Clinical trials: Thymus Neoplasms
Cancer
Intrapleural BG00001 in Treating Patients With Malignant Pleural Mesothelioma or Malignant Pleural Effusions
RATIONALE: Using BG00001 to insert the gene for interferon-beta into a person's pleural cavity may improve the body's ability to fight cancer.
- Trial name
- NCT00066404
- Testing
- recombinant adenovirus-hIFN-beta
- Where
- United States
- Sponsor
- Abramson Cancer Center at Penn Medicine
Thymoma and Thymic Carcinoma
Hypofractionated Chemoradiotherapy and Thymosin α1 in Unresectable or Recurrent Thymic Epithelial Tumor
This phase II study was to assess the efficacy and toxicity of hypofractionated radiotherapy (HRT) combined with weekly docetaxel/platinum and thymosin α1 in patients with unresectable or recurrent thymic epithelia tumors (TETs).
- Trial name
- NCT03663764
- Testing
- Thymosin a1, hypofractionated radiotherapy, concurrent chemoradiotherapy
- Where
- China
- Volunteers
- 57 people
- Sponsor
- Sun Yat-sen University
Thymoma
Application of 68Ga-Pentixafor PET/CT for Thymoma
Chemokine receptor CXCR4 was expressed in T cells and CXCR4-targeting molecular imaging- 68Ga-Pentixafor PET/CT could be a promising technique to evaluate the extent of thymoma with higher accuracy.
- Trial name
- NCT06086327
- Testing
- 68Ga-Pentixafor
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Peking Union Medical College Hospital
Neoplasms
Phase 1b Multi-indication Study of Anetumab Ravtansine in Mesothelin Expressing Advanced Solid Tumors
The key purpose of the main part of the study is to assess efficacy and safety of anetumab ravtansine as monotherapy or combination therapy for mesothelin expressing advanced solid tumors.
- Trial name
- ARCS-Multi (NCT03102320)
- Testing
- Cisplatin, Gemcitabine, Anetumab ravtansine (BAY94-9343)
- Where
- 72 sites in United States, Australia and 10 more
- Volunteers
- 173 people
- Sponsor
- Bayer
Neuroendocrine Tumors, Carcinoma, Small Cell Lung
PEN-221 in Somatostatin Receptor 2 Expressing Advanced Cancers Including Neuroendocrine and Small Cell Lung Cancers
Protocol PEN-221-001 is an open-label, multicenter Phase 1/2a study evaluating PEN-221 in patients with SSTR2 expressing advanced gastroenteropancreatic (GEP) or lung or thymus or other neuroendocrine tumors or small cell lung…
- Conditions
- Neuroendocrine Tumors, Carcinoma, Small Cell Lung, Neuroendocrine Carcinoma
- Trial name
- NCT02936323
- Testing
- PEN-221
- Where
- 13 sites in United States, United Kingdom
- Volunteers
- 89 people
- Sponsor
- Tarveda Therapeutics
Breast Cancer
Radiation Therapy and Thymus Function in Young Women With Breast Cancer
Breast cancer treatment sometimes includes radiation to the breast or chest wall. There is a small gland, called the thymus, located in the upper chest that may receive a small amount of the radiation aimed at the breast.
- Trial name
- NCT07725172
- Testing
- Blood draw for the laboratory assessment
- Where
- United States
- Volunteers
- 125 people
- Sponsor
- Duke University
Thymoma, Thymic Tumor
Prospective Study of Stereotactic Body Radiation Therapy for Thymoma Inoma: Therapeutic Effect and Toxicity Assessment
For patients with unresectable or recurrent disease, radiation is routinely administered, often in combination with systemic chemotherapy.
- Trial name
- NCT03078699
- Testing
- stereotactic body radiation therapy
- Where
- China
- Volunteers
- 32 people
- Sponsor
- Third Military Medical University
Thymic Carcinoma
Survival Nomogram for Patients With Thymic Carcinoma
Background Thymic carcinoma (TC) is a rare and aggressive mediastinal malignancy with poor prognosis. Our study aimed to develop a nomogram to predict overall survival (OS) of TC patients.
- Trial name
- NCT07179341
- Testing
- Thymectomy for thymic carcinoma
- Where
- China
- Volunteers
- 156 people
- Sponsor
- Weijie Ye
NSCLC, Mesothelioma
Folinic Acid for Prevention of Pemetrexed-induced Toxicity
Objective The main objective is to evaluate the haematological toxicity in patients who use pemetrexed with and without rescue therapy with folinic acid.
- Conditions
- NSCLC, Mesothelioma, Thymoma
- Trial name
- FLEX (NCT06010277)
- Testing
- Folinic acid
- Where
- 2 sites in Netherlands
- Volunteers
- 50 people
- Sponsor
- Amphia Hospital
Thymoma, Stomach Neoplasms
Tissue Procurement and Natural History Study of Patients With Malignant Mesothelioma
Background: Malignant mesothelioma is a malignancy arising from the mesothelial cells of the pleura, peritoneum, pericardium, or tunica vaginalis. Mesothelioma accounts for 0.10% of deaths annually in the United States.
