Clinical trials: Thyroid Cancers
Thyroid Cancer
Study of Irofulven Plus Capecitabine in Patients With Advanced Thyroid Cancer
Irofulven is an investigational chemotherapeutic agent being studied in a variety of solid tumors. The purpose of this study is to assess the efficacy and safety of irofulven/capecitabine combination therapy in patients with…
- Trial name
- NCT00124527
- Testing
- Irofulven + capecitabine
- Where
- 10 sites in United States, Argentina and 4 more
- Volunteers
- 35 people
- Sponsor
- Eisai Inc.
Malignant Digestive System Neoplasm, Metastatic Head and Neck Carcinoma
Thermal Ablation and Spine Stereotactic Radiosurgery in Treating Patients With Spine Metastases at Risk for Compressing the Spinal Cord
This phase II clinical trial studies how well thermal ablation and spine stereotactic radiosurgery work in treating patients with cancer that has spread to the spine (spine metastases) and is at risk for compressing the spinal…
- Conditions
- Malignant Digestive System Neoplasm, Metastatic Head and Neck Carcinoma, Metastatic Kidney Carcinoma, Metastatic Malignant Neoplasm in the Spine
- Trial name
- NCT02713269
- Testing
- Computed Tomography, Quality-of-Life Assessment, Questionnaire Administration
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- M.D. Anderson Cancer Center
Malignant Neoplasm of Breast, Malignant Neoplasms of Digestive Organs
Selumetinib and Olaparib in Solid Tumors
This study has 2 phases: Phase 1 (dose escalation) and Phase 2 (dose expansion). The goal of Phase 1 of this clinical research study is to find the highest tolerable dose combination of selumetinib and olaparib that can be given…
- Conditions
- Malignant Neoplasm of Breast, Malignant Neoplasms of Digestive Organs, Malignant Neoplasms of Female Genital Organs, Malignant Neoplasms of Male Genital Organs
- Trial name
- NCT03162627
- Testing
- Selumetinib, Olaparib
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- M.D. Anderson Cancer Center
Thyroid Carcinoma, Pediatric Cancer
Thyroid Carcinoma in Cancer Patients Undergoing Radiotherapy
This study aims to define the optimal surveillance strategy for children exposed to radiotherapy by assessing the incidence, risk factors, and timing of thyroid nodules and differentiated thyroid cancer.
- Trial name
- NCT07473518
- Where
- 2 sites in Italy
- Volunteers
- 2,550 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Ovarian Cancer, Breast Cancer
A Follow-up Study of Women Evaluated and Treated for Infertility
To assess the relations of infertility causes and treatment to cancer risk, we will conduct a retrospective cohort study of approximately 12,000 women evaluated for infertility between 1965-1988.
- Conditions
- Ovarian Cancer, Breast Cancer, Endometrial Cancer, Thyroid Cancer
- Trial name
- NCT00342446
- Where
- United States
- Volunteers
- 12,193 people
- Sponsor
- National Cancer Institute (NCI)
Thyroid Nodule
The Diagnostic Value of Shear Wave Elastography
Background: The main goal when diagnosing thyroid nodules, is to differentiate the few malignant from the overwhelming background of benign nodules.
- Trial name
- NCT02150772
- Testing
- Shear Wave Elastography (SWE)
- Where
- Denmark
- Volunteers
- 308 people
- Sponsor
- University of Aarhus
Thyroid Cancers That Contain the PAX8-PPARgamma Fusion Gene
Pioglitazone in Thyroid Cancers
Through this trial the investigators hope to learn if a drug, Actos (pioglitazone), is useful in treating a certain kind of metastatic thyroid cancer. Actos is approved by the FDA to treat diabetes.
- Trial name
- NCT01655719
- Testing
- Pioglitazone
- Where
- 4 sites in United States
- Volunteers
- 1 people
- Sponsor
- University of Michigan
Thyroid Cancer, Thyroid Nodules
Radiation Exposure and Thyroid Disease in Kazakhstan
Residents of certain villages in Kazakhstan were exposed during childhood to radioactive fallout from nuclear tests conducted at the Semipalatinsk Nuclear Test Site (SNTS) between 1949 and 1962.
- Conditions
- Thyroid Cancer, Thyroid Nodules, Other Thyroid Disease
- Trial name
- NCT00480428
- Where
- Kazakhstan
- Volunteers
- 117 people
- Sponsor
- National Cancer Institute (NCI)
Thyroid Cancer
Selective Coverage Versus Comprehensive Coverage Radiotherapy in Poorly Differentiated and Anaplastic Thyroid Cancer
To explore the efficacy and safety of selective coverage radiotherapy in poorly differentiated and anaplastic thyroid cancer
- Trial name
- NCT07777536
- Testing
- Selective coverage radiotherapy, comprehensive coverage radiotherapy
- Where
- China
- Volunteers
- 72 people
- Sponsor
- Fudan University
Papillary Thyroid Carcinoma, Thermal Ablation
A Study of Factors Influencing Recurrence After Thermal Ablation of Papillary Thyroid Carcinoma
A prospective cohort of papillary thyroid carcinoma(PTC), patients who received thermal ablation in our hospital since February 2023 was established as the study object.
