Clinical trials: Therapy Strategies
Cancer, Malignancy
Novel Outreach Methods to Increase Enrollment to Early Phase Clinical Trials
This trial will study different outreach methods to assess impact on enrollment of underrepresented minorities (specifically African Americans) to early phase cancer clinical treatment trials.
- Conditions
- Cancer, Malignancy, Malignant Neoplasm
- Trial name
- NCT05886764
- Testing
- Digital Intervention, Community Outreach
- Where
- United States
- Volunteers
- 134 people
- Sponsor
- University of Chicago
Bipolar Disorder, Manic Depression
Inositol Hexaphosphate: A Novel Treatment Strategy for Bipolar Disorder?
Inositol hexaphosphate (IP6, also called inositol hexakisphosphate, and phytic acid) is a naturally occurring phosphorylated derivative of myo-inositol.
- Trial name
- NCT02081287
- Testing
- IP6, Lamotrigine
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- San Diego Veterans Healthcare System
Chronic Depression
Getting Biased Treatment Study: How Psychotherapy and Antidepressants Change Brain Activity in Chronic Depression
The purpose of this study is to determine how psychotherapy and pharmacotherapy respectively change brain activity in patients suffering from chronic depression.
- Trial name
- GETTY (NCT00596986)
- Testing
- Duloxetine, Cognitive Behavioural Analysis System of Psychotherapy
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- Charite University, Berlin, Germany
Hypertension
Personalised Pharmacometabolomic-guided Strategy Trial to Optimise Treatment for Hypertension
High blood pressure (hypertension) affects 1 in 3 adults and can lead to serious health issues like strokes and heart attacks. Medication can lower blood pressure (BP) and reduce complications.
- Trial name
- HYPERMARKER (NCT07294794)
- Testing
- Standard of Care (SOC), Pharmacometabolomic approach
- Where
- 4 sites in Germany, Netherlands and 2 more
- Volunteers
- 400 people
- Sponsor
- University of Birmingham
Mild-to-moderate Ulcerative Colitis
Study to Assess Effectiveness of Therapy Timely Adjustment Based on Self-monitoring in Patients Suffering From Mild-to-moderate Ulcerative Colitis (OPTIMISE Study)
The purpose of this study is to provide evidence that a therapy of Ulcerative Colitis (UC) disease adjusted on tight monitoring of non-invasive parameters, such as clinical symptoms and faecal calprotectin (FC) (substance that is…
- Trial name
- OPTIMISE (NCT04340895)
- Testing
- Faecal Calprotectin Home Test, PRO-2 Scoring
- Where
- 42 sites in Czechia, Hungary and 4 more
- Volunteers
- 250 people
- Sponsor
- Ferring Pharmaceuticals
Colorectal Cancer
PCSK9 Inhibitors in Combination With Advanced Treatment Strategies for the Treatment of Advanced Colorectal Cancer With pMMR/MSS
The purpose of this study is to preliminarily observe the efficacy and safety of PCSK9 inhibitors in combination with standard advanced first-line regimens in the treatment of advanced colorectal cancer with pMMR/MSS.
- Trial name
- NCT06391905
- Testing
- PCSK9 inhibitor in combination with standard advanced first-line regimen group, standard advanced first-line regimen group
- Volunteers
- 60 people
- Sponsor
- Guangdong Provincial People's Hospital
Tobacco Use, Smoking Cessation
Overcoming Nicotine Dependence to Enable Quitting
Tobacco use disorder is a chronic, relapsing health condition that necessitates a chronic care approach. However, traditional smoking cessation treatment programs allocate nearly all their resources only to those smokers who are…
- Conditions
- Tobacco Use, Smoking Cessation, Smoking Behaviors, Nicotine Dependence
- Trial name
- ON-DEQ (NCT05513872)
- Testing
- Nicotine Replacement Therapy (NRT) Sampling, Practice Quitting (PQ) Counseling, Motivational Interviewing (MI) Counseling
- Where
- United States
- Volunteers
- 780 people
- Sponsor
- Rush University Medical Center
Rejection Heart Transplant, Immunosuppression
Improving Immunosuppressive Therapy in Heart Transplantation
Cardiac allograft rejection (CAR) occurs in 30% to 40% of transplant recipients within the first year post-transplant, and carries an increased risk of both acute graft failure and reduced graft longevity.
- Trial name
- NCT03932539
- Where
- 4 sites in Italy
- Volunteers
- 25 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Stroke, Anesthesia
"GOLIATH" - General Or Local Anaestesia in Intra Arterial THerapy
Patients suffering a stroke with a large vessel occlusion is often treated intra veneous thrombolyse and on top of that also intra arterial therapy. It is unknown what form of anaestesia is best during intra arterial therapy.
- Conditions
- Stroke, Anesthesia, Cerebral Revascularization
- Trial name
- GOLIATH (NCT02317237)
- Testing
- Local anesthesia
- Where
- Denmark
- Volunteers
- 128 people
- Sponsor
- University of Aarhus
HIV, Substance Use
Couples Health CoOp Plus
This study addresses HIV prevention and treatment for young couples living in Cape Town, South Africa, through a comprehensive biobehavioral multilevel approach-the Couples Health CoOp Plus (CHC+).
