Clinical trials: Therapy Strategies
Patient Participation
Electronic Health Record Strategies to Promote Diverse Participation in Research
The purpose of this study is to determine the effectiveness of enhanced features in an online patient portal including banners, a chatbot, and direct to patient message and traditional mailed letters on increasing interest in…
- Trial name
- NCT05348603
- Testing
- Traditional Letter, Direct to Patient Message, Chatbot
- Where
- United States
- Volunteers
- 726,199 people, healthy volunteers welcome
- Sponsor
- Yale University
Airway Disease, Intubation; Difficult or Failed
Sequential Strategy vs Palpation vs Routine Ultrasound for Detection of Cricothyroid Membrane
EcoID is a study designed as an adaptive controlled clinical trial with a first phase of superiority and a second phase of non-inferiority with change of control, of parallel groups, random assignment and blinding of…
- Conditions
- Airway Disease, Intubation; Difficult or Failed, Ultrasound Therapy
- Trial name
- EcoID (NCT05535127)
- Testing
- Palpation with " laryngeal handshake" technique, Palpation strategy plus sequential ultrasound, Identification of the cricothyroid membrane with routine ultrasound
- Where
- Colombia
- Volunteers
- 258 people
- Sponsor
- Universidad de Antioquia
Acute Myocardial Infarction (AMI), Gastrointestinal Bleeding
Routine Use of Potassium Competitive Acid Blocker vs. Guideline-Directed Gastrointestinal Protection Strategy in Acute Myocardial Infarction
This study aims to compare the clinical outcomes between routine use of potassium competitive acid blocker (P-CAB) and guideline-directed gastrointestinal (GI) protection strategy in patients with acute myocardial infarction…
- Trial name
- PCAB-AMI (NCT07467213)
- Testing
- Zastaprazan, Proton Pump Inhibitors (PPI)
- Where
- South Korea
- Volunteers
- 5,000 people
- Sponsor
- Samsung Medical Center
Ischemic Stroke
Combination of Conditioned Medium and Umbilical Cord-Mesenchymal Stem Cells Therapy for Acute Stroke Infarct
The purpose of this study was to determine the effectiveness of a combination of intranasal conditioned medium (CM) with intraparenchymal umbilical cord mesenchymal stem cells (UC-MSCs) transplantation in acute stroke patients to…
- Trial name
- NCT05008588
- Testing
- Conditioned Medium, Umbilical Cord Mesenchymal Stem Cells, Neurologic and Neutrophic Drugs
- Where
- 2 sites in Indonesia
- Volunteers
- 15 people
- Sponsor
- PT. Prodia Stem Cell Indonesia
ARDS (Acute Respiratory Distress Syndrome), AI (Artificial Intelligence)
Exploration of Diagnosis and Treatment Strategies and Prognostic Prediction Models for Acute Respiratory Distress Syndrome Based on Radiographic Evaluations Assessed by Artificial Intelligence
By using multi-center chest CT data, an intelligent assessment model for the severity of ARDS was constructed. Based on CT quantitative features and clinical characteristics, a prediction model for short-term critical events…
- Trial name
- NCT07328997
- Testing
- CT scan
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Shanghai Zhongshan Hospital
Colorectal Cancer
Biological-guided Metronomic Chemotherapy as Maintenance Strategy in Metastatic Colorectal Cancer
Based upon biological behavior, those mCRC patients who respond well (SD, PR or CR according to RECIST Criteria) after 16-18 weeks of standard doublet chemotherapy as induction may enrolled into this study, randomly divided into…
- Trial name
- NCT03158610
- Testing
- Capecitabine
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Ruijin Hospital
Prostate Cancer
Identifying the Best Follow up Approach for People Who Have Had Treatment to Cure Newly Diagnosed Prostate Cancer
Over 20,000 patients a year in the UK get surgery or radiotherapy to cure their prostate cancer. These men then undergo regular check-ups to manage potential side effects and see if cancer recurs so it can be treated quickly.
- Trial name
- FOLLOW-UP (NCT07264088)
- Testing
- Hospital based follow up, Primary care based follow up, Planned shared care follow up
- Where
- United Kingdom
- Volunteers
- 100,000 people
- Sponsor
- Imperial College London
Preventive Effect of Quintuple Therapy on Metachronous Liver Metastases in Patients With Colorectal Cancer
Early Blocking Strategy for Metachronous Liver Metastasis of Colorectal Cancer Based on Pre-hepatic CTC Detection
In this study, the Quintuple method was applied for early intervention of prehepatic CTC-positive bowel cancer patients without dominant liver metastasis, aiming to explore the blocking effect of the Quintuple method on the…
- Trial name
- NCT05720559
- Testing
- Oxaliplatin, S1, Cetuximab
- Volunteers
- 100 people
- Sponsor
- Liaoning Cancer Hospital & Institute
Developmental Delay Disorders, Chromosome Deletion
Treatment Strategies for Children With Smith-Magenis Syndrome
This study will examine the effect of bright light or melatonin treatment on sleep in children with Smith-Magenis syndrome (SMS), a genetic disorder characterized by certain physical, behavioral and developmental features.
- Conditions
- Developmental Delay Disorders, Chromosome Deletion, Mental Retardation, Sleep Disorders, Circadian Rhythm
- Trial name
- NCT00506259
- Testing
- dTR Melatonin (NIH CC PDS), Phototherapy (Bright Light), Melatonin CR
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- National Human Genome Research Institute (NHGRI)
Social Anxiety Disorder, Tobacco Use Disorder
Adaptive Treatment Strategies for Improving Engagement With a Web-Based Smoking Intervention in Socially Anxious Smokers
This phase I trial will use a pilot sequential multiple assignment randomized trial (SMART) to examine protocol feasibility and acceptability of new components of a web-based intervention for socially anxious smokers.
