Clinical trials: Thumb Osteoarthritis
Thumb Osteoarthritis
The THumb Osteoarthritis Exercise TriAl
THIS TRIAL WAS PROSPECTIVELY REGISTERED ON FEBRUARY 27, 2020 IN THE DUTCH TRIAL REGISTRY (www.trialregister.nl), BUT THIS TRIAL REGISTRY WAS TERMINATED.
- Trial name
- THETA (NCT05772715)
- Testing
- orthosis + exercise therapy, Orthosis
- Where
- 5 sites in Netherlands
- Volunteers
- 166 people
- Sponsor
- Erasmus Medical Center
Thumb Carpometacarpal Osteoarthritis
LRTI vs Internal Brace for CMC OA
Carpometacarpal osteoarthritis (CMC OA) is a prevalent and disabling disease. Trapeziectomy with ligament reconstruction and tendon interposition (LRTI), the most frequently performed procedure for CMC OA, requires prolonged…
- Trial name
- NCT03971188
- Testing
- Trapeziectomy with Internal Brace
- Where
- 3 sites in United States
- Volunteers
- 31 people
- Sponsor
- Washington University School of Medicine
Arthritis Wrist
Orthotic Management of CMC Osteoarthritis
This study will investigate the effectiveness of 3D printed splints for the treatment of thumb osteoarthritis (CMC OA). Currently, these splints are made by Occupational Therapists and Physical Therapists out of low temperature…
- Trial name
- NCT04297943
- Testing
- Orthosis fabrication, Thermal Sensor Monitoring of Orthosis Use, 4D CT Scan
- Volunteers
- 68 people
- Sponsor
- Western University, Canada
Osteoarthritis Thumb, Thumb Carpometacarpal Joint Osteoarthritis
TOUCH® CMC 1 New Enrollment US Study
The purpose of this study is to meet a PMA (P240020) condition of approval of the TOUCH® CMC 1 Prosthesis to evaluate the effectiveness and safety of the prosthesis in the United States (US) population.
- Trial name
- PAS002 (NCT07405983)
- Testing
- TOUCH® CMC 1 Prosthesis
- Where
- 4 sites in United States
- Volunteers
- 163 people
- Sponsor
- Keri Medical SA
Thumb Osteoarthritis
Autologous Stromal Vascular Fraction in the Treatment of Thumb Basal Joint Osteoarthritis
Trial purpose is to research the outcome after thumb carpometacarpal injection with stromal vascular fraction (SVF) derived from adipose tissue. The study compares SVF injection therapy with thumb splinting vs. splinting only.
- Trial name
- REMEDY SVF (NCT04455763)
- Testing
- SVF, Splint
- Where
- Finland
- Volunteers
- 60 people
- Sponsor
- Töölö Hospital
Pain, Postoperative, Osteoarthritis Thumb
Pain Relief After Trapeziectomy: Ibuprofen & Acetaminophen Versus Oxycodone
In the US, pain management after surgery for surgical treatment of osteoarthritis at the base of the thumb typically consists of prescription opioids during the early recovery phase.
- Trial name
- NCT04676802
- Testing
- NSAID capsules, Opioid capsule
- Where
- 2 sites in United States
- Volunteers
- 73 people
- Sponsor
- Stanford University
Osteoarthritis Thumb
Pivotal Study to Evaluate Efficacy and Safety of SP5M001 Inj. as Compared to Synovian Inj. in Patients With Mild to Moderate Knee Osteoarthritis
This is a randomized, double-blind, multicenter, non-inferiority, pivotal clinical trial to assess the efficacy and safety of the novel hexamethylenediamine (HMDA) cross-linked hyaluronate intra-articular injection (SP5M001)…
- Trial name
- NCT06307847
- Testing
- SP5M001 inj, Synovian inj
- Where
- 14 sites in South Korea
- Volunteers
- 223 people
- Sponsor
- Shin Poong Pharmaceutical Co. Ltd.
Osteoarthritis Thumb
Thumb Osteoarthritis Prognosis for Supported Self-managment
Background Thumb base osteoarthritis (OA) is common in adults 40 years and over. It affects a person's ability to work, be independent and care for others.
- Trial name
- TOPS (NCT05932628)
- Testing
- This study will observe participants who receive a supported self management approach for thumb base osteoarthritis but it is not an interventional study.
- Where
- 4 sites in United Kingdom
- Volunteers
- 150 people
- Sponsor
- University Hospitals of Derby and Burton NHS Foundation Trust
Trapeziometacarpal Osteoarthritis, Thumb Osteoarthritis
ICF-Based Biopsychosocial Assessment With AI-Assisted Profile Prediction: Trapeziometacarpal Osteoarthritis Model
Trapeziometacarpal osteoarthritis (TMC OA) is a common condition affecting the base of the thumb that causes pain, weakness, and difficulty with daily hand use.
