Clinical trials: Thyroid Cancers
Advanced Cancer, Malignant Neoplasm of Breast
Lenvatinib and Capecitabine in Patients With Advanced Malignancies
There are 2 phases in this study: Phase 1 (dose escalation) and Phase 2 (dose expansion). The goal of Phase 1 of this clinical research study is to find the highest tolerable dose of lenvatinib and Xeloda (capecitabine) that can…
- Conditions
- Advanced Cancer, Malignant Neoplasm of Breast, Malignant Neoplasms of Bone and Articular Cartilage, Malignant Neoplasms of Digestive Organs
- Trial name
- NCT02915172
- Testing
- Lenvatinib, Capecitabine
- Sponsor
- M.D. Anderson Cancer Center
Thyroid Cancer, Papillary Thyroid Carcinoma
Necessity of TSH Suppression Therapy in Active Surveillance for Thyroid Cancer Patients.
This study is a multicenter randomized controlled trial conducted in Korea. A parallel, two-group randomized design will be with thyroid stimulating hormone suppression therapy group(low TSH group; intervention) is different from…
- Trial name
- MAeSTro-TSH (NCT06971965)
- Testing
- Levothyroxin
- Volunteers
- 578 people
- Sponsor
- National Cancer Center, Korea
Anaplastic Thyroid Cancer, ATC
The Efficacy and Safety of HLX208 in Advanced Anaplastic Thyroid Cancer (ATC) With BRAF V600 Mutation
The purpose of this study was to assess efficacy, safety and PK in anaplastic thyroid cancer (ATC) given HLX208 (BRAF V600E inhibitor).
- Trial name
- NCT05102292
- Testing
- HLX208
- Where
- China
- Volunteers
- 25 people
- Sponsor
- Shanghai Henlius Biotech
Thyroid Cancer
Psycho-oncological Intervention Through Counselling in Patients With Differentiated Thyroid Cancer in Treatment With Radioiodine
Diagnosis and treatment of differentiated thyroid carcinomas cause anxiety and depression. Additionally, these patients suffer hormonal alterations, associated with psychological symptoms (changes in mood, emotional instability…
- Trial name
- COUNTHY (NCT05054634)
- Testing
- Psycho-oncological Intervention Based on Counselling (PIBC)
- Where
- Spain
- Volunteers
- 75 people
- Sponsor
- Quironsalud
Thyroid Cancer, Papillary
Intraoperative Pathologic Evaluation of Central Lymph Nodes in Papillary Thyroid Carcinoma
Efficacy of Intraoperative pathologic evaluation of central lymph nodes
- Trial name
- NCT07066644
- Testing
- central node dissection
- Where
- South Korea
- Volunteers
- 509 people
- Sponsor
- Seoul National University Hospital
Healthy, Pituitary Disease
Study of Thyrotropin-Releasing Hormone in Normal Volunteers and in Patients With Thyroid or Pituitary Abnormalities
This study will determine the safety and activity of a new formulation of thyrotropin-releasing hormone (TRH), a drug used for diagnosing and evaluating patients with certain thyroid gland abnormalities.
- Conditions
- Healthy, Pituitary Disease, Thyroid Disease
- Trial name
- NCT00054756
- Testing
- TRH (Thyrotropin Releasing Hormone)
- Where
- United States
- Volunteers
- 96 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Medullary Thyroid Carcinoma
Radiolabelled CCK-2/Gastrin Receptor Analogue for Personalized Theranostic Strategy in Advanced MTC
The study is a phase I multicentre randomized, open, parallel-arm clinical trial conducted to investigate the IMP, namely 111In-CP04.
- Trial name
- GRAN-T-MTC (NCT03246659)
- Testing
- 111In-CP04, 111In-CP04 with co-administration of gelofusine/gelaspan
- Where
- 5 sites in Austria, Germany and 3 more
- Volunteers
- 16 people
- Sponsor
- Paola Anna Erba
Carcinoid Cancer, Neuroendocrine Tumors
68Ga DOTATATE PET/CT in Neuroendocrine Tumors (Expanded Access)
To evaluate 68Ga-DOTATATE PET/CT for staging of patients with carcinoid, neuroendocrine tumors, medullary thyroid cancer and other cancers expressing somatostatin receptors.
- Conditions
- Carcinoid Cancer, Neuroendocrine Tumors, Medullary Thyroid Cancer, Cancers Expressing Somatostatin Receptors
- Trial name
- NCT02174679
- Testing
- 68Ga DOTATATE
- Where
- United States
- Sponsor
- Jonsson Comprehensive Cancer Center
Differentiated Thyroid Carcinoma, Papillary Thyroid Carcinoma
Bethesda Classification and Risk Stratification in Differentiated Thyroid Carcinoma
This observational study aims to evaluate the relationship between preoperative Bethesda classification of fine-needle aspiration cytology and postoperative American Thyroid Association (ATA) risk stratification in patients with…
- Conditions
- Differentiated Thyroid Carcinoma, Papillary Thyroid Carcinoma, Follicular Thyroid Carcinoma
- Trial name
- NCT07858097
- Volunteers
- 100 people
- Sponsor
- Assiut University
Medullary Thyroid Carcinoma
Study of Anlotinib in Patients With Medullary Thyroid Carcinoma(ALTER01031)
To compare the effects and safety of Anlotinib with placebo in patients with Medullary Thyroid Carcinoma.
- Trial name
- NCT02586350
- Testing
- Anlotinib
- Where
- 19 sites in China
- Volunteers
- 91 people
- Sponsor
- Chia Tai Tianqing Pharmaceutical Group Co., Ltd.
