Clinical trials: Thinness
Cachexia, Lymphoma
Celecoxib in Managing Pain, Weight Loss, and Weakness in Patients With Advanced Cancer
RATIONALE: Celecoxib may help relieve moderate or severe pain associated with cancer. It may also decrease weight loss and improve muscle strength in cancer patients.
- Conditions
- Cachexia, Lymphoma, Melanoma (Skin), Ovarian Cancer
- Trial name
- NCT00093678
- Testing
- celecoxib, anticachectic therapy, nutritional support
- Sponsor
- Eastern Cooperative Oncology Group
Mechanical Ventilation
Study of Muscle Effects of BYM338 in Mechanically Ventilated Patients
The purpose of this study is to evaluate the effect of BYM338 on muscle mass and function in Group III failure to wean patients, as compared to placebo controls.
- Trial name
- NCT01868685
- Testing
- BYM338
- Sponsor
- Novartis Pharmaceuticals
Stage IV Non-small Cell Lung Cancer, Cachexia
Ruxolitinib for Cancer Cachexia
To assess toxicity with use of Ruxolitinib in NSCLC cachexia patients; to associate levels of JAK/STAT signaling in blood, adipose, and muscle pre- and post-ruxolitinib treatment with changes in cachexia and anorexia.
- Trial name
- NCT04906746
- Testing
- Identify any dose-limiting toxicity (DLT) when ruxolitinib is administered to NSCLC cachexia patients.
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Tu Dan
Cachexia
Single and Multiple Ascending Dose Study of NGM120 in Healthy Adult Subjects
The purpose is to evaluate the safety, tolerability, and PK of NGM120 in healthy adult subjects
- Trial name
- NCT03392116
- Testing
- NGM120
- Where
- Australia
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- NGM Biopharmaceuticals, Inc
Nutritional Deficiency, Cachexia
Optimal Protein Supplementation and Early Exercise In Mechanically Ventilated Patients
A Pilot Randomized Controlled Trial (RCT) will be conducted where where mechanically ventilated patients will be randomized to optimal protein (Achieve 80% protein supplementation adequacy with daily titration) versus standard…
- Trial name
- NCT05603585
- Testing
- Optimal protein supplementation to achieve 80% protein adequacy.
- Where
- Singapore
- Volunteers
- 150 people
- Sponsor
- National University Hospital, Singapore
Cachexia, Pancreatic Neoplasms
A Study of the Safety and Effectiveness of Infliximab (Remicade) in Patients With Pancreatic Cancer Related Cachexia
The purpose of this study is to evaluate the effectiveness and safety of infliximab, the active ingredient in Remicade, for the treatment of cachexia in pancreatic cancer patients who are receiving chemotherapy with gemcitabine.
- Trial name
- NCT00060502
- Testing
- Infliximab; Gemcitabine
- Volunteers
- 73 people
- Sponsor
- Centocor, Inc.
Cachexia
SUN11031 in Cachexia Associated With Chronic Obstructive Pulmonary Disease (COPD)
To evaluate SUN11031 for subcutaneous injection compared to placebo in subjects with cachexia associated with Chronic Obstructive Pulmonary Disease (COPD) to determine the effect on physical performance and body composition.
- Trial name
- NCT00698828
- Testing
- SUN11031 20 μg/kg, SUN11031 40 μg/kg
- Where
- 43 sites in United States, Argentina and 4 more
- Volunteers
- 227 people
- Sponsor
- Daiichi Sankyo
Visceral Leishmaniasis, Malnutrition
Visceral Leishmaniasis and Malnutrition in Amhara Regional State, Ethiopia
The project Visceral Leishmaniasis and Malnutrition is a cohort study that aimed to assess the association between malnutrition and visceral leishmaniasis (VL).
- Trial name
- VL&MNEthio (NCT02148822)
- Volunteers
- 520 people
- Sponsor
- Instituto de Salud Carlos III
Undernutrition, Underweight
Satiation Study With Children Attending a Tertiary Feeding Clinic
This is a pilot study of children attending the Glasgow feeding clinic (GFC) which looks after children with severe feeding problems who commonly have low appetite and extreme thinness.
- Trial name
- NCT04851327
- Testing
- High Energy preload, Low energy preload, Test meal
- Where
- United Kingdom
- Volunteers
- 17 people
- Sponsor
- University of Glasgow
Hematologic Diseases, Cachexia; Cancer
WB-EMS and Nutrition in Patients With Hematological Malignancies
This study evaluates the effects of a whole-body electromyostimulation (WB-EMS) training combined with individualized nutritional support on skeletal muscle mass, body composition, muscle strength/function, quality of life…
- Conditions
- Hematologic Diseases, Cachexia; Cancer, Leukemia, Myeloma
- Trial name
- NCT03556748
- Testing
- whole-body electromyostimulation
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- University of Erlangen-Nürnberg Medical School
Cancer, Cachexia; Cancer
Improvement of Neuromuscular Function, Fatigue and Quality of Life by Optimizing Muscle Building and Nutrition in Colorectal Cancer: a Pilot Study
This study is based on the assumption that muscle strength and muscle mass will be better preserved in an "intervention" group with specific management combining retraining and nutritional monitoring compared to the "no…
- Trial name
- ColCanter (NCT04136249)
- Testing
- Over physical activity
- Where
- France
- Volunteers
- 30 people
- Sponsor
- GCS Ramsay Santé pour l'Enseignement et la Recherche
Cachexia; Cancer; Sarcopenia
Telemedicine Nutritional Counseling for Cancer Cachexia in Pakistan
What is this study about? Cancer often causes unwanted weight loss and loss of appetite, a condition called "cancer cachexia." This affects patients' strength, quality of life, and ability to tolerate cancer treatment.
