Clinical trials: Thoracic Spinal Cord Trauma
Spinal Cord Injury (SCI)
Trunk Balance and Functional Independence in Individuals With SCI
This study investigates the relationship between trunk balance, position sense, wheelchair skills, and functional independence in individuals with thoracic spinal cord injury.
- Trial name
- SCI (NCT06612112)
- Testing
- No Interventions
- Where
- Turkey (Türkiye)
- Volunteers
- 32 people
- Sponsor
- Afyonkarahisar Health Sciences University
Spinal Cord Injury
Modified Yoga for Pulmonary Function and Quality of Life in Spinal Cord Injury Patients
This pilot interventional study evaluated whether adding wheelchair-adapted Modified Yoga Therapy to conventional physical rehabilitation could improve pulmonary function, respiratory muscle strength, and quality of life in…
- Trial name
- Leave blank (NCT07842003)
- Testing
- Conventional Physical Rehabilitation Therapy, Modified Yoga Therapy
- Where
- India
- Volunteers
- 29 people
- Sponsor
- Government (CL&SC) Spine Institute and Hospital, Ahmedabad
Hypotension, Spinal Cord Injury
Effect of Tadalafil (Cialis) on the Cardiovascular System of Spinal Cord Injury (SCI) Males
To address the effect of tadalafil (Cialis) on the cardiovascular system of men with complete spinal cord injury at T-6 and above. The hypothesis is that tadalafil will cause significant hypotension in people with tetraplegia.
- Trial name
- NCT01067391
- Testing
- tadalafil
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University of Manitoba
Spinal Cord Injuries
Extracorporeal Shockwave Therapy (ESWT) to Improve Function in Chronic ASIA-A Patients
The global prevalence of spinal cord injury is estimated between 236 to 4187/Million. A spontaneous recovery of the sense-motoric function is decreasing with the time after injury and is only seen sporadically after 1 to 2 years.
- Trial name
- NCT03399968
- Testing
- ESWT
- Where
- 2 sites in Austria
- Volunteers
- 25 people
- Sponsor
- AUVA Trauma Center Meidling
Spinal Cord Injuries
Transcutaneous Spinal Cord Stimulation Combined With Arm Bike for Cardiovascular Recovery in SCI
Spinal cord injury (SCI) can make it hard for the body to self-regulate some of its automatic functions like blood pressure, breathing, and heart rate.
- Trial name
- NCT06313515
- Testing
- Transcutaneous Spinal Cord Stimulation, Arm-crank bike exercise
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- University of Washington
Spinal Cord Injuries (Complete and Incomplete), Spinal Cord Injury
Electrical Neuromodulation for Modifying Spinal Network Involved in Spasticity
Muscle stiffness and muscle spasms are common after spinal cord injury. They can interfere with washing and dressing, moving between the bed and a wheelchair, walking, and sleep, and they can cause pain.
- Conditions
- Spinal Cord Injuries (Complete and Incomplete), Spinal Cord Injury, Spinal Cord Injury Cervical, Spinal Cord Injury Thoracic
- Trial name
- NCT07792616
- Testing
- Transcutaneous spinal stimulation at 30 Hz, Transcutaneous spinal stimulation at 75 Hz, Tizanidine
- Where
- 2 sites in United States
- Volunteers
- 12 people
- Sponsor
- University of Mississippi Medical Center
Spinal Cord Injury, Spinal Cord Injury Thoracic
Investigating the Impact of Spinal Cord Electrical Stimulation Combined With Individualized Physical Therapy on Lower Extremity Function in Patients With Spinal Cord Injury
This study aims to understand the differences in the effects of two rehabilitation approaches on lower limb function recovery in patients with spinal cord injuries: 1.
