Clinical trials: Thoracic Aortic Aneurysms
Aortic Dissection, Aneurysm, Aortic Arch
Concave Supra-arch Branched Stent-Graft System for Treatment of Aortic Arch Diseases
There are no endoluminal stent systems available on the Chinese market for the effective treatment of aortic arch lesions (involving aortic arch aneurysms, aortic coarctation, aortic pseudoaneurysms, aortic ulcers, and intermural…
- Conditions
- Aortic Dissection, Aneurysm, Aortic Arch, Aortic Pseudoaneurysm, Aortic Ulcer, Penetrating
- Trial name
- NCT05996354
- Testing
- Concave Supra-arch Branched stent-graft system
- Where
- 3 sites in China
- Volunteers
- 10 people
- Sponsor
- China National Center for Cardiovascular Diseases
Aortic Aneurysm, Thoracic
Minimally Invasive Aortic Root and Aorta surGery rEgistry
Minimally invasive aortic valve (AV) surgery has become widely accepted alternative to standard sternotomy. Despite possible reduction in morbidity, this approach is not routinely performed for aortic surgery.
- Trial name
- MIRAGE (NCT04814238)
- Testing
- Aortic Root Surgery
- Where
- Poland
- Volunteers
- 2,000 people
- Sponsor
- Nicolaus Copernicus University
Aortic Dissection, Left Subclavian Artery Occlusion
Endovascular Repair With In Situ nEedle feNestration of Left Subclavian Artery to Treat AoRtic Dissection(RISEN STAR):A Multicenter Prospective Trial.
Background: Aortic dissection (AD) is a common emergency in vascular surgery, which seriously threatens human life and health. The rupture of Stanford type B dissection is located in aortic arch and the dissection range is from…
- Conditions
- Aortic Dissection, Left Subclavian Artery Occlusion, Vascular Diseases, Interventional Therapy
- Trial name
- NCT05186181
- Testing
- In situ fenestration
- Where
- China
- Volunteers
- 217 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Penetrating Ulcer of Aorta, Aneurysm Aortic
Evaluation of the Valiant Captivia Physician Fenestrated Stent Graft System in Aortic Arch and Descending Thoracic Aorta Pathologies
The study objectives are to assess safety and effectiveness, measured acutely and at the 30-day visit after implantation of the Valiant Captivia physician fenestrated Stent Graft.
- Conditions
- Penetrating Ulcer of Aorta, Aneurysm Aortic, Type B Aortic Dissection, Residual Dissection After Type A Repair
- Trial name
- EVERGREEN (NCT05479305)
- Testing
- The Valiant Captivia Stent Graft
- Where
- 4 sites in France
- Volunteers
- 30 people
- Sponsor
- Ceric Sàrl
Thoracic Aortic Aneurysm, Aortic Dissection
B-SAFER: Branched Stented Anastomosis Frozen Elephant Trunk Repair
A prospective, single-center, non-blind, non-randomized safety and feasibility study of the hybrid repair of thoracic aortic pathologies requiring repair of the aortic arch proximal to the origin of innominate artery.
- Conditions
- Thoracic Aortic Aneurysm, Aortic Dissection, Congenital Aortic Anomaly
- Trial name
- B-SAFER (NCT04747626)
- Testing
- B-SAFER
- Where
- United States
- Volunteers
- 590 people
- Sponsor
- Eric Roselli, M. D.
Genetic Predisposition, Paraganglioma
Using the EHR to Advance Genomic Medicine Across a Diverse Health System
Given the expansion of indications for genetic testing and our understanding of conditions for which the results change medical management, it is imperative to consider novel ways to deliver care beyond the traditional genetic…
- Conditions
- Genetic Predisposition, Paraganglioma, Pheochromocytoma, ALS
- Trial name
- NCT06377033
- Testing
- Behavioral nudge
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- University of Pennsylvania
Aorta, Thoracic Pathologies, Aortic Aneurysm, Thoracic
RE-GENERATION: The Safety and Performance of the Relay Pro and Relay NBS Pro Stent-graft Devices in the European Union (EU)
The objective of the study is to evaluate the safety and performance of Relay Pro and Relay NBS Pro devices in humans having thoracic aortic pathologies. Clinical results will be used to apply for the CE certification.
