Clinical trials: Thiamine
Heart Failure, Diabetes
Thiamine and Acute Decompensated Heart Failure: Pilot Study
Heart failure remains an increasing cause of morbidity and mortality in the United States even in the face of recent advances in the treatment of cardiovascular disease.
- Trial name
- NCT00680706
- Testing
- Thiamine
- Where
- 2 sites in United States
- Volunteers
- 131 people
- Sponsor
- Baystate Medical Center
Thyrotoxicosis
Thiamine Supplement in Patients With Severe Hyperthyroidism
Thyrotoxicosis is a hypermetabolic state in which there is increased utilization of thiamine. Thiamine deficiency has been observed in association with hyperthyroidism.
- Trial name
- NCT02767245
- Testing
- Thiamine
- Where
- Thailand
- Volunteers
- 12 people
- Sponsor
- Ramathibodi Hospital
Thiamine Deficiency
Trial of Thiamine Supplementation in Cambodia
Beriberi is a potentially fatal disease caused by vitamin B1 (thiamine) deficiency that still occurs in Southeast Asia despite near eradication elsewhere.
- Trial name
- NCT03616288
- Testing
- thiamine (as thiamine hydrochloride)
- Where
- Cambodia
- Volunteers
- 335 people
- Sponsor
- Mount Saint Vincent University
Congestive Heart Failure, Ischemic Cardiomyopathy
Feasibility and Effectiveness of Micronutrients as Palliative Care Therapy in Patients With Congestive Heart Failure
The purpose of this project is to conduct a preliminary test of the feasibility of a multi-micronutrient intervention to improve micronutrient status, cardiac function and quality of life in Veterans with Congestive Heart Failure…
- Trial name
- NCT01474486
- Testing
- Micronutrients
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Phoenix VA Health Care System
Primary Ciliary Dyskinesia
Glycine and Magnesium+Thiamine for the Treatment of Primary Ciliary Dyskinesia
Patients with primary ciliary dyskinesia (PCD) have trouble with clearing their bronchi from mucus, which in the long-term may produce severe damage to the lungs.
- Trial name
- NCT06959251
- Testing
- Glycine, Magnesium+thiamine
- Where
- Mexico
- Volunteers
- 60 people
- Sponsor
- Instituto Nacional de Enfermedades Respiratorias
Cancer, Neuropathy
Nutritional Supplement for Treating Chemotherapy Induced Neuropathy
Administration of a nutritional supplement containing palmitoyethanolamide, alpha lipoic acid, vitamin B12, vitamin B6 , vitamin B1, nicotinamide, magnesium, zinc, vitamin E, and superoxide of dismutase in individuals receiving…
- Conditions
- Cancer, Neuropathy, Chemotherapy Induced Pain Neuropathy, Chemotherapy-Induced Peripheral Neuropathy
- Trial name
- NCT07022938
- Testing
- Epineuron
- Where
- Greece
- Volunteers
- 71 people
- Sponsor
- Aristotle University Of Thessaloniki
Thiamine Deficiency, Congenital Heart Disease
Thiamine Influenced on Substrate Energy Effectiveness in Indonesian Children Undergoing Cardiopulmonary Bypass
This is a randomized, double-blind, controlled trial design. It was conducted with a main purpose of evaluating the effect of thiamine supplementation on serum lactate and lactate-pyruvate ratio after surgery as direct indicators…
- Conditions
- Thiamine Deficiency, Congenital Heart Disease, Cardiopulmonary Bypass
- Trial name
- NCT04453761
- Testing
- Neurobion
- Where
- Indonesia
- Volunteers
- 50 people
- Sponsor
- National Cardiovascular Center Harapan Kita Hospital Indonesia
Chronic Heart Failure
Thiamine Supplementation in Heart Failure Patients Receiving Full Medical Therapy
The study is performed to consider the effect of thiamine supplementation on symptoms and signs of patients with heart failure and systolic and diastolic function of left ventricle.
- Trial name
- NCT01115504
- Testing
- Thiamine
- Where
- Iran
- Volunteers
- 50 people
- Sponsor
- Mashhad University of Medical Sciences
Pharmacokinetics in Healthy Subjects
Pharmacokinetics of Oral Thiamine
Elevated levels of thiamine may increase cellular energy metabolism by increasing the activity of pyruvate dehydrogenase complex.
- Trial name
- NCT01433952
- Testing
- Thiamine
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Baystate Medical Center
Septic Shock, Ascorbic Acid Deficiency
Outcomes of Septic Shock Patients Treated With a Metabolic Resuscitation Bundle Consisting of Intravenous Hydrocortisone, Ascorbic Acid and Thiamine.
This is a retrospective chart review that will measure the impact on outcomes in septic shock patients who were resuscitated with a novel combination of medicines called iHAT (intravenous hydrocortisone -ascorbic acid-thiamine).
