Clinical trials: Tick-Borne Disease
COVID-19, Lyme Disease
The Burden of Lyme Disease (BOLD) in a Pandemic - Insights From an Online Cross-sectional and Prospective Cohort Survey
A cross-sectional descriptive survey of the BOLD for individuals after having been ill with COVID-19 or have taken the COVID-19 vaccine will be compared with that of individuals who have neither been ill with COVID-19 nor taken…
- Conditions
- COVID-19, Lyme Disease, COVID-19 Vaccine
- Trial name
- NCT05312619
- Testing
- Cross sectional survey
- Where
- United States
- Volunteers
- 2,000 people
- Sponsor
- Dr. Daniel Cameron & Associates
Lyme Disease
First Clinical Study of the Safety and Blood Levels of a Human Monoclonal Antibody (2217LS) Against Lyme Disease Bacteria in Healthy People
This is a research study of the investigational drug 2217LS in healthy volunteers. Investigational means 2217LS is a new drug that has not been approved for the treatment of any disease.
- Trial name
- NCT04863287
- Testing
- 2217LS, 0.9% Sodium Chloride (NaCl)
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- MassBiologics
Lyme Disease
Understanding Tick-borne Diseases
Ticks are the major arthropod vectors transmitting pathogenic agents to humans and domestic animals in Europe, and currently, the incidence of tick-borne disease is rising.
- Trial name
- OHTICKS (NCT03501407)
- Testing
- Blood samples, skin biopsy
- Where
- France
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Institut Pasteur
Encephalitis, Tick-Borne
TBE Antibody Persistence and Booster Vaccination Study in Children and Adolescents (Follow-up to Study 209)
The purpose of this study is to assess the seropersistence of TBE antibodies in children and adolescents aged 1 to 15 years at the time of their first vaccination, 24 months and 34 months after completion of primary immunization…
- Trial name
- NCT00161967
- Testing
- Tick-Borne Encephalitis (TBE) Vaccine (Inactivated)
- Where
- 3 sites in Austria, Germany and 1 more
- Volunteers
- 375 people, healthy volunteers welcome
- Sponsor
- Pfizer
Lyme Borreliosis, Nervous System
Doxycycline Boosted Therapy in Lyme Borreliosis: DoBo Study.
The goal of this clinical trial is to learn if hydroxychloroquine works to treat long-term complaints attributed to Lyme borreliosis in adults.
- Trial name
- DoBo (NCT07230028)
- Testing
- Hydroxychloroquin, Doxycycline
- Volunteers
- 50 people
- Sponsor
- Radboud University Medical Center
Babesioses, Human
Surveillance of Emerging Pathogens to Ensure Blood Supply Safety
Babesia is a parasite that can be transmitted from the bite of a tick to an individual. While many some people may not have any symptoms from infection, others may experience anything from flu-like symptoms to joint pain…
- Trial name
- NCT06462677
- Testing
- Babesia NAT
- Volunteers
- healthy volunteers welcome
- Sponsor
- Canadian Blood Services
Tick-borne Encephalitis
Tick-borne Encephalitis Virus Research in Limousin
Cases of encephalitis of varying severity have been described in recent years in eastern France involving tick-borne encephalitis virus (TBEV).
- Trial name
- VITAL (NCT05941546)
- Testing
- anti-TBEV serology
- Where
- France
- Volunteers
- 878 people
- Sponsor
- University Hospital, Limoges
Aseptic Meningitis
Aseptic Meningoencephalitis in Slovenia
The main objective of this study is: to establish etiology of acute aseptic meningitis/meningoencephalitis in Slovenia to assess the clinical course and outcome of tick-borne encephalitis and Lyme neuroborreliosis to characterize…
- Trial name
- NCT02328469
- Testing
- symptomatic therapy, Ceftriaxone or Doxycycline, questionnaire
- Where
- 2 sites in Slovenia
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- University Medical Centre Ljubljana
Lyme Disease, Post-Treatment Lyme Disease
Pregnancy and Early Neurodevelopmental Outcomes Following In Utero Lyme Disease Exposure
The purpose of this pilot study is to assess the feasibility of longitudinal neurodevelopmental evaluation of fetuses and infants exposed to Lyme disease in utero.
- Conditions
- Lyme Disease, Post-Treatment Lyme Disease, Chronic Lyme Disease, Tick-Borne Infections
- Trial name
- NCT06026969
- Testing
- Neurodevelopmental assessments and follow-up
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Children's National Research Institute
Erythema Migrans, Erythema Chronicum Migrans
Comparing 3 Antibiotic Regimes for Erythema Migrans in General Practice
Tick borne diseases are increasing in Norway. Lyme borreliosis is the most common infection. Erythema migrans is mainly diagnosed and treated in general practice.