- Conditions
- Aorta, Thoracic Pathologies, Aortic Aneurysm, Thoracic, Aortic Aneurysm
- Trial name
- RE-GENERATION (NCT03207568)
- Testing
- Thoracic Endovascular Aortic Repair (TEVAR)
- Volunteers
- 30 people
- Sponsor
- Bolton Medical
Aortic Aneurysm, Thoracic
Impact of Anesthesia on the Dimension of the Ascending Aorta
The aim of this study is to evaluate the accuracy and reliability of intra-operative TEE after the induction of anesthesia when assessing proximal thoracic aorta diameters in a cohort of aortic aneurysm patients.
- Trial name
- NCT03431870
- Testing
- Trans-esophageal echocardiography
- Where
- Israel
- Volunteers
- 20 people
- Sponsor
- Sheba Medical Center
Acute Aortic Dissection, Aortic Rupture
Thoraflex Hybrid Post-Market Study
This is a global, prospective non-interventional, multi-centre, post-market study of the Vascutek Thoraflex™ Hybrid system in patients with acute thoracic aortic syndrome, subacute/chronic dissection of the aorta and aortic…
- Conditions
- Acute Aortic Dissection, Aortic Rupture, Penetrating Aortic Ulcer, Aortic Dissection
- Trial name
- THOR (NCT03414866)
- Testing
- EQ-5D-5L QOL questionnaire
- Where
- 7 sites in Canada, Germany and 2 more
- Volunteers
- 182 people
- Sponsor
- Vascutek Ltd.
Aortic Dissection, Aortic Aneurysm
A PMCF Study in Patients With Acute or Chronic Aortic Dissection or Aortic Aneurysm Treated With E-vita OPEN NEO
The NEOS post-market clinical follow-up study is undertaken to demonstrate the safety and clinical performance of E-vita OPEN NEO in the treatment of aneurysm or dissection in the ascending aorta, aortic arch and descending…
- Trial name
- NEOS (NCT04676672)
- Testing
- Open repair
- Where
- 2 sites in Austria, Germany
- Volunteers
- 163 people
- Sponsor
- JOTEC GmbH
Myocardial Infarction, Ischemic Stroke
Understanding the Role of Autoimmune Disorders on the Initial Presentation of Cardiovascular Disease
Autoimmune diseases are diseases in which inappropriate immune responses that have the capability of harming host cells play an important role.
- Conditions
- Myocardial Infarction, Ischemic Stroke, Stroke, Subarachnoid Haemorrhage
- Trial name
- NCT02062021
- Testing
- No intervention
- Where
- United Kingdom
- Volunteers
- 200,000 people, healthy volunteers welcome
- Sponsor
- University College, London
Abdominal Aortic Aneurysm, Thoracic Aortic Aneurysm
Terumo Aortic Global Endovascular Registry
Multi-arm, multi-center, open label, prospective observational registry designed to obtain safety and performance data on the use of CE marked and custom Terumo Aortic endovascular grafts.
- Conditions
- Abdominal Aortic Aneurysm, Thoracic Aortic Aneurysm, Surgery
- Trial name
- TiGER (NCT04246463)
- Testing
- Thoracic, Abdominal, Custom Device
- Where
- 58 sites in United States, Belgium and 8 more
- Volunteers
- 1,000 people
- Sponsor
- Vascutek Ltd.
Thoracic Aortic Aneurysm
Intravascular Ultrasound (IVUS) in Complex Aortic Endovascular Interventions
The study aims to investigate the applicability of intravascular ultrasound (IVUS) in the endovascular therapy of juxta-, supra- and thoracoabdominal aortic aneurysms.
