Risperidone vs. Fluphenazine in Treatment Resistant Schizophrenia
The purpose of this study is to: 1. Evaluate the efficacy and safety of the new antipsychotics, quetiapine (300-500mg/day) and risperidone (3-4mg/day) compared to each other and to fluphenazine (10-15mg/day), a high potency…
- Trial name
- NCT00161018
- Testing
- Quetiapine, Risperidone, Fluphenazine
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of Maryland, Baltimore
Stroke
Cognitive Strategies for Improving Health Outcomes And Managing Risk Post-Stroke
The proposed research will further develop the CHAMPS intervention which is self-management intervention to learn new skills, despite current health status of experience a stroke.
- Trial name
- CHAMPS (NCT06066788)
- Testing
- CHAMPS
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of New Mexico
Non Small Cell Lung Cancer, EGFR Gene Mutation
Treatment Strategies and Survival Outcome for Non-small Cell Lung Cancer With Oncogenic Mutation
The purpose of this study is to assess the Treatment Strategies and Survival Outcome for Non-small Cell Lung Cancer With Oncogenic Mutation.
- Conditions
- Non Small Cell Lung Cancer, EGFR Gene Mutation, ALK Gene Mutation, ROS1 Gene Mutation
- Trial name
- PIKACHU (NCT04322890)
- Testing
- Osimertinib, Alectinib 150 MG, Crizotinib 250 MG
- Where
- China
- Volunteers
- 6,000 people
- Sponsor
- Hunan Province Tumor Hospital
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