Clinical trials: Third Degree Burns
Burn; Multiple Body Regions, Max. Second Degree, Third-Degree Burn
Safety, Tolerability and Efficacy of Nefopam Cream in Burn Patients
Burn patients very commonly develop abnormal scars after injury which can be red, raised or elevated, painful and very itchy. They can prevent normal movement of hands and other joints and lead to ugly deformities which makes…
- Conditions
- Burn; Multiple Body Regions, Max. Second Degree, Third-Degree Burn, Burn Degree Second
- Trial name
- NCT04685577
- Testing
- Nefopam
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- University of Alberta
Traumatic Skin Loss, 2nd and 3rd Degree Burn, Post Tumour Excision - Raw Areas Undergoes Split- Thickness Skin Grafts
Evaluation of the Use of Minced Skin Grafts for Promoting Donor Site Wound Healing After Split-Thickness Skin Grafting
Split-thickness skin grafting (STSG) is one of the most commonly performed procedures to achieve wound closure. Most studies are concerned on improving the appearance of scars and shortening the healing time of the recipient…
- Trial name
- NCT06488612
- Testing
- Minced skin grafts for donor site
- Where
- Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Sohag University
Deep Full-thickness Burn Injury (Disorder)
Evaluation of Safety and Efficacy of realSKIN® (Skin Xenotransplant) for Complete Closure of Severe Burn Wounds
This is a Phase 1/2, Open-label, Multi-center, Clinical Trial to evaluate the safety, tolerability, and efficacy of realSKIN® to provide complete wound closure of severe and extensive deep-partial and full-thickness burn wounds.
- Trial name
- NCT03695939
- Testing
- realSKIN (skin xenotransplant), Human Cadaver Allograft
- Where
- 2 sites in United States
- Volunteers
- 25 people
- Sponsor
- XenoTherapeutics, Inc.
Third Degree Burns, Diabetes
Study of ST266 in Diabetic Subjects With Deep Burns Managed With Skin Grafts
This study is a randomized, double blind, placebo controlled trial at a single site. The primary objective is to evaluate the safety of ST266 in diabetic subjects with deep burns.
- Trial name
- NCT01715012
- Testing
- ST266, Saline
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Noveome Biotherapeutics, formerly Stemnion
Burn Injury
Exercise in Burn Survivors: Cooling Modalities
This project will identify the efficacy of cooling modalities aimed to attenuate excessive elevations in skin and internal body temperatures during physical activity in well-healed burn survivors.
- Trial name
- NCT04512976
- Testing
- Control (no cooling modalities), Water Spray Only, Fan Only
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Burn Any Degree Involving 20-29 Percent of Body Surface, Burn Any Degree Involving 30-39 Percent of Body Surface
Predictive Mortality Scales in the Burn Patient Admitted to the Intensive Care Unit
The data for this retrospective study were collected from the records of patients admitted to the intensive care unit (ICU) for burns at Hospital La Paz from January 1, 2019 to May 31, 2023.
- Conditions
- Burn Any Degree Involving 20-29 Percent of Body Surface, Burn Any Degree Involving 30-39 Percent of Body Surface, Burn Any Degree Involving 40-49 Percent of Body Surface, Burn Any Degree Involving 50-59 Percent of Body Surface
- Trial name
- NCT07526610
- Where
- Spain
- Volunteers
- 465 people
- Sponsor
- Universidad Rey Juan Carlos
Second-degree Burn, Third-Degree Burn
Manuka Honey in Second- and Grafted Third-degree Burns
Treatment strategies of II. degree burn wounds and split-skin grafted III. degree burn wounds aim at reducing infection and improving reepithelialization.
- Trial name
- NCT03048188
- Testing
- wound dressing
- Where
- 2 sites in Germany
- Volunteers
- 10 people
- Sponsor
- University Hospital Schleswig-Holstein
Split-skin Grafted Third-degree Burn Wound
Trial of Different Wound Dressings in Split-skin Grafted Third Degree Burns
In plastic and reconstructive surgery, treatment strategies of second-degree burn wounds and split-skin grafted third-degree burn wounds aim at reducing infection and improving reepithelialization.
- Trial name
- NCT03674151
- Testing
- Silver Nylon dressing, Manuka-Honey, Povidone-Iod (PVP-Iod)
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- University Hospital Schleswig-Holstein
Burn With Full-Thickness Skin Loss
Autologous Keratinocyte Suspension Versus Adipose-Derived Stem Cell-Keratinocyte Suspension for Post-Burn Raw Area
In this study 1. Assess the efficiency of non-cultured autologous keratinocyte suspension in treating post-burn raw area. 2. Compare the results of keratinocyte suspension alone versus Adipose-derived mesenchymal stem…
- Trial name
- NCT03686449
- Testing
- Non-cultured Autologous Keratinocyte Suspension, Adipose-Derived Stem cell-Keratinocyte Suspension, Split skin graft
- Volunteers
- 33 people
- Sponsor
- Assiut University
Burn Degree Second, Burn Degree Third
Biological Skin Graft With Keratinocyte-stem Cell Co-cultre for Burn Patients
The goal of this clinical trial is to test whether artificial skin graft can substitute autologous skin graft in current burn treatment.