- Trial name
- NCT05962892
- Testing
- No Intervention
- Where
- China
- Volunteers
- 600 people
- Sponsor
- Beijing Friendship Hospital
Thyroid Cancer, Intermediate Risk
Systematic Radioiodine Administration Versus Decision of Radioiodine Treatment Guided by a Post-operative Work-up
This trial is comparing two strategies in intermediate-risk differentiated thyroid cancer patients: Systematic radioiodine administration versus decision of radioiodine treatment guided by a post-operative work-up based on serum…
- Trial name
- INTERMEDIATE (NCT04290663)
- Testing
- Systematic RAI-treatment, Decision of RAI-treatment guided by a post-operative assessment
- Where
- 29 sites in France
- Volunteers
- 368 people
- Sponsor
- Centre Francois Baclesse
Recurrent Cutaneous Melanoma, Recurrent Lip and Oral Cavity Carcinoma
Donor Natural Killer Cells, Cyclophosphamide, and Etoposide in Treating Children and Young Adults With Relapsed or Refractory Solid Tumors
This phase I trial studies the side effects and best dose of cord blood-derived expanded allogeneic natural killer cells (donor natural killer [NK] cells) and how well they work when given together with cyclophosphamide and…
- Conditions
- Recurrent Cutaneous Melanoma, Recurrent Lip and Oral Cavity Carcinoma, Recurrent Malignant Endocrine Neoplasm, Recurrent Malignant Female Reproductive System Neoplasm
- Trial name
- NCT03420963
- Testing
- Cord Blood-derived Expanded Allogeneic Natural Killer Cells, Cyclophosphamide, Etoposide
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- M.D. Anderson Cancer Center
Medullary Thyroid Carcinoma
Stromal Desmoplastic Reaction as a Predictive Factor for Lymph Node Metastasis in Medullary Thyroid Cancer
This is a prospective multicenter observational study on medullary thyroid cancer , aiming to investigate the correlation of stromal desmoplastic reaction with tumor aggressiveness.
- Trial name
- DESMED (NCT07851324)
- Testing
- lobectomy with lymph node dissection
- Volunteers
- 74 people
- Sponsor
- Aristotle University Of Thessaloniki
Metastatic Thyroid Gland Carcinoma, Unresectable Thyroid Gland Carcinoma
Dabrafenib and Lapatinib in Treating Patients With Refractory Thyroid Cancer That Cannot Be Removed by Surgery
This phase I trial studies the side effects and best dose of lapatinib when given together with dabrafenib in treating patients with thyroid cancer that cannot be removed by surgery and has not responded to previous treatment…
- Trial name
- NCT01947023
- Testing
- Biopsy Procedure, Biospecimen Collection, Computed Tomography
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- National Cancer Institute (NCI)
Thyroid Cancer, Thyroid Nodule
AI-Assisted Ultrasound Review Before Thyroid Surgery
This prospective, single-center, single-arm study evaluates a locked artificial intelligence (AI) system as a surgeon-led second-read tool before thyroid surgery.
- Trial name
- NCT06498674
- Testing
- Locked AI-Assisted Thyroid Ultrasound Repeat Examination and Review
- Where
- China
- Volunteers
- 515 people
- Sponsor
- Fujian Medical University
Thyroid Cancer Patients
Effect of Carum Carvi on Thyroid Hormones and TSH Level
Carum Carvi has been frequently used in traditional medicine for a variety of disease ranging from dyspepsia to Alzheimer's disease.We observed high TSH levels in few patients with thyroid cancer who receiving Carum Carvi despite…
- Trial name
- NCT01471288
- Testing
- Carum Cravi
- Where
- Iran
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Mashhad University of Medical Sciences
Papillary Thyroid Cancer, Lymph Node Metastasis
Improvements in Thyroid Tumor Surgery and the Prognosis, Diagnosis, Recurrence and Metastasis of Patients
The objective of this research is to investigate the clinical outcomes of modified surgical techniques such as omitting the cervical linea alba suture in transthoracic endoscopic thyroidectomy.
- Conditions
- Papillary Thyroid Cancer, Lymph Node Metastasis, Carcinogenesis
- Trial name
- NCT06468696
- Testing
- Suturing the cervical linea alba during endoscopic thyroid surgery., Performing transcriptome sequencing
- Where
- China
- Volunteers
- 170 people
- Sponsor
- Second Affiliated Hospital of Xi'an Jiaotong University
Thyroid Cancer, Thyroid Nodule
Molecular Profile of Thyroid Nodules
Profiling and comparative analysis of genomic alterations and miRNA expression in benign and malignant thyroid tumors using histological and cytological specimens will be performed.
- Trial name
- MPTN (NCT05323669)
- Testing
- Molecular testing
- Volunteers
- 400 people
- Sponsor
- Belarusian State Medical University
Thyroid Nodule, Thyroid Neoplasms
The Role of Elastography in the Diagnosis of Thyroid Nodules
The primary objective of this study is to evaluate the role of elastography (along with echographic and cytological data) as a diagnostic tool for thyroid cancer
- Trial name
- NCT01292044
- Testing
- Elastography
- Where
- France
- Volunteers
- 188 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Thyroid Cancer, Thyroid Nodule
Active Surveillance for Bethesda IV Thyroid Nodules
The traditional surgical approach for Bethesda IV thyroid nodules burdens healthcare systems and patients with costs, perioperative morbidity, and potential long-term consequences of hemithyroidectomy, including hypothyroidism…
- Trial name
- NCT07370675
- Testing
- Active surveillance (6, 12, 18, 24, 36, 48, 60 months)
- Where
- Denmark
- Volunteers
- 165 people
- Sponsor
- Christian Grønhøj Larsen
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