Clinical trials: Thinness
Advanced Cancer, Weight Loss
Olanzapine in Patients With Advanced Cancer and Weight Loss
The goal of this clinical research study is to find the highest tolerable dose of the drug Olanzapine that can be given to patients with advanced cancer who are experiencing weight loss.
- Trial name
- NCT00489593
- Testing
- Olanzapine
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- M.D. Anderson Cancer Center
Anorexia
Mirtazapine Versus Megestrol Acetate in Treatment of Anorexia-cachexia in Advanced Cancer Patients.
This study was 8 weeks randomized, double-blind trail to assess the effect of mirtazapine versus megestrol acetate in treatment of anorexia-cachexia in advanced cancer patients in 80 patients.
- Trial name
- NCT05380479
- Testing
- Mirtazapine, Megestrol Acetate
- Where
- Bangladesh
- Volunteers
- 80 people
- Sponsor
- Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
Cachexia, Chronic Obstructive Pulmonary Disease
Safety, Tolerance and Efficacy of an Oral Nutritional Supplement in Chronic Heart Failure and Chronic Obstructive Pulmonary Disease Patients
To test the compliance, tolerance, safety and to get preliminary insights into the efficacy of a new oral nutritional supplement (containing n-3 fatty acids, amino acids and antioxidants) designed to prevent or delay cachexia and…
- Conditions
- Cachexia, Chronic Obstructive Pulmonary Disease, Chronic Heart Failure
- Trial name
- NCT00852020
- Testing
- oral nutrition supplement, food for special medical purposes
- Where
- 4 sites in Germany, Poland
- Volunteers
- 60 people
- Sponsor
- Fresenius Kabi
Cancer
Effect of Nutritional Formula (Protison) on Various Cancer Patients: A Randomized Clinical Trial
Many studies (including ASPEN/ESPEN) have demonstrated that balanced diet formula rich in omega 3 fatty acids (ω-3 FA), fibers, protein as well as mineral, vitamins (trace elements) are essential for cancer patients to improve…
- Trial name
- Protison (NCT04643613)
- Testing
- Protison cancer nutritional formula (PCNF)
- Where
- Taiwan
- Volunteers
- 42 people
- Sponsor
- Chung Shan Medical University
Cachexia
Retrospective Review of Cachexia in Lung and Gastrointestinal Cancer Patients
The objective is to perform a retrospective chart review of patients with cachexia related to cancer in patients treated at UT Southwestern Medical Center and Parkland Hospital to evaluate the prognosis and practice patterns in…
- Trial name
- NCT03606317
- Volunteers
- 20,000 people
- Sponsor
- University of Texas Southwestern Medical Center
Hepatocellular Carcinoma
Effects of EPA Supplementation on Patients With Unresectable Hepatocellular Carcinoma.
Dietary intervention with eicosapentaenoic acid combined with chemotherapy may shift inflammatory mediators toward resolution in non-resectable hepatocarcinoma and help to preserve muscle mass.
- Trial name
- NCT07664007
- Testing
- Eicosapentaenoic acid oral lipidic emulsion, Pacebo oral lipidic emulsion
- Where
- Spain
- Volunteers
- 18 people
- Sponsor
- Instituto de Investigación Sanitaria Aragón
Chronic Obstructive Pulmonary Disease (COPD), Muscle Atrophy
The Effect of Two Weeks of Voluntary Reduced Physical Activity in Chronic Obstructive Pulmonary Disease (COPD)
Chronic Obstructive Pulmonary Disease (COPD) is the most common pulmonary disease, responsible for considerable morbidity and mortality and is the third leading cause of death worldwide.
- Trial name
- NCT02221804
- Testing
- 14 days of voluntary step count reduction to no more than 1500 steps/day.
- Where
- United Kingdom
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust
Multiple Sclerosis
Safety and Efficacy of Fingolimod in Pediatric Patients With Multiple Sclerosis
To evaluate the safety and efficacy of fingolimod vs. interferon beta-1a i.m. in pediatric patients with multiple sclerosis (MS)
- Trial name
- NCT01892722
- Testing
- Interferon beta-1a, Fingolimod
- Where
- 73 sites in United States, Australia and 23 more
- Volunteers
- 240 people
- Sponsor
- Novartis Pharmaceuticals
Underweight
The Effect of Hormonal Contraceptives on Breast-milk Production and Infant Growth
The investigators propose a randomized clinical trial comparing the effect of 30 mcg ethinyl estradiol and LNG 150 combination oral contraceptive pills versus placebo, or LNG-IUS or Etonogestrel-releasing contraceptive implant…
- Trial name
- NCT01388582
- Testing
- LNG-IUS, Implanon, 30 mcg EE and 150 LNG oral contraceptive (Microvlar)
- Where
- Brazil
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Campinas, Brazil
Anorexia, Cachexia
Docetaxel With or Without Infliximab in Treating Weight Loss, Loss of Appetite, and Fatigue in Patients With Unresectable Non-Small Cell Lung Cancer (Infliximab Treatment Discontinued Effective 10/05/05)
RATIONALE: Drugs used in chemotherapy, such as docetaxel, work in different ways to stop tumor cells from dividing so they stop growing or die. Infliximab may improve cancer-related weight loss, lack of appetite, and fatigue.