- Conditions
- Thymoma, Stomach Neoplasms, Pancreatic Neoplasms, Mesothelioma
- Trial name
- NCT01950572
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- National Cancer Institute (NCI)
Lung Cancer, Prostate Cancer
Cognitive Testing of Tobacco Use Measurement Items for Administration With Cancer Patients and Survivors
Background: People who have cancer have more medical problems if they smoke. Some studies show that smoking even makes cancer treatment less effective.
- Conditions
- Lung Cancer, Prostate Cancer, Bladder Cancer, Thymic Cancer
- Trial name
- NCT02233842
- Testing
- Participant interview
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- National Cancer Institute (NCI)
Thymoma
Efficacy of Octreotide Treatment in Patients With Primary Inoperable Thymoma
This study will investigate the efficacy of treatment with octroetide in patients with primary inoperable thymoma to reduce tumor size.
- Trial name
- NCT00332969
- Testing
- Octreotide
- Where
- Germany
- Volunteers
- 25 people
- Sponsor
- Novartis Pharmaceuticals
Thymic Carcinoma
Neoadjuvant Adebrelimab Plus CRT for Locally Advanced Thymic Carcinoma
The goal of this clinical trial (Phase II) is to evaluate the efficacy and safety of neoadjuvant Adebrelimab combined with chemoradiation in patients with locally advanced thymic carcinoma.
- Trial name
- NCT07479628
- Testing
- adebrelimab plus chemoradiation
- Volunteers
- 31 people
- Sponsor
- Shanghai Chest Hospital
Thymoma
Biology of Thymic Tumors
This is a retrospective analysis of biological characteristics of thymoma and thymic carcinoma patients.
- Trial name
- NCT00965627
- Where
- Italy
- Volunteers
- 134 people
- Sponsor
- Istituto Clinico Humanitas
Primary Inoperable Thymoma, Local Recurrent Thymoma
Efficacy of Medical Treatment With SOM230 LAR in Patients With Primary Inoperable Thymoma and/or With Local Recurrent Thymoma to Reduce Tumor Size
This is a monocenter, single-arm, open label phase II trial evaluating the effect of SOM230 LAR in adult patients with inoperable primary thymoma and thymoma metastasis (Masaoka II-IVa).
- Trial name
- NCT02021942
- Testing
- SOM230 LAR
- Where
- Germany
- Volunteers
- 16 people
- Sponsor
- Prof. Dr. Berthold Schalke
Thymoma, Advanced Thymic Epithelial Tumour
Selinexor in Patients With Advanced Thymoma and Thymic Carcinoma
The aim of the study is to determine the efficacy of selinexor in adults with TETs determined by overall response rate (RECIST 1.1) in two parallel cohorts of patients with advanced thymomas or thymic carcinomas.
- Trial name
- TET-SEL (NCT03466827)
- Testing
- Selinexor
- Where
- 4 sites in Denmark, France
- Volunteers
- 25 people
- Sponsor
- Morten Mau-Soerensen
Adenocarcinoma, Adenocystic Carcinoma
The Registry of Oncology Outcomes Associated With Testing and Treatment
This study is to collect and validate regulatory-grade real-world data (RWD) in oncology using the novel, Master Observational Trial construct. This data can be then used in real-world evidence (RWE) generation.
- Conditions
- Adenocarcinoma, Adenocystic Carcinoma, Anal Cancer, Appendix Cancer
- Trial name
- ROOT (NCT04028479)
- Testing
- Biomarker Testing (L), Systemic Treatment (T), Patient Reported Outcomes (P)
- Where
- 2 sites in United States
- Volunteers
- 167 people
- Sponsor
- Taproot Health
Thymoma Staging, Clinical Presentations
Characteristics of Patients With Thymoma in Chulalongkorn Hospital
The purpose of this study is to study characteristics of patients with thymoma in Chulalongkorn hospital between 2003-2007.
- Conditions
- Thymoma Staging, Clinical Presentations, Associated Disorders, Laboratory Findings
- Trial name
- NCT01123590
- Where
- Thailand
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Chulalongkorn University
Efgartigimod, Intravenous Immunoglobulin
EFG vs IVIG in TAMG
This study is a prospective, multi-center, randomized controlled study to evaluate the efficacy and safety of efgartigimod (EFG) and intravenous immunoglobulin (IVIG) in the perioperative application for acetylcholine receptor…
- Conditions
- Efgartigimod, Intravenous Immunoglobulin, Myasthenia Gravis Associated With Thymoma
- Trial name
- NCT07231523
- Testing
- Efgartigimod + Thymectomy, Intravenous immunglobulin + Thymectomy
- Where
- China
- Volunteers
- 64 people
- Sponsor
- Shanghai Zhongshan Hospital
Thymoma
A Study of BKM120 (Buparlisib) in Relapsed or Refractory Thymomas
Thymic tumors are rare tumors, but represent the most common tumors of the anterior mediastinum. Thymoma has an indolent course in advanced disease and has the propensity to spread to the pleura.
- Trial name
- NCT02220855
- Testing
- BKM120
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Patrick Joseph Loehrer Sr.