Clinical trials: Tissue Engineering
Normal Eyes
Evaluation of Heidelberg Engineering SPECTRALIS OCT Signal to Noise Ratio Effect on Parameter Measurements
Evaluation of effect of various OCT scan speeds and filters on parameter measurements.
- Trial name
- NCT04961398
- Testing
- OCT imaging
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Heidelberg Engineering GmbH
Supraspinatus Tear
Mesenchymal Stem Cells and Amniotic Membrane Composite for Supraspinatus Tendon Repair Augmentation
This is a non-randomized clinical trial conducted in a single tertiary hospital which investigates the efficacy of allogeneic adipose-derived mesenchymal stem cells and human amniotic membrane (AAdMSC-HAM) composite for…
- Trial name
- NCT04670302
- Testing
- Tendon repair procedure, Tendon repair augmented with AAdMSC-HAM composite
- Where
- Indonesia
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Dr. Soetomo General Hospital
Normal Eyes, Eye Abnormalities
The Heidelberg Engineering BI US Evaluation Study
Evaluation of defined parameters measured in pathological and non-pathological eyes with the Heidelberg BI
- Trial name
- NCT03578302
- Testing
- BI Anterior Segment Mode, BI Anterior Segment and IOL Biometry Mode
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Heidelberg Engineering GmbH
Retinal Vascular, Normal Eyes
Evaluation of the Repeatability and Reproducibility of OCTA Image Quality With the Heidelberg Engineering SPECTRALIS With OCT Angiography Module
Repeatability and Reproducibility of OCTA Image Quality with the Heidelberg Engineering SPECTRALIS
- Trial name
- NCT03530449
- Testing
- OCT Angiography, Color Fundus Photography, Optical Coherence Tomography
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Heidelberg Engineering GmbH
Liver Cirrhosis, Liver Insufficiency
Hepatocyte Matrix Implant Study Indonesia
This clinical investigation of the hepatocyte matrix implant is an evaluation blinded non-randomized and monocentric pilot study of Phase I, which is conducted as a therapeutic investigation.
- Conditions
- Liver Cirrhosis, Liver Insufficiency, Chronic Liver Disease
- Trial name
- HMIIndo (NCT01335568)
- Testing
- Hepatocyte Matrix Implant
- Where
- Indonesia
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Baermed
Bone Loss, Vertical Alveolar Bone Loss
Bioactive Glass (Sol-gel) for Alveolar Bone Regeneration After Surgical Extraction
The purpose of the present research is to evaluate the effect of bioactive glass in bone regeneration immediately following extraction of mandibular and maxillary premolars.The hypothesis of the study assumes that this treatment…
- Conditions
- Bone Loss, Vertical Alveolar Bone Loss, Horizontal Alveolar Bone Loss
- Trial name
- NCT01878084
- Testing
- bioactive glass (sol-gel), empty extraction socket
- Where
- Egypt
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Alexandria University
Eyes With Normal Anterior Segment, Eyes With Abnormal Anterior Segment
Heidelberg Engineering ANTERION Software Comparison Study
This study is conducted to compare the the investigational device ANTERION with software version 1.5 against the ANTERION with software version 1.2.4 (cleared version)
- Trial name
- NCT06657716
- Testing
- ANTERION investigational
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Heidelberg Engineering GmbH
Bone Loss, Osteoclastic, Bone Loss, Alveolar
Autogenous Mesenchymal Stem Cell Culture-Derived Signalling Molecules as Enhancers of Bone Formation in Bone Grafting
This study aims to evaluate bone formation in grafts in terms of its quality (density), quantity (volume) and maturation obtained with the application of a tissue-engineered bone grafting compound containing concentrated…
- Conditions
- Bone Loss, Osteoclastic, Bone Loss, Alveolar, Alveolar Bone Loss, Alveolar Bone Atrophy
- Trial name
- NCT04998058
- Testing
- Maxillary sinus floor elevation grafting with synthetic bone substitute.
- Where
- Brazil
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Pontificia Universidade Católica do Rio Grande do Sul
Bone Regeneration, Tissue Engineering
In Vivo Investigation of 6 Membranes Including Their Physical, Chemical and Biological Properties.
A wide range of resorbable and non-resorbable membranes have been investigated over the last decades. Barrier membranes protect bone defects from ingrowth of soft tissue cells, provide mechanical stability of the defect area and…
- Trial name
- NCT05443776
- Testing
- Biomaterial implantation
- Where
- Spain
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Universitat Internacional de Catalunya
Retinal Vascular, Normal Eyes
Evaluation of Heidelberg Engineering SPECTRALIS With OCT Angiography Module
Assessment of image quality and clinical relevance of OCT Angiography via comparison to FA/ICGA.
