Clinical trials: Tissue Engineering
Spina Bifida, Urothelial Neoplasm
Urothelium Tissue Engineering Using Biopsies From Transurethral Resection of Prostate
Different clinical conditions can require urinary bladder augmentation or replacement. Tissue engineered bladder has been clinically evaluated but is not recommended due to diverse side effects.
- Conditions
- Spina Bifida, Urothelial Neoplasm, Bladder, Neurogenic, Bladder Exstrophy
- Trial name
- IMOPU (NCT03698721)
- Testing
- Transurethral Resection of Prostate
- Volunteers
- 365 people
- Sponsor
- Central Hospital, Nancy, France
Severe Trophic Corneal Ulcers Refractory to Conventional Treatment, Sequelae of Previous Trophic Corneal Ulcers
Allogeneic Tissue Engineering (Nanostructured Artificial Human Cornea) in Patients With Corneal Trophic Ulcers in Advanced Stages, Refractory to Conventional (Ophthalmic) Treatment
This is a prospective, phase I-II, randomised, open-label clinical trial that will evaluate the safety and feasibility, as well as clinical efficacy evidence, of a bioengineered anterior corneal substitute in adults with severe…
- Trial name
- NCT01765244
- Testing
- Anterior lamellar nanostructured artificial human cornea., Amniotic membrane transplantation
- Where
- 11 sites in Spain
- Volunteers
- 16 people
- Sponsor
- Andalusian Initiative for Advanced Therapies - Fundación Pública Andaluza Progreso y Salud
Colorectal Cancer, Healthy, no Evidence of Disease
Study of Biomarkers in Blood & Tissue Samples From Patients With Colorectal Cancer or Polyps & Patients Without Polyps
RATIONALE: Studying samples of blood and tissue in the laboratory from patients with cancer, patients with colorectal polyps and from patients without polyps may help doctors learn more about changes that occur in DNA and…
- Conditions
- Colorectal Cancer, Healthy, no Evidence of Disease, Precancerous Condition
- Trial name
- NCT00898378
- Testing
- gene expression analysis, polymerase chain reaction, polymorphism analysis
- Where
- United States
- Volunteers
- 551 people
- Sponsor
- Indiana University
Wounds, Trauma
Limb Salvage Through Tissue Engineering: A Novel Treatment Modality Using Dehydrated Human Amnion/Chorion Membrane
Extremity wounds with exposed critical structures, including bone and tendon are a major burden on the American healthcare system with limited treatment options.
- Conditions
- Wounds, Trauma, Injury, Limb Salvage
- Trial name
- NCT03521258
- Testing
- Dehydrated Human Amnion/Chorion Membrane, Flap-Based Reconstructive Surgery
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- Louisiana State University Health Sciences Center in New Orleans
Mesenchymal Stem Cells
Cartilage Tissue Engineering
In this study, the investigators explored the hypothesis that osteoarthritic cartilage fragments can promote chondrogenesis of MSCs.
- Trial name
- NCT01301664
- Testing
- total knee / hip replacement
- Sponsor
- Chin-Hung Chang
Pterygium
Tissue Engineering Conjunctiva for the Treatment of Pterygium and Atretoblepharia
The purpose of this study is to determine whether tissue engineering conjunctiva is effective in the treatment of pterygium and atretoblepharia.
- Trial name
- TECTPA (NCT02911532)
- Testing
- Tissue engineering conjunctiva transplantation
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Shandong Eye Hospital
Eyes With Normal Anterior Segment, Eyes With Abnormal Anterior Segment
Heidelberg Engineering ANTERION Software Comparison Study
This study is conducted to compare the the investigational device ANTERION with software version 1.5 against the ANTERION with software version 1.2.4 (cleared version)
- Trial name
- NCT06657716
- Testing
- ANTERION investigational
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Heidelberg Engineering GmbH
Patellofemoral Osteoarthritis
Treatment of Patellofemoral Osteoarthritis With Engineered Cartilage.
The purpose of this investigator-initiated study is to assess the efficacy of treating patellofemoral osteoarthritis with an Advanced Therapy Medicinal Product (ATMP), autologous nasal chondrocyte tissue engineered cartilage…
- Trial name
- NCT06163573
- Testing
- N-TEC, Platelet rich plasma
- Where
- 9 sites in Croatia, Germany and 1 more
- Volunteers
- 75 people
- Sponsor
- University Hospital, Basel, Switzerland
Epidermolysis Bullosa Dystrophica
Self-Assembled Skin Substitute for the Treatment of Epidermolysis Bullosa
Single patient study. Patient diagnosed with dystrophic epidermolysis bullosa presenting chronic open wounds that are not responding to dressings, topical preparations (antimicrobials, antibiotics) and systemic agents…
- Trial name
- SASS (NCT04171661)
- Testing
- SASS
- Where
- Canada
- Volunteers
- 1 people
- Sponsor
- CHU de Quebec-Universite Laval
Cleft of Alveolar Ridge
Concomitant Use of Buccal Fat Pad Derived Cells and Autogenous Bone in Alveolar Cleft Osteoplasty
Our aim was to combine regenerative techniques with bone grafting in human models to increase predictability and survival of reconstructed tissue.
