Clinical trials: Thoracic Trauma
COVID-19
A Study to Assess the Efficacy and Safety of Gimsilumab in Subjects With Lung Injury or Acute Respiratory Distress Syndrome Secondary to COVID-19 (BREATHE)
Study KIN-1901-2001 is a multi-center, adaptive, randomized, double-blind, placebo-controlled study to assess the efficacy and safety of gimsilumab in subjects with lung injury or acute respiratory distress syndrome (ARDS)…
- Trial name
- NCT04351243
- Testing
- Gimsilumab
- Where
- 33 sites in United States
- Volunteers
- 227 people
- Sponsor
- Kinevant Sciences GmbH
Pulmonary Contusion , Chest Trauma , Prediction Model
Establishment of a Prognosis Prediction Model and Scoring Criteria of Pulmonary Contusion Caused by Severe Thoracic Trauma
Pulmonary contusion caused by severe thoracic trauma is a complex disease. Some patients may be secondary to severe complications such as pulmonary infection or even acute respiratory distress syndrome.
- Trial name
- NCT04518904
- Volunteers
- 800 people
- Sponsor
- Shanghai Jiao Tong University Affiliated Sixth People's Hospital
Post-Traumatic Respiratory Failure
Efficacy of Non-Invasive Mechanical Ventilation in Early Hypoxia Secondary to Thoracic Trauma
Severe post-traumatic hypoxia is mainly due to lung contusion. The intubation rate of these patients is near 20%. Treatment before intubation is needed, is based on pain control with epidural anesthesia and oxygen.
- Trial name
- NCT00557752
- Testing
- Non-invasive ventilation
- Where
- 2 sites in Spain
- Volunteers
- 50 people
- Sponsor
- Hospital Virgen de la Salud
Ventilator-Induced Lung Injury
Pressure Support Ventilation During Laparoscopic and Abdominal Robotic Surgery.
This study is a single-center, blind, prospective, randomized, controlled trial of pressure support ventilation (PSVpro) versus pressure control ventilation - volume guaranteed (PCV - VG) during laparoscopic and robotic abdominal…
- Trial name
- NCT04815733
- Testing
- Mandatory ventilation, pressure support ventilation
- Where
- Russia
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- Moscow Clinical Scientific Center
Bleeding, Hypoxia
Video-guided Percutaneous Tracheostomy (PCT): A Feasibility Study
The purpose of this study is to determine the feasibility, safety and effectiveness of an endotracheal tube embedded with a mini video-camera as a guiding tool for percutaneous tracheostomy.
- Conditions
- Bleeding, Hypoxia, Atelectasis, Pneumothorax
- Trial name
- NCT01013298
- Testing
- video-guided PCT
- Where
- Israel
- Volunteers
- 10 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Single Level Stable Thoracolumbar Fracture Type AO A3, Multiple Level Stable Thoracolumbar Fracture Type AO A3
Spine FA3 - a Prospective, International, Multicenter Cohort Study on Treatment of of AO A3 Thoracolumbar Fractures
Thoracolumbar fractures are the most common spinal fractures with an average annual incidence between 18 and 30 per 100'000 inhabitants. The majority of these fractures are AO type A3 ("burst fractures").
- Trial name
- FA3 (NCT01751633)
- Testing
- Surgical, Conservative treatment
- Where
- 8 sites in Brazil, Chile and 4 more
- Volunteers
- 38 people
- Sponsor
- AO Clinical Investigation and Publishing Documentation
Vaping Related Disorder
Radiology and BAL in Vaping Associated Lung Injury
Radiology and BAL in Vaping associated lung disease
- Trial name
- NCT07499557
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Alexandria University
Lung Injury, Acute
Serum Level of Calpains Product as a Novel Biomarker of Acute Lung Injury Following Cardiopulmonary Bypass
More than 2 million patients worldwide receive heart surgery every year, majority of these surgical patients will undergo cardiopulmonary bypass.
- Trial name
- CPB (NCT05610475)
- Testing
- blood cell analysis, blood gas surveillance, chest radiograph and echocardiography
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Yangzhou University
Angina Pectoris
Cardioprotective Effects of GLP-1 and Their Mechanisms
Ischaemic heart disease is the most common cause of death in the UK. Glucagon-like peptide-1 (GLP-1) has been demonstrated to protect the heart when it is deprived of blood supply (ischaemia).
