Clinical trials: Thyroid Cancers
Thyroid Cancer
99mTc Sestamibi Scans In Thyroglobulin Positive Scan Negative Differentiated Thyroid Cancer (DTC) Patients
This study is being done to see if the radioisotope 99mTc sestamibi scans can locate what is causing the elevated serum thyroglobulin in persons with differentiated thyroid cancer who have elevated serum thyroglobulin levels and…
- Trial name
- NCT03065218
- Testing
- 99mTc sestamibi
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Medstar Health Research Institute
Thyroid Nodule, Thyroid Dysfunction
Postoperative Hypocalcemia After Thyroidectomy
This retrospective cohort study investigates predictors of postoperative hypocalcemia following thyroidectomy procedures at Minia University Hospital over a 10-year period (2014-2024).
- Conditions
- Thyroid Nodule, Thyroid Dysfunction, Hypocalcemia, Thyroid Cancer
- Trial name
- NCT07428057
- Where
- Egypt
- Volunteers
- 600 people
- Sponsor
- Minia University
Papillary Thyroid Carcinoma; Molecular Heterogeneity; Multi-model Analysis; Artificial Intelligence; Lymph Node Metastases; Disease-free Survival
AI-Based Multimodal Multi-tasks Analysis Reveals Tumor Molecular Heterogeneity, Predicts Preoperative Lymph Node Metastasis and Prognosis in Papillary Thyroid Carcinoma
This study involved a comprehensive analysis of 256 PTC patients from Sun Yat-sen Memorial Hospital of Sun Yat-sen University (SYSMH) and 499 patients from The Cancer Genome Atlas.
- Trial name
- NCT06241092
- Where
- China
- Volunteers
- 256 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Thyroid Cancer, Thyroid Cancer, Follicular
PDR001 Combination Therapy for Radioiodine-Refractory Thyroid Cancer
The purpose of this study is to find out whether a drug called PDR001, combined with either trametinib or dabrafenib, is a safe and effective treatment for thyroid cancer.
- Conditions
- Thyroid Cancer, Thyroid Cancer, Follicular, Papillary Thyroid Cancer, Follicular Thyroid Cancer
- Trial name
- NCT04544111
- Testing
- Trametinib, Dabrafenib, PDR001
- Where
- 7 sites in United States
- Volunteers
- 19 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Thyroid Cancer
Anlotinib and Benmelstobart in DTC
This study is a multicenter, open-label, phase II study to evaluate the efficacy and safety of Benmelstobart in combination with Anlotinib as a second-line treatment for locally advanced or metastatic differentiated thyroid…
- Trial name
- NCT07193186
- Testing
- Anlotinib and Benmelstobart
- Volunteers
- 23 people
- Sponsor
- Fudan University
Thyroid Cancer, Lymph Node
UNN-RADS Scale for Diagnosing Lymph Node Metastasis in Patients With History of Thyroid Cancer
In 2020, Sarda-Inman et al., developed the Ultrasound Neck Node Reporting and Data System (UNN-RADS) scale that allows decision-making about when it is appropriate to perform FNA of a cervical lymph node, evaluating seven…
- Trial name
- NCT06124469
- Testing
- US-guided fine needle aspiration (FNA)
- Where
- Mexico
- Volunteers
- 99 people
- Sponsor
- Instituto Mexicano del Seguro Social
Thyroidectomy, Goiter
Prospective Comparison of the Effect on Antiadhesive Barriers During Thyroid Surgery
Despite use of meticulous surgical techniques and regardless of surgical access via conventional open or endoscopy, postoperative adhesions develop in the vast majority of patients undergoing neck surgery.
- Conditions
- Thyroidectomy, Goiter, Thyroid Cancer
- Trial name
- NCT05851560
- Testing
- Oxidized regenerated cellulose(ORC), Hyaluronic acid(HA)
- Where
- Taiwan
- Volunteers
- 45 people
- Sponsor
- National Taiwan University Hospital
Thyroid Neoplasm, Goiter
Total Thyroidectomy With Harmonic Scalpel®
Harmonic scalpel is a new surgical instrument. Its use has been recommended in patients submitted to total thyroidectomy. Few randomized controlled trials has been published.
- Conditions
- Thyroid Neoplasm, Goiter, Thyroid Nodule
- Trial name
- NCT00385983
- Testing
- Harmonic Scalpel
- Where
- 9 sites in Brazil
- Volunteers
- 280 people
- Sponsor
- Brazilian Society of Head and Neck Surgery
Hyperthyreosis and Goiter, Thyroid Cancer
The Incidence of Thyroid Cancer in 4474 Patients Treated for Hyperthyroidism or Goiter
Patients with hyperthyroidism and/or goiter are evaluated with blood samples and scintiscan before they are treated with radioiodine for their thyroid disease.
- Trial name
- NCT01384786
- Where
- Denmark
- Volunteers
- 4,474 people
- Sponsor
- Copenhagen University Hospital at Herlev
Thyroid Cancer, Medullary, Neuroendocrine Tumor of the Lung Grade 1 and 2
177Lu-PP-F11N for Receptor Targeted Therapy and Imaging of Metastatic Thyroid Cancer.
The purpose of this study is to determine the use of 177Lu-PP-F11N for imaging and therapy of patients with advanced medullary thyroid carcinoma (MTC). 177Lu-PP-F11N is a gastrin analogon, binding to cholecystokinin-2 receptors.
