Clinical trials: Thyroid Cancers
Thyroid Cancer
Anxiety & Depression in Thyroid Cancer Patients
1. To identify the prevalence of both anxiety and depression in thyroid cancer patients 2. To assess quality of life in thyroid cancer patients
- Trial name
- NCT06269731
- Testing
- Hamilton depression Rating Scale
- Volunteers
- 159 people
- Sponsor
- Assiut University
Metastatic Differentiated Thyroid Cancer
Metastatic Thyroid Cancer Therapy Optimization With 124I PET Dosimetry
Failure of conventional radioiodine therapy of metastatic differentiated thyroid cancer could be explained by: a suboptimal therapeutic approach, based on the administration of empirically fixed amount of radioactivity the…
- Trial name
- 131THEROPT124 (NCT05299437)
- Testing
- Radioiodine optimized therapy
- Where
- 2 sites in Italy
- Volunteers
- 50 people
- Sponsor
- Carlo Chiesa
Thyroid Cancer
Assess Vitamin D Levels in Those With & Without Thyroid Cancer
The purpose of this study is to evaluate Vitamin D levels in thyroid cancer patients with active disease compared with thyroid cancer patients in remission and patients with thyroid nodules.
- Trial name
- NCT00719615
- Where
- United States
- Volunteers
- 111 people
- Sponsor
- University of Nebraska
Thyroid Nodules
The Outcomes of Ultrasound-guided Thermal Ablation for Benign Thyroid Nodules
1. To evaluate the clinical outcomes of ultrasound-guided thermal ablationfor the treatment of benign thyroid nodules; 2. To develop and validate a artificial intelligence model to predict the outcomes of ultrasound-guided…
- Trial name
- NCT06340945
- Testing
- ultrasound-guided thermal ablation
- Where
- China
- Volunteers
- 1,500 people
- Sponsor
- Chinese PLA General Hospital
Thyroid Carcinoma
Study of Sulfatinib in Treating Advanced Medullary Thyroid Carcinoma and Iodine-refractory Differentiated Thyroid Carcinoma
A multi-center , opened, Phase II study to assess the efficacy and safety of Sulfatinib 300 mg Sulfatinib in advanced Medullary Thyroid Carcinoma ( MTC) and iodine-refractory differentiated thyroid carcinoma (DTC).
- Trial name
- NCT02614495
- Testing
- Surufatinib
- Where
- 2 sites in China
- Volunteers
- 66 people
- Sponsor
- Hutchison Medipharma Limited
Thyroid Cancer
Safety and Efficacy of Sorafenib in Patients With Advanced Thyroid Cancer: a Phase II Clinical Study
Differentiated thyroid cancer includes papillary, follicular, Hurthle cell, and C-cell/medullary carcinoma. Even though incidence is relatively low (1% of all neoplasms), a rise in this disease has been recorded in the country…
- Trial name
- NCT02084732
- Testing
- Sorafenib
- Where
- Colombia
- Volunteers
- 35 people
- Sponsor
- Instituto Nacional de Cancerologia, Columbia
Metastatic Sporadic Medullary Thyroid Cancer
Molecular Profile of Metastatic Sporadic Medullary Thyroid Cancer Patients and Correlation With Vandetanib
Vandetanib has been approved for patients with unresectable and/or metastatic medullary thyroid cancer (MTC) by the Food and Drug Administration, by the European Medicines Agency and, very recently, it has been licensed also by…
- Trial name
- NCT02268734
- Where
- Italy
- Volunteers
- 36 people
- Sponsor
- Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
Differentiated Thyroid Cancer
Hemithyroidectomy or Total-Thyroidectomy in 'Low-risk' Thyroid Cancers
This is a multi-centre, randomised, non-inferiority, phase III study in patients with low risk differentiated thyroid cancer. Patients will be identified via oncology multidisciplinary team meetings.
- Trial name
- HoT (NCT05604963)
- Testing
- Total Thyroidectomy, Hemithyroidectomy
- Where
- 33 sites in United Kingdom
- Volunteers
- 456 people
- Sponsor
- University College, London
Thyroid, Thyroid Cancer
Three-dimensional Ultrasonography Thyroid Volume Measurement.
The purpose of this clinical trial is to investigate the accuracy of applying three-dimensional ultrasound on thyroid gland patients when determining a gland volume.
- Conditions
- Thyroid, Thyroid Cancer, Thyroid Diseases, Graves Disease
- Trial name
- NCT05510609
- Testing
- BK 5000 Ultrasound Machine
- Where
- Denmark
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Cancer, Tumor, Solid
Study of JK08 in Patients with Unresectable Locally Advanced or Metastatic Cancer
This is a Phase 1/2, open-label, multi-center, first-in-human, dose escalation and cohort expansion study evaluating multiple doses and schedules of subcutaneously administered JK08 in patients with unresectable locally, advanced…
- Conditions
- Cancer, Tumor, Solid, Advanced Solid Tumor, Metastatic Cancer
- Trial name
- NCT05620134
- Testing
- JK08, Pembrolizumab, Lenvatinib Pill
- Where
- 11 sites in Belgium, Spain
- Volunteers
- 263 people
- Sponsor
- Salubris Biotherapeutics Inc
Solid Tumors, CNS Tumors
Study Of Entrectinib (Rxdx-101) in Children and Adolescents With Locally Advanced Or Metastatic Solid Or Primary CNS Tumors And/Or Who Have No Satisfactory Treatment Options
This is an open-label, Phase 1/2 multicenter dose escalation study in pediatric patients with relapsed or refractory extracranial solid tumors (Phase 1), with additional expansion cohorts (Phase 2) in patients with primary brain…
- Trial name
- STARTRK-NG (NCT02650401)
- Testing
- Entrectinib
- Where
- 26 sites in United States, Canada and 7 more
- Volunteers
- 69 people
- Sponsor
- Hoffmann-La Roche
Head and Neck Cancer
Gefitinib in Treating Patients With Locally Advanced or Metastatic Thyroid Cancer That Did Not Respond to Iodine Therapy
RATIONALE: Gefitinib may stop the growth of tumor cells by blocking the enzymes necessary for their growth. PURPOSE: Phase II trial to study the effectiveness of gefitinib in treating patients who have locally advanced or…
- Trial name
- NCT00095836
- Testing
- Gefitinib
- Where
- 2 sites in United States
- Volunteers
- 27 people
- Sponsor
- Massachusetts General Hospital
Prostate Cancer, Bladder Cancer
Project HERO: Health Empowerment & Recovery Outcomes
Project HERO is a 12-week study of the efficacy of Body Mind Training (BMT, i.e. Tai Chi and Qigong in this project) for reducing fatigue in male cancer survivors.