- Trial name
- NCT03913468
- Testing
- Intravenous Ascorbic Acid
- Where
- United States
- Volunteers
- 206 people
- Sponsor
- University of Wisconsin, Madison
Septic Shock
Blessing or Curse? Combined Vitamin Therapy in Non Viral Septic Shock.
Introduction: Septic shock leads to high morbidity and mortality in critically ill patients. Several lower-case scientific studies have supported the synergistic positive effect of vitamin C, thiamine, and hydrocortisone on…
- Trial name
- NCT06152458
- Testing
- Vitamin C
- Where
- Hungary
- Volunteers
- 43 people
- Sponsor
- University of Pecs
Dry Beriberi
Thiamine in Patients With Clinically Suspected Dry Beriberi
Abstract Background: Thiamine deficiency related disorders are increasingly being reported in countries where polished rice is the main dietary constituents and diet is not balanced in calorie, protein and micronutrients…
- Trial name
- NCT04977557
- Testing
- Thiamine
- Where
- Bangladesh
- Volunteers
- 55 people
- Sponsor
- Chittagong Medical College
Septic Shock, Critical Illness
Evaluation of Hydrocortisone, Vitamin C and Thiamine for the Treatment of Septic Shock
Despite recent medical advances, sepsis and septic shock remain a major cause of death. Sepsis is a syndrome with a wide array of physiologic, pathologic, and biochemical abnormalities.
- Trial name
- HYVITS (NCT03380507)
- Testing
- Triple therapy group
- Where
- Qatar
- Volunteers
- 106 people
- Sponsor
- Hamad Medical Corporation
Septic Shock
Vitamin C, Steroids, and Thiamine, and Cerebral Autoregulation and Functional Outcome in Septic Shock
This study has been approved as a nested substudy of a multicenter trial (CORVICTES, Clinicaltrials.gov Identifier: NCT03592693).
- Trial name
- CORVICTES-ΥΜ (NCT03649633)
- Testing
- Stress-dose Hydrocortisone plus Vitamin C
- Where
- Greece
- Volunteers
- 26 people
- Sponsor
- University of Athens
Septic Shock, Sepsis
Ascorbic Acid and Thiamine Effect in Septic Shock
The aim of this study is to evaluate the efficacy of early metabolic resuscitation with combination therapy using vitamin C and thiamine in improving organ function and survival in patients with septic shock.
- Trial name
- ATESS (NCT03756220)
- Testing
- Combination therapy of vitamin C and thiamine, Normal saline solution
- Where
- 6 sites in South Korea
- Volunteers
- 116 people
- Sponsor
- Tae Gun Shin
Septic Shock
Effects of Glucocorticoid Combined With Vitamin C and Vitamin B1 on Microcirculation in Severe Septic Shock
This study aimed to investigate the effect of Glucocorticoid combined with vitamin C and vitamin B1 versus hydrocortisone alone on microcirculation in septic shock patients.
- Trial name
- NCT03821714
- Testing
- Glucocorticoid combination therapy, Glucocorticoid
- Where
- China
- Volunteers
- 22 people
- Sponsor
- Southeast University, China
Alcoholism
High Dose Vitamin B1 to Reduce Abusive Alcohol Use
B1AS tests the hypothesis that increased vitamin B1 (thiamine) intake can repair brain systems damaged by alcohol and help people with alcohol problems control their alcohol use.
- Trial name
- B1AS (NCT00680121)
- Testing
- Benfotiamine
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of Kansas
Lactate Blood Increase, Thiamine Deficiency
The Thiamine Administration After Cardiac Surgery Trial
Thiamine (Vitamin B1) is essential for cell function and as a co-factor of the enzyme Pyruvate Dehydrogenase to initiate the Krebs cycle and thus the aerobic metabolism of glucose.
- Trial name
- TAACS (NCT04641104)
- Testing
- Thiamine 500 MG
- Where
- Belgium
- Volunteers
- 200 people
- Sponsor
- Sarah Saxena
Healthy
Dose-dependent Kinetics of Thiamin in Healthy Volunteers With and Without Functional OCT1 Hepatic Transporters
This study investigates the differences in thiamin (vitamin B1) kinetic parameters in two cohorts of healthy volunteers: Cohort 1) OCT1 wild type genotypes n = 12 Cohort 2) OCT1 deficient genotypes n = 12 Participants will be…
- Trial name
- THIAMO-1 (NCT06122701)
- Testing
- Thiamin p.o., Thiamin i.v.
- Where
- Germany
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University Medicine Greifswald
Delirium
Thiamine Administration and Prevalence of Delirium in the Intensive Care Unit: A Before-after Study
Delirium is a very common condition among ICU-admitted patients, and its prevalence is estimated between 30-40%. Delirium is associated with increased morbidity and mortality and future cognitive decline, along with increased…
- Trial name
- NCT04214106
- Testing
- intravenous Thiamine
- Where
- Israel
- Volunteers
- 1,000 people
- Sponsor
- Meir Medical Center