Clinical trials: Tibial Fractures
Tibial Plateau Fractures
Local Anesthetic for Plateau Fractures
Subjects may receive an injection at the end of the surgery to fix their broken leg that may reduce their pain and hospital stay
- Trial name
- NCT06474949
- Testing
- Bupivacaine injection, Saline
- Volunteers
- 100 people
- Sponsor
- University of Washington
Fracture
Optimal Vitamin D3 Supplementation Strategies for Acute Fracture Healing
The objective is to determine the effect of vitamin D3 supplementation on fracture healing at 3 months.
- Trial name
- Vita-Shock (NCT02786498)
- Testing
- Vitamin D3
- Where
- 2 sites in United States, Canada
- Volunteers
- 102 people
- Sponsor
- University of Maryland, Baltimore
Wrist Injury, Tibial Fracture
Pilot Study Comparing Diagnostic Imaging Versus Tomosynthesis in Detection of Hip, Wrist or Tibia Injury
To acquire and build a library of image sets to determine if Fuji's TOMO imaging device can replace or compliment current imaging standards to assess patients with hip, wrist or tibia injuries.
- Conditions
- Wrist Injury, Tibial Fracture, Hip Injury
- Trial name
- TOMO (NCT01927575)
- Testing
- Standard X-Ray + CT, Standard X-Ray + MRI, TOMO
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Fujifilm Medical Systems USA, Inc.
Nonunion of Fracture of Tibia (Diagnosis)
Risk Factors for Post-Operative Nonunion of Tibial Shaft Fractures Based on a Path Analysis Model
Tibial shaft fractures is common long tubular fracture that account for about 13.7% of all fractures. And the incidence of nonunion of tibial shaft fracture varied from 1% to 80%.
- Trial name
- NCT03928912
- Where
- China
- Volunteers
- 234 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Tibial Plateau Fracture
Predictors of Fracture-Dislocation in Schatzker IV Tibial Plateau Fractures: A Reproducible, Quantitative MRI-Based Injury-Pattern Analysis
This retrospective observational case-control study aims to evaluate imaging features and associated soft-tissue injury patterns in patients with Schatzker type IV tibial plateau fractures.
- Trial name
- fracture (NCT07481929)
- Testing
- Is it dislocation?
- Where
- China
- Volunteers
- 77 people
- Sponsor
- Second Affiliated Hospital of Soochow University
Osteoarthritis, Knee, Rheumatoid Arthritis
A Comparison of Two Surgical Techniques Using the Unity Knee™ Total Knee System
A comparison of two Unity Knee™ tissue-balancing techniques by analysing the results from X-rays and patient questionnaires.
- Conditions
- Osteoarthritis, Knee, Rheumatoid Arthritis, Post-Traumatic Osteoarthritis of Knee, Varus Deformity, Not Elsewhere Classified, Knee
- Trial name
- NCT03511144
- Testing
- Unity Knee™ TKR using measured resection, Unity Knee™ TKR using ligament balancing
- Sponsor
- Corin
Femoral Fractures, Tibial Fractures
Reamed Locked Plating - Metaphyseal Fractures of the Distal Femur and Tibia
Comminuted metaphyseal fractures (OTA classification A2/3 and C2/3) of the distal femur and distal tibia are difficult to treat and typically have more complications than other metaphyseal fractures.
- Trial name
- NCT01553630
- Testing
- RIA bone graft, Surgery without bone graft
- Where
- 2 sites in United States
- Volunteers
- 6 people
- Sponsor
- Florida Orthopaedic Institute
Tibial Fracture
Study Evaluating CERAMENT™|G in Open Diaphyseal Tibial Fractures
The purpose of this study is to demonstrate the safety and effectiveness of CERAMENT™|G used in conjunction with standard-of-care treatment compared to standard-of-care treatment alone in the care of subjects with open fractures…
- Trial name
- NCT02820363
- Testing
- CERAMENT|G, SOC treatment
- Where
- 31 sites in United States, Germany and 2 more
- Volunteers
- 201 people
- Sponsor
- BONESUPPORT AB
Tibial Fractures, Nonunion of Fracture
Intramedullary Bone Grafting for Open Tibial Shaft Fractures
This study will examine if there is a difference between the time to full union between the control group and the study group. Each group will be composed of patients who have an open fracture in the mid tibia.
- Conditions
- Tibial Fractures, Nonunion of Fracture, Delayed Union of Fracture
- Trial name
- NCT03891888
- Testing
- Intramedullary Bone Graft
- Where
- 2 sites in United States
- Volunteers
- 130 people
- Sponsor
- University of Louisville
Tibial Shaft Fracture, Tibial Plateau Fracture
Gene Expression in Lower Extremity Acute Traumatic Compartment Syndrome
The purpose of this study is to evaluate both genotypic differences and differences in local gene expression in individuals who develop acute traumatic compartment syndrome relative to control patients with at-risk lower…
- Trial name
- NCT05521958
- Testing
- Acute injury without compartment syndrome, Acute injury with compartment syndrome, Exertional compartment syndrome
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Utah
Acute Tibial Fracture Requiring Intramedullary Nailing
T1Rho MRI Evaluation of Patellofemoral Changes After Tibial IM Nailing
This study will utilize T1-Rho MRI to evaluate the effect of intramedullary nailing on patellofemoral articular cartilage when the surgery is performed using the infrapatellar vs. the suprapatellar approach.