- Conditions
- Prostate Cancer, Bladder Cancer, Kidney Cancer, Colon Cancer
- Trial name
- HERO (NCT03345563)
- Testing
- Body Mind Training (BMT), Body Training (BT):, Usual Care (UC)
- Where
- United States
- Volunteers
- 113 people
- Sponsor
- Rutgers, The State University of New Jersey
Locally Advanced Solid Tumors, Metastatic Solid Tumors
A Study of Repotrectinib (TPX-0005) in Patients With Advanced Solid Tumors Harboring ALK, ROS1, or NTRK1-3 Rearrangements
Phase 1 dose escalation will determine the first cycle dose-limiting toxicities (DLTs), the maximum tolerated dose (MTD), the biologically effective dose and recommended Phase 2 dose (RP2D) of repotrectinib given to adult…
- Trial name
- TRIDENT-1 (NCT03093116)
- Testing
- Oral repotrectinib (TPX-0005)
- Where
- 165 sites in United States, Australia and 17 more
- Volunteers
- 500 people
- Sponsor
- Turning Point Therapeutics, Inc.
Thyroid Nodule
Elastography and FNAC in Thyroid Nodule
Evaluate the accuracy of USE in comparison with FNAC in characterization of solitary thyroid nodule and assessment the risk of malignancy
- Trial name
- NCT05734326
- Testing
- Ultrasound elastography
- Volunteers
- 50 people
- Sponsor
- Assiut University
Papillary Thyroid Carcinoma, Central Compartment Neck Dissction
The Role of Prophylactic Central Compartment Neck Dissection in the Management of 2 to 4 cm Papillary Thyroid Carcinoma
Papillary thyroid carcinoma (PTC) is the most common endocrine malignancy and is frequently associated with microscopic central neck lymph node metastases, even in the absence of preoperative clinical evidence of nodal…
- Conditions
- Papillary Thyroid Carcinoma, Central Compartment Neck Dissction, Thyroidectomy, Thyroid Lobectomy
- Trial name
- PRO-COMAND (NCT06899347)
- Testing
- Total Thyroidectomy + Central Compartment Neck Dissection, Thyroid Lobectomy + ipCCND
- Volunteers
- 392 people
- Sponsor
- Leonardo Rossi
Thyroid Nodules
Study on HRQOL and Cost-effectiveness Analysis in Management of Patients With <2cm Thyroid Nodules
Ideally randomized controlled trials should be carried out to compare the cost-effectiveness between FNAC and watchful waiting but such studies are very difficult to conduct in practice because they require following up very…
- Trial name
- NCT02398721
- Testing
- Fine Needle Aspiration Cytology
- Where
- Hong Kong
- Volunteers
- 314 people
- Sponsor
- The University of Hong Kong
Recurrent Thyroid Gland Carcinoma, Stage I Thyroid Gland Papillary Carcinoma
Selumetinib in Treating Patients With Papillary Thyroid Cancer That Did Not Respond to Radioactive Iodine
This phase II trial is studying how well selumetinib works in treating patients with papillary thyroid cancer that did not respond to radioactive iodine.
- Conditions
- Recurrent Thyroid Gland Carcinoma, Stage I Thyroid Gland Papillary Carcinoma, Stage II Thyroid Gland Papillary Carcinoma, Stage III Thyroid Gland Papillary Carcinoma
- Trial name
- NCT00559949
- Testing
- Laboratory Biomarker Analysis, Selumetinib
- Where
- 6 sites in United States, Canada
- Volunteers
- 39 people
- Sponsor
- National Cancer Institute (NCI)
Thyroid Nodule
Protein Classifier for Thyroid Indeterminate Nodules
In multi-center, prospective, double-blind cohorts, PCT-DIA/MS protein classifier supported by artificial neural networks will be validated to classify thyroid indeterminate nodules.
- Trial name
- NCT04477798
- Testing
- PCT-DIA/MS
- Where
- China
- Volunteers
- 320 people
- Sponsor
- Luo Dingcun
Hypocalcemia
Prevention of Hypocalcemia in Patients Undergoing Total Thyroidectomy Plus Central Neck Dissection
the increased risk of hypocalcemia following total thyroidectomy plus central neck dissection can be minimized by routine administration of oral calcium and vitamin D supplements during the early postoperative period.
- Trial name
- NCT00630214
- Testing
- Oral calcium plus vitamin D, Oral calcium alone
- Where
- South Korea
- Volunteers
- 200 people
- Sponsor
- Asan Medical Center
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.