- Trial name
- NCT05652816
- Testing
- Split-thickness skin graft, Artificial skin graft, Artificial skin graft co-culture
- Where
- Indonesia
- Volunteers
- 20 people
- Sponsor
- Universitas Indonesia
Second- or Third-degree Burns
Allogeneic ADSCs and Platelet-Poor Plasma Fibrin Hydrogel to Treat the Patients With Burn Wounds (ADSCs-BWs)
The purpose of this study is to evaluate safety and efficacy of tissue engineered construct based on allogeneic cultured adipose-derived multipotent mesenchymal stromal cells (ALLO-ADSCs) and platelet-poor plasma fibrin hydrogel…
- Trial name
- ADSCs-BWs (NCT03113747)
- Testing
- ALLO-ASCs
- Where
- Ukraine
- Volunteers
- 20 people
- Sponsor
- A.A. Partners, LLC
Burns, Full Thickness Burn
A Single-stage Bilayered Skin Reconstruction With Glyaderm®
The study will explore the potential of utilizing Glyaderm® in a single-stage engrafting process, aiming for a more cost-effective approach.
- Conditions
- Burns, Full Thickness Burn, Necrotizing Fascitis
- Trial name
- NCT06249971
- Testing
- Dermal subsitute Glyaderm + skin graft, Skin graft alone
- Where
- Belgium
- Volunteers
- 82 people
- Sponsor
- University Hospital, Ghent
Third-degree Burns, Reconstructive Surgery
Evaluation of NEVELIA® in Terms of Safety and Efficacy for Third-degree Burns Treatment or Reconstructive Surgery
The dermal substitute NEVELIA® has received CE marking in July 9, 2013. Its use in the NEVAL protocol will be in accordance with its leaflet, i.e. for the treatment of burns or in case of reconstructive plastic surgery.
- Trial name
- NEVAL (NCT02089490)
- Testing
- NEVELIA® implantation
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Symatese
Second or Third Degree Burns
Acute and Long-Term Outcome Investigations of Fenofibrate on Severely Burned Patients
The purpose of this study is to learn the following: whether long-term treatment (6 months) with fenofibrate will decrease burn related sugar and fat increased in the blood and help prevent muscle loss and improve wound healing.
- Trial name
- NCT01574131
- Testing
- Fenofibrate, Sugar Pill
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- The University of Texas Medical Branch, Galveston
Burns
Fish Skin Compared to Cadaver Skin as Temporary Cover for Full Thickness Burns
Objectives and rationale: Optimal burn management involves removing all the dead or burned tissue as early as feasible and cover with an autograft called split thickness skin graft (STSG) taken from the patient.
- Trial name
- Kereburn (NCT03984331)
- Testing
- Fish skin, Cadaver skin
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Kerecis Ltd.
Burn Degree Second, Burn Degree Third
The Effect of Reflexology Massage and Passive Music Therapy Intervention Before Burn Dressing
Reflexology massage applied before burn dressing reduces pain, anxiety and sleep problems
- Trial name
- NCT04200053
- Testing
- Reflexology massage, Reflexology massage and passive music
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people
- Sponsor
- Saglik Bilimleri Universitesi
Third Degree Burns
Comparing Modified Meek and Mesh Techniques
This is a clinical trial study that compare two plastic surgery techniques in patients with third degree of burning and both techniques are used in all patients but in different areas of burning sites of the patients.
- Trial name
- NCT02285517
- Testing
- modified Meek skin grafting technique, mesh skin grafting technique
- Volunteers
- 20 people
- Sponsor
- Shahraki, Babak N., M.D.
Second or Third Degree Burns
Hypoalbuminemia in Burn Patients
The purpose of this study is to determine whether 5% human albumin solution, given to correct hypoalbuminemia, could improve organ dysfunction in burn patients as assessed by a change in the SOFA score from baseline to day 7 (or…
- Trial name
- Halburns (NCT01436292)
- Testing
- 5% human albumin solution (HAS)
- Where
- Canada
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Burn Wounds, Third-Degree Burn Wounds
HUMSCs Combined With Col I to Third-Degree Burn Wound
To evaluate the safety and tolerability of human umbilical cord mesenchymal stem cells combined with bovine type I collagen in the treatment of third-degree burn wounds.
- Trial name
- NCT07530003
- Testing
- HUMSCs combined with bovine type I collagen, bovine type I collagen, Sterile blank dressing / Vaseline gauze
- Where
- China
- Volunteers
- 108 people
- Sponsor
- The First Affiliated Hospital of Xinxiang Medical College
Burns, Self Efficacy
Smartphone Assisted Self-management Education for Adult Burn Patient At Aftercare
Burn rehabilitation management is dependent on the patients themselves, non-treatment adherence may delay the optimal timing of burn rehabilitation and it may not be regained easily.
- Conditions
- Burns, Self Efficacy, Burn Second Degree, Burns Third Degree
- Trial name
- NCT06263296
- Testing
- Self Management Education
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Queen Mary Hospital, Hong Kong