Clinical trials: Thromboprophylaxis
Venous Thromboembolism, Varicose Veins
THRomboprophylaxis in Individuals Undergoing Superficial endoVEnous Treatment (THRIVE)
Endovenous interventions are keyhole operations for varicose veins that are carried out from within the vein itself. Varicose veins are enlarged veins close to the surface of the skin.
- Trial name
- THRIVE (NCT05735639)
- Testing
- Dalteparin Sodium, Tinzaparin Sodium, Enoxaparin Sodium
- Where
- United Kingdom
- Volunteers
- 3,175 people
- Sponsor
- Imperial College London
Deep Venous Thrombosis
Catheter-Related Early Thromboprophylaxis With Enoxaparin (CRETE) Trial
The purpose of this phase 2a, multi-center, randomized controlled study, is to explore the efficacy of early prophylaxis against catheter-associated deep venous thrombosis (CADVT) in critically ill children.
- Trial name
- CRETE (NCT03003390)
- Testing
- Enoxaparin
- Where
- 6 sites in United States
- Volunteers
- 51 people
- Sponsor
- Yale University
Deep Venous Thrombosis
Low-Molecular-Weight Heparin (LMWH) for Deep Venous Thrombosis (DVT) Prophylaxis
1. The use of LMWH following open reduction and internal fixation of ankle fractures will reduce the number of thrombi formed. 2. The rates of clinically significant DVT will be equivalent between two groups.
- Trial name
- NCT01029821
- Testing
- Low-Molecular-Weight Heparin
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Tennessee
Morbid Obesity
Two Different Regimens of Bemiparin as a Thromboprophylaxis in Morbidly Obese Surgical Patients
Morbid obesity, is known to be associated with a high risk of VTE and, unfortunately, fixed doses of anticoagulant regimens may not provide optimal VTE prophylaxis in these patients especially after surgery.
- Trial name
- NCT05569681
- Testing
- Bemiparin 3500, Bemiparin 5000 IU
- Where
- Iraq
- Volunteers
- 1,248 people, healthy volunteers welcome
- Sponsor
- Hawler Medical University
Postpartum Hemorrhage, Venous Thromboembolism
Timing of Thromboprophylaxis After Postpartum Hemorrhage
Postpartum hemorrhage is a leading cause of maternal morbidity and mortality worldwide. Women who experience severe postpartum hemorrhage are at increased risk of both recurrent bleeding and venous thromboembolism.
- Conditions
- Postpartum Hemorrhage, Venous Thromboembolism, Pulmonary Embolism, Deep Vein Thrombosis
- Trial name
- NCT07689136
- Testing
- Pharmacologic Thromboprophylaxis
- Where
- Tunisia
- Volunteers
- 236 people
- Sponsor
- University Tunis El Manar
Thromboprophylaxis, Thromboembolism, Venous
Thromboembolic Risk Assessment in Patients Admitted With Acute Medical Diseases to Conventional and At Home Hospitalization
The thromboembolic disease is a common complication of patients admitted to conventional hospitalization units. To prevent such complications, thromboprophylaxis is indicated in high-risk patients identified with validated…
- Conditions
- Thromboprophylaxis, Thromboembolism, Venous, Atrial Fibrillation, Physical Inactivity
- Trial name
- TROMBODOM (NCT06110949)
- Testing
- Triaxial accelerometry
- Where
- Spain
- Volunteers
- 1,953 people
- Sponsor
- Universidad Pública de Navarra
Deep Vein Thrombosis (DVT), Pulmonary Embolism
Bemiparin as a Thromboprophylaxis After Gynaecological Surgeries
The use of prophylaxis for venous thromboembolism (VTE) remains grossly underused for women who undergo gynecologic surgery for benign conditions world wide and especially in developing countries including our region.