- Trial name
- NCT04663074
- Testing
- IVUS control
- Where
- 6 sites in Denmark, Germany and 2 more
- Volunteers
- 80 people
- Sponsor
- University Hospital Muenster
Aortic Aneurysm, Thoracic, Aorta, Lesion
Evaluation of the GORE® TBE Device in the Treatment of Lesions of the Aortic Arch and Descending Thoracic Aorta, Zone 0/1
The objective of this study is to determine whether the GORE® TAG® Thoracic Branch Endoprosthesis is safe and effective in treating lesions of the aortic arch and descending thoracic aorta.
- Trial name
- SSB 11-02 (NCT02777528)
- Testing
- GORE® TAG® Thoracic Branch Endoprosthesis, Revascularization Procedure
- Where
- 39 sites in United States, Japan
- Volunteers
- 79 people
- Sponsor
- W.L.Gore & Associates
Aortic Dissection
Safety and Efficacy Study Of The Thoracic Aortic Stent Graft System Treating Aortic Dissection
This is a prospective, multicenter and single-arm trail to study the safety and efficacy of the thoracic aortic stent graft system that specially designed for treating aortic dissection.
- Trial name
- NCT05430672
- Testing
- The Thoracic Aortic Stent Graft System (Zylox-Tonbridge Medical Technology Co., Ltd. )
- Where
- 14 sites in China
- Volunteers
- 120 people
- Sponsor
- Zhejiang Zylox Medical Device Co., Ltd.
Hemorrhage, Thoracic Aneurysm
Bloodtranfusions After Aortic Surgery
The purpose of this study is to answer the following question: Leads a primary coagulation corrected with a single dose of fibrinogen concentrate after ascending aorta-arc reconstruction to a decrease in the number of allogenic…
- Trial name
- FIBTEG (NCT02299947)
- Testing
- Haemocomplettan P
- Where
- Netherlands
- Volunteers
- 27 people
- Sponsor
- St. Antonius Hospital
Solitary Pulmonary Nodules, Multiple Pulmonary Nodules
Extracolonic Findings on Computed Tomography (CT) Colonography
The ACRIN 7151 trial will use medical records abstraction data from participants with extracolonic findings (ECFs) reported from the ACRIN 6664 National CT Colonography Trial to: 1) measure incidence of diagnostic imaging…
- Conditions
- Solitary Pulmonary Nodules, Multiple Pulmonary Nodules, Renal Neoplasms, Adrenal Gland Neoplasms
- Trial name
- ACRIN7151 (NCT01465425)
- Volunteers
- 520 people
- Sponsor
- American College of Radiology Imaging Network
Familial Thoracic Aortic Aneurysm and Aortic Dissection
Application of Linkage Analysis in the Identification of Novel Hereditary Factors in Familial Aneurysms
The aim of this study is to describe the effectiveness of the application of Linkage Analysis, compared to the standard procedures currently provided by the italian NHS, in the identification of thoracic aortic aneurysms and…
- Trial name
- ORPHADIAG (NCT06783803)
- Testing
- Linkage Analysis
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- IRCCS Policlinico S. Donato
Surgical Procedures
Study of GSK1278863 to Reduce Ischemic Events in Patients Undergoing Thoracic Aortic Aneurysm Repair
This study will test the hypothesis that GSK1278863 will reduce neurologic, renal, and/or cardiac ischemia in patients undergoing elective descending thoracic aorta/thoracoabdominal aortic aneurysm (DTA/TAAA) repair, a population…
- Trial name
- NCT01920594
- Testing
- GSK1278863
- Where
- 15 sites in United States, Canada
- Volunteers
- 57 people
- Sponsor
- GlaxoSmithKline
Stable Angina, Unstable Angina
Serum Uric Acid Levels and Onset of Cardiovascular Diseases: a CALIBER Study
Serum uric acid level is a commonly measured biomarker. The association between serum uric acid level and the risk of developing cardiovascular diseases has been observed in some studies, while others showed controversial…
- Conditions
- Stable Angina, Unstable Angina, Myocardial Infarction, Unheralded Coronary Heart Disease Death
- Trial name
- NCT03425305
- Volunteers
- 180,000 people, healthy volunteers welcome
- Sponsor
- University College, London