- Conditions
- Anorexia, Cachexia, Fatigue, Lung Cancer
- Trial name
- NCT00040885
- Testing
- infliximab, docetaxel
- Where
- 188 sites in United States
- Volunteers
- 67 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Cancer-related Cachexia
Pilot Study of APD209 in Cancer Cachexia
Primary Objective: To assess the efficacy of APD209 in adult patients with active cachexia associated with advanced malignancy and not caused by simple starvation.
- Trial name
- NCT00895726
- Testing
- APD209
- Where
- United Kingdom
- Volunteers
- 13 people
- Sponsor
- Acacia Pharma Ltd
Malnutrition
Stunting Prevention Project in Thatta and Sujawal Districts, Sindh Province, Pakistan
Widespread food insecurity and malnutrition are largely the main impairing factors for human capital development in Pakistan. Rates of chronic malnutrition are very high, and acute malnutrition is critical: 44% of children under…
- Trial name
- NCT02422953
- Testing
- Wheat Soya Blend (WSB), Wawa Mum, Micronutrient Powders (MNP)
- Where
- Pakistan
- Volunteers
- 4,020 people, healthy volunteers welcome
- Sponsor
- Aga Khan University
Old Age; Cachexia, Dietary Habits
The Nutritionist's Educational Intervention on the Protein Intake in Hospitalized Elderly People
The food intake is often compromised in the elderly, and during hospitalization, dietary restrictions may be imposed, making them more susceptible to the risk of malnutrition and sarcopenia.
- Conditions
- Old Age; Cachexia, Dietary Habits, Sarcopenia, Protein Malnutrition
- Trial name
- NCT05502445
- Testing
- educational intervention
- Where
- Brazil
- Volunteers
- 58 people
- Sponsor
- Hospital Israelita Albert Einstein
Child Malnutrition, Breastfeeding
Impact of Behavior Change Communications and Market-based Approach to Delivering Micronutrient Powders on Stunting, Infant Feeding Practices and Anemia in Bangladesh
This complex evaluation of a large-scale program uses a cluster-randomized design where 20 geographic clusters (subdistricts) were randomized to study two sets of interventions.
- Conditions
- Child Malnutrition, Breastfeeding, Complementary Feeding, Childhood Anemia
- Trial name
- NCT01678716
- Testing
- EHC + BCC, Micronutrient powders, Mass media
- Where
- Bangladesh
- Volunteers
- 8,800 people, healthy volunteers welcome
- Sponsor
- International Food Policy Research Institute
Cancer, Psychosocial Functioning
Body Composition and Psychosocial Factors in ICI-Treated Cancer Patients
Evaluation of the effects of body composition, psychosocial factors, and drug-related problems on clinical progression (such as toxicity, treatment response, and quality of life) in cancer patients treated with immune checkpoint…
- Conditions
- Cancer, Psychosocial Functioning, Treatment Side Effects, Cachexia
- Trial name
- NCT07130981
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people
- Sponsor
- Hacettepe University
Cachexia; Cancer; Sarcopenia
The Role of the Muscle-nervous System Interface in Cancer Cachexia
Sarcopenia is an important component of cachexia associated with cancer, and their high incidence in cancer patients emphasizes the need for a better understanding of its mechanisms, which can result in better therapeutic…
- Trial name
- NUMANCAN (NCT03477721)
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- University of Roma La Sapienza
Non-small Cell Lung Cancer (NSCLC), Cachexia
A Study to Learn About the Study Medicine Called Ponsegromab in Adults With Lung Cancer-Associated Significant Body Weight Loss
Study to investigate the effect of ponsegromab on skeletal muscle mass and physical function in adult participants with non-small cell lung cancer associated cachexia.
- Trial name
- NCT07663630
- Testing
- ponsegromab
- Where
- 7 sites in United States, China
- Volunteers
- 80 people
- Sponsor
- Pfizer
Cachexia; Cancer
The Effect of Colon Cancer on Muscle Gene Expression, Body Composition, Muscle Function, and Muscle Metabolism
Rationale: Cancer cachexia is a complex metabolic syndrome characterized by clinically relevant loss of muscle mass with or without loss of fat mass.
- Trial name
- COMUNEX (NCT03789136)
- Testing
- Not applicable, observational study
- Where
- Netherlands
- Volunteers
- 55 people
- Sponsor
- Wageningen University
PCOS (Polycystic Ovary Syndrome), Stone, Urinary
Polycystic Ovary Syndrome and Urinary Tract Stones: a BMI-Adjusted Analysis in Iraqi Women
The goal of this observational case-control study is to find out the impact of PCOS as a risk factor for the presence of urinary tract stones taking into account the BMI of women aged 18-40 years consulting the gynecology and…
- Conditions
- PCOS (Polycystic Ovary Syndrome), Stone, Urinary, BMI, Obesity
- Trial name
- NCT06729359
- Testing
- Ultrasonography of the abdomen and pelvis
- Where
- Iraq
- Volunteers
- 407 people, healthy volunteers welcome
- Sponsor
- Al-Kindy College of Medicine
Lipid Overnutrition, Constitutional Thinness
Adaptation of Lipid and Energy Metabolism During a Lipid Overnutrition in Constitutional Thinness
For a given food intake, fat and energy metabolism in adipose tissue and muscle adapt to nutrient intakes. This adaptation to nutrition may be impaired in susceptible individuals or in obese patients by promoting weight gain…
- Trial name
- Surnutrition (NCT01224561)
- Testing
- Lipid overnutrition
- Where
- 3 sites in France
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne