Clinical trials: Thermogenesis
Diet-induced Thermogenesis, Brown Adipose Tissue Activation
Creatine Effect on Brown Adipose Tissue Activation
Pre-clinical studies indicate that creatine may play a substantial role in diet-induced thermogenesis and may have a profound effect on energy balance.
- Trial name
- CreaBAT (NCT04086381)
- Testing
- Creatine monohydrate
- Where
- Netherlands
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Maastricht University
Obesity, Diabetes
A Role for Brown Adipose Tissue in Postprandial Thermogenesis?
Brown adipose (fat) tissue (BAT) is a type of fat tissue found in certain small rodents and human babies that is capable of extremely high rates of energy burning.
- Conditions
- Obesity, Diabetes, Cardiovascular Disease
- Trial name
- NCT01974778
- Testing
- Meal
- Where
- Australia
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Bayside Health
Obesity
Effects of b3-Adrenergic Receptor Agonists on Brown Adipose Tissue
This study will test the hypothesis that human brown adipose tissue (BAT) can be activated using a β3-adrenergic receptor (AR) agonist.
- Trial name
- NCT01783470
- Testing
- beta3-adrenergic receptor agonist
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Aaron Cypess
Overweight
Whey Protein Micelles and Thermogenesis in Overweight Subjects
The main objective of the trial is to measure the thermogenic effect of two different doses of whey protein microgels. It will be a randomized crossover double-blind design conducted in 20 subjects.
- Trial name
- Thermowhey (NCT02303080)
- Testing
- Control (WPM 0), WPM 30, WPM 50
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Société des Produits Nestlé (SPN)
Obesity, Weight Loss
Effects of Intermittent Versus Continuous Energy Restriction on Metabolic Adaptation in Women With Obesity
One of the major challenges for treating obesity is to maintain a weight reduced state on the long term due to the high rate of weight regain.
- Trial name
- BREAK (NCT05184361)
- Testing
- Intermittent energy restriction (IER), Continuous energy restriction (CER)
- Where
- Portugal
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Universidade do Porto
Effect of Asthma Medication Salbutamol on Obesity
The Regulatory Function of Inhaled Asthma Medication Salbutamol on Thermogenesis
In recent years, obesity and its complications have severely threatened human health. Given the limited options for obesity treatment currently available, there is an urgent need to develop new drugs and therapeutic methods to…
- Trial name
- NCT06319183
- Testing
- Salbutamol
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Tongji University
Healthy
Effects of Dihydrocapsiate on Adaptive and Diet-Induced Thermogenesis With a High Protein Very Low Calorie Diet
The study is designed to determine the effects of a non-pungent supplement from sweet chilli pepper on resting metabolic rate and diet-induced thermogenesis (DIT) after a period of very low calorie intake over 4 weeks.
- Trial name
- NCT01142687
- Testing
- dihydrocapsiate capsule
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Diet Induced Thermogenesis
Effect of Within-Meal Consumption of Allulose on Diet-induced Thermogenesis
The objective of this study is to investigate the within-meal effects of allulose compared to sucralose and stevia on diet-induced thermogenesis, substrate oxidation, glycemic response, and subjective appetite in healthy normal…
- Trial name
- NCT07231133
- Testing
- Allulose, Stevia, Sucralose
- Where
- Canada
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Toronto Metropolitan University
Hypothyroidism
Effect of Hypothyroidism on Brown Adipose Tissue
The investigators aim to study whether hypothyroidism negatively affects Brown adipose tissue (BAT) function in humans and whether BAT function can be restored to normal by thyroid hormone supplementation.
- Trial name
- NCT02364102
- Where
- Switzerland
- Volunteers
- 42 people
- Sponsor
- University Hospital, Basel, Switzerland
Caffeine-Induced Thermogenesis, Brown Adipose Tissue Activation
Caffeine-Induced Thermogenesis Assessed by Infrared Thermography
This study evaluated thermogenic and physiological responses to 200 mg of caffeine administered following a carbohydrate gel in healthy adults.
- Trial name
- NCT07868302
- Testing
- Carbohydrate Gel, Caffeine
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Istanbul Health and Technology University
Diet-induced Thermogenesis
Inter-Individual Variability in Early Diet-Induced Thermogenesis After a Standardized Meal
This study aims to characterize how individuals differ in their metabolic response to food intake, specifically focusing on early diet-induced thermogenesis (DIT).
