Clinical trials: Thumb Arthritis
Carpometacarpal (CMC) Osteoarthritis
Randomized Placebo Controlled Study of Triamcinolone Acetonide Extended Release Injection for Thumb (CMC) Osteoarthritis
The goal of this study is to investigate if a timed release steroid injection may be beneficial in treating carpometacarpal (CMC) joint (thumb) osteoarthritis. The main questions to be answered are: 1.
- Trial name
- NCT06237153
- Testing
- Triamcinolone Acetonide extended release suspension
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Marie Badalamente
Thumb Osteoarthritis
Thumb Carpometacarpal Joint Denervation Versus Trapeziectomy
This is a prospective study tracking the outcomes of patients who undergo either of two treatments for thumb carpo-metacarpal joint arthritis: trapeziectomy with ligament reconstruction (LRTI) or denervation.
- Trial name
- NCT03558204
- Testing
- Denervation of the thumb CMC joint, trapeziectomy with ligament reconstruction (LRTI)
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- Johns Hopkins University
Anomaly; Hand
The Prevalence of the Linburg-Comstock Variation
The purpose of this study is to explore the physical exam characteristics of patients referred to orthopedic surgeons with a diagnosis of thumb carpometacarpal (CMC) arthritis.
- Trial name
- LCV (NCT06142370)
- Testing
- Descriptive
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Russell Sage College
Osteoarthritis, Osteoarthritis Thumb Base Joint
Efficacy of a Single Injection of CTM for Post-Operative CMC Arthritis
The goal of this study is to determine the success rate of a single Carpometacarpal (CMC) thumb injection after arthroplasty surgery for primary osteoarthritis of the CMC joint.
- Conditions
- Osteoarthritis, Osteoarthritis Thumb Base Joint, Carpometacarpal Osteoarthritis, Thumb
- Trial name
- CTM CMC (NCT06171529)
- Testing
- CTM
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Indiana Hand to Shoulder Center
Osteoarthritis Thumb Base Joint
Thumb Hemi-Arthroplasty With Natural Kinematics (THANKS) Trial
This clinical trial aims to evaluate the safety and effectiveness of the lnDx Implant in the treatment of thumb base joint arthritis.
- Trial name
- THANKS (NCT05644132)
- Testing
- InDx Implant for the carpometacarpal joint
- Where
- Belgium
- Volunteers
- 15 people
- Sponsor
- Loci Orthopaedics
Osteoarthritis
Safety Study of Thumb Orthoses in Osteoarthritis in the Base of the Thumb (BTOA)
The prevalence of digital osteoarthritis varies according to whether a radiological or clinical definition is adopted. Interventions: Thumb orthoses to be worn at night and usual care vs usual care.
- Trial name
- NCT00350896
- Testing
- Thumb orthoses
- Volunteers
- 120 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Basilar Thumb Arthritis, Wrist Fracture
Measurement of Grip and Pinch Forces Needed for Activities of Daily Living, Work and Prehistoric Stone Tool Production
Very little is known about the pinch and grip forces that are critical for activities of daily living (ADL) or work. Human success in evolution is a result of the combination of great brain power and great hand ability to…
- Conditions
- Basilar Thumb Arthritis, Wrist Fracture, Measure Pressure Distribution and Resultant Forces Needed
- Trial name
- NCT03316768
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Shaare Zedek Medical Center
Thumb Osteoarthritis, Thumb Carpometacarpal Joint Osteoarthritis
Surgery for Thumb Base Osteoarthritis: Joint Replacement vs. Trapeziectomy
The goal of this clinical trial is to learn if the surgical method with total joint arthroplasty, (TOUCH joint prosthesis), is as good as or better than the traditional surgical method, trapezectomy, to treat thumb base joint…
- Conditions
- Thumb Osteoarthritis, Thumb Carpometacarpal Joint Osteoarthritis, Carpometacarpal (CMC) Joint Arthritis, Basal Thumb Osteoartrithis
- Trial name
- BASTION (NCT07569549)
- Testing
- Implantation of trapeziometacarpal prosthesis, Trapeziectomy with Capsuloplasty
- Where
- Sweden
- Volunteers
- 84 people
- Sponsor
- Uppsala University
Osteoarthritis Thumb
Influence of the Radiological Stage on the Efficiency of Viscosupplementation in Basal Thumb Arthritis
The rhizarthrose is the most frequent affection of the hand at the age fifty and beyond. For the moderate forms of the disease, the majority of the studies recommend the recourse to the viscosupplement because of its efficiency…
- Trial name
- INSTINCT (NCT03622736)
- Where
- France
- Volunteers
- 122 people
- Sponsor
- Labrha
Osteoarthritis
Thumb Muscle Thickness and Strength in CMC Osteoarthritis
A total of 34 patients aged between 50-80 years, diagnosed with first carpometacarpal joint osteoarthritis based on hand radiographs taken within the last 3 months, will be included in the study from the Physical Therapy and…
- Trial name
- NCT06730698
- Testing
- No intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 34 people
- Sponsor
- Beylikduzu State Hospital
Rhizarthrosis
Study of Medical Ultrasound for Rhizarthrosis
It was never investigated which preservative non-invasive treatments are superior to treat rhizarthrosis. This randomized study compares the effect of 1. hand therapy vs. 2. therapeutic ultrasound vs. 3.