- Trial name
- NCT02859025
- Testing
- anterior iliac crest graft, lateral ramus cortical bone+BFPSC+NBBM, anterior iliac crest graft+BFPSC+NBBM
- Where
- Iran
- Volunteers
- 10 people
- Sponsor
- Shahid Beheshti University of Medical Sciences
Impacted Mandibular Third Molar, Alveolar Bone Loss
Healing of Mandibular Third Molar Extraction Sockets Using Platelet Concentrates and Photobiomodulation
Surgical removal of impacted mandibular third molars is a common procedure that may be associated with postoperative pain, swelling, limited mouth opening, and delayed bone healing.
- Conditions
- Impacted Mandibular Third Molar, Alveolar Bone Loss, Impacted Mandibular Third Molar Extraction
- Trial name
- NCT07324213
- Testing
- Mandibular Third Molar Extraction With Primary Wound Closure, Autologous Platelet Concentrates, Photobiomodulation
- Where
- Poland
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- Medical Innovation Center Wroclaw
Lupus Erythematosus, Systemic
CD19-Directed CAR-T Cell Therapy in Refractory Systemic Lupus Erythematosus
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease in which the immune system mistakenly attacks the body's own tissues and organs.
- Trial name
- CLEVER-SLE (NCT07659704)
- Testing
- Autologous CD19-Directed CAR-T Cells Manufactured at Ribeirão Preto Blood Center
- Where
- 2 sites in Brazil
- Volunteers
- 16 people
- Sponsor
- University of Sao Paulo
Burn Injury, Soft Tissue Injury
Phase I Study for Autologous Dermal Substitutes and Dermo-epidermal Skin Substitutes for Treatment of Skin Defects
The purpose of this study is the evaluation of the safety of autologous tissue-engineered dermal substitutes "denovoDerm" (first arm) and dermo-epidermal skin substitutes "denovoSkin" (second arm) transplanted onto the wound bed…
- Conditions
- Burn Injury, Soft Tissue Injury, Skin Necrosis, Scars
- Trial name
- NCT02145130
- Testing
- denovoDerm, denovoSkin
- Where
- 2 sites in Switzerland
- Volunteers
- 12 people
- Sponsor
- University of Zurich
Retinal Vascular, Normal Eyes
Evaluation of Heidelberg Engineering SPECTRALIS With OCT Angiography Module
Assessment of image quality and clinical relevance of OCT Angiography via comparison to FA/ICGA.
- Trial name
- NCT03279939
- Testing
- OCT Angiography, Color Fundus Photography, Fluorescein Angiography
- Where
- United States
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Heidelberg Engineering GmbH
Eye Abnormalities, Normal Eyes
The Heidelberg Engineering ANTERION Imaging Agreement Study
This is a prospective clinical study that will be conducted at one clinical site located in the United States to assess image quality of acquired biometry images of the eye
- Trial name
- NCT04068818
- Testing
- ANTERION
- Where
- United States
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- Heidelberg Engineering GmbH
Esophageal Stenosis
Esophageal Replacement With a Decellularized Human Esophagus Graft
The aim of the study is to analyze over a 12 month-period, the safety and the efficacy of a circumferentiel oesophageal replacement of the esophagus by a decelularized human esophagus, in 24 patient with a short esophageal…
- Trial name
- ESOGRAFT (NCT06662370)
- Testing
- Replacement of the esophagus with a decellularized human esophagus graft
- Volunteers
- 24 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Meniscus Tear, Knee Meniscus Injury
High-Purity Type I Collagen Augmentation in Meniscal Repair
This prospective, single-arm feasibility study evaluates the safety, procedural feasibility, and early clinical outcomes of High-Purity Type I Collagen used as an adjunct in arthroscopic meniscal repair.
- Conditions
- Meniscus Tear, Knee Meniscus Injury, Meniscal Repair, Knee Arthroscopy (for Diagnostic or Therapy)
- Trial name
- NCT07352410
- Testing
- High-Purity Type I Collagen
- Where
- India
- Volunteers
- 18 people
- Sponsor
- Adichunchanagiri Institute of Medical Sciences, B G Nagara
Cleft Lip and Palate
Use of Mesenchymal Stem Cells for Alveolar Bone Tissue Engineering for Cleft Lip and Palate Patients
The aim of this study is to perform the bone tissue engineering to reconstruct the alveolar bone defect in cleft lip and palate patients using mesenchymal stem cells from deciduous dental pulp associated with a collagen and…
- Trial name
- NCT01932164
- Testing
- maxillary alveolar graft by tissue engineering, Bone tissue engineering using mesenchymal stem cells
- Where
- Brazil
- Volunteers
- 5 people
- Sponsor
- Hospital Sirio-Libanes
Tear; Knee, Cartilage, Articular
Clinical Trial for the Regeneration of Cartilage Lesions in the Knee
The purpose of this study is to investigate the efficacy of an engineered cartilage transplant (N-TEC) in comparison to a cell-activated matrix (N-CAM) for the treatment of articular cartilage lesions in the knee.
- Trial name
- NosetoKnee2 (NCT02673905)
- Testing
- Tissue Engineered Product
- Where
- 5 sites in Croatia, Germany and 2 more
- Volