Clinical trials: Thyroid Gland Nodule
Thyroid Nodule (Benign), Graves Disease
Thyroid Artery Goitre Embolization Trial A Pilot Study Investigating Thyroid Artery Embolisation as a Treatment for Large Thyroid Nodules
Large non-cancerous thyroid nodules (lumps in the thyroid gland) can cause pressure or discomfort in the neck or cosmetic issues. The standard treatment options include radiofrequency ablation, radioactive iodine, and surgery.
- Conditions
- Thyroid Nodule (Benign), Graves Disease, Goitre
- Trial name
- TArGET (NCT07046546)
- Testing
- Thyroid artery embolization
- Where
- United Kingdom
- Volunteers
- 10 people
- Sponsor
- Royal Berkshire NHS Foundation Trust
Thyroid Nodule, Thyroid Carcinoma
CEUS Improves the Diagnostic Performance of SRSS of Thyroid Carcinoma
Contrast-enhanced ultrasound (CEUS) can sensitively show the blood perfusion characteristics of thyroid nodules, which is a useful supplement to gray-scale ultrasound.
- Trial name
- NCT06146764
- Testing
- Contrast-enhanced Ultrasound
- Where
- China
- Volunteers
- 800 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Thyroid Nodular Disease
Thyroid Fine Needle Biopsy and Impact on Pain and Diagnostic Adequacy
This randomized study compares patient pain and comfort during ultrasound-guided thyroid fine needle biopsy using 21-gauge versus 27-gauge needles. Patients with thyroid nodules were randomly assigned to one of two needle sizes.
- Trial name
- THY-BPSY (NCT07683039)
- Testing
- Thyroid fine needle biopsy with 21-gauge needle, Thyroid fine needle biopsy with 27-gauge needle
- Where
- Turkey (Türkiye)
- Volunteers
- 159 people
- Sponsor
- Izmir Ataturk Training and Research Hospital
Benign Thyroid Nodules
Treatment of Benign Thyroid Nodules With FastScan HIFU
This study evaluates the efficacy of the HIFU for the treatment of benign thyroid nodules with the FastScan version using assessment of patient experience and adverse event reporting.
- Trial name
- NCT02491502
- Testing
- Echopulse
- Where
- Bulgaria
- Volunteers
- 36 people
- Sponsor
- Theraclion
Tumor
Study of PXD101 Alone and in Combination With 5-Fluorouracil (5-FU) in Patients With Advanced Solid Tumors
This is a study to assess the combination of PXD101 and 5-Fluorouracil (5-FU)in patients with advanced solid tumors. The primary goal of the study is to understand the safety, anti-tumor activity, and how the study drug behaves…
- Trial name
- NCT00413322
- Testing
- belinostat, 5-Fluorouracil (5-FU)
- Where
- 3 sites in United States
- Volunteers
- 35 people
- Sponsor
- Valerio Therapeutics
Thyroid Nodule
Health-Related Quality of Life and Emotions in Patients with Thyroid Nodules
The purpose of this observational research is to evaluate and compare the health-related quality of life and emotional well-being of patients with thyroid nodules before and after treatment.
- Trial name
- NCT06610604
- Testing
- thermal ablation, thyroidectomy
- Where
- China
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Ming-an Yu
Differentiated Thyroid Cancer (DTC), Papillary Thyroid Carcinoma
Serum Treg/Th17-Related Cytokines and Systemic Inflammatory Indices in Differentiated Thyroid Cancer
This study measures circulating immune-signalling molecules before thyroid surgery to determine whether they differ between patients whose thyroid nodule proves to be a differentiated thyroid carcinoma and patients whose nodule…
- Conditions
- Differentiated Thyroid Cancer (DTC), Papillary Thyroid Carcinoma, Thyroid Cancer, Thyroid Nodule
- Trial name
- THINC (NCT07907432)
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Marmara University
Thyroid Nodule
Levothyroxine Treatment in Thyroid Benign Nodular Goiter
We will study the effect of taking eltroxin at different time, i.e. fasting or postprandial periods. We will also study the effect of levothyroxin treatment in Chinese people
- Trial name
- NCT00552253
- Testing
- Levothyroxin treatment
- Where
- Taiwan
- Volunteers
- 10 people
- Sponsor
- National Taiwan University Hospital
Thyroid
Randomized Trial Comparing Performance of Molecular Markers for Indeterminate Thyroid Nodules
The purpose of this study is to compare the performance of Afirma GSC and ThyroSeq v.3 in indeterminate thyroid nodules to determine which test can allow more patients to avoid unnecessary surgery and preserve quality of life.
- Trial name
- NCT02681328
- Testing
- Afirma GEC, ThyroSeq v.2, Afirma GSC
- Where
- United States
- Volunteers
- 328 people
- Sponsor
- Jonsson Comprehensive Cancer Center
Thyroid Nodule
Human-AI Collaboration for Ultrasound Diagnosis of Thyroid Nodules - a Clinical Trial
This is an experimental study wherein groups of medical students and physicians of varying degrees of experience in head-and-neck ultrasound were asked to scan the same five patients each with a thyroid nodule.