- Conditions
- Thyroid Cancer, Medullary, Neuroendocrine Tumor of the Lung Grade 1 and 2, Neuroendocrine Tumor of the Thymus Grade 1 and 2, Neuroendocrine Tumor GEP Grade 1-3
- Trial name
- Lumed (NCT02088645)
- Testing
- 177Lu-PP-F11N
- Where
- Switzerland
- Volunteers
- 24 people
- Sponsor
- University Hospital, Basel, Switzerland
Thyroid Cancer Metastatic
Study of the Efficacy of Lenvatinib Combined With Denosumab in the Treatment of Patients With Predominant Bone Metastatic Radioiodine Refractory Differentiated Thyroid Carcinomas
This study evaluates the combination of lenvatinib with denosumab in bone-predominant metastatic Radioiodine Refractory Differentiated Thyroid Carcinomas. All patients will receive this combination of treatments.
- Trial name
- LENVOS (NCT03732495)
- Testing
- Lenvatinib + Denosumab
- Where
- 14 sites in France
- Volunteers
- 35 people
- Sponsor
- Centre Leon Berard
Hypertension, Depression
Patient-Centred Innovations for Persons With Multimorbidity - Quebec
The aim of Patient-Centred Innovations for Persons With Multimorbidity (PACE in MM) study is to reorient the health care system from a single disease focus to a multimorbidity focus; centre on not only disease but also the…
- Conditions
- Hypertension, Depression, Anxiety, Musculoskeletal Pain
- Trial name
- PACEinMM-QC (NCT02789800)
- Testing
- DIMAC02
- Where
- 2 sites in Canada
- Volunteers
- 284 people
- Sponsor
- Université de Sherbrooke
Papillary Thyroid Carcinoma, Lymph Node Cancer Metastatic
Multiomics Study of Biological Behavior of Lymph Node Metastasis in Papillary Thyroid Carcinoma
Establish a predictive model for assessing neck lymph node metastasis of papillary thyroid carcinoma based on metabolomics, proteomics, and imaging omics data, exploring an ideal protocal for the precise diagnosis and treatment…
- Trial name
- NCT06725628
- Testing
- Thy_CLNM_multi_omics
- Volunteers
- 2,000 people
- Sponsor
- Tianhan Zhou
Thyroid Neoplasms
Comparative Study in Oral, Breast Approach and Open Thyroidectomy
Purpose: Total endoscopic thyroidectomy including oral approach and breast approach has excellent cosmetic and several functional results.
- Trial name
- NCT03479801
- Testing
- Thyroid Surgical Methods
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Low Risk Differentiated Thyroid Cancer
Differentiated Thyroid Cancer: is There a Need for Radioiodine Ablation in Low Risk Patients?
Open-label randomized phase III trial, using a non-inferiority comparison design. After randomization,patients will receive either post-operative radioiodine ablation with an activity of 1.1 GBq (30 mCi) after stimulation by…
- Trial name
- ESTIMABL2 (NCT01837745)
- Testing
- rhTSH stimulation, I131, Follow up
- Where
- France
- Volunteers
- 776 people
- Sponsor
- Gustave Roussy, Cancer Campus, Grand Paris
Recurrent Thyroid Cancer
Ultrasound-guided Thermal Ablation for Recurrent Thyroid Cancer
To evaluate the long-term outcomes of ultrasound-guided thermal ablation for recurrent thyroid cancer
- Trial name
- NCT06733766
- Testing
- ultrasound-guided thermal ablation
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Chinese PLA General Hospital
Maligant Solid Tumor, Head & Neck Cancer
The Safety, Dosimetry and Efficacy of 177Lu-INN805 in Patients With Malignant Solid Tumors
This study is a prospective, single-arm, open-label, dose-escalation study. A total of 4 dose groups were pre-defined in this study. The drug was administered once every 6 weeks.The drug would be administered for 1 to 4 cycles.
- Conditions
- Maligant Solid Tumor, Head & Neck Cancer, Thyroid Cancer, Lung Cancer - Non Small Cell Squamous
- Trial name
- NCT07459283
- Testing
- INN805
- Where
- China
- Volunteers
- 10 people
- Sponsor
- FindCure Biosciences (ZhongShan) Co., Ltd.
Differentiated Thyroid Cancer, Advanced Cancer
Lenvatinib in Locally Advanced Invasive Thyroid Cancer
This research is being done to evaluate the safety and efficacy of neoadjuvant lenvatinib on surgical outcomes of patients with invasive extrathyroidal differentiated thyroid cancer (DTC).
- Trial name
- NCT04321954
- Testing
- LENVATINIB
- Where
- 3 sites in United States
- Volunteers
- 29 people
- Sponsor
- Massachusetts Eye and Ear Infirmary
Papillary Thyroid Cancer, Papillary Thyroid Carcinoma
Active Surveillance and Surgery Outcomes in Low Risk Papillary Thyroid Cancer
This is a prospective, observational, multi-center study examining the long-term outcomes of patients with small, low risk papillary thyroid cancer who offered the choice of active surveillance (close follow-up to monitor for…
- Conditions
- Papillary Thyroid Cancer, Papillary Thyroid Carcinoma, Papillary Microcarcinoma of the Thyroid
- Trial name
- NCT04624477
- Where
- 8 sites in Canada
- Volunteers
- 450 people
- Sponsor
- University Health Network, Toronto
Thyroid Cancer
A Pilot Clinical Trial for Poorly Differentiated Thyroid Cancer - Correlation to Retinoid and Peroxisome-proliferator-activated Receptor (PPARy) Expression
This study plans to learn more about a drug called bexarotene for the treatment of advanced thyroid cancer. Subjects are asked to be in this study because they have thyroid cancer that will not respond to radioactive iodine…
- Trial name
- NCT00718770
- Testing
- Bexarotene
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Colorado, Denver
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