- Trial name
- NCT02128022
- Testing
- GLP-1 (7-36) amide, Glibenclamide
- Where
- United Kingdom
- Volunteers
- 32 people
- Sponsor
- Papworth Hospital NHS Foundation Trust
Muscular Diseases
The Role of Ischaemia-reperfusion Injury in the Pathogenesis of Muscle Wasting After Thoracic Aortic Surgery
Single-centre observational study over one year investigating the mechanisms of muscle homeostasis in patients with acute skeletal muscle atrophy following major aortic surgery
- Trial name
- RIMMAS (NCT03354767)
- Testing
- Aortic and aortic valve surgery
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Contusions Pulmonary, Lung Injury
Efficacy of Lung Ultrasound in Monitoring Fluid Resuscitation in Chest Trauma Patients
Efficacy of Lung ultrasound in monitoring fluid resuscitation in chest trauma patients with lung contusions
- Conditions
- Contusions Pulmonary, Lung Injury, Chest Trauma, Fluid Overload Pulmonary Edema
- Trial name
- NCT05054270
- Testing
- Chest examination with Ultrasound device
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Assiut University
Lung Injury, Acute, Respiratory Distress Syndrome, Adult
Study of Enbrel (Etanercept) for the Treatment Sub-Acute Pulmonary Dysfunction After Allogeneic Stem Cell Transplant
The purpose of this study is to determine the effectiveness of etanercept in the treatment of patients with sub-acute lung injury following a bone marrow transplant.
- Conditions
- Lung Injury, Acute, Respiratory Distress Syndrome, Adult, Bronchiolitis Obliterans
- Trial name
- NCT00141726
- Testing
- Etanercept
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- University of Michigan Rogel Cancer Center
Breast Cancer, Colorectal Cancer
Growth Factor Levels in the Blood of Patients Undergoing Radiation Therapy for Epithelial Cancer
RATIONALE: Measuring levels of transforming growth factor-beta (TGF-beta) in the blood of patients with epithelial cancers (head and neck, lung, breast, colorectal, and prostate) may help doctors predict how patients will respond…
- Conditions
- Breast Cancer, Colorectal Cancer, Head and Neck Cancer, Lung Cancer
- Trial name
- NCT00897793
- Testing
- venipuncture, radiation therapy
- Where
- 3 sites in United States
- Volunteers
- 25 people
- Sponsor
- Vanderbilt-Ingram Cancer Center
Blunt Traumatic Aortic Injury, BTAI
Blunt Traumatic Aortic Injury
This is a retrospective and prospective multi-center observational study of the management and outcomes of BTAI. This study will include patients who meet the registry inclusion criteria as documented in EPIC and chart review…
- Trial name
- BTAI (NCT07490015)
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Methodist Health System
Rib Fractures, Serratus Anterior Plane Block
Comparison of the Analgesic Efficacy of Serratus Anterior Plane Block and Intercostal Block
More than 50% of patients presenting with chest trauma experience rib fractures and these rib fractures are associated with significant morbidity, mortality, and long-term disability.
- Conditions
- Rib Fractures, Serratus Anterior Plane Block, Erector Spinae Plane Block, Acute Pain
- Trial name
- NCT05160155
- Testing
- Serratus Anterior Plane Block, Intercostal Block
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Atatürk Chest Diseases and Chest Surgery Training and Research Hospital
Rib Fractures, Analgesia
Lidocaine Spray for Pain Control in Rib Fractures
In this study, we aimed to compare the analgesic efficacy of lidocaine spray with tramadol hydrochloride and fentanyl citrate in rib fractures.
- Trial name
- NCT05500677
- Testing
- Lidocaine topical
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people
- Sponsor
- Ankara City Hospital Bilkent
Chest Trauma, Hypoxia
HFNC Compared With Facial Mask in Patients With Chest Trauma Patients
Guidelines for noninvasive ventilation (NIV) recommend continuous positive airway pressure in patients with thoracic trauma who remain hypoxic . However, no any suggestion was applied for high flow nasal cannula (HFNC).
- Trial name
- NCT05828030
- Testing
- high flow nasal cannula, Oxygen mask
- Where
- 2 sites in Taiwan
- Volunteers
- 100 people
- Sponsor
- National Taiwan University Hospital
Dissection of Thoracic Aorta
Incidence and Risk Factors of Acute Kidney Injury After Thoracic Aortic Surgery Due to Dissection
Acute kidney injury (AKI) is one of the most frequently encountered and prognostically significant complications after cardiovascular surgery.
- Trial name
- NCT02190487
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Yonsei University
Congestive Heart Failure, Angina Pectoris
Randomized Controlled Trial of Health Care to Elderly Patients.
To study the efficacy of multicomponent treatment and care for patients with acute illness or deterioration of a chronic disease at a nursing home in primary health care compared to traditional treatment at hospital.
- Conditions
- Congestive Heart Failure, Angina Pectoris, Asthma, Pneumonia
- Trial name
- NCT00235404
- Testing
- Multicomponent treatment, usual care
- Where
- Norway
- Volunteers
- 142 people
- Sponsor
- Norwegian University of Science and Technology
Rib Fracture, Trauma
Analysis of the Status, Treatment and Outcomes of Rib Fractures
A retrospective analysis of all patient presenting with multiple rib fractures to the emergency room of Penn State Hershey Medical Center between 2010-2012.
- Trial name
- NCT02487264
- Volunteers
- 921 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center