Microbiota
Intestinal Microbiota and Thyroid Cancer
Thyroid cancer (TC), the most common malignancy of the endocrine system, is currently the fifth most common malignancy diagnosed in women (1).
- Trial name
- NCT03543891
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Harbin Medical University
Recurrent Malignant Solid Neoplasm, Recurrent Melanoma
Cabozantinib S-Malate in Treating Younger Patients With Recurrent or Refractory Solid Tumors
This phase I trial studies the side effects and best dose of cabozantinib S-malate in treating younger patients with solid tumors that have come back or no longer respond to treatment.
- Conditions
- Recurrent Malignant Solid Neoplasm, Recurrent Melanoma, Recurrent Primary Central Nervous System Neoplasm, Recurrent Thyroid Gland Carcinoma
- Trial name
- NCT01709435
- Testing
- Cabozantinib S-malate, Laboratory Biomarker Analysis, Pharmacological Study
- Where
- 23 sites in United States, Canada
- Volunteers
- 41 people
- Sponsor
- National Cancer Institute (NCI)
Metabolic Syndrome, Thyroid Nodule
Relationship of Metabolic Syndrome and Its Components With Thyroid Nodule(s)
To investigate the association between metabolic syndrome (MS) and thyroid nodule(s).
- Trial name
- NCT03009279
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Lin Liao
Malignant Neoplasm of Thyroid Stage I, Malignant Neoplasm of Thyroid Stage II
Effect of Metformin on Decrement in Levothyroxin Dose Required for Thyroid Stimulating Hormone (TSH) Suppression in Patients With Differentiated Thyroid Cancer
Differentiated thyroid cancer is the most common neoplasm of endocrine system. After surgery and radioiodine treatment, thyroid stimulating hormone (TSH) suppression is the main goal which is achieved with levothyroxine…
- Trial name
- NCT01341886
- Testing
- Metformin
- Where
- Iran
- Volunteers
- 51 people
- Sponsor
- Mashhad University of Medical Sciences
Differentiated Thyroid Gland Carcinoma, Malignant Adrenal Gland Pheochromocytoma
Effect of Cabozantinib S-Malate or Lenvatinib Mesylate on Weight and Body Composition in Patients With Metastatic Endocrine Cancer
The goal of this clinical research study is to learn about possible weight, muscle, and/or fat loss in patients receiving cabozantinib or lenvatinib.
- Conditions
- Differentiated Thyroid Gland Carcinoma, Malignant Adrenal Gland Pheochromocytoma, Malignant Paraganglioma, Thyroid Gland Medullary Carcinoma
- Trial name
- NCT02592356
- Testing
- Computed Tomography, Dual X-ray Absorptiometry, Physical Examination
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- M.D. Anderson Cancer Center
Thyroid Gland Carcinoma
Evaluation of DNA Methylation Signatures for the Diagnosis and Management of Thyroid Nodules
This clinical trial evaluates deoxyribonucleic acid (DNA) methylation signatures in diagnosing and managing thyroid nodules. The purpose of this research is to develop a new test for thyroid cancer.
- Trial name
- NCT05229341
- Testing
- Diagnostic Procedure, Electronic Health Record Review, Needle Biopsy
- Where
- United States
- Volunteers
- 1,450 people
- Sponsor
- City of Hope Medical Center
Thyroid Nodule (Benign), Thyroid Nodule (Diagnosis)
Mortality Benefit of Ultrasound for Thyroid Nodules Identified With PET Imaging: Non-Inferiority Emulated Target Trial
The investigators hypothesize that all-cause mortality in patients with an incidental thyroid nodule on PET-CT who did not have thyroid ultrasound (the exposure) within 3 months of the PET-CT is non-inferior within a 5% margin to…
- Conditions
- Thyroid Nodule (Benign), Thyroid Nodule (Diagnosis), Thyroid Cancer
- Trial name
- NCT07255482
- Testing
- Thyroid Ultrasound
- Where
- United States
- Volunteers
- 874 people
- Sponsor
- Brigham and Women's Hospital
Thyroid Cancer, Graves Disease
Personalized Treatment in Thyroid Disorders
The Collar Therapy Indicator (CoTI) (A device that is placed in collar around the neck resembling a turtle neck sweater collar with a wire and recording box) has been shown in a single small previously published experience to…
- Trial name
- NCT03517579
- Testing
- Cervical Collar Therapy Indicator (COTI)
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Johns Hopkins University
Cholangiocarcinoma, Chondrosarcoma
Study of LY3410738 Administered to Patients With Advanced Solid Tumors With IDH1 or IDH2 Mutations
This is an open-label, multicenter Phase 1 study to evaluate safety, tolerability and preliminary efficacy of oral LY3410738 in patients with isocitrate dehydrogenase 1 (IDH1) arginine 132 (R132)-mutant advanced solid tumors…
- Conditions
- Cholangiocarcinoma, Chondrosarcoma, Glioma, Any Solid Tumor
- Trial name
- NCT04521686
- Testing
- LY3410738, Gemcitabine, Cisplatin
- Where
- 33 sites in United States, Australia and 7 more
- Volunteers
- 200 people
- Sponsor
- Eli Lilly and Company
Thyroid Neoplasms
Nexavar® Versus Placebo in Locally Advanced/Metastatic RAI-Refractory Differentiated Thyroid Cancer
Trial of sorafenib versus placebo in the treatment of locally advanced or metastatic differentiated thyroid cancer refractory to radioiodine
- Trial name
- NCT00984282
- Testing
- Sorafenib (Nexavar, BAY43-9006)
- Where
- 81 sites in United States, Austria and 16 more
- Volunteers
- 417 people
- Sponsor
- Bayer
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