Clinical trials: Thoracic Trauma
Epiphora
Topical Cyclosporine vs. Placebo for Epiphora Associated With Docetaxel
Objective: To evaluate the safety and efficacy of topical cyclosporine eye drops (Restasis®) for the treatment of epiphora caused by canalicular stenosis secondary to Docetaxel (Taxotere®) treatment for various cancers.
- Trial name
- NCT00824811
- Testing
- Cyclosporine Eye Drops (Restasis), Lubricant Eye Drops (Refresh Endura™), Fluorometholone Eye Drops (FML Forte®)
- Sponsor
- M.D. Anderson Cancer Center
Peripheral Nerve Injuries, Pain
Effect of Rufinamide on Chronic Postthoracotomy Pain Syndrome
The purpose of this study is to test if rufinamide has an effect on chronic neuropathic pain in patients with a post thoracotomy pain syndrome.
- Trial name
- RUFPTPS (NCT02095899)
- Testing
- Rufinamide
- Where
- Switzerland
- Sponsor
- University of Zurich
Thoracic; Sympathetic Ganglion, Injury
Thoracic Sympathetic Ganglion Block Inadvertent Spread
This study wants to identify the incidence of inadvertend intercostal or epidural spread of thoracic sympathetic block
- Trial name
- NCT03995576
- Testing
- thoracic sympathetic ganglion block
- Where
- 2 sites in South Korea
- Volunteers
- 53 people
- Sponsor
- Keimyung University Dongsan Medical Center
Thoracic Aortic Aneurysm
STARZ-TX2 Clinical Study: Study of Thoracic Aortic Aneurysm Repair With the Zenith TX2 Endovascular Graft
The STARZ-TX2 trial (Study of Thoracic Aortic Aneurysm Repair with the Zenith TX2(R) TAA [Thoracic Aortic Aneurysm] Endovascular Graft) is a clinical trial approved by the United States Food and Drug Administration (FDA) to study…
- Trial name
- STARZ-TX2 (NCT00111176)
- Testing
- Endovascular repair, Surgical
- Where
- 41 sites in United States, Canada and 1 more
- Volunteers
- 260 people
- Sponsor
- Cook Group Incorporated
Rib Fractures
Ultrasound-guided Erector Spinae Plane Blocks
The purpose of this study is to determine the feasibility of using the ultrasound-guided erector spinae plane blocks to provide additional pain relief to patients with rib fractures in the Emergency Department (ED) and Intensive…
- Trial name
- NCT04916691
- Testing
- EPSB for rib fractures, Ropivacaine
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Critically Ill, Acute Lung Injury
Respiratory Mechanics and Pleural Effusion
The investigators aim to compare the respiratory mechanics in acute lung injury (ALI)/acute respiratory diseases syndrome (ARDS) patients with and without pleural effusion.
- Conditions
- Critically Ill, Acute Lung Injury, ARDS
- Trial name
- NCT00258518
- Testing
- mechanical ventilation/CT Scan
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- Policlinico Hospital
Kidney Injury Following Open-Chest Cardiac Surgery
A Phase 2b Dose Finding Study of RMC-035 in Participants Undergoing Open-chest Cardiac Surgery
The goal of this clinical trial is to identify the optimal dose of RMC-035 for protection of long-term renal function in adult patients undergoing cardiac surgery who are at high risk of kidney injury.
- Trial name
- POINTER (NCT06475274)
- Testing
- RMC-035
- Where
- 19 sites in Canada, Czechia and 2 more
- Volunteers
- 170 people
- Sponsor
- Guard Therapeutics AB
Cardiotoxicity, Lung Cancer Stage III
Cardiotoxicity in Locally Advanced Lung Cancer Patients Treated With Chemoradiation Therapy
This observational cohort will evaluate the cardiovascular effects of chemoradiation used to treat locally advanced, non-small cell lung cancer.
- Conditions
- Cardiotoxicity, Lung Cancer Stage III, Lung Cancer Stage II, Radiation Toxicity
- Trial name
- CLARITY (NCT04305613)
- Testing
- Chemoradiation
- Where
- 8 sites in United States
- Volunteers
- 221 people
- Sponsor
- Abramson Cancer Center at Penn Medicine
Rib Fracture
The Analgesic Effect of Retro-laminar Block Versus Paravertebral Block in Patients With Multiple Fracture Ribs
Rib fractures are a common injury, occurring in up to 10% of all trauma patients. Multiple rib fractures can be particularly painful and debilitating, making it difficult for patients to breathe and cough.