- Conditions
- Erythema Migrans, Erythema Chronicum Migrans, Borreliosis, Lyme Disease
- Trial name
- NorTick_EM (NCT01368341)
- Testing
- Doxycycline, Phenoxymethylpenicillin, Amoxicillin
- Where
- Norway
- Volunteers
- 225 people
- Sponsor
- Morten Lindbaek
Babesiosis, Human
Description of Case of Infection With a New Species of Babesia and Its Molecular Diagnosis
Babesiosis is a potentially very serious infection, but too little known. investigators want to raise their clinical colleagues and remind fellow biologists of the importance of choosing a good molecular diagnosis so as not to…
- Trial name
- BADIAG (NCT04960995)
- Where
- France
- Volunteers
- 1 people
- Sponsor
- University Hospital, Strasbourg, France
Crimean-Congo Haemorrhagic Fever
Development Of A Rapid Diagnostic Test To Identify Crimean-Congo Haemorrhagic Fever At The Point-Of-Care
The goal of this medical device diagnostic evaluation study is to determine if this novel lateral flow device can detect Crimean-Congo Hemorrhagic Fever (CCHF) at the point of care in secondary health care clinics in Turkey.
- Trial name
- NCT06624787
- Testing
- Rapid Diagnostic Test
- Where
- 6 sites in Turkey (Türkiye)
- Volunteers
- 492 people
- Sponsor
- Liverpool School of Tropical Medicine
Rocky Mountain Spotted Fever
Efficacy of Azithromycin Plus Doxycycline Versus Doxycycline Plus Placebo in Patients With Rocky Mountain Spotted Fever
The aim of this study is to impove the pharmacological treatment of Rocky mountain spotted fever, since is a very ancient disease with an antibiotic therapy that have not changed much the mortality rates, being compared with the…
- Trial name
- Rocky-Z (NCT05398055)
- Testing
- Azithromycin + Doxycycline
- Where
- Mexico
- Volunteers
- 86 people
- Sponsor
- Hospital General de Mexicali
Tick Borne Encephalitis, Lyme Disease
Tick-borne Encephalitis and Possible Borrelial Serology
In Europe, tick-borne encephalitis (TBE) virus causing TBE is transmitted by the bite of Ixodes ricinus tick, which can also transmit Lyme borreliae , the causative agent of Lyme borreliosis (LB).
- Trial name
- NCT03958058
- Testing
- Anti-borrelial antibiotic therapy, No antibiotic.
- Where
- Slovenia
- Volunteers
- 690 people
- Sponsor
- University Medical Centre Ljubljana
Lyme Disease
Novel Diagnostics for Early Lyme Disease
There are more than 300,000 new cases of Lyme disease every year in the US. Lyme disease is a dangerous bacterial infection transmitted by tick bites and it becomes increasingly severe as the infection progresses.
- Trial name
- NCT03963635
- Testing
- MicroB-plex Lyme Immunoassay
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- MicroB-plex, Inc.
Tick-Borne Encephalitis
Cervicovaginal Immune Responses to 3 Deltoid or Thigh Intramuscular (IM) TicoVac
Many viral infections of global importance, including HIV, are transmitted across the mucosal surface of the genital tract. As immunity against these infections is likely to be primarily mediated by antibodies in mucosal…
- Trial name
- CRC306 (NCT01710189)
- Testing
- TicoVac
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Surrey
Tick-borne Encephalitis
Investigation of the Seropersistence of TBE Antibodies and the Booster Response to FSME-IMMUN 0.5 ml in Adults Aged 18 - 67 Years
The purpose of this study is to assess: TBE antibody persistence 2 and 3 years after the third TBE vaccination with FSME-IMMUN 0.5ml by means of ELISA and neutralization test (NT).
- Trial name
- NCT00161785
- Testing
- FSME-IMMUN 0.5ml
- Where
- 2 sites in Poland
- Volunteers
- 340 people, healthy volunteers welcome
- Sponsor
- Pfizer
Tick-Borne Encephalitis, European
The NOrwegian Tick-borne Encephalitis Study
During 2018, 2019, and 2020, the reported TBE-cases have increased markedly in Norway. Surveillance studies conducted by the Norwegian Institute of Public Health demonstrate that cases are associated with tick bites in the…
- Trial name
- NOTES (NCT05138055)
- Testing
- No intervention
- Where
- 3 sites in Norway
- Volunteers
- 153 people
- Sponsor
- Sykehuset Telemark
Tick Borne Encephalitis (TBE), Lyme Borreliosis
FINtick - a Prospective Multicenter Study on Tick-borne Infections in Finland
Ticks in Finland can carry several microbes that may infect humans. The best known tick-borne diseases are Lyme borreliosis and tick-borne encephalitis (TBE).
- Conditions
- Tick Borne Encephalitis (TBE), Lyme Borreliosis, Neoehrlichiosis, Tick-Borne Diseases
- Trial name
- FINtick (NCT07897825)
- Where
- 3 sites in Finland
- Volunteers
- 850 people
- Sponsor
- Turku University Hospital
Immune Modulation, Tuberculosis
CD8 Reactivity to Microorganisms in Blood and Breast Milk
Background: When a person is exposed to something that causes an infection, the body sends a type of cell called CD8 T cells to attack it. Those cells are also found in breast milk.
- Conditions
- Immune Modulation, Tuberculosis, Leprosy, Pertussis
- Trial name
- NCT03084614
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)