- Conditions
- Spinal Cord Injury, Spinal Cord Injury Thoracic, Spinal Cord Injury/Damage, Spinal Cord Injury T1-L2
- Trial name
- NCT07037628
- Where
- Taiwan
- Volunteers
- 76 people
- Sponsor
- Lian-Cing Yan, MSPT
Amyotrophic Lateral Sclerosis (ALS), Angina, Stable
Quest to Analyze One Thousand Humans Meditating
This study will be focused on assessing the molecular, physiological, and emotional correlates of an intensive meditation experience in the context of a retreat setting in a large 2000 plus-person cohort comprised of healthy and…
- Conditions
- Amyotrophic Lateral Sclerosis (ALS), Angina, Stable, Anxiety, Asthma
- Trial name
- QUANTUM (NCT06583395)
- Testing
- Advanced multi-component meditation practice
- Where
- United States
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Tobias Moeller-Bertram
Spinal Cord Injury, Tetraplegia
Effect of Air-stacking on Peak Cough Flow in Patients With Acute Cervical or High Thoracic Spinal Cord Injury
Respiratory complications continue to be one of the leading causes of morbidity and mortality in people with spinal cord injury, especially among cervical and higher thoracic injuries.
- Trial name
- NCT01046175
- Testing
- Air-stacking with a manual resuscitator, Air-stacking with ventilator
- Where
- Norway
- Volunteers
- 10 people
- Sponsor
- Ullevaal University Hospital
Spinal Cord Injury, Paralysis
Restoration of Standing and Walking With ISMS in Humans
Spinal cord neural circuitry exists in the lumbar enlargement that makes it possible to stand and create synergistic, rhythmic stepping activity in the lower limbs.
- Trial name
- ISMS (NCT02899858)
- Testing
- Movement Assessment, MRI Scan, IntraSpinal Micro-Stimulation
- Where
- United States
- Sponsor
- Vanderbilt University
Spinal Cord Injuries, Spinal Cord Diseases
Stimulation With Wire Leads to Restore Cough
The purpose of this trial is to determine the efficacy of spinal cord stimulation, using wire leads, to produce an effective cough in patients with spinal cord injuries.
- Conditions
- Spinal Cord Injuries, Spinal Cord Diseases, Paralysis, Central Nervous System Diseases
- Trial name
- NCT01659541
- Testing
- Expiratory muscle stimulator, Implantation of device
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- MetroHealth Medical Center
Thoracic Spinal Cord Injury
Safety of CRT100 on Treatment Spinal Cord Injury
The goal of this clinical trial is to test CRT100 treatment in participants with acute thoracic spinal cord injury. The main questions it aims to answer is safety of CRT100.
- Trial name
- CRT100 (NCT05739734)
- Testing
- CRT100
- Where
- 3 sites in Brazil
- Volunteers
- 5 people
- Sponsor
- Cristália Produtos Químicos Farmacêuticos Ltda.
Spinal Cord Injury Cervical, Spinal Cord Injury Thoracic
A Study to Evaluate the Safety of a Delivery Device for Administering LCTOPC1 in Participants With Spinal Cord Injury
The DOSED clinical study evaluates the safety and utility of a novel delivery device to deliver LCTOPC1, a cell therapy, to the spinal cord of patients with a spinal cord injury (SCI).
- Conditions
- Spinal Cord Injury Cervical, Spinal Cord Injury Thoracic, Spinal Cord Injury, Acute, Spinal Cord Injury
- Trial name
- DOSED (NCT06841770)
- Testing
- OPC1
- Where
- 2 sites in United States
- Volunteers
- 10 people
- Sponsor
- Lineage Cell Therapeutics, Inc.
Spinal Cord Injuries, Spinal Cord Diseases
Sub-study to Spinal Cord Stimulation to Restore Cough
Evaluation of Wire Electrodes to Activate the Expiratory Muscles to Restore Cough
- Conditions
- Spinal Cord Injuries, Spinal Cord Diseases, Paralysis, Central Nervous System Diseases
- Trial name
- NCT00995215
- Testing
- Spinal Cord Stimulation, Expiratory Muscle Stimulator
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- MetroHealth Medical Center
Spinal Cord Injuries, Spinal Cord Injury
Neuromodulation to Reduce Muscle Stiffness Following Spinal Cord Injury
People with spinal cord injuries may experience muscle tightness or uncontrollable spasms. This study is being conducted to investigate whether transcutaneous spinal stimulation can improve these symptoms.