- Trial name
- NCT07610759
- Testing
- Standardized Liquid Meal
- Where
- Israel
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Tel Aviv University
Diet Induced Thermogenesis
Effect of Allulose on Diet-induced Thermogenesis
The objective of this study is to investigate the dose-response effect of allulose on diet-induced thermogenesis, substrate oxidation, glycemic response, and subjective appetite in healthy normal weight adults.
- Trial name
- NCT06515340
- Testing
- Allulose Dose 1, Allulose Dose 2, Allulose Dose 3
- Where
- Canada
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Toronto Metropolitan University
Heat Stress, Diet Induced Thermogenesis
Carbohydrate or Protein Drinks Before Exercise in the Heat
This project examines whether consuming a high-protein or high-carbohydrate beverage before exercise in the heat impacts metabolism and heat balance during exercise, with the following research questions: 1.
- Conditions
- Heat Stress, Diet Induced Thermogenesis, Protein Consumption
- Trial name
- NCT07646990
- Testing
- Protein shake, Carbohydrate shake
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Providence College
Obesity
Effects of Estrogen Deficiency on Energy Expenditure
Menopause is associated with weight gain, but the reasons why are not clear. In this study, the investigators will determine if reducing estrogen levels causes a decrease in the ability of the body to produce heat.
- Trial name
- NCT01846728
- Testing
- Estrogen suppression
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Neonatal Hypothermia, Brown Adipose Tissue
Investigation of the Mechanisms of the Tendency to Hypothermia in Newborns and Premature Neonates
Newborns have thermoregulatory mechanisms that differ from those of adults. Instead of producing heat through shivering, newborns primarily rely on non-shivering thermogenesis by the brown adipose tissue.
- Conditions
- Neonatal Hypothermia, Brown Adipose Tissue, Preterm and Term Infants, Neonate
- Trial name
- NCT06803069
- Where
- 2 sites in Hungary
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Pecs
Obesity & Overweight
Postprandial Thermogenesis in Obese Adolescents: Effect of Weight Loss
The prevention and management of pediatric obesity require a thorough understanding and consideration of the various components of energy balance (i.e., intake and expenditure) and their interactions.
- Trial name
- TEFAL (NCT07400159)
- Testing
- Anthropometric measurements, Body composition assessment, Leeds Foods Preference Questionnaire
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Centre Hospitalier Emile Roux
Overweight, Obesity
Energy Expenditure and Substrate Oxidation in a Whole Room Calorimeter
The investigators aim to establish a protocol for metabolic rate measurements obtained using continuous monitoring of oxygen consumption and carbon dioxide production in a whole room calorimeter setting.
- Conditions
- Overweight, Obesity, Body Weight
- Trial name
- NCT04061369
- Testing
- Low fat meal, Moderate fat meal, High fat meal
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- USDA, Western Human Nutrition Research Center
Type 2 Diabetes, Obesity
Activation of Brown Adipose Tissue Thermogenesis in Humans Using Formoterol Fumarate (GB10)
One emerging, highly modifiable homeostatic mechanism for energy expenditure in humans is brown adipose tissue (BAT) thermogenesis.
- Trial name
- GB10 (NCT05553184)
- Testing
- Formoterol Fumarate 12 micrograms Inhalation Powder, Nicotinic Acid 50 MG Oral Tablet, Acute Cold Exposure
- Where
- Canada
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Université de Sherbrooke
Healthy
Chronic Cold Exposure and Energy Metabolism in Humans
Background: Researchers are studying how metabolism and hormone levels change in response to mild changes in environmental temperature. Changes in metabolism may lessen with time because of hormonal adaptations.
- Trial name
- NCT01730105
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Energy Expenditure, Appetite
Evaluation of Metabolism-Boosting Beverages
The purpose of this study is to assess the effect of Metabolism-boosting Beverages (MBB) containing green tea extract with a standardized amount of epigallocatechin gallate (EGCG) and caffeine.
- Trial name
- NCT01029236
- Testing
- Medifast Metabolism-boosting Beverages
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Medifast, Inc.