- Trial name
- NCT06306599
- Testing
- S-Detect for Thyroid
- Where
- Denmark
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Thyroid Abnormalities
Thyroid Abnormalities Associated With Exposure to Atmospheric Emissions of Radioactive Iodine
Background: An inadequate filtering system at the Mayak nuclear weapons production facility in Ozyorsk, Russia, allowed the release of various radioactive materials, particularly I-131 (radioactive iodine) into the city's…
- Trial name
- NCT00342693
- Where
- United States
- Volunteers
- 360 people
- Sponsor
- National Cancer Institute (NCI)
Head and Neck Cancer
Genetic Analysis in Diagnosing Thyroid Cancer in Patients With Thyroid Nodules
RATIONALE: Finding genetic markers for thyroid cancer in a biopsy specimen may help doctors diagnose thyroid cancer. PURPOSE: This clinical trial is studying how well genetic analysis works in diagnosing thyroid cancer in…
- Trial name
- NCT00316823
- Testing
- gene expression analysis, polymerase chain reaction, reverse transcriptase-polymerase chain reaction
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- University of California, San Francisco
Thyroid Neoplasms Benign, Thyroid Nodule
Red Blood Cell Distributions (RDW, RDW-CW) and Lymphocyte Monocyte Ratios (LMR) for the Malignant Thyroid Nodules
Thyroid surgery is the most common type of surgery among endocrine surgeries. This surgery is performed for patients with suspected malignancy, patients diagnosed with malignancy, and toxic nodular goiter.
- Conditions
- Thyroid Neoplasms Benign, Thyroid Nodule, Thyroid Cancer, Thyroid Diseases
- Trial name
- NCT06283368
- Testing
- Thyroidectomy, Bilaterally Total, Thyroidectomy, Unilaterally Total, Thyroidectomy, Complementary
- Volunteers
- 172 people
- Sponsor
- Kahramanmaras Sutcu Imam University
Nodule Solitary Thyroid, Toxic Multinodular Goiter
An Assessment of the Occurrence of Hypothyroidism in Patients Treated With RAI for Hyperthyroidism.
Low RAIU in patients with hyperthyroidism represents a common obstacle in the treatment with RAI. Therefore, a higher dose of RAI must be administered to cure hyperthyroidism in these patients.
- Conditions
- Nodule Solitary Thyroid, Toxic Multinodular Goiter, Radioactive Iodine-Induced Hypothyroidism
- Trial name
- NCT04663451
- Testing
- radioacive iodine therapy
- Where
- Belgium
- Volunteers
- 150 people
- Sponsor
- Universitair Ziekenhuis Brussel
Thyroid Cancer, Thyroid Nodules
Radiation Exposure and Thyroid Disease in Kazakhstan
Residents of certain villages in Kazakhstan were exposed during childhood to radioactive fallout from nuclear tests conducted at the Semipalatinsk Nuclear Test Site (SNTS) between 1949 and 1962.
- Conditions
- Thyroid Cancer, Thyroid Nodules, Other Thyroid Disease
- Trial name
- NCT00480428
- Where
- Kazakhstan
- Volunteers
- 117 people
- Sponsor
- National Cancer Institute (NCI)
Differentiated Thyroid Carcinoma, Papillary Thyroid Carcinoma
Bethesda Classification and Risk Stratification in Differentiated Thyroid Carcinoma
This observational study aims to evaluate the relationship between preoperative Bethesda classification of fine-needle aspiration cytology and postoperative American Thyroid Association (ATA) risk stratification in patients with…
- Conditions
- Differentiated Thyroid Carcinoma, Papillary Thyroid Carcinoma, Follicular Thyroid Carcinoma
- Trial name
- NCT07858097
- Volunteers
- 100 people
- Sponsor
- Assiut University
Thyroid Nodule
Benign Thyroid Nodules / Benign Goiter. What Subjective Problems Are Improved With an Operation and Can This be Predicted Preoperatively?
Nodules in the thyroid gland are common. Patients discover these lumps either because of their visible size increase or because of local discomforts such as difficulty swallowing, difficulty breathing or voice changes.
- Trial name
- NCT05526261
- Testing
- Hemithyroidectoy
- Where
- Sweden
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Linkoeping University
Thyroid Nodule
Comparison of the Vocal Cord Imaging Techniques After Thyroidectomy
Recurrent nerve palsy is a complication of thyroidectomy. Most surgeons want to visualize the vocal cords after tyroidectomy. The aim is to compare the direct laringoscopy, videolaringoscopy, fiberoptic laringoscopy and…
- Trial name
- NCT02410928
- Testing
- direct laringoscopy, fiberoptic nasal laringoscopy, ultrasonograph
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people
- Sponsor
- Diskapi Teaching and Research Hospital
Thyroid Nodule
Clinical Study of Ultrasonic Artificial Intelligence and Fine Needle Aspiration in Qualitative Diagnosis of Thyroid Nodules
To study the value of thyroid artificial intelligence diagnosis system and fine needle puncture in the diagnosis of benign and malignant thyroid nodules, so as to provide evidence-based medical evidence for the diagnosis of…
- Trial name
- NCT05407506
- Testing
- THYROID AI
- Volunteers
- 1,000 people
- Sponsor
- Luo Dingcun
Thyroid Cancer
To Perform a Post-market Study of the Performance of the Idylla ThyroidPrint Assay Using Clinical Samples in Predicting the Nature of Indeterminate Thyroid Nodules (ITNs) Across Multiple Centers.
To perform a post-market study of the performance of the Idylla™ ThyroidPrint® Assay using clinical samples in predicting the nature of indeterminate thyroid nodules (ITNs) across multiple centers.
- Trial name
- NCT06849284
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- Royal Cornwall Hospitals Trust