Clinical trials: Tinnitus
Noise-induced Hearing Loss and Tinnitus
TUNE! Teaching the UK About Noise Exposure: A Pilot Study
In 1986 The Medical Research Council estimated that 4 million UK adolescents were at risk of hearing damage from over-exposure to loud music from personal audio players (PAPs), gigs, clubs, pubs and festivals.
- Trial name
- gildeaf1 (NCT00916305)
- Testing
- Modified Audio video, Unmodified audio video
- Where
- United Kingdom
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Posttraumatic Stress Disorder, Tinnitus
Neurobiological Similarities of Tinnitus and PTSD
Psychiatric distress caused by PTSD may increase attention toward tinnitus, as well as perceived loudness and discomfort. It is important to understand how tinnitus-related distress and PTSD negatively interact together, in order…
- Trial name
- NCT05981391
- Testing
- resting-state functional MRI, Clinician Administered PTSD Scale for the DSM-5 (CAPS-5), Tympanometry
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio
Idiopathic Intracranial Hypertension
Idiopathic Intracranial Hypertension Treatment Trial
Idiopathic intracranial hypertension (IIH), also called pseudotumor cerebri, is a disorder of elevated intracranial pressure of unknown cause [Corbett, et al., 1982; Wall, et al., 1991].
- Trial name
- IIHTT (NCT01003639)
- Testing
- Acetazolamide, Formal weight loss counselling program
- Where
- 41 sites in United States, Canada
- Volunteers
- 165 people, healthy volunteers welcome
- Sponsor
- St. Luke's-Roosevelt Hospital Center
Tinnitus
CBT-based Internet Intervention for Adults With Tinnitus in the United States
Nearly 50 million people in the U.S. experience tinnitus, of which about 20 million people have burdensome chronic tinnitus. Tinnitus can be very debilitating as many aspects of daily life can be affected, such as sleep, mood…
- Trial name
- NCT04004260
- Testing
- Internet-based Cognitive Behavior Therapy
- Where
- United States
- Volunteers
- 315 people, healthy volunteers welcome
- Sponsor
- Lamar University
Tinnitus
AM-101 in the Treatment of Post-Acute Tinnitus 1
The purpose of this research study is to test the safety and local tolerance of repeated treatment cycles of AM-101.
- Trial name
- AMPACT1 (NCT01934010)
- Testing
- AM-101
- Where
- United States
- Volunteers
- 260 people
- Sponsor
- Auris Medical, Inc.
Tinnitus
Effect of rTMS on Resting State Brain Activity in Tinnitus
One out of every five people experiences tinnitus (a ringing, buzzing, or roaring sound in the ear) ranging from mild to severe impairment.
- Trial name
- NCT00926237
- Testing
- Active 1 Hz rTMS - Active repetitive transcranial magnetic stimulation delivered at 1 Hz frequency, Active 10 Hz rTMS - active repetitive transcranial magnetic stimulation delivered at 10 Hz frequency
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- University of Arkansas
Tinnitus
rTMS To The Dorsolateral Prefrontal Cortex For Patients With Subjective Idiopathic Tinnitus. A Pilot Study
The neurological basis of tinnitus is uncertain when there is no evidence of damage to the peripheral auditory system. However, neuroimaging studies of tinnitus patients show hyperactivity in several cortical regions, especially…
- Trial name
- NCT00886938
- Testing
- Repetitive Transcranial Magnetic Stimulation (rTMS), pilot study
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Washington University School of Medicine
Subjective Tinnitus
OTO-313 in Subjects With Unilateral Subjective Tinnitus
The purpose of this study is to determine the efficacy of OTO-313 in subjects with unilateral tinnitus and to determine the safety and tolerability of OTO-313 in subjects with unilateral tinnitus.
- Trial name
- NCT04829214
- Testing
- OTO-313
- Where
- 48 sites in United States, Germany and 2 more
- Volunteers
- 153 people
- Sponsor
- Otonomy, Inc.
Tinnitus, Subjective
OTO-313 in Subjects With Subjective Tinnitus
The purpose of this study is to evaluate the safety, tolerability, plasma pharmacokinetics (PK), and exploratory efficacy of OTO-313 administered as an intratympanic injection for the treatment of subjective tinnitus.
- Trial name
- NCT03918109
- Testing
- OTO-313
- Where
- 16 sites in United States
- Volunteers
- 43 people
- Sponsor
- Otonomy, Inc.