- Trial name
- TELE-CACHE (NCT07606417)
- Testing
- Telemedicine-Delivered Nutritional Counseling, Standard In-Person Nutritional Counseling
- Where
- Pakistan
- Volunteers
- 80 people
- Sponsor
- King Edward Medical University
Peritoneal Dialysis, Wasting and Malnutrition
The Effects Nutrition Status and Body Composition On Peritoneal Dialysis Outcome
A prospective long-term follow up of peritoneal dialysis patients' outcome correlates with nutritional status and body composition.
- Trial name
- NCT00990171
- Where
- Taiwan
- Volunteers
- 300 people
- Sponsor
- National Taiwan University Hospital
Moderate Acute Malnutrition (MAM), Undernutrition
Effectiveness of Positive Deviance/Hearth in Treating Uncomplicated Moderate Acute Malnutrition in Children 6-59 Months in Mymensingh Division, Bangladesh
The goal of this clinical trial (cluster randomized controlled trial) is to learn whether a Positive Deviance/Hearth (PDH) intervention can effectively treat moderate acute malnutrition (MAM) and reduce relapse compared to…
- Conditions
- Moderate Acute Malnutrition (MAM), Undernutrition, Wasting
- Trial name
- PD/Hearth MAM (NCT07591064)
- Testing
- PD/Hearth is a behavioral change program that teaches caregivers how to cook and feed their children. A nutrient-dense meal using local ingredients will be fed to children during Hearth sessions., Standard of Care (Investigator Selected)
- Where
- Bangladesh
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- World Vision US
Malnutrition, Stunting
Child Health, Nutrition and Microbiome Development
Childhood malnutrition is a global public health issue with devastating consequences on the health, well-being, and psychosocial development of children.
- Conditions
- Malnutrition, Stunting, Wasting, Underweight
- Trial name
- CHAMP (NCT05793294)
- Where
- 2 sites in Pakistan
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Khyber Medical University Peshawar
Underweight, Malnutrition
Study of Effect of Microfinance on Under 5 Health in Rural India
Investigators propose a feasibility and pilot study for a cluster randomised controlled trial. The proposed trial will evaluate the effects of an economic intervention (microfinance) in self-help groups of poor and marginalised…
- Trial name
- NCT01845545
- Testing
- Early provision of microfinance
- Where
- India
- Volunteers
- 2,469 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Shock Hypovolemic, Shock, Septic
Management of Shock in Children With SAM or Severe Underweight and Diarrhea
Diarrhea is one of the leading causes of under-five childhood mortality and accounts for 8% of 5.4 million global under-5 deaths.
- Conditions
- Shock Hypovolemic, Shock, Septic, Blood Transfusion, Adrenaline
- Trial name
- NCT04750070
- Testing
- Blood and Dopamine, Blood and adrenaline
- Where
- Bangladesh
- Volunteers
- 135 people
- Sponsor
- International Centre for Diarrhoeal Disease Research, Bangladesh
HIV, Pregnancy
Maternal Determinants of HIV-exposed and HIV-unexposed Fetal Growth, Birth Outcomes and Early Infant Growth
The purpose of this study is to understand how differences in the nutritional status and concentration of hormones and cytokines associated with cachexia in HIV+ and HIV- pregnant women living in a semi-rural and rural region of…
- Conditions
- HIV, Pregnancy, Malnutrition, Cachexia
- Trial name
- NCT01647841
- Where
- Tanzania
- Volunteers
- 218 people, healthy volunteers welcome
- Sponsor
- Cornell University
Resectable Pancreatic Adenocarcinoma
Identify microRNAs in Cachexia in Pancreatic Carcinoma
The purpose of this study is to determine the proportion of pancreatic patients who experience weight loss and cachexia, and to identify any differences in the genes between patient groups.
- Trial name
- SCC-miRPanCa (NCT05275075)
- Testing
- Pancreatic cancer microRNA and messenger RNA expression.
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Oklahoma
Chronic Kidney Diseases, Cachexia
CKD Cachexia and Gut Microbiome
Cachexia is common in patients with chronic kidney disease (CKD) and is associated with increased morbidity and mortality. Cachexia is a complex syndrome, in which inflammation and retention of uremic toxins are two main…
- Trial name
- DYNAMICA (NCT06986265)
- Testing
- Collection of clinical data and biological sampling
- Where
- 2 sites in Belgium
- Volunteers
- 157 people
- Sponsor
- Université Catholique de Louvain