Clinical trials: Thyroid Cancers
Malignant Struma Ovarii, Papillary Thyroid Cancer
Metabolic Effects of Synthetic Thyroid Hormone for Thyroid Cancer Treatment
Background: Thyroid hormone is produced by the thyroid gland, an organ at the base of the neck. Thyroid hormone controls the body's metabolism and the function of many organs.
- Conditions
- Malignant Struma Ovarii, Papillary Thyroid Cancer, Hurthle Cell Thyroid Cancer, Follicular Thyroid Cancer
- Trial name
- NCT01441154
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Follicular Thyroid Cancer
Aberrant Helix Pomatia Agglutinin Binding Glycan Expression in Follicular Thyroid Tumours
Aberration of glycosylation is a hallmark of cancer cells, and plays an important role in oncogenesis and cancer progression, including metastasis.
- Trial name
- NCT05052359
- Testing
- Lectin-histochemistry retrospectively performed
- Where
- Singapore
- Volunteers
- 37 people
- Sponsor
- National University Health System, Singapore
Medullary Thyroid Carcinoma
A Study of HA121-28 Tablets in Patients With Medullary Thyroid Carcinoma (MTC)
This is a single-arm, open-label, multicenter study designed to evaluate the preliminary antineoplastic activity, safety and tolerability of HA121-28 tablets administered orally in patients with medullary thyroid cancer (MTC).
- Trial name
- NCT04787328
- Testing
- HA121-28 tablets
- Where
- 13 sites in China
- Volunteers
- 30 people
- Sponsor
- CSPC ZhongQi Pharmaceutical Technology Co., Ltd.
Papillary Thyroid Cancer, Follicular Thyroid Cancer
A Drug-Drug Interaction Study of the Effects of XL184 (Cabozantinib) on Rosiglitazone in Subjects With Solid Tumors
The primary objective of this clinical study is to determine whether the inhibition of cytochrome P450 (CYP) isozyme CYP2C8 by XL184 observed in in vitro preclinical studies translates into the potential for clinically…
- Conditions
- Papillary Thyroid Cancer, Follicular Thyroid Cancer, Huerthle Cell Thyroid Cancer, Renal Cell Carcinoma
- Trial name
- NCT01100619
- Testing
- rosiglitazone, XL184
- Where
- 5 sites in United States
- Volunteers
- 40 people
- Sponsor
- Exelixis
Thyroid Cancer
MRG003 and Pucotenlimab to Treat Locally Advanced or Metastatic ATC/PDTC
This study is a single-arm, open-label, multi-cohort, single-center phase II clinical trial designed to observe and evaluate the efficacy and safety of MRG003 (a EGFR-ADC) in combination with pucotenlimab (a PD-1 inhibitor) for…
- Trial name
- NCT07235566
- Testing
- MRG003 in combination with pucotenlimab
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Fudan University
Thyroid Cancer
Effects of Systemic Lidocaine on Postoperative Quality of Recovery After Robot-assisted Thyroidectomy
Systemic lidocaine infusion may improve the patients' recovery quality and chronic post surgical pain after robot-assisted thyroidectomy
- Trial name
- NCT01907997
- Testing
- Systemic intravenous lidocaine infusion, normal saline infusion
- Where
- South Korea
- Volunteers
- 90 people
- Sponsor
- Yonsei University
Thyroid Nodule
Mini-flap BABA (Bilateral Axillo-breast Approach) Robotic Thyroidectomy is Safe
In this study, a randomized controlled study was conducted between two groups of 40 recipients of conventional flap during BABA robotic-thyroidectomy and 40 recipients of Mini-flap method during BABA robotic-thyroidectomy.
- Trial name
- NCT05216718
- Testing
- Mini-flap, Conventional flap
- Where
- South Korea
- Volunteers
- 82 people
- Sponsor
- Inje University
Thyroid Cancer, Recurrence
Diagnostic Utility of [18F]-FDG-PET/CT and [124I]-PET/CT for Detection of Recurrence in Differentiated Thyroid Carcinoma
Several studies have indicated that [124I]-PET/CT or [18F]-FDG-PET/CT may be useful to locate recurrent differentiated thyroid carcinoma lesions in patients with elevated thyroglobulin levels but who do not show pathological…
- Trial name
- NCT01374659
- Where
- South Korea
- Volunteers
- 50 people
- Sponsor
- Korean Association of Endocrine Surgeons
Thyroid Nodule
Surgical Versus Non Surgical Management of Thyroid Nodule
To compare between surgical (hemi thyroidectomy and total thyroidectomy) and non-surgical (medical, ethanol injection,thermal ablation and laser photo coagulation) management of simple thyroid nodule regarding: Outcome of every…
- Trial name
- NCT04580199
- Testing
- thyroidectomy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Mahmoud Fahd
Anaplastic Thyroid Cancer
Nivolumab Plus Lenvatinib Against Anaplastic Thyroid Cancer (NAVIGATION)
This study is an open-label phase 2 study to evaluate the safety and efficacy of Nivolumab plus Lenvatinib in patients with unresectable anaplastic thyroid cancer.
- Trial name
- NCT05696548
- Testing
- Lenvatinib, Nivolumab
- Where
- 10 sites in Japan
- Volunteers
- 51 people
- Sponsor
- National Cancer Center Hospital East
Papillary Thyroid Carcinoma
Multimodal Deep Learning for Lymph Node Metastasis in Thyroid Cancer
Papillary thyroid carcinoma (PTC) is the most common endocrine malignancy in clinical practice, accounting for approximately 85% of all thyroid malignancies.