- Conditions
- HIV, Substance Use, Stigma, Social
- Trial name
- CHC+ (NCT05310773)
- Testing
- Community Stigma Awareness and Education Workshop, Couples Health CoOp Plus (CHC+)
- Where
- South Africa
- Volunteers
- 962 people, healthy volunteers welcome
- Sponsor
- RTI International
Fluid Therapy, Postoperative Period
Effects of Restrictive Fluid Strategy on Postoperative Oliguric Pancreatic Surgery Patients
Reduced urinary output is a common postoperative issue for patients going through major surgery such as pancreatic surgery. Commonly this is treated by increasing fluid administration to the patients and sometimes also diuretics.
- Conditions
- Fluid Therapy, Postoperative Period, Postoperative Complications, Pancreas Disease
- Trial name
- NCT03553394
- Testing
- Ringer's Acetate
- Where
- Sweden
- Volunteers
- 53 people
- Sponsor
- Uppsala University
Adolescent Depression
An Adaptive Treatment Strategy for Adolescent Depression
The purpose of the study is: 1. to find out how long teenagers getting talk therapy (interpersonal psychotherapy) for depression should get therapy before the therapist decides whether or not the teenager is improving enough, and…
- Trial name
- PTAD (NCT01802437)
- Testing
- Fluoxetine, Increased Dose of Interpersonal Psychotherapy, Continue to Receive Initial Dose of Interpersonal Psychotherapy
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Minnesota
Treatment Resistant Depression
Psilocybin Versus Ketamine in Treatment-Resistant Depression
The main goal is to compare the antidepressant effects of psilocybin and ketamine in patients with TRD versus the antidepressant inactive substance midazolam.
- Trial name
- PSIKET_001 (NCT05383313)
- Testing
- Psilocybin, Ketamine Hydrochloride, Midazolam Ph. Eur 9.0
- Where
- Czechia
- Volunteers
- 60 people
- Sponsor
- National Institute of Mental Health, Czech Republic
Coronary Heart Disease
Harmonizing Optimal Strategy for Treatment of Coronary Artery Stenosis- EXtended Antiplatelet Monotherapy (HOST-EXAM)
Objectives : To compare the efficacy and safety of clopidogrel monotherapy with aspirin monotherapy in patients who received dual or triple antiplatelet therapy for 1 year (± 6 months) after drug-eluting stent implantation for…
- Trial name
- NCT02044250
- Testing
- Clopidogrel, Aspirin
- Where
- South Korea
- Volunteers
- 5,530 people
- Sponsor
- Seoul National University Hospital
Ischemic Cardiovascular Disease
CoPing strategIes-psyChological flexibiliTy in Patients Hospitalized for Ischemic cardiovascUlaR disEase (PICTURE)
The aim of this trial is to investigate the coping strategies/physiological flexibility construct in patients hospitalized for ischemic cardiovascular disease and the possible association with recurrence of clinical events (any…
- Trial name
- PICTURE (NCT05696873)
- Where
- Switzerland
- Volunteers
- 80 people
- Sponsor
- Cardiocentro Ticino
Degenerative Lumbar Spinal Stenosis
the Evaluation of Four Non-operative Treatments for Degenerative Lumbar Spinal Stenosis
Arthritis of the spine causes narrowing of the spinal canals and compression of the spinal nerves traveling into the legs, limiting walking ability.
- Trial name
- NCT02592642
- Testing
- Self-management Program, Workbook, Video, Pedometer, Instructional Workbook, Video, and Pedometer, Para-spinal TENS
- Where
- Canada
- Volunteers
- 104 people
- Sponsor
- Mount Sinai Hospital, Canada
Anxiety Disorders
Fluoxetine vs CBT in Childhood Anxiety Disorders
Treatment of every child with anxiety disorder begins with the question of which treatment to start first. Both fluoxetine and CBT have strong empirical support, but few studies have compared their initial effectiveness…
- Trial name
- SMART (NCT04760275)
- Testing
- Fluoxetine, Cognitive Behavioral Therapy (CBT)
- Where
- United States
- Volunteers
- 316 people
- Sponsor
- Children's Hospital Los Angeles
Gallbladder Stone
A Strategy for Gallstone Expulsion Through Dietary Therapy
This study is a double-blind, prospective, single-center controlled trial conducted at a tertiary hospital, aiming to determine whether dietary therapy can effectively expel gallstones.
- Trial name
- NCT06699030
- Testing
- Functional fatty acids
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Hepatopancreatobiliary Surgery Institute of Gansu Province
Gender Differences, Adherence, Medication
Gender Differences in Prevention Strategies and Therapeutic Adherence After Acute Myocardial Infarction
PARTICIPANT CENTERS: 25 hospitals managing routinely acute myocardial infarction (AMI) and representing different regions from Spain will be invited to participate.
- Conditions
- Gender Differences, Adherence, Medication, Therapeutic Adherence, Type 1 Acute Myocardial Infarction
- Trial name
- GENAMI (NCT05619601)
- Where
- 25 sites in Spain
- Volunteers
- 530 people
- Sponsor
- Spanish Society of Cardiology
Lung Cancer
Piloting 'mPal,' a Multilevel Strategy for Palliative Care Implementation
The purpose of this study is to assess the feasibility and acceptability of mPal, a multilevel implementation strategy to improve palliative care use among advanced stage lung cancer patients receiving cancer treatment.
- Trial name
- NCT05270395
- Testing
- mPal
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Laurie McLouth
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