Clinical trials: Thyroid Cancers
Papillary Thyroid Cancer, Follicular Thyroid Cancer
Sutent Adjunctive Treatment of Differentiated Thyroid Cancer
This study is comparing a drug called Sutent with standard of care treatment for people with advanced thyroid cancer. Because advanced thyroid cancer is becoming increasingly common and effective treatment options are limited…
- Conditions
- Papillary Thyroid Cancer, Follicular Thyroid Cancer, Differentiated Thyroid Cancer
- Trial name
- IIT Sutent (NCT00668811)
- Testing
- SU011248, Sutent
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Medstar Health Research Institute
Head and Neck Cancer, Thyroid Cancer
New MRI Biomarkers in Head and Neck Cancers
Magnetic resonance imaging (MRI) is a diagnostic technique that takes pictures of organs of the body. It uses magnetic fields and radio waves that cannot be felt.
- Trial name
- NCT03483337
- Testing
- MRI examinations
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Selenium Deficiency, Thyroid Cancer TNM Staging
Clinical Study on the Effect of Selenium Yeast Capsule on Prognosis of Differentiated Thyroid Carcinoma
Oxidative stress is involved in the pathogenesis of thyroid cancer, but the mechanism is not clear. The thyroid is the organ with the most abundant selenium content, and selenium may be involved in protecting the gland from the…
- Conditions
- Selenium Deficiency, Thyroid Cancer TNM Staging, Recurrence, Metastasis
- Trial name
- NCT04683575
- Testing
- Selenium Yeast
- Where
- China
- Volunteers
- 5,000 people
- Sponsor
- Qianfoshan Hospital
Thyroid Neoplasms, Hypothyroidism
Individual Dosing of Levothyroxine After Thyroidectomy
Recently, Zaborek et al. raised a Poisson regression model for levothyroxine(LT4) dosing scheme to predict individual dose of LT4 after thyroidectomy: daily LT4 dose=e[2.02+0.01(W)-0.0037(A…
- Conditions
- Thyroid Neoplasms, Hypothyroidism, Surgery
- Trial name
- NCT05240911
- Testing
- Levothyroxine Sodium Tablets
- Where
- China
- Volunteers
- 202 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Metastatic Sporadic Medullary Thyroid Cancer
Molecular Profile of Metastatic Sporadic Medullary Thyroid Cancer Patients and Correlation With Vandetanib
Vandetanib has been approved for patients with unresectable and/or metastatic medullary thyroid cancer (MTC) by the Food and Drug Administration, by the European Medicines Agency and, very recently, it has been licensed also by…
- Trial name
- NCT02268734
- Where
- Italy
- Volunteers
- 36 people
- Sponsor
- Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
Cancer, Tumor, Solid
Study of JK08 in Patients with Unresectable Locally Advanced or Metastatic Cancer
This is a Phase 1/2, open-label, multi-center, first-in-human, dose escalation and cohort expansion study evaluating multiple doses and schedules of subcutaneously administered JK08 in patients with unresectable locally, advanced…
- Conditions
- Cancer, Tumor, Solid, Advanced Solid Tumor, Metastatic Cancer
- Trial name
- NCT05620134
- Testing
- JK08, Pembrolizumab, Lenvatinib Pill
- Where
- 11 sites in Belgium, Spain
- Volunteers
- 263 people
- Sponsor
- Salubris Biotherapeutics Inc
Genomics, Thyroid Cancer
Integrating Tumor Genomics and Urinary Exosomal Proteomics to Establish a Multi-Layer Biomarker Framework for Early Risk Stratification and Post-Treatment Surveillance in Fresh Thyroid Cancer Patients
Thyroid cancer is the most common endocrine malignancy, and although differentiated thyroid cancer (DTC) generally confers favorable outcomes, 10-20% of patients still face substantial postoperative risks, including local…
- Conditions
- Genomics, Thyroid Cancer, NGS
- Trial name
- NCT07532356
- Volunteers
- 100 people
- Sponsor
- National Taiwan University Hospital
Thyroid Cancer Stage IV
Stereotactic Body Radiotherapy for the Treatment of Distant Metastases in Thyroid Cancer: A Phase II Prospective Clinical Study
The goal of this observational study is to evaluate the efficacy and safety of Stereotactic Body Radiotherapy in the treatment of distant metastatic thyroid cancer.
- Trial name
- NCT07755423
- Testing
- SBRT
- Where
- China
- Volunteers
- 44 people
- Sponsor
- Fudan University
Thyroid Cancer
Efficacy and Tolerability of ZD6474 in Patients With Thyroid Cancer
The purpose of this open label, two stage, phase II study is to evaluate the efficacy and tolerability of ZD6474 in patients with locally advanced or metastatic hereditary medullary thyroid carcinoma.
- Trial name
- NCT00098345
- Testing
- ZD6474 (vandetanib)
- Where
- 6 sites in United States, France
- Volunteers
- 40 people
- Sponsor
- Genzyme, a Sanofi Company
Thyroid Cancer, Thyroid Nodule
Molecular Profile of Thyroid Nodules
Profiling and comparative analysis of genomic alterations and miRNA expression in benign and malignant thyroid tumors using histological and cytological specimens will be performed.