- Conditions
- Spinal Cord Injuries, Spinal Cord Injury, Spinal Cord Injury Cervical, Spinal Cord Injury Thoracic
- Trial name
- NCT06274021
- Testing
- Transcutaneous spinal stimulation at 100 Hz, Transcutaneous spinal stimulation at 50 Hz, Transcutaneous spinal stimulation at 50 Hz and single dose of baclofen
- Where
- 2 sites in United States
- Volunteers
- 16 people
- Sponsor
- University of Mississippi Medical Center
Thoracic Spinal Cord Injury, Spinal Cord Injury
Study of Human Central Nervous System Stem Cells (HuCNS-SC) in Patients With Thoracic Spinal Cord Injury
This study will evaluate the effect of single transplantation of HuCNS-SC cells into the thoracic spinal cord of patients with sub-acute spinal cord injury.
- Conditions
- Thoracic Spinal Cord Injury, Spinal Cord Injury, Spinal Cord Injury Thoracic, Spinal Cord Trauma
- Trial name
- NCT01321333
- Testing
- HuCNS-SC cells
- Where
- 3 sites in Canada, Switzerland
- Volunteers
- 12 people
- Sponsor
- StemCells, Inc.
Spinal Tumor, Traumatic Injury of Spine
Study to Evaluate the Safety and Clinical Outcome of Using Navigation System in Pedicle Screw Placement in Spine Surgery
The research project is testing whether in screw insertion of spine surgery using "Anatase" Spine Surgery Navigation System is at least as safe and accurate as using O-arm assisted spine surgery- Medtronic Stealthstation S7…
- Conditions
- Spinal Tumor, Traumatic Injury of Spine, Degenerative Spine Disease
- Trial name
- NCT04578691
- Testing
- "Anatase" Spine Surgery Navigation System, Medtronic Stealthstation S7 Treatment Guidance System
- Where
- Taiwan
- Volunteers
- 55 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Spinal Cord Injuries, Spinal Cord Diseases
Spinal Cord Stimulation to Restore Cough
The purpose of this trial is to determine the efficacy of spinal cord stimulation to produce an effective cough in patients with spinal cord injuries.
- Conditions
- Spinal Cord Injuries, Spinal Cord Diseases, Paralysis, Central Nervous System Diseases
- Trial name
- NCT00116337
- Testing
- Spinal Cord Stimulation to restore cough, Expiratory Muscle Stimulator
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- MetroHealth Medical Center
Injury, Spinal Cord
Study of Probable Benefit of the Neuro-Spinal Scaffold™ in Subjects With Complete Thoracic AIS A Spinal Cord Injury as Compared to Standard of Care
This is a randomized, controlled, single-blind, multicenter, two Arm (Treatment or "Scaffold" Arm; Standard of Care or "Comparator" Arm) of a Neuro-Spinal Scaffold to evaluate whether the Scaffold is safe and demonstrates…
- Trial name
- INSPIRE 2 (NCT03762655)
- Testing
- Neuro-Spinal Scaffold
- Where
- 16 sites in United States
- Volunteers
- 20 people
- Sponsor
- InVivo Therapeutics
Metastatic Spinal Cord Compression, Radiation Toxicity
Esophagus-sparing Radiotherapy for Metastatic Spinal Cord Compression.
Metastatic spinal cord compression (MSCC) is a serious complication to metastatic cancer and when diagnosed life expectancy is short. Treatment is palliative radiotherapy (RT).
- Conditions
- Metastatic Spinal Cord Compression, Radiation Toxicity, Esophagitis, Patient Reported Outcome Measures
- Trial name
- ESO-SPARE (NCT05109819)
- Testing
- Esophagus sparring radiotherapy treatment
- Where
- 2 sites in Denmark
- Volunteers
- 200 people
- Sponsor
- Herlev Hospital