- Trial name
- NCT04115085
- Testing
- Hand therapy (18 treatments), Therapeutic ultrasound (18 treatments), Combined hand therapy and therapeutic ultrasound (18 treatments)
- Where
- Germany
- Volunteers
- 200 people
- Sponsor
- Waldfriede Hospital
Thumb Carpometacarpal Arthritis
Suture Fixation System Versus Tendonous Reconstruction in Carpometacarpal (CMC) Arthroplasty
Thumb carpometacarpal (CMC) arthritis affect 1 in 4 females and 1 in 12 males. Patients who fail to respond to conservative treatment may benefit from surgery; however, controversy exists over the most effective surgical…
- Trial name
- NCT01121874
- Testing
- Ligament reconstruction with suture fixation system, Ligament Reconstruction with Tendon Interposition (LRTI)
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- J&M Shuler
Osteoarthritis, Hip, Osteoarthritis Thumb
Evaluate Clinical Benefit of Local Treatment With KD Intra-Articular® Gel in Patients With Osteoarthritis (NO-DOLOR2)
Prospective observational, national, multicentre, open study with a class III medical device with EC marking. Study to evaluate the clinical benefit of local treatment with KD intra-articular® gel in patients with osteoarthritis…
- Conditions
- Osteoarthritis, Hip, Osteoarthritis Thumb, Osteoarthritis Ankle
- Trial name
- NO-DOLOR2 (NCT05275244)
- Testing
- KD Intra-Articular® gel
- Where
- Spain
- Volunteers
- 67 people
- Sponsor
- Procare Health Iberia S.L.
Hand Osteoarthritis
Effect of Immobilization of the Metacarpophalangeal Joint in Thumb Osteoarthritis
The aim of this study is to compare the effect of Whale and Colditz static orthosis on pain and functional abilities of hand in thumb carpometacarpal osteoarthritis as a unique treatment.
- Trial name
- NCT02780999
- Testing
- Whale orthosis, Colditz orthosis
- Where
- Spain
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- University of Malaga
Thumb Carpometacarpal Osteoarthritis
LRTI vs Internal Brace for CMC OA
Carpometacarpal osteoarthritis (CMC OA) is a prevalent and disabling disease. Trapeziectomy with ligament reconstruction and tendon interposition (LRTI), the most frequently performed procedure for CMC OA, requires prolonged…
- Trial name
- NCT03971188
- Testing
- Trapeziectomy with Internal Brace
- Where
- 3 sites in United States
- Volunteers
- 31 people
- Sponsor
- Washington University School of Medicine
Arthritis Wrist
Orthotic Management of CMC Osteoarthritis
This study will investigate the effectiveness of 3D printed splints for the treatment of thumb osteoarthritis (CMC OA). Currently, these splints are made by Occupational Therapists and Physical Therapists out of low temperature…
- Trial name
- NCT04297943
- Testing
- Orthosis fabrication, Thermal Sensor Monitoring of Orthosis Use, 4D CT Scan
- Volunteers
- 68 people
- Sponsor
- Western University, Canada
Osteoarthritis Thumb
Pivotal Study to Evaluate Efficacy and Safety of SP5M001 Inj. as Compared to Synovian Inj. in Patients With Mild to Moderate Knee Osteoarthritis
This is a randomized, double-blind, multicenter, non-inferiority, pivotal clinical trial to assess the efficacy and safety of the novel hexamethylenediamine (HMDA) cross-linked hyaluronate intra-articular injection (SP5M001)…
- Trial name
- NCT06307847
- Testing
- SP5M001 inj, Synovian inj
- Where
- 14 sites in South Korea
- Volunteers
- 223 people
- Sponsor
- Shin Poong Pharmaceutical Co. Ltd.
CMC Arthritis
Thumb Metacarpophalangeal Hyperextension in an Arthritic Population; Part 2
This is the second phase of a clinical study to assess MP hyperextension in CMC arthritis. In the first phase, submitted for publication, the investigators demonstrated that there is poor correlation between dynamic control of…
- Trial name
- NCT05835830
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Indiana Hand to Shoulder Center
Post-traumatic; Arthrosis, Osteoarthritis Thumb
The Angle of the Metacarpophalangeal Joint of the Thumb During Maximal Pinch Strength
The aim of the study is to measure the position of the metacarpophalangeal joint of the thumb during key-pinch, tripod-pinch and opposition-pinch in normal volunteers, to determine the optimal position of metacarpophalangeal…
- Trial name
- NCT04875156
- Testing
- measurement of range of motion and strength
- Where
- Belgium
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University Hospital, Ghent
CMC Joint Arthritis
Thumb Hemi-Arthroplasty With Natural Kinematics; a Prospective Multicenter Study to Confirm the Safety and Efficacy of the InDx Implant
Prospective, multicentric non-comparative confirmatory study to evaluate the safety and performance of the InDx CMC implant for the treatment of CMC joint arthritis.
- Trial name
- THANKS PRO (NCT06467760)
- Testing
- InDx CMC Implant
- Where
- 2 sites in Belgium, Netherlands
- Volunteers
- 14 people
- Sponsor
- Loci Orthopaedics