- Trial name
- NCT01630148
- Testing
- Bemiparin
- Where
- Iraq
- Volunteers
- 774 people
- Sponsor
- Hawler Medical University
Total Knee Arthroplasty, Venous Thromboembolism
Comparison of DOACs and LMWH for Thromboprophylaxis After Total Knee Arthroplasty
Yes. For these two fields, I would enter the following in English, based on your study protocol. 1. Brief Summary Copy and paste: This study aims to compare three thromboprophylaxis regimens in adults undergoing primary total…
- Trial name
- DOLOTHROK (NCT07869615)
- Testing
- Apixaban, Rivaroxaban, Enoxaparin (LMWH)
- Where
- Tunisia
- Volunteers
- 138 people
- Sponsor
- Military Hospital of Tunis
Thromboembolism, Pregnancy
Pregnancy and Risk of Venous Thromboembolism
The management of venous thromboembolism (VTE) risk in pregnancy still remains a challenge. An individual assessment of the VTE risk is crucial for optimal thromboprophylaxis, but there is no validated tool to help clinicians…
- Trial name
- PRESCOT (NCT03659708)
- Testing
- Lyon-VTE score, recommendations currently available
- Where
- France
- Volunteers
- 600 people
- Sponsor
- Hospices Civils de Lyon
Pelvic Fractures, Acetabular Fractures
Incidence of Venous Thromboembolism in Patients With Pelvic and Acetabular Fractures (PAF)
The goal of this observational study is to investigate the incidence of venous thromboembolism (VTE) in patients with pelvic and acetabular fractures (PAF).
- Conditions
- Pelvic Fractures, Acetabular Fractures, Pelvic Trauma, Venous Thromboembolic Event
- Trial name
- PAF-VTE (NCT07165587)
- Testing
- Bilateral duplex ultrasonography
- Where
- Germany
- Volunteers
- 81 people
- Sponsor
- Department of Trauma and Reconstructive Surgery at Eberhard Karls University Tuebingen, BG Klinik Tu
Transcatheter Aortic Valve Replacement, Transcatheter Heart Valve Thrombosis
Low-dose Colchicine for Thromboprophylaxis After Transcatheter Aortic Valve Replacement
This prospective, randomized, open-label study aims to evaluate the efficacy and safety of low-dose colchicine (0.5 mg daily) in reducing transcatheter heart valve (THV) thrombosis in patients after TAVR.
- Conditions
- Transcatheter Aortic Valve Replacement, Transcatheter Heart Valve Thrombosis, Anti-inflammatory Therapy
- Trial name
- LoDoCo-TAVR (NCT07411768)
- Testing
- Colchicine, Standard Care
- Where
- China
- Volunteers
- 116 people
- Sponsor
- China National Center for Cardiovascular Diseases
Venous Thromboembolism (VTE), Post Partum Women
Prevention of Postpartum Venous Thromboembolism in Women at Intermediate Risk
Venous thromboembolism (VTE) is currently the second cause of death in women of reproductive age worldwide. The incidence of VTE during pregnancy is 1.2 to 1.4/1000 women, half of VTE occurring during postpartum and as PE in…
- Trial name
- MUM-VTE (NCT06845423)
- Testing
- Low molecular weight heparin
- Where
- 18 sites in France
- Volunteers
- 2,400 people
- Sponsor
- University Hospital, Brest
Pulmonary Embolism, Deep Vein Thrombosis
Angel® Catheter Early Feasibility Clinical Study
The primary objective of this clinical trial is to obtain initial insights into the safety of the Angel® Catheter in critically ill subjects with high risk of venous thromboembolism (VTE) disease AND who are not receiving…
- Conditions
- Pulmonary Embolism, Deep Vein Thrombosis, Venous Thromboembolism
- Trial name
- NCT01847196
- Testing
- Angel® Catheter
- Where
- 4 sites in United States
- Volunteers
- 6 people
- Sponsor
- BiO2 Medical
COVID-19
Early Prophylactic Low-molecular-weight Heparin (LMWH) in Symptomatic COVID-19 Positive Patients
Evidence has shown that COVID-19 infections can lead to an increased risk of blood clots. These blood clots can lead to individuals being admitted to hospital, or, unfortunately in severe cases, death.
