Clinical trials: Tissue Adhesion
Cancer
Phase I Study to Evaluate Safety, Pharmacokinetics and Pharmacodynamics of GSK2256098 in Healthy Volunteers
The purpose of this study is to test the safety of a new drug and to look at how the drug is handled by your body. This is the first time the drug will be given to people, the drug has been safely given to animals over many days…
- Trial name
- FTIH (NCT00996671)
- Testing
- GSK2256098
- Where
- Australia
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Cancer
A Study Of PF-04554878 In Patients With Advanced Non-Hematologic Malignancies
Phase 1 safety, pharmacokinetics, and pharmacodynamics trial of the focal adhesion kinase (FAK) inhibitor PF-04554878 in patients with advanced non-hematologic malignancies, including patients with malignancies appropriate for…
- Trial name
- B0761001 (NCT00787033)
- Testing
- PF-04554878
- Where
- 5 sites in United States, Canada
- Volunteers
- 46 people
- Sponsor
- Verastem, Inc.
Coronary Arterial Disease (CAD), Coronary Artery Bypass
Comparison of Bidirectional Palpation Test and Transit Time Flow Measurement for LIMA-LAD Graft Patency
The most important factor determining mortality and morbidity after coronary artery bypass graft (CABG) surgery is graft patency.
- Conditions
- Coronary Arterial Disease (CAD), Coronary Artery Bypass, LIMA, Graft Patency
- Trial name
- NCT06934993
- Where
- Turkey (Türkiye)
- Volunteers
- 116 people
- Sponsor
- Abdulgani Orhun YENİGÜN
Tissue Adhesions, Surgery-Induced
Post Approval Study to Evaluate the Safety and Performance of GENTA-FOIL Resorb® in Hand Surgery
Single arm study to evaluate the safety and performance of Genta-Foil resorb® for the prevention of tissue adhesions
- Trial name
- NCT04482140
- Testing
- Genta-Foil resorb®
- Where
- 3 sites in Greece, United Kingdom
- Volunteers
- 15 people
- Sponsor
- Advanced Medical Solutions Ltd.
Neovascular Age-related Macular Degeneration
Intravitreal Ranibizumab in Exudative Age-related Macular Degeneration With Posterior Vitreomacular Adhesion
The main objective is to determine the efficacy of intravitreal administration of Ranibizumab combined with intravitreous injection of expansile gas and induction of posterior vitreous detachment on best-corrected visual acuity…
- Trial name
- NCT01291121
- Testing
- Intravitreal expansile gas and ranibizumab injection
- Where
- South Korea
- Volunteers
- 30 people
- Sponsor
- Yonsei University
Recurrent Miscarriage
3D Ultrasound to Assess in Recurrent Miscarriage
This observational study aims to compare the prevalence of acquired abnormalities of the uterus (fibroids, polyps, intrauterine adhesions, adenomyosis) in women who have recurrent miscarriages with the fertile population.
- Trial name
- 3D-ARM (NCT06164015)
- Testing
- 3D Ultrasound scan with power Doppler angiography
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University Hospitals of Derby and Burton NHS Foundation Trust
Small Bowel Obstruction
Early Small Bowel Obstruction Following Laparotomy For Trauma
The formation of intraperitoneal adhesion following abdominal surgery is accepted by clinicians as an inevitable consequence. More than 90% of patients undergoing a surgical procedure in the abdomen will develop intraperitoneal…
- Trial name
- NCT01068340
- Where
- United States
- Volunteers
- 571 people
- Sponsor
- University of Southern California
Polyetheretherketone
Microbial Adhesion to Metallic Versus Non Metallic Surfaces of Bounded Removable Partial Denture
a split mouth randomized clinical trial that compares quantity and quality of bacterial adhesion under both PEEK versus cobalt chromium alloy denture base.
- Trial name
- splitmouth (NCT03008317)
- Testing
- PEEK
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Cairo University
Pelvic Adhesions, Post Hysterectomy Pain
Effects of Soft Tissue Mobilization and Pelvic Floor Muscle Exercises on Pelvic Adhesions
Adhesions are permanent tissue connections that are created by fibrin deposition between different tissue planes or organs. They are a part of the internal healing process and inflammatory reactions that go through several…
- Trial name
- NCT06658210
- Testing
- soft tissue mobilization with pelvic floor muscle exercises, soft tissue mobilization without pelvic floor muscle exercises
- Where
- Pakistan
- Volunteers
- 56 people
- Sponsor
- Riphah International University
Leukemia, Lymphocytic, Chronic, B-Cell, Abnormalities Cell Epithelial
Determination of Blood Tumor Cells
Magnetic nanoparticles coated with anti-EpCAM or anti-CD52 antibodies will be tested ex-vivo in patients blood .
- Trial name
- NCT04290923
- Where
- Switzerland
- Volunteers
- 71 people
- Sponsor
- University of Zurich
Pancreas Cancer, Cancer of the Pancreas
Stereotactic Body Radiotherapy and Focal Adhesion Kinase Inhibitor in Advanced Pancreas Adenocarcinoma
Patients with advanced pancreas adenocarcinoma will be randomized on a 6:1 basis to receive standard of care chemotherapy followed by adaptive stereotactic body radiotherapy (SBRT) with concurrent and adjuvant FAK inhibitor…
- Conditions
- Pancreas Cancer, Cancer of the Pancreas, Pancreas Adenocarcinoma
- Trial name
- NCT04331041
- Testing
- Adaptive stereotactic body radiation therapy, Defactinib, Tumor biopsy
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Washington University School of Medicine
Small Bowel Obstruction, Small Bowel Obstruction Adhesion
Effectiveness of Small Bowel Decompression Techniques in Patients With Small Bowel Obstruction
This study will compare results of different intestinal decompression techniques in patients with small bowel obstruction.