- Conditions
- Trapeziometacarpal Osteoarthritis, Thumb Osteoarthritis, Carpometacarpal Osteoarthritis, Thumb Basal Joint Osteoarthritis
- Trial name
- ICF (NCT07458971)
- Where
- Turkey (Türkiye)
- Volunteers
- 93 people
- Sponsor
- Hacettepe University
Thumb Osteoarthritis
Magnesium as an Adjunct for Pain Treatment After Surgery for Thumb Base Arthrosis
A randomised controlled trial of addition to the standard pain treatment of 1000 mg oral magnesium citrate or placebo for 7 Days during surgery for thumb base arthrosis.
- Trial name
- NCT04613154
- Testing
- magnesiumcitrate
- Where
- Sweden
- Volunteers
- 9 people
- Sponsor
- Region Örebro County
Post-traumatic; Arthrosis, Osteoarthritis Thumb
The Angle of the Metacarpophalangeal Joint of the Thumb During Maximal Pinch Strength
The aim of the study is to measure the position of the metacarpophalangeal joint of the thumb during key-pinch, tripod-pinch and opposition-pinch in normal volunteers, to determine the optimal position of metacarpophalangeal…
- Trial name
- NCT04875156
- Testing
- measurement of range of motion and strength
- Where
- Belgium
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University Hospital, Ghent
Thumb Osteoarthritis
The Role of the Proprioceptive Training in Functional Recovery of Patient With Thumb Base Osteoarthritis
Diseases that have implications for the thumb impact its function, and consequently, people occupational performance. Carpometacarpal joint (CMC) thumb degeneration translates into osteoarthritis (OA).
- Trial name
- NCT04892589
- Testing
- Proprioceptive thumb exercises.
- Where
- 2 sites in Argentina, Spain
- Volunteers
- 50 people
- Sponsor
- Clinica Universitaria Reina Fabiola, Universidad Catolica de Cordoba
Arthritis of Carpometacarpal Joint of Left Thumb, Arthritis of Carpometacarpal Joint of Right Thumb
Oral Curcumin for the Treatment of Pain of Thumb Base Joint (CMC) Arthritis
The goal of this clinical trial is to learn about the use of turmeric (Curcumin) as a treatment for pain of thumb-joint arthritis. Turmeric is commonly being used as an over-the-counter treatment for musculoskeletal pain.
- Trial name
- NCT06359665
- Testing
- Curcumin
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Brent DeGeorge
Osteoarthrosis of the Carpometacarpal Joint of the Thumb
Use of FlexHD as Post Trapeziectomy Spacer
The objective of this study is to show that using FlexHD® (or HADM) to fill the empty space created by removal of the trapezium improves the subject's outcome and subsequent functionality of the basilar joint arthroplasty…
- Trial name
- MTF (NCT01998594)
- Testing
- Arthroplasty
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Cedars-Sinai Medical Center
Osteoarthritis
A Study of Hyaluronan for the Treatment of Osteoarthritis in the Thumb
Hyaluronan is a man-made preparation of a protein complex that occurs naturally in joints and that is often low in people with osteoarthritis.
- Trial name
- NCT00398866
- Testing
- Synvisc (Hylan G-F20; hyaluronan injection), Bupivicaine (local anesthesia injection), Kenalog (triamcinolone; corticosteroid injection)
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Hospital for Special Surgery, New York
Thumb Carpometacarpal Joint Osteoarthritis
Prolotherapy Versus Steroids for Thumb Carpo-metacarpal Joint Arthritis
Arthritis of the base of the thumb is a common debilitating problem. It is believed that laxity (loosening) of the joint leads to worsening arthritis in this joint.
- Trial name
- NCT00685880
- Testing
- Prolotherapy (10% dextrose solution), Betamethasone
- Where
- United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Thumb Osteoarthritis
A Study on the Effect of Platelet Rich Plasma (PRP) on Osteoarthritis in the Thumb Base
Randomized comparison between Platelet Rich Plasma (PRP) and placebo (Saline) for thumb base.osteoarthritis.
- Trial name
- NCT04218591
- Testing
- PRP
- Where
- Sweden
- Volunteers
- 90 people
- Sponsor
- Karolinska Institutet
CBD, Hand Osteoarthritis
Is Topical CBD Effective in Treating Thumb Joint Arthritis
Rationale: CBD is commonly being used as an over-the-counter treatment for arthritis-related pain, however no clinical trial has been performed to establish efficacy.
- Trial name
- NCT04611347
- Testing
- CBD, Shea Butter
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Rhizarthrosis
Assessment of Pain After Intra-articular Botulinum Toxin Injections in Carpometacarpal Osteoarthritis of the Thumb
Only 4 randomized controlled clinical trials have been published to date to assess the short-term effectiveness of intra-articular Botulinum Toxin injection on pain, function and quality of life in patients suffering from chronic…
- Trial name
- NCT04829565
- Testing
- Botulinum toxin
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Thumb Osteoarthritis
Can Video Assisted Therapy Replace In-Person Occupational Therapy After Hand Surgery: a Noninferiority Study
This study will investigate a video assisted, home therapy program where participants complete hand therapy on their own following thumb arthroplasty. In this program, participants will receive prerecorded informational videos.
- Trial name
- NCT04625244
- Testing
- Video assisted home therapy
- Where
- United States
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- Carilion Clinic