- Trial name
- ETHIC (NCT04492254)
- Testing
- Enoxaparin
- Where
- 3 sites in Australia, Belgium and 1 more
- Volunteers
- 219 people
- Sponsor
- Thrombosis Research Institute
Thrombosis, Arterial Occlusive Diseases
Thromboelastography With Platelet Mapping to Guide Antiplatelet Therapy After Lower Extremity Revascularization
The goal of this clinical trial is to learn if a blood clotting test called thromboelastography with platelet mapping (TEG-PM) can guide blood-thinning medication decisions in adults more than 60 years and older with peripheral…
- Conditions
- Thrombosis, Arterial Occlusive Diseases, Thromboelastography (TEG), Peripheral Arterial Disease(PAD)
- Trial name
- TARGET (NCT07597239)
- Testing
- Aspirin, Clopidogrel, Ticagrelor
- Where
- United States
- Volunteers
- 144 people
- Sponsor
- Massachusetts General Hospital
Esophageal Neoplasms, Thrombosis
Thromboprophylaxis in Oesophageal Cancer Patients
The purpose of the study is to examine the efficacy and safety of prolonged thromboprophylactic treatment with Fragmin® in oesophageal cancer patients undergoing intended curative surgery.
- Conditions
- Esophageal Neoplasms, Thrombosis, Thromboembolism
- Trial name
- TOP-RCT (NCT05067153)
- Testing
- Fragmin 5000 UNT in 0.2 ML Prefilled Syringe
- Where
- Denmark
- Volunteers
- 100 people
- Sponsor
- University of Aarhus
Hip and Knee Prosthesis Implantation
Aspirin Thromboprophylaxis After First-line Total Hip and Knee Replacement
Annually, more than 100,000 total hip prostheses (THA) and more than 100,000 total knee prostheses (TKA) are implanted for osteoarthritis in France, and these figures are set to increase significantly in the future as in all…
- Trial name
- TBP-ASPIR (NCT05128214)
- Where
- France
- Volunteers
- 200 people
- Sponsor
- University Hospital, Strasbourg, France
Deep Vein Thrombosis, Pulmonary Embolism
Thromboprophylaxis for Patients Undergoing Surgical Resection for Colon Cancer
The blood thinner "tinzaparin" might increase survival in patients with colon cancer undergoing surgical resection. The investigators want to assess if a trial allocating patients to prolonged treatment with tinzaparin versus…
- Conditions
- Deep Vein Thrombosis, Pulmonary Embolism, Cancer
- Trial name
- PERI-OP (NCT00967148)
- Testing
- Tinzaparin
- Where
- Canada
- Volunteers
- 18 people
- Sponsor
- Ottawa Hospital Research Institute
Deep Vein Thrombosis
The STOP CLOT Pilot Study: Study of Low Molecular Weight Heparin in High Risk Cesarean Section
Venous thromboembolism (VTE) remains the most common cause of maternal death in the developed world. VTE includes two conditions, deep vein thrombosis (DVT) and pulmonary embolism (PE).
- Trial name
- NCT00225108
- Testing
- Tinzaparin
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Ottawa Hospital Research Institute
Venous Thrombosis Due to Central Venous Access Device (Disorder), Prophylactic Anticoagulation
Prophylactic Anticoagulation for Catheter-related Thrombosis
The main objective of this study is to compare the efficacy and safety of aspirin, low molecule heparin and rivaroxaban for preventing catheter-related thrombosis in middle-to-high-risk ambulatory patients with cancer and…
- Conditions
- Venous Thrombosis Due to Central Venous Access Device (Disorder), Prophylactic Anticoagulation, Patients With Tumor
- Trial name
- NCT04256525
- Testing
- Rivaroxaban 10mg, Aspirin 100mg, low molecule heparin
- Where
- 28 sites in China
- Volunteers
- 1,640 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine