Clinical trials: Thrombotic Microangiopathies
Immune Thrombocytopenia
An Open Phase 3 Study of IV-Globulin SN Inj.10% to Treat Immune Thrombocytopenia
Human immunoglobulin (Ig) is the most commonly used blood product. It has been well-defined the efficacy in patients with immunodeficiencies, Kawasaki disease, asthma and other immune diseases.
- Trial name
- NCT02063789
- Testing
- Human immunoglobulin intravenous
- Where
- 14 sites in South Korea
- Volunteers
- 81 people
- Sponsor
- Green Cross Corporation
Idiopathic Thrombocytopenic Purpura, Thrombocytopenia in Pediatric Subjects With Immune (Idiopathic) Thrombocytopenic Purpura (ITP)
Safety and Efficacy Study of Romiplostim (AMG 531) to Treat ITP in Pediatric Subjects
The purpose of this study is to evaluate the safety and tolerability of romiplostim (AMG 531) in the treatment of thrombocytopenia in pediatric subjects with chronic ITP.
- Conditions
- Idiopathic Thrombocytopenic Purpura, Thrombocytopenia in Pediatric Subjects With Immune (Idiopathic) Thrombocytopenic Purpura (ITP), Thrombocytopenia in Subjects With Immune (Idiopathic) Thrombocytopenic Purpura (ITP)
- Trial name
- NCT00515203
- Testing
- AMG 531
- Volunteers
- 22 people
- Sponsor
- Amgen
Immune Thrombocytopenia
Oxidant Status and Effect of Antioxidant in Immune Thrombocytopenia
Oxidative stress occurs as a result of increased activity of free radical-producing enzymes, decreased activity of free radical-removing enzymes, and insufficient levels of antioxidants.
- Trial name
- ITP (NCT01763658)
- Testing
- Antox tablets(Mepaco), drug therapy for ITP
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Ain Shams University
Hemolytic-Uremic Syndrome, Children
Haemolytic Uraemic Syndrome in Childhood: Clinical, Cognitive and Psychological Aspects
The purpose of this study is to investigate the clinical, cognitive outcome and psychosocial outcome of haemolytic uraemic syndrome in childhood.
- Conditions
- Hemolytic-Uremic Syndrome, Children, Parents, Psychological Adjustment
- Trial name
- NCT01666548
- Where
- Switzerland
- Volunteers
- 89 people
- Sponsor
- University Children's Hospital, Zurich
Immune Thrombocytopenia, Systemic Lupus Erythematosus
Retrospective Analysis of the Safety and Efficacy of Hydroxychloroquine in Immune Thrombocytopenia
Retrospective study of the safety and efficacy of hydroxychloroquine among patients with immune Thrombopenia (ITP).
- Trial name
- HCQITP (NCT01549184)
- Volunteers
- 40 people
- Sponsor
- Henri Mondor University Hospital
Primary Immune Thrombocytopenia
Romiplostim Plus Dexamethasone vs Dexamethasone in Patients With Newly Diagnosed Primary Immune Thrombocytopenia
Phase III, open-labeled, randomized and multicenter clinical trial to evaluate the superiority of romiplostim plus dexamethasone vs dexamethasone alone in patients with newly diagnosed primary immune thrombocytopenia
- Trial name
- RODEX (NCT05325593)
- Testing
- romiplostim plus dexamethasone, Dexamethasone
- Where
- 30 sites in Italy, Spain and 1 more
- Volunteers
- 129 people
- Sponsor
- Fundación Pública Andaluza para la gestión de la Investigación en Sevilla
Primary Immune Thrombocytopenia (ITP), Primary Evans Syndrome (ES)
A Study to Assess the Tolerability of Ianalumab (VAY736) With Investigator's Choice Thrombopoietin Receptor Agonist (IC TPO-RA) in Patients With Primary Immune Thrombocytopenia (ITP)
The purpose of this study is to investigate the tolerability of ianalumab (9 mg/kg) with investigator's choice thrombopoietin receptor agonist (IC TPO-RA) in participants diagnosed with primary immune thrombocytopenia (ITP) who…
- Trial name
- VAY2EXPLORE (NCT07421167)
- Testing
- ianalumab, thrombopoietin receptor agonist (TPO-RA)
- Where
- 20 sites in United States
- Volunteers
- 164 people
- Sponsor
- Novartis Pharmaceuticals
Immune Thrombocytopenia
Polymorphism and Auto-reactive B and T Cells Subsets in Adult's Immune Thrombocytopenia (ITP)
Aims of the study : 1) To determine whether the presence of the V158 allele of Fc gammaRIIIA gene is associated with a better outcome of Immune Thrombocytopenia (ITP) in adults and especially with a higher response-rate to…
- Trial name
- Poly-ITP (NCT02287649)
- Testing
- blood sample
- Where
- France
- Volunteers
- 45 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Systemic Lupus Erythematosus, Immune Thrombocytopenia
Sirolimus in Patients With Systemic Lupus Erythematosus-Associated Immune Thrombocytopenia
The goal of this clinical trial is to learn if sirolimus, added to standard background therapy (corticosteroids and hydroxychloroquine), works to treat systemic lupus erythematosus-associated immune thrombocytopenia (SLE-ITP) in…
- Trial name
- NCT07657793
- Testing
- Sirolimus
- Where
- China
- Volunteers
- 164 people
- Sponsor
- Chinese SLE Treatment And Research Group
Atypical Hemolytic Uremic Syndrome (aHUS)
Study of Ravulizumab in Children and Adolescents With Atypical Hemolytic Uremic Syndrome (aHUS)
The purpose of the study is to assess the efficacy of ravulizumab to control disease activity in children and adolescents with aHUS who have not previously used a complement inhibitor (complement inhibitor treatment-naïve), as…
- Trial name
- NCT03131219
- Testing
- Ravulizumab
- Where
- 18 sites in United States, Belgium and 5 more
- Volunteers
- 34 people
- Sponsor
- Alexion Pharmaceuticals, Inc.
