Clinical trials: Thyroid Cancers
Thyroid Diseases, Thyroid Cancer
RAman For Thyroid cancER
Ex vivo vibrational spectroscopy (VS), including Raman spectroscopy (RS) of thyroid tissue samples, collected from patients undergoing routine diagnostic thyroid biopsies for diagnosis of potential thyroid cancer.
- Trial name
- RAFTER (NCT04040673)
- Testing
- thyroid lobectomy, Raman spectroscopy probe measurement
- Where
- United Kingdom
- Sponsor
- Gloucestershire Hospitals NHS Foundation Trust
Thyroid Cancer, Recurrent Laryngeal Nerve Injuries
Effect of Reversed Tracking Method for Identification of EBSLN in Thyroid Surgery
The feasibility and effectiveness of Reversed Tracking Method for the identification and protection of extralaryngeal nerve branches in thyroid surgery were analyzed.
- Trial name
- NCT03680222
- Testing
- Reversed Tracking Method
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Fujian Medical University
Thyroid Nodules
Realtime-Elastography (RTE) and Thyroid Nodules
The study is an open, prospective multicenter study. According to the statistical sample size calculation 593 patients with thyroid nodules ≥ 5mm in size will be included in the study.
- Trial name
- NCT01609946
- Testing
- Realtime-Elastography, linear ultrasound probe, Hitachi EUB-900, Japan, Cytology (FNAB) or Surgery
- Where
- 10 sites in Germany
- Volunteers
- 602 people
- Sponsor
- Johannes Vermehren
Thyroid Carcinoma, Anaplastic
Taiwanese Anaplastic Thyroid Cancer Registry
Primary treatment strategies for ATC have included surgical resection combined with radiotherapy, chemotherapy, or concurrent chemoradiation therapy.
- Trial name
- TATC (NCT07138261)
- Where
- 9 sites in Taiwan
- Volunteers
- 100 people
- Sponsor
- National Health Research Institutes, Taiwan
Anaplastic Thyroid Cancer
Study of the Rechallenge Concept in Patients With BRAF-positive Anaplastic Thyroid Cancer After Progression on Anti-BRAF Therapy
This pilot phase 2 study evaluates the effectiveness and safety of the Rechallenge concept in patients with BRAF-positive anaplastic thyroid cancer after progression on anti-BRAF therapy.
- Trial name
- NCT06362694
- Testing
- Dabrafenib + Trametinib
- Where
- Russia
- Volunteers
- 10 people
- Sponsor
- Saint Petersburg State University, Russia
Head and Neck Cancer
Everolimus in Treating Patients With Progressive or Recurrent, Unresectable, or Metastatic Thyroid Cancer
RATIONALE: Everolimus may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth and by blocking blood flow to the tumor.
- Trial name
- NCT01118065
- Testing
- everolimus
- Where
- Netherlands
- Volunteers
- 42 people
- Sponsor
- Leiden University Medical Center
Metastatic Thyroid Gland Carcinoma, Poorly Differentiated Thyroid Gland Carcinoma
Trametinib in Increasing Tumoral Iodine Incorporation in Patients With Recurrent or Metastatic Thyroid Cancer
This phase II trial studies how well trametinib works in increasing tumoral iodine incorporation in patients with thyroid cancer that has come back or spread to another place in the body.
- Conditions
- Metastatic Thyroid Gland Carcinoma, Poorly Differentiated Thyroid Gland Carcinoma, Recurrent Thyroid Gland Carcinoma, Refractory Thyroid Gland Carcinoma
- Trial name
- NCT02152995
- Testing
- Computed Tomography, Iodine I 124, Iodine I-131
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- National Cancer Institute (NCI)
Thyroid Cancer
The Effect of the Number of Central Lymph Nodes on Changes in Parathyroid Function
This study collected data from patients who underwent thyroidectomy in the Breast and Thyroid Surgery Department of Shandong Provincial Hospital from January 2020 to December 2023 by reviewing medical records.
- Trial name
- NCT06432244
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- Shandong Provincial Hospital
Thyroid Cancer, Atypia of Undetermined Significance
The Risk Stratification of Papillary Thyroid Cancer With AUS/FLUS by FNA
Purpose: To investigate the clinical characteristics of papillary thyroid cancer (PTC) with Bethesda category III (AUS/FLUS) by fine needle aspiration (FNA) and to assisted the precision treatment.
- Conditions
- Thyroid Cancer, Atypia of Undetermined Significance, FLUS
- Trial name
- NCT04601298
- Where
- China
- Volunteers
- 290 people
- Sponsor
- Shanghai 10th People's Hospital
Metastatic Radioactive Iodine Refractory Thyroid Cancer Patients With RAS or BRAF Mutation
Efficacy of MEK (Trametinib) and BRAFV600E (Dabrafenib) Inhibitors With Radioactive Iodine (RAI) for the Treatment of Refractory Metastatic Differentiated Thyroid Cancer
This is a multicentric prospective non-randomized phase II trial, with two independent arms: one for patients with RAS mutation and one for patients with BRAFV600E mutation.