- Trial name
- NCT01879215
- Testing
- Intramedullary nailing of the tibia
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Pennsylvania
Deep Vein Thrombosis, Pulmonary Embolism
The D-KAF (Dalteparin in Knee-to-Ankle Fracture) Trial
It is known that patients who fracture their legs sometimes develop blood clots (known as deep vein thrombosis) in their legs. These clots may cause pain and swelling in the leg or they may detach and travel to the lungs…
- Trial name
- NCT00187408
- Testing
- Low Molecular Weight Heparin (dalteparin)
- Where
- 13 sites in Canada
- Volunteers
- 700 people
- Sponsor
- Sunnybrook Health Sciences Centre
Bone Fracture, Tibia Fracture
Efficacy and Safety of SurgiFill™in Patients With Femur or Tibia Fracture
This study is designed to investigate the safety and efficacy of SurgiFill™, a bone grafting material, in patients with femur or tibia fracture.
- Conditions
- Bone Fracture, Tibia Fracture, Femur Fracture
- Trial name
- NCT07518836
- Testing
- femur or tibia fracture, SurgiFill™
- Where
- 3 sites in South Korea
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Cellontech Co., Ltd.
Fractures, Bone, Fractures, Closed
Post Market Evaluation of Clinical Safety and Performance of the Fitbone Transport and Lengthening System
This is an open-label, prospective, observational, post-market, uncontrolled, multi-center study intended to evaluate the safety and clinical performance of the FITBONE Transport and Lengthening Nail when used according to the…
- Conditions
- Fractures, Bone, Fractures, Closed, Fractures, Open, Fracture of Femur
- Trial name
- NCT06400732
- Testing
- Fitbone Transport and Lengthening System
- Where
- 9 sites in United States
- Volunteers
- 1 people
- Sponsor
- Orthofix Inc.
Tibial Fractures, Fractures, Open
Percutaneous Autologous Bone-marrow Grafting for Open Tibial Shaft Fracture
The treatment of open tibial shaft fracture is often complicated by delayed union or non-union. The objective of this study is to evaluate the efficacy of autologous concentrated bone-marrow to accelerate healing of open tibial…
- Trial name
- IMOCA (NCT00512434)
- Testing
- Osteosynthesis
- Where
- 11 sites in France
- Volunteers
- 85 people
- Sponsor
- University Hospital, Tours
Fracture of Tibia, Wound Heal
Incisional Negative Pressure Wound Therapy to Reduce Infection and Complications in High-Risk Fractures
This is a multi-center, pragmatic, parallel arm randomized controlled trial (RCT) of 352 patients with high-risk open or closed tibial plateau fracture, high-risk open or closed tibial pilon fracture, or open tibial shaft…
- Conditions
- Fracture of Tibia, Wound Heal, Infected Wound, Wound Complication
- Trial name
- iVAC (NCT06337292)
- Testing
- Incisional Negative Pressure Wound Therapy (NPWT)
- Where
- 6 sites in United States
- Volunteers
- 352 people
- Sponsor
- Major Extremity Trauma Research Consortium
Distal Femur Fracture, Tibial Plateau Fracture
Early Advanced Weight Bearing for Peri-articular Knee and Pilon Injuries
The overall objective of this study is to compare outcomes following early advanced weight bearing (EAWB) using the AlterG antigravity treadmill versus standard of care physical therapy for adult patients with lower extremity…
- Conditions
- Distal Femur Fracture, Tibial Plateau Fracture, Distal Tibia Fracture, Pilon Fracture
- Trial name
- AlterG (NCT03562364)
- Testing
- AlterG anti-gravity treadmill
- Where
- 10 sites in United States
- Volunteers
- 81 people
- Sponsor
- Major Extremity Trauma Research Consortium
Closed Fracture, Open Fracture
Efficacy of DBM on Fractures of the Shinbone (Tibia)
The Tibia bone (shinbone) is located in the leg, itis the most frequently fractured bone in the body and has very poor blood supply because it is surrounded by skin and fat instead of muscle like the thighbone causing healing…
- Trial name
- NCT00299052
- Testing
- Grafton DBM, Reamings
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Emory University
Severe Open Fractures of the Tibia (Shin) Bone
Assessment of Fixation Strategies for Severe Open Tibia Fractures
The purpose of this study is to compare the use of modern ring external fixation versus internal fixation for fracture stabilization of severe open tibia fractures.
- Trial name
- FIXIT (NCT01494519)
- Testing
- Surgery with an external ring fixator, Definitive fixation with a locked IM nail or plate
- Where
- 33 sites in United States
- Volunteers
- 442 people
- Sponsor
- Major Extremity Trauma Research Consortium
Tibial Fractures
ACTiF- Assessment of Closed Tibial Fractures
The purpose of this study is to find out the good and bad effects of an investigational drug called CP-533,536 in patients with closed fracture of the tibial shaft undergoing internal fixation using reamed inter-locked IM nailing…
- Trial name
- NCT00533377
- Testing
- CP-533, 536, Standard of Care, CP-533,536
- Where
- 56 sites in United States, Australia and 9 more
- Volunteers
- 276 people
- Sponsor
- Pfizer