Immune Mediated Anemia, Immune Mediated Thrombocytopenia
Extension Study (Extended Access) of Syk-inhibition Using Fostamatinib to Treat Posttransplant Immune-mediated Cytopenias
Background: People who have a blood stem cell transplant can sometimes develop cytopenia. This means that their levels of one or more types of blood cell, such as the red cells or platelets, are lower than they should be.
- Conditions
- Immune Mediated Anemia, Immune Mediated Thrombocytopenia, Chronic GVHD
- Trial name
- NCT05509582
- Testing
- fostamatinib
- Where
- United States
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
ITP - Immune Thrombocytopenia, Chronic ITP
Real World Evaluation of the Activity and Safety of Fostamatinib in Consecutive Adult Patients With ITP
This is a retrospective and prospective multicenter observational study with the aim to evaluate the real-life use of Fostamatinib in adult patients with chronic ITP, refractory to other treatments.
- Conditions
- ITP - Immune Thrombocytopenia, Chronic ITP, Refractory ITP
- Trial name
- NCT05613296
- Testing
- Fostamatinib
- Where
- 21 sites in Italy
- Volunteers
- 95 people
- Sponsor
- Gruppo Italiano Malattie EMatologiche dell'Adulto
Thrombotic Thrombocytopenic Purpura
The ConNeCT Study: Neurological Complications of TTP
Thrombotic thrombocytopenic purpura (TTP) is a rare condition, which has a very high risk of death if not recognised and given immediate treatment. TTP is caused by a very low level of an enzyme in the body, called ADAMTS13.
- Trial name
- NCT04981028
- Testing
- Questionnaires (including PHQ-9, TYM and SF-36)
- Where
- United Kingdom
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Liverpool University Hospitals NHS Foundation Trust
Thrombocytopenia, Idiopathic Thrombocytopenic Purpura
Study on Bone Marrow Morphology in Adults Receiving Romiplostim for Treatment of Thrombocytopenia Associated With Immune Thrombocytopenia Purpura (ITP)
The purpose of this study is to evaluate changes in bone marrow morphology (structure) after long-term exposure to romiplostim.
- Trial name
- NCT00907478
- Testing
- romiplostim
- Volunteers
- 169 people
- Sponsor
- Amgen
Immune Thrombocytopenia
Association of Platelet Parameters With Bleeding Severity in Children With ITP
Patients with severe immune thrombocytopenia (ITP) present with similarly low platelet counts but varying bleeding symptoms, making it difficult to predict the disease course and to decide on an appropriate treatment plan.
- Trial name
- ITP-APPS (NCT03810352)
- Where
- 6 sites in United States
- Volunteers
- 95 people
- Sponsor
- Boston Children's Hospital
Atypical Hemolytic Uremic Syndrome
Open Label Controlled Trial of Eculizumab in Adult Patients With Plasma Therapy-sensitive Atypical Hemolytic Uremic Syndrome (aHUS)
The purpose of this study is to determine whether eculizumab is safe and effective in the treatment of adult patients with plasma therapy-sensitive Atypical Hemolytic-Uremic Syndrome (aHUS).
- Trial name
- aHUS (NCT00838513)
- Testing
- eculizumab
- Where
- 13 sites in Canada, France and 5 more
- Volunteers
- 15 people
- Sponsor
- Alexion Pharmaceuticals, Inc.
Purpura, Thrombocytopenic, Idiopathic, Acute Idiopathic Thrombocytopenic Purpura
Subject Variability in Two Lots of E5501 Administered to Fed and Fasted Healthy Subjects
This will be a randomized, open-label, four-group, two-period, replicate design study to evaluate the effect of food on within and between subject variability in second generation formulation 20-mg tablet strengths, Lots…
- Conditions
- Purpura, Thrombocytopenic, Idiopathic, Acute Idiopathic Thrombocytopenic Purpura, Chronic Thrombocytopenia
- Trial name
- NCT01327872
- Testing
- E5501 40 mg 2 x 20-mg tablets, orally, fasted, E5501 40 mg 2 x 20-mg tablets, orally, with food, E5501 40mg 2 x 20-mg tablets, orally, fasted
- Where
- Netherlands
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Eisai Inc.
Purpura, Thrombocytopenic
ASPirin in Immune thRombocytopenia Patients With Cardiovascular disEase
The incidence of immune thrombocytopenia increases with older age. This population is at risk for arterial thrombosis. Due to an increased turn-over of platelets, low-dose aspirin once daily may be insufficient in this population…
- Trial name
- ASPIRE (NCT04912505)
- Testing
- Aspirin
- Where
- France
- Volunteers
- 4 people
- Sponsor
- University Hospital, Toulouse
Thrombotic Microangiopathies
Study Evaluating the Efficacy of Eculizumab in the Treatment of Gemcitabine-induced Thrombotic Microangiopathies
The main objective of this prospective multisite trial is to study the evolution of TMA (thrombotic microangiopathy) induced by gemcitabin and treated by eculizumab.
- Trial name
- GEMECULI (NCT05702996)
- Testing
- Eculizumab administration
- Where
- 2 sites in France
- Sponsor
- University Hospital, Rouen
ITP - Immune Thrombocytopenia
Explore the Relationship Between Platelet Count and Bleeding Score in ITP
Assessment of bleeding scores in immune thrombocytopenia purpuria to explore the relationship between platelet count and bleeding score in immune thrombocytopenia purpura (ITP) and compare the clinical practicability of bleeding…
- Trial name
- NCT06273956
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Assiut University