Tinnitus
Resting-State Neural Connectivity in Patients With Subjective Tinnitus Without Bother
Tinnitus is the occurrence of an auditory sensation without the presence of an acoustic stimulus. Approximately, 50 million people in the United States experience chronic tinnitus and 15 million of these people have bothersome…
- Trial name
- NCT01049828
- Testing
- No intervention
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Washington University School of Medicine
Subjective Tinnitus
Tinnitus Retraining Therapy Trial
The primary purpose of the Tinnitus Retraining Therapy Trial (TRTT) is to assess the efficacy of tinnitus retraining therapy (TRT) as a treatment for severe debilitating tinnitus.
- Trial name
- TRTT (NCT01177137)
- Testing
- Conventional sound generator (SG), Standard of Care (SC), Directive Counseling (DC)
- Where
- 6 sites in United States
- Volunteers
- 151 people
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Meniere's Disease
Study to Evaluate SPI-1005 in Adults With Meniere's Disease
This study will evaluate the safety and efficacy of three dose levels of SPI-1005 compared to placebo on vertigo, tinnitus and sensorineural hearing loss in 40 adults with Meniere's disease.
- Trial name
- NCT02603081
- Testing
- SPI-1005
- Where
- 5 sites in United States
- Volunteers
- 40 people
- Sponsor
- Sound Pharmaceuticals, Incorporated
Pulsatile Tinnitus
Internal Jugular Vein Compression Collar for Novel Symptomatic Treatment of Venous Pulsatile Tinnitus
This study seeks to pilot an evaluation of whether an external jugular vein compression collar approved by the US Food and Drug Administration (FDA) for contact sports can provide symptomatic relief of venous pulsatile tinnitus.
- Trial name
- NCT05441540
- Testing
- Internal Jugular Vein Compression Collar
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Tinnitus, Hearing Aids
Feasibility and Acceptability of Using Low-Gain Hearing Aids for Bothersome Tinnitus
Tinnitus - defined as ringing, humming, or other sounds in the ears or head - is a very common problem for Veterans. Hearing aids that deliver low-level amplification are being used by audiologists to help people with tinnitus…
- Conditions
- Tinnitus, Hearing Aids, Normal Hearing
- Trial name
- NCT03904264
- Testing
- Receiver in the canal (RIC) hearing aids
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- VA Office of Research and Development
Tinnitus
A CBT-based Internet Intervention for Adults With Tinnitus in the United Kingdom
The purpose of this study is to determine the feasibility and effectiveness of a CBT-based internet intervention for adults with tinnitus in the United Kingdom
- Trial name
- NCT02370810
- Testing
- CBT-based internet-intervention for tinnitus
- Where
- United Kingdom
- Volunteers
- 146 people, healthy volunteers welcome
- Sponsor
- Anglia Ruskin University
Tinnitus
Nitrous Oxide Treatment for Tinnitus
Tinnitus is perception of sound without the presence of an external acoustic stimulus. Approximately 50 million Americans experience chronic tinnitus and of these, 10 million have bothersome tinnitus.
- Trial name
- NCT03365011
- Testing
- Nitrous oxide gas for inhalation
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Tinnitus
A Trial of Magnesium Dependent Tinnitus
The purpose of this study was to examine any potential benefit in lessening the severity of tinnitus (ringing or booming sensation in one or both ears) in subjects supplemented with magnesium (532 mg daily).
- Trial name
- NCT01273883
- Testing
- Magnesium
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Mayo Clinic
Tinnitus
AM-101 in the Treatment of Acute Tinnitus 2
The purpose of this research study is to test the safety and effectiveness of the study drug, AM-101. AM-101 is tested for the treatment of tinnitus that started as the result of an injury to the inner ear or due to middle ear…
- Trial name
- TACTT2 (NCT01803646)
- Testing
- AM-101
- Where
- United States
- Volunteers
- 343 people
- Sponsor
- Auris Medical, Inc.
Tinnitus
Study of Low Level Laser Therapy and Tinnitus Relief
The purpose of this study is to determine if low level laser light therapy might help to relieve tinnitus in adults.
- Trial name
- NCT00845975
- Testing
- Erchonia Hearing Lasers #1 & #2
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Erchonia Corporation
Tinnitus
Regulating Homeostatic Plasticity and the Physiological Response to rTMS
This device-study includes a pilot, physiological investigation of normal human subjects. The aim is to determine how existing non-invasive neuromodulation devices affect brain circuitry as measured by EEG recording.
- Trial name
- NCT03309696
- Testing
- active tDCS and active rTMS
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Arkansas