- Trial name
- NCT07299318
- Testing
- not intervention
- Where
- China
- Volunteers
- 3,200 people
- Sponsor
- West China Hospital
Intermediate-to-High Risk Differentiated Thyroid Cancer
Desiccated Thyroid Extract Combined With Levothyroxine for TSH Suppression Therapy in DTC
The global incidence of Differentiated Thyroid Cancer (DTC) is rising. While surgery followed by TSH suppression is the standard of care, achieving target TSH levels with levothyroxine (L-T4) monotherapy remains challenging, with…
- Trial name
- DELTA (NCT07239674)
- Testing
- desiccated thyroid extract (DTE)+levothyroxine (L-T4)
- Volunteers
- 646 people
- Sponsor
- West China Hospital
Differentiated Thyroid Cancer
Cabozantinib In Advanced Radioactive-Iodine Refractory Differentiated Thyroid Cancer.
CABOTHYROID is a prospective, exploratory, biomarker-focused, phase II, single-arm, non-randomized, non-blinded, investigator-initiated study of cabozantinib in patients with previously treated advanced radioactive-iodine…
- Trial name
- CABOTHYROID (NCT05660954)
- Testing
- Cabozantinib
- Where
- 9 sites in Spain
- Volunteers
- 41 people
- Sponsor
- Grupo Espanol de Tumores Neuroendocrinos
Papillary Thyroid Cancer
Radiofrequency Ablation of Papillary Thyroid Microcarcinoma
Traditionally, surgery has been the standard recommendation for treating papillary thyroid cancer. The risk of surgery including permanent hoarseness, permanent hypocalcemia, a mid-cervical scar, and the potential for permanent…
- Trial name
- NCT05132205
- Testing
- Radiofrequency Ablation
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Johns Hopkins University
Differentiated Thyroid Cancer, Thyroid Cancer
Thyroid Hormone Replacement After Radio Iodine: Value and Efficacy
This study will be a multicentre prospective cohort study on TH-substitution after thyroid hormone withdrawal preceding radioiodine treatment.
- Conditions
- Differentiated Thyroid Cancer, Thyroid Cancer, Levothyroxine, Liothyronine
- Trial name
- THRIVE (NCT06647602)
- Testing
- Euthyrox (levothyroxine), Cytomel (liothyronine)
- Where
- 2 sites in Netherlands
- Volunteers
- 40 people
- Sponsor
- University Medical Center Groningen
Genomics, Thyroid Cancer
Integrating Tumor Genomics and Urinary Exosomal Proteomics to Establish a Multi-Layer Biomarker Framework for Early Risk Stratification and Post-Treatment Surveillance in Fresh Thyroid Cancer Patients
Thyroid cancer is the most common endocrine malignancy, and although differentiated thyroid cancer (DTC) generally confers favorable outcomes, 10-20% of patients still face substantial postoperative risks, including local…
- Conditions
- Genomics, Thyroid Cancer, NGS
- Trial name
- NCT07532356
- Volunteers
- 100 people
- Sponsor
- National Taiwan University Hospital
Thyroid Nodule
Comparison of Anesthesia Effects of Sevoflurane and Propofol Combined With Dexmedetomidine in Intraoperative Neuromonitoring During Thyroidectomy
According to the previous studies, it is reported that the use of sevoflurane in the maintenance of anesthesia may lead to delayed occurrence of positive electromyographic (EMG) signal and lower obtained signal amplitude.
- Trial name
- NCT04680650
- Testing
- Anesthesia was maintained with sevoflurane, Anesthesia was maintained with propofol
- Where
- China
- Volunteers
- 66 people
- Sponsor
- Affiliated Cancer Hospital & Institute of Guangzhou Medical University
Thyroid Cancer
Long Non Coding RNA HOTAIR and Midkine as Biomarkers in Thyroid Cancer
Thyroid cancer is the most prevalent endocrine malignancy.Papillary thyroid carcinomas and follicular thyroid carcinomas account for 95% of all thyroid cancer cases.
- Trial name
- NCT03469544
- Testing
- complete blood picture ,serum urea and creatinine,liver function test,T3,T4,thyroid stimulating hormone,thyroglobuline and thyroglobuline anti body specific test Real time polymerase chain reaction
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Assiut University
Thyroid Neoplasms, Hypothyroidism
Individual Dosing of Levothyroxine After Thyroidectomy
Recently, Zaborek et al. raised a Poisson regression model for levothyroxine(LT4) dosing scheme to predict individual dose of LT4 after thyroidectomy: daily LT4 dose=e[2.02+0.01(W)-0.0037(A…
- Conditions
- Thyroid Neoplasms, Hypothyroidism, Surgery
- Trial name
- NCT05240911
- Testing
- Levothyroxine Sodium Tablets
- Where
- China
- Volunteers
- 202 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Differentiated Thyroid Cancer (DTC), Robotic Assistance
Robotic Surgery Via Bilateral Axillo-breast Approach for Relatively Low-risk Papillary Thyroid Carcinoma With Lateral Cervical Lymph Node Metastasis: a Safe and Effective Cosmetic Procedure in the Context of Prevalent Thyroid Ultrasound Screening
The goal of this observational study is to learn the efficacy, cosmetic effectiveness and safety of robotic modified radical neck dissection in well-selected cases, through direct comparison with conventional open surgery in…
- Trial name
- NCT07229859
- Where
- China
- Volunteers
- 332 people
- Sponsor
- Ruijin Hospital
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.