- Trial name
- NCT06757803
- Testing
- rertrolaminar block, paravertebral block
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Assiut University
Chest Trauma
Evaluating Validity of Clinical Criteria for Requesting Chest X-Rays in Trauma Patients
The purpose of this study is to identify the clinical criteria for requesting a chest x-ray in a patient with blunt trauma and its findings such as clinical signs with a high sensitivity could be used in a larger study to codify…
- Trial name
- NCT01134744
- Where
- 2 sites in Iran
- Volunteers
- 385 people, healthy volunteers welcome
- Sponsor
- Isfahan University of Medical Sciences
Aortic Rupture
In Vivo Evaluation of Growth and Risk of Rupture of Dilated Ascending Aorta Using 4D Cardiac Magnetic Resonance
Ascending aorta aneurysmal disease is common and can be complicated by dissection or rupture. There is substantial variation in individual aneurysm progression: established risk factors for an accelerated aneurysm growth rate…
- Trial name
- NCT03172390
- Testing
- 4D Cardiac Magnetic Resonance
- Where
- France
- Volunteers
- 41 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Aortic Rupture
Analysis of Risk Factors for Death After Blunt Traumatic Rupture of the Thoracic Aorta
Aortic injuries after blunt thoracic trauma are compared to the great incidence of accidents relatively rare, but potentially serious leading to death at scene in most of the cases.
- Trial name
- NCT01632774
- Where
- Switzerland
- Volunteers
- 85 people
- Sponsor
- University of Zurich
Rib Fractures, Rib Fracture Multiple
US-guided SAPB for Rib Fractures in the ED
The purpose of this randomized controlled study is to determine whether the serratus anterior plane block reduces pain more than the usual treatment for rib fractures in the same amount of time.
- Trial name
- NCT03619785
- Testing
- Bupivacaine, Fentanyl, morphine, hydromorphone, hydrocodone, acetaminophen, ketorolac, gabapentin, ketamine, ibuprofen
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Andrew A Herring
Stable Angina, Acute Kidney Injury
CI-AKI in Patients With Stable CAD and Comorbidities. Are we Doing Better?
Patients aged 18-89 with stable CAD and comorbidities receiving optimal medical treatment requiring PCI with iodinated contrast media.
- Conditions
- Stable Angina, Acute Kidney Injury, Contrast-induced Nephropathy
- Trial name
- NCT04014153
- Testing
- Iodinated contrast media
- Volunteers
- 1,023 people
- Sponsor
- I.M. Sechenov First Moscow State Medical University
Carcinoma, Non-small-cell Lung
Prevention of Radiation Pneumonitis After Three-dimensional Conformal Radiation Therapy (3D-CRT) in Patients With Non-small-cell Lung Cancer
The purpose of this study is to evaluate the interest of breath holding for the prevention of radiation pneumonitis following conformal radiation therapy.
- Trial name
- NCT00349102
- Testing
- Free breathing, Breath holding
- Where
- 7 sites in France
- Volunteers
- 242 people
- Sponsor
- Centre Leon Berard
Blunt Chest Wall Trauma, Rib Fracture
Intercostal Liposomal Bupivacaine for the Management of Blunt Chest Wall Trauma
This is a study of liposomal bupivacaine for pain control in patients with blunt chest wall trauma.
- Conditions
- Blunt Chest Wall Trauma, Rib Fracture, Sternal Fracture
- Trial name
- NCT02749968
- Testing
- Liposomal bupivacaine, 0.9% sodium chloride
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Cincinnati
Rib Fractures, Polytrauma
Blunt Thoracic Trauma: Definition of a Standard Operating Procedure
Rib fractures are the most frequent injury after blunt thoracic trauma. It is very important to choose the most appropriate interventions to prevent complications.
- Conditions
- Rib Fractures, Polytrauma, Thoracic Injury, Respiratory Failure
- Trial name
- NCT05617404
- Testing
- CT scan
- Where
- Spain
- Volunteers
- 553 people
- Sponsor
- Corporacion Parc Tauli
Thoracic Surgery, Obesity
Association Between Body Roundness Index and Wound Healing
Background Obesity is a significant risk factor for adverse postoperative outcomes, including impaired wound healing. This study aimed to investigate the association between the Body Roundness Index (BRI) and impaired wound…
- Conditions
- Thoracic Surgery, Obesity, BMI, Visceral Fat
- Trial name
- NCT07065890
- Where
- China
- Volunteers
- 422 people
- Sponsor
- Zhao bo
Heart Valve Diseases, Aortic Diseases
Effective Myocardial Protection Time of Del Nido Cardioplegia in Adult Cardiac Surgery
This single-center, prospective, observational cohort study quantifies the effective myocardial protection window of Del Nido cardioplegia during adult open-heart surgery performed under cardiopulmonary bypass (CPB) and aortic…
- Conditions
- Heart Valve Diseases, Aortic Diseases, Myocardial Ischemia, Reperfusion Injury, Myocardial
- Trial name
- DN-TIME-2025 (NCT07249424)
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Muhammet Talha Ceran, MD
Rib Fractures
Continuous Intercostal Nerve Blockade for Traumatic Rib Fractures
Rib fractures are common injuries in accident patients and can be associated with significant pain during recovery. If poorly controlled, pain from splinting due to rib fractures can result in difficulty in breathing leading to…
- Trial name
- NCT02604589
- Testing
- hydromorphone hydrochloride, Infusion catheter placement, bupivicaine 0.25%
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Anthony Iacco