- Trial name
- NCT03279939
- Testing
- OCT Angiography, Color Fundus Photography, Fluorescein Angiography
- Where
- United States
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Heidelberg Engineering GmbH
Difficult to Heal Wounds
The Activity of Tissue Engineering Skin Substitutes
The main purpose of this experiment was to evaluate the activity of tissue engineering skin substitutes safety and efficacy studies for the treatment of difficult to heal wounds
- Trial name
- MSCs (NCT02668042)
- Testing
- liveness tissue skin
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Chinese PLA General Hospital
Tooth, Impacted
Dental Stem Cells and Bone Tissue Engineering (CELSORDINO)
The main limitation in bone regeneration is the lack of vascularization of the newly shaped tissue. The main objective of this project is to check if the simultaneous differentiation of dental mesenchymal stem cells toward…
- Trial name
- CELSORDINO (NCT03194451)
- Testing
- non-interventional study
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Central Hospital, Nancy, France
Cleft Lip and Palate
Bone Tissue Engineering With Dental Pulp Stem Cells for Alveolar Cleft Repair
Iliac crest autogenous bone graft is accepted as the most effective method for secondary alveolar cleft repair. However this method is associated with complications.
- Trial name
- CLOSE (NCT03766217)
- Testing
- Mesenchymal stem cells associated with biomaterials, Iliac crest autogenous bone graft
- Where
- Brazil
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Hospital Sirio-Libanes
Normal Cornea, Corneal Abnormality
The Heidelberg Engineering ANTERION Corneal Epithelium Thickness Precision and Agreement Study
This is a prospective clinical study that will be conducted at one clinical site located in the United States to assess corneal epithelial thickness parameters with the ANTERION
- Trial name
- NCT05051813
- Testing
- ANTERION
- Where
- United States
- Volunteers
- 151 people, healthy volunteers welcome
- Sponsor
- Heidelberg Engineering GmbH
Craniofacial Microsomia
Clinical Trial of Fat Grafts Supplemented With Adipose-derived Regenerative Cells
Although first reports of the clinical use of adipose-derived regenerative cells (ADRC) suggest that this approach may be feasible and effective for soft tissue augmentation, there is a lack of randomized, controlled clinical…
- Trial name
- NCT01674439
- Testing
- Supplementation of ADRC, Without supplementation of ADRC
- Where
- Brazil
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Bone Regeneration, Fracture Healing
Procurement of Tissue Samples for Cell Cultures and Analyses
This study will determine if bone marrow stromal cells can be used as a graft for regeneration of bony defects. These cells have the ability to form new bone and to support the formation of blood.
- Conditions
- Bone Regeneration, Fracture Healing, Cell Culture Techniques, Tissue Engineering
- Trial name
- NCT00435877
- Where
- United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- National Institute of Dental and Craniofacial Research (NIDCR)
Impacted Mandibular Third Molar, Alveolar Bone Loss
Healing of Mandibular Third Molar Extraction Sockets Using Platelet Concentrates and Photobiomodulation
Surgical removal of impacted mandibular third molars is a common procedure that may be associated with postoperative pain, swelling, limited mouth opening, and delayed bone healing.
- Conditions
- Impacted Mandibular Third Molar, Alveolar Bone Loss, Impacted Mandibular Third Molar Extraction
- Trial name
- NCT07324213
- Testing
- Mandibular Third Molar Extraction With Primary Wound Closure, Autologous Platelet Concentrates, Photobiomodulation
- Where
- Poland
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- Medical Innovation Center Wroclaw
Eye Abnormalities, Normal Eyes
The Heidelberg Engineering ANTERION Imaging Agreement Study
This is a prospective clinical study that will be conducted at one clinical site located in the United States to assess image quality of acquired biometry images of the eye
- Trial name
- NCT04068818
- Testing
- ANTERION
- Where
- United States
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- Heidelberg Engineering GmbH
Eyes With Normal Anterior Segment, Eyes With Abnormal Anterior Segment
The Heidelberg Engineering ANTERION Software Comparison Precision and Agreement Study
This study is conducted to compare the the investigational device ANTERION with software version 1.5 against the ANTERION with software version 1.2.4 (cleared version)
- Trial name
- NCT06397976
- Testing
- ANTERION investigational
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Heidelberg Engineering GmbH
Retinal Vascular, Normal Eyes
Evaluation of Additional Heidelberg Engineering SPECTRALIS With OCT Angiography Module (OCTA Module) Scan Types
Assessment of image quality and clinical relevance of OCT Angiography at different speed/ART combinations
- Trial name
- OCTA (NCT04604002)
- Testing
- OCT Angiography, Color Fundus Photography, Optical Coherence Tomography
- Where
- United States
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Heidelberg Engineering GmbH