Clinical trials: Therapy Strategies
Leptospirosis, Jarisch Herxheimer Reaction
Ex Vivo Study of Leukocyte Responses in the Blood of Patients With Leptospirosis and ex Vivo Testing of a New Host-targeted Therapeutic Strategy to Restore Phagocytosis of Leptospira
Leptospirosis is a neglected zoonosis caused by pathogenic spirochetes of the genus *Leptospira*, occurring mainly in humid tropical and subtropical regions.
- Trial name
- NEUTROLEPTO-NC (NCT07611591)
- Testing
- 24 ml blood sample at H0, 16 ml blood sample at H3
- Volunteers
- 70 people
- Sponsor
- Institut Pasteur
Chronic Hepatitis B
A Novel Combination Therapeutic Strategy Aiming to Functional Cure for Chronic Hepatitis B Virus Infection (A)
Hepatitis B virus (HBV) infection is a major public health threat in China. At present, a functional cure, also known as clinical cure or sustained Hepatitis B surface antigen (HBsAg) loss, is recommended as the ideal endpoint of…
- Trial name
- NCT07852091
- Testing
- Sintilimab/Envafolimab, ETV/TDF/TAF
- Where
- China
- Volunteers
- 1,200 people
- Sponsor
- The Second Affiliated Hospital of Chongqing Medical University
Coronary Artery Disease
Harmonizing Optimal Strategy for Treatment of Coronary Artery Stenosis- CloPidogREl for Primary preVENTION (HOST-PREVENTION)
The investigators will evaluate the efficacy and safety of clopidogrel for primary prevention in patients diagnosed with coronary atherosclerosis on imaging that did not require revascularization therapy.
- Trial name
- NCT05845489
- Testing
- Clopidogrel treatment group, No antiplatelet or anticoagulant group
- Where
- 61 sites in South Korea
- Volunteers
- 11,086 people
- Sponsor
- Seoul National University Hospital
Stroke
Upper Limb Rehabilitation in First Year After Stroke Using Modern Treatment Strategies - a Single Case Study
Stroke is a major cause of disability in worldwide, causing billions of euros direct and indirect costs to the community. Upper limb motor dysfunction is seen in about 50% stroke survivors.
- Trial name
- NCT05520489
- Testing
- Repetitive Transcranial Magnetic stimulation, Robot Assisted Therapy, Enhanced upper limb therapy programme
- Where
- Finland
- Volunteers
- 15 people
- Sponsor
- Satasairaala
Obesity & Overweight
Scannographic Predictive Factors of Change of Strategy During Metabolic Bariatric Surgery
Background: Laparoscopic Roux-en-Y Gastric By-pass (LRYGB) is not always feasible due to intraoperative difficulties, necessitating a change during surgical procedure.
- Trial name
- SCANOBE (NCT07296224)
- Where
- France
- Volunteers
- 288 people
- Sponsor
- Central Hospital, Nancy, France
Rheumatoid Arthritis
TrEatment Targets in Rheumatoid Arthritis: TETRA-study
There is currently no cure for rheumatoid arthritis (RA), but many treatment options are available. The central aim of RA treatment is lowering disease activity.
- Trial name
- TETRA (NCT06046950)
- Testing
- Treatment target DAS28CRP-LDA, Treatment target SDAI-remission
- Where
- Netherlands
- Volunteers
- 340 people
- Sponsor
- Sint Maartenskliniek
Alcoholism
New Therapeutic Strategies for Inhibitory Control in Alcoholism
This experimental research studies the efficacy of two different treatments for inhibitory control improvement in alcohol-dependent individuals, one consisting of Retrieval-Extinction Learning ( alcohol AAT Task) and the other…
- Trial name
- NCT03058276
- Testing
- Retrieval-Extinction Learning, rTMS, SAM
- Where
- Spain
- Volunteers
- 105 people
- Sponsor
- Hospital Universitario 12 de Octubre
Multiple Myeloma
A Study to Assess Two Different Strategies of Combining Dexamethasone and VELCADE
The purpose of this study is to give patients who have had 4 or more prior lines of therapy for multiple myeloma access to VELCADE.
- Trial name
- NCT00063791
- Testing
- Bortezomib
- Where
- 3 sites in United States
- Sponsor
- Millennium Pharmaceuticals, Inc.
Hepatitis C, Hepatitis B
Simplified Antiviral Treatment Strategy for Hepatitis C in Myanmar
The project will evaluate cost and treatment outcomes of a simplified hepatitis C virus (HCV) testing, treatment and care model integrated with HIV testing and treatment among key affected populations including people who inject…
- Conditions
- Hepatitis C, Hepatitis B, HIV Infections
- Trial name
- NCT03579576
- Testing
- sofosbuvir 400 mg/velpatasvir 100 mg (SOF/VEL) orally once daily for 12 weeks with or without weight-based ribavirin.