- Trial name
- NCT04260776
- Testing
- Phase 1: Web-based intervention (MyWebQuit) with 1-way text messages, Phase 1: Web-based intervention (MyWebQuit) with interactive, 2-way text messages, Phase 2: re-engagement text messages
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Fred Hutchinson Cancer Center
Endometriosis, Infertility, Female
Innovative Non-Invasive Diagnostics and Personalized Treatment Strategies for Endometriosis Through Advanced Multi-Omics and Ultrasound Integration
Endometriosis is a prevalent gynecological condition affecting approximately 10% of women of reproductive age worldwide. It presents with nonspecific but often severe symptoms, including chronic pelvic pain (in 70% of cases) and…
- Trial name
- ENDO-NOVA (NCT07570225)
- Testing
- Non-invasive diagnosis of endometriosis
- Volunteers
- 365 people
- Sponsor
- Region Stockholm
Tooth Sensitivity
Non-carious Cervical Lesions and Treatments
This study will compare clinically the efficacy, time to action and duration of different treatments for patients with non-carious cervical lesions (NCCLs) that caused dentin hypersensitivity (DH).
- Trial name
- NCCL (NCT03403088)
- Testing
- Experimental: • Group LA, Experimental: • Group DE, Experimental: • Group RGI
- Where
- Brazil
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Schizophrenia
Treatment Strategy for Refractory Schizophrenia: Drug Interaction Between Clozapine and Fluvoxamine
Clozapine has been virtually the only psychopharmacological choice in patients with schizophrenia who either did not response to typical neuroleptics or experienced severe extrapyramidal side effects and consequently did not…
- Trial name
- NCT01401491
- Testing
- clozapine plus fluvoxamine
- Where
- Taiwan
- Volunteers
- 80 people
- Sponsor
- Taipei Medical University Hospital
Non-Small Cell Lung Cancer
A Retrospective Study About Treatment Strategy After First/Second Line EGFR-TKI Failure
This is a multi-center retrospective study, designing to access the best treatment strategy in non-small cell lung cancer (NSCLC) patients harboring EGFR mutant type after first/second line EGFR-TKI failure.
- Trial name
- NCT02618590
- Where
- China
- Volunteers
- 800 people
- Sponsor
- Sun Yat-sen University
Attention Deficit Disorder With Hyperactivity, Conduct Disorder
Medication Strategies for Treating Aggressive Behavior in Youth With Attention Deficit Hyperactivity Disorder
This study will assess whether adding a mood stabilizer, divalproex sodium, to stimulant treatment is more effective than stimulant treatment alone in reducing aggressive behavior among children with attention deficit…
- Conditions
- Attention Deficit Disorder With Hyperactivity, Conduct Disorder, Oppositional Defiant Disorder
- Trial name
- NCT00228046
- Testing
- Divalproex Sodium, Methylphenidate, Dextroamphetamine
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- Stony Brook University
Cervical Precancer, Cervical Intraepithelial Neoplasia
Point of Care - Triage and Treatment for Cervical Pre-cancer
This study evaluates a modified two-probe thermal ablation protocol using the IRIS™ device and retrospectively assesses an AI-based Automated Visual Evaluation (AVE) triage algorithm among HPV-positive women in El Salvador.
- Conditions
- Cervical Precancer, Cervical Intraepithelial Neoplasia, Human Papillomavirus Infection
- Trial name
- POC (NCT07461818)
- Testing
- IRIS™ Thermal Ablation Device
- Where
- El Salvador
- Volunteers
- 5,000 people
- Sponsor
- Basic Health International, Inc.
Hypertension
Personalised Pharmacometabolomic-guided Strategy Trial to Optimise Treatment for Hypertension
High blood pressure (hypertension) affects 1 in 3 adults and can lead to serious health issues like strokes and heart attacks. Medication can lower blood pressure (BP) and reduce complications.
- Trial name
- HYPERMARKER (NCT07294794)
- Testing
- Standard of Care (SOC), Pharmacometabolomic approach
- Where
- 4 sites in Germany, Netherlands and 2 more
- Volunteers
- 400 people
- Sponsor
- University of Birmingham
Atherosclerosis, Coronary Artery Disease
Efficacy CompariSon of Pre-stenting Atherectomy Versus Scoring ballooN for calcifieD Coronary Lesions Coronary Lesions
Design: The proposed study is a randomized study comparing the relative effectiveness of three lesion modification strategies (RA, SBS, or OAS) in the treatment of obstructive CCLs using the change in lumen size measurements…
- Trial name
- ECSPAND (NCT02819531)
- Testing
- Rotational atherectomy, Orbital atherectomy, Scoring balloon system
- Volunteers
- 30 people
- Sponsor
- North Texas Veterans Healthcare System
Cardiac Failure, Renal Failure
Protocolized Diuretic Strategy in Cardiorenal Failure
This research study is a randomized clinical trial to evaluate if taking diuretics (medications that increase urine production and help with fluid removal from the body) in a standardized fashion (using a guideline for adjusting…
- Conditions
- Cardiac Failure, Renal Failure, Kidney Failure
- Trial name
- ProDiuS (NCT01921829)
- Testing
- Protocolized Diuretic Strategy
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Kelly V. Liang, MD
Type 1 Diabetes
Closed-loop Control of Glucose Levels in the Context of Exercise in Adults With Type-1 Diabetes
Recent developments of continuous glucose sensors and insulin infusion pumps have motivated the research toward closed-loop strategies to regulate glucose levels in patients with type 1 diabetes.
- Trial name
- CLASS-01 (NCT01297946)
- Testing
- Conventional continuous subcutaneous insulin infusion therapy, Dual-hormone closed-loop
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- Institut de Recherches Cliniques de Montreal
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