- Trial name
- MPTN (NCT05323669)
- Testing
- Molecular testing
- Volunteers
- 400 people
- Sponsor
- Belarusian State Medical University
BRAF NP_004324.2:p.V600E, BRAF V600K Mutation Present
Dabrafenib, Trametinib, and IMRT in Treating Patients With BRAF Mutated Anaplastic Thyroid Cancer
This trial studies how well dabrafenib, trametinib, and intensity modulated radiation therapy (IMRT) work together in treating patients with BRAF mutated anaplastic thyroid cancer.
- Conditions
- BRAF NP_004324.2:p.V600E, BRAF V600K Mutation Present, Thyroid Gland Anaplastic Carcinoma
- Trial name
- NCT03975231
- Testing
- Dabrafenib, Intensity-Modulated Radiation Therapy, Trametinib
- Where
- 3 sites in United States
- Volunteers
- 6 people
- Sponsor
- City of Hope Medical Center
Thyroid
IMRT Followed by Pembrolizumab in the Adjuvant Setting in Anaplastic Cancer of the Thyroid (IMPAACT): Phase II Trial Adjuvant Pembrolizumab After IMRT in ATC
This is an open label, single center, phase 2 trial of adjuvant pembrolizumab after external beam radiation to the primary tumor in patients with stage IVB (disease localized to the neck) ATC.
- Trial name
- NCT05059470
- Testing
- Pembrolizumab
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- M.D. Anderson Cancer Center
Quality of Life
A Follow-up Study on Total Endoscopic Thyroidectomy Bilateral Areola Approach
Endoscopic thyroidectomy bilateral areola approach (ETBAA) is one of the most widely applied approach in China, meanwhile its safety and effectiveness has been broadly discussed since being introduced.
- Trial name
- NCT05315219
- Testing
- Endoscopic Thyroidectomy Bilateral Areola Approach
- Volunteers
- 295 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Thyroid Nodule
Artificial Intelligence-assisted Contrast-enhanced Ultrasound Diagnosis of Thyroid Nodules
The goal of this intervention study is to learn about the diagnostic performance of artificial intelligence to assist the contrast-enhanced ultrasound diagnosis of thyroid nodules. The main questions it aims to answer are: 1.
- Trial name
- AIA-CEUD-TN (NCT05982821)
- Testing
- Artificial Intelligence
- Where
- China
- Volunteers
- 1,955 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Thyroid Nodule
In Vivo Multispectral Optoacoustic Imaging of Thyroid Nodules
Thyroid nodules are common in clinical practice. Head and neck ultrasound is recommended as a routine examination for all patients with thyroid lesions.
- Trial name
- THYNODE (NCT04730726)
- Testing
- MSOT Acuity Echo
- Where
- Netherlands
- Volunteers
- 50 people
- Sponsor
- University Medical Center Groningen
Thyroid Diseases, Goiter
Thyroidectomy-specific Enhanced Recovery After Surgery (ERAS) Protocol
Thyroidectomy is generally considered a low-to-moderate risk operation; however, postoperative pain, nausea/vomiting, and prolonged hospital stays remain common issues.
- Conditions
- Thyroid Diseases, Goiter, Thyroid Neoplasms
- Trial name
- NCT07575243
- Testing
- Enhanced Recovery After Surgery protocol, Conventional perioperative care
- Where
- Egypt
- Volunteers
- 143 people
- Sponsor
- Assiut University
Salivary Gland Cancer, Thyroid Cancer
Sacituzumab Govitecan in Metastatic Salivary Gland and Thyroid Cancers (SG-SGTC)
The goal of this clinical trial is to learn if the drug, sacituzumab govitecan, works to treat: 1. Salivary gland cancers that have spread to other parts of the body or come back after previous treatment, and cannot be removed by…
- Trial name
- TROP2 (NCT06923826)
- Testing
- Sacituzumab govitecan
- Where
- Singapore
- Volunteers
- 32 people
- Sponsor
- National University Hospital, Singapore
Medullary Thyroid Cancer
Study in Healthy Volunteers to Assess Effect of Omeprazole and Ranitidine on the Pharmacokinetics of Vandetanib
Study in healthy volunteers to assess effect of omeprazole and ranitidine on the pharmacokinetics of vandetanib
- Trial name
- Vandetanib (NCT01539655)
- Testing
- vandetanib, omeprazole, ranitidine
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Sanofi
Graves Disease, Graves' Disease in Remission
Graves' Disease Induced by Epstein-Barr Virus Lytic Reactivation
Previous studies have proved that the lytic reactivation of latent Epstein-Barr virus (EBV) was significantly associated with the onset of Graves'disease (GD), however, the morbidity of GD and recurrence rate of hyperthyroidism…
- Conditions
- Graves Disease, Graves' Disease in Remission, Epstein-Barr Virus
- Trial name
- NCT06426758
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Xiao-Ming Mao
Thyroid Goiter, Thyroid Nodule
Analgesia for Thyroidectomy Using Bilateral Superficial Cervical Plexus Block With Bupivacaine Only or Adding Ketorolac to it.
Thyroidectomy is considered a common operation with moderate to severe postoperative pain in some patients. Patients are divided into two groups.
- Trial name
- NCT05180214
- Testing
- Bupivacain, Ketorolac
- Where
- Egypt
- Volunteers
- 46 people
- Sponsor
- Sohag University
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