- Trial name
- MERAIODE (NCT03244956)
- Testing
- Trametinib, Dabrafenib, 131I
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Gustave Roussy, Cancer Campus, Grand Paris
Poorly Differentiated Thyroid Gland Carcinoma, Recurrent Thyroid Gland Carcinoma
Cabozantinib-S-Malate in Treating Patients With Refractory Thyroid Cancer
This phase II trial studies how well cabozantinib-s-malate works in treating patients with thyroid cancer that does not respond to treatment.
- Conditions
- Poorly Differentiated Thyroid Gland Carcinoma, Recurrent Thyroid Gland Carcinoma, Stage I Thyroid Gland Follicular Carcinoma, Stage I Thyroid Gland Papillary Carcinoma
- Trial name
- NCT01811212
- Testing
- Cabozantinib S-malate, Laboratory Biomarker Analysis
- Where
- 7 sites in United States
- Volunteers
- 25 people
- Sponsor
- National Cancer Institute (NCI)
Thyroid Cancer, Thyroid Cancer, Medullary
Adaptive Tyrosine Kinase Inhibitor (TKI) Therapy In Patients With Thyroid Cancer
Participants will have been diagnosed with advanced progressive thyroid cancer and are about to start treatment with a tyrosine kinase inhibitor (TKI).
- Conditions
- Thyroid Cancer, Thyroid Cancer, Medullary, Differentiated Thyroid Cancer, Papillary Thyroid Cancer
- Trial name
- NCT03630120
- Testing
- Lenvatinib, Sorafenib, Cabozantinib
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
Device
Comparison of Record in VERITON Camera to the Anger Camera Procedure in Patients Treated by 131-iodine
The aim of this study is to show that the SPECT/CT whole body recording procedure lasting less than or equal to 30 minutes in a VERITON-CT™ camera, can be substituted for the classic procedure, giving at least equivalent…
- Trial name
- VERICATH (NCT05713123)
- Testing
- A SPECT-CT whole body is added in VERITON-CT camera
- Where
- France
- Volunteers
- 77 people
- Sponsor
- Central Hospital, Nancy, France
Thyroid Cancer
Intervention to Decrease Overtreatment of Patients With Low-risk Thyroid Cancer
The study will include 50 patients newly diagnosed with low-risk thyroid cancer ranging from 18-80 years of age. After scheduling their surgeon visit, the investigators will enroll patients and measure their intended treatment…
- Trial name
- NCT06073223
- Testing
- Usual Care, CQUPLE
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Michigan Rogel Cancer Center
Thyroid Cancer
Use of a Decision Aid to Resolve Uncertainty About Radioactive Iodine Treatment in Patients With Intermediate Risk Thyroid Cancer
The goal of this study is to learn if a decision aid (DA) website helps people with thyroid cancer make informed decisions about radioactive iodine (RAI) treatment.
- Trial name
- NCT06980103
- Testing
- Decision Aid, Usual Care
- Where
- 3 sites in United States
- Volunteers
- 408 people
- Sponsor
- Georgetown University
Cancer, Thyroid
Thyroid Ultrasound Elasticity (TrUE) Imaging
In this study the researchers will scan the thyroid nodules of patients scheduled for surgical removal of these nodules. During their preadmission testing, but prior to their surgery, the researchers will perform standard…
- Trial name
- NCT03307694
- Testing
- Ultrasound, Shear wave elasticity imaging, Multi-angle compound shear wave elasticity imaging
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Emory University
Thyroid Nodules
Xiaojin Pill/Neixiao Luoli Pill for the Treatment of Thyroid Nodules
The goal of this clinical trial is to learn whether Xiaojin Pill or Neixiao Luoli Pill can safely treat thyroid nodules in adults aged 18 to 65 years with benign or low-risk thyroid nodules.
- Trial name
- NCT07340177
- Testing
- Xiaojin Pill, Neixiao Luoli Pill, Lifestyle Intervention
- Where
- China
- Volunteers
- 108 people
- Sponsor
- Zhejiang Provincial People's Hospital
Thyroid Cancer, Papillary Thyroid Microcarcinoma
Active Surveillance on Papillary Thyroid Microcarcinoma
The study is a multi-center prospective cohort study of active surveillance in papillary thyroid cancer with low risk. The purpose of the study is to observe natural course of low risk papillary thyroid cancer in Korean…
- Trial name
- NCT02938702
- Where
- South Korea
- Volunteers
- 1,211 people
- Sponsor
- Seoul National University Hospital
Thyroid Nodule, Thyroid Neoplasms
The Role of an Optical Probe in Thyroid Cancer Diagnosis: Pilot Study
This study will investigate the usefulness of an optical probe in the differentiation of thyroid cancer from normal thyroid tissue in a thyroidectomy specimen.
- Conditions
- Thyroid Nodule, Thyroid Neoplasms, Thyroid Cancer
- Trial name
- NCT01792492
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Boston Medical Center
Thyroid Cancer
Method of Endogenous TSH Stimulation in the Follow-up of Differentiated Thyroid Cancer
The treatment of differentiated thyroid cancer (DCT) includes surgery followed by radioiodine treatment. In the follow-up of patients it is necessary to induce TSH elevation to test for cancer recurrence.
- Trial name
- NCT01840332
- Testing
- L-thyroxin
- Where
- 2 sites in Estonia
- Volunteers
- 20 people
- Sponsor
- University of Tartu
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