- Conditions
- Small Bowel Obstruction, Small Bowel Obstruction Adhesion, Small-Bowel Obstruction Due to Volvulus, Hernia Incarcerated
- Trial name
- NCT06175442
- Testing
- Intraoperative intestinal decompression
- Where
- 8 sites in Russia
- Volunteers
- 500 people
- Sponsor
- North-Western State Medical University named after I.I.Mechnikov
Advanced Pancreatic Cancer
Safety, Pharmacokinetics and Efficacy of CT-707, Toripalimab and Gemcitabine in Advanced Pancreatic Cancer
This study will assess the safety, tolerability, pharmacokinetics and antineoplastic activity of CT-707 in combination with toripalimab and gemcitabine in patients with advanced pancreatic cancer
- Trial name
- NCT05580445
- Testing
- CT-707, Toripalimab, Gemcitabine
- Where
- China
- Volunteers
- 114 people
- Sponsor
- Shouyao Holdings (Beijing) Co. LTD
Missing Tooth/Teeth
Effect of Bio-activation on Epithelial and Connective Cell Adhesion to Titanium Abutments: Split Mouth Clinical Trial
The aim of this "in vivo" controlled trial is to assess soft tissue cell adhesion to titanium abutments subjected to different cleaning procedures - no treatment (as they come from the industry), and cleaning by plasma- at an…
- Trial name
- NCT07069231
- Testing
- the test group were placed in an Argon plasma reactor
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Universita degli Studi di Genova
Asherman Syndrome
Estrogen in the Prevention of Adhesion Reformation
Asherman syndrome, which occurs after trauma to the basalis layer of the endometrium.It seems that the role of postoperative estrogen therapy in the prevention of recurrence of IU adhesions is still controversial.
- Trial name
- NCT03620929
- Testing
- Estradiol Valerate
- Where
- China
- Volunteers
- 186 people
- Sponsor
- Fu Xing Hospital, Capital Medical University
Malignancy, Digestive Cancer
Target-specific immunoPET Imaging of Digestive System Carcinoma
The aim of this study is to establish and optimize the target-specific PET/CT imaging method, and its physiological and pathological distribution characteristics, on the basis of which the diagnostic efficacy of the above imaging…
- Conditions
- Malignancy, Digestive Cancer, Digestive System Neoplasm, Digestive System Carcinoma
- Trial name
- NCT06715839
- Testing
- [68Ga]Ga-DOTA-H2D3, [18F]F-RESCA-RB14, [68Ga]Ga-NOTA-T4
- Where
- China
- Volunteers
- 400 people
- Sponsor
- RenJi Hospital
Biofilm Formation
Randomized and Controlled Clinical Trial to Evaluate Bacterial Adhesion on Multi-Im® Transepithelial Components
This study evaluates the efficacy of Mutli-Im® transepithelial components in the inhibition of bacterial adhesion. The control group will be the Multi-Im® transepithelial component with the conventional surface (Multi-IM®…
- Trial name
- NCT03554876
- Testing
- Multi-Im Machined transepithelial component., Multi-Im Nanogolden transepithelial component, Multi-Im Ti-Golden transepithelial component
- Where
- Spain
- Volunteers
- 17 people
- Sponsor
- Fundación Eduardo Anitua
Non-small Cell Lung Cancer Metastatic
SAR408701 Versus Docetaxel in Previously Treated, Carcinoembryonic Antigen-related Cell Adhesion Molecule 5 (CEACAM5) Positive Metastatic Non-squamous Non-small-cell Lung Cancer Patients
Primary Objectives: Study was designed with multiple primary endpoints analyzed on randomized participants at the time of the cut-off date for each given analysis (progression free survival [PFS] and overall survival [OS]) Study…
- Trial name
- CARMEN-LC03 (NCT04154956)
- Testing
- SAR408701, Docetaxel
- Where
- 169 sites in United States, Argentina and 24 more
- Volunteers
- 389 people
- Sponsor
- Sanofi
Vitreomacular Adhesion
Prevalence of Vitreomacular Adhesion in Patients 40 Years and Older
The purpose of this study is to evaluate the prevalence of vitreomacular adhesion (VMA) in patients 40 years and older using Spectral Domain Optical Coherence Tomography.
- Trial name
- VAST (NCT02160340)
- Where
- 18 sites in United States
- Volunteers
- 1,584 people, healthy volunteers welcome
- Sponsor
- Nova Southeastern University
Periodontitis
The Use of Adhesion Molecule Loaded Hydrogel With Minimally Invasive Surgical Technique in Treatment of Periodontal Intrabony Defect
Primary aim of the study is to evaluate efficacy of RGD adhesion molecule loaded hydrogel with minimally invasive surgical technique in treatment of periodontal intrabony defect at baseline and 6months.
- Trial name
- NCT05653245
- Testing
- RGD Peptide
- Where
- 2 sites in Egypt
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Minia University