- Where
- 3 sites in Burma
- Volunteers
- 803 people
- Sponsor
- Right to Care
Ulcerative Colitis, Unspecified
Impact of Anti-cytomegalovirus Treatment in the Management of Relapsing Ulcerative Colitis Requiring Vedolizumab Therapy
Ulcerative Colitis (UC) is an inflammatory bowel disease that can require the use of anti-TNF alpha therapy. When anti-TNF alpha failed to obtain a clinical response, the use of a new anti-integrin therapy, vedolizumab, can be…
- Trial name
- CYTOVEDO (NCT04064697)
- Testing
- Valganciclovir
- Where
- 8 sites in France
- Volunteers
- 6 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Acute Coronary Syndrome
High On-treatment Platelet Reactivity Identified by Multiple Platelet Function Assay
High on-treatment platelet reactivity to adenosine diphosphate was a important reason to cause ischemic events in antiplatelet therapy.
- Trial name
- HOPEmultiPFA (NCT02699008)
- Testing
- Clopidogrel, Ticagrelor
- Where
- China
- Volunteers
- 477 people
- Sponsor
- Wuhan Asia Heart Hospital
Lower Limb Ischemia
Use Art-assist and Neupogen to Treat Chronic Limb Ischemia
The purpose of this study is to measure the concentration of cells and proteins in the patient's blood during administration of Nuopogen (Filgrastim), a medication that is FDA approved for stem cell mobilization, in combination…
- Trial name
- NCT02408991
- Testing
- Neupogen, Art-Assist Device
- Where
- United States
- Sponsor
- University of Chicago
Follicular Lymphoma
Follicular Lymphoma IV/SC Rituximab Therapy (FLIRT)
Patient will receive either one infusion of rituximab IV and seven administrations of rituximab SC (experimental arm) or four infusions of rituximab IV (standard arm).
- Trial name
- FLIRT (NCT02303119)
- Testing
- Rituximab IV, Rituximab SC
- Where
- 50 sites in France
- Volunteers
- 221 people
- Sponsor
- The Lymphoma Academic Research Organisation
Incurable Disease
Generating Novel Therapeutic Strategies Based on Evolutionary Tumor Board
This study will evaluate the ability of a multidisciplinary group, the Evolutionary Tumor Board (ETB), to develop therapeutic strategies in patients without curative options.
- Trial name
- NCT04343365
- Testing
- Evolutionary Tumor Board (ETB)
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
Hepatoblastoma
A Multi-institutional Study for Treatment of Children With Newly Diagnosed Hepatoblastoma Using a Modified PHITT Strategy
A Phase 3 multi-institutional study for treatment of children with newly diagnosed hepatoblastoma using a modified Paediatric Hepatic International Tumour Trial (PHITT) strategy incorporating a randomized assessment of sodium…
- Trial name
- NCT04478292
- Testing
- Sodium Thiosulfate Injection, Primary surgery resection, mono CDDP-Group A2
- Where
- China
- Volunteers
- 330 people
- Sponsor
- Shanghai Children's Medical Center
Idiopathic Pulmonary Arterial Hypertension
Features of the Clinical Course and Prognosis in Patients With Idiopathic Pulmonary Hypertension When Using Modern Strategies of Specific Therapy
This study will be performed based on a retrospective analysis of the cases of 150-170 patients with IPAH observed at the Research Institute of Clinical Cardiology over the past 10 years, for a comparative assessment of the…
- Trial name
- NCT06587074
- Where
- Russia
- Volunteers
- 150 people
- Sponsor
- Russian Cardiology Research and Production Center
HIV/AIDS
The Intensified Treatment Monitoring Strategy to Prevent Accumulation of Drug Resistance (ITREMA) Trial
The ITREMA trial is an open-label randomized controlled trial (RCT) in which HIV-1 infected patients initiating first-line ART and already on first-line ART will be enrolled.
- Trial name
- ITREMA (NCT03357588)
- Testing
- Intensified monitoring, Standard of care monitoring
- Where
- South Africa
- Volunteers
- 501 people
- Sponsor
- UMC Utrecht
Overweight and Obesity
Familial Overweight: Comparing Use of Strategies
The purpose of this study is to compare the efficacy of two different approaches (prescribed \& self-directed) to the treatment of childhood obesity and their relative impact on child weight status, physical activity, and diet.
- Trial name
- FOCUS (NCT00746629)
- Testing
- FOCUS
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Seattle Children's Hospital
Sepsis
Controlled Fluid Resuscitation in Sepsis
To evaluate two different strategy of fluid resuscitation in sepsis patients
- Trial name
- NCT03214913
- Testing
- Early Goal Directed Therapy, Ruijin Strategy
- Volunteers
- 550 people
- Sponsor
- Ruijin Hospital
HIV Infections
Strategies for Delivering Anti-HIV Therapy in South Africa
Providing effective anti-HIV therapy in developing countries is challenging. This study will evaluate new strategies for delivering anti-HIV medications to people in South Africa.
- Trial name
- NCT00080522
- Testing
- Monitoring by HIV-trained primary care nurses, Community-based directly observed therapy (DOT), stavudine
- Where
- 2 sites in South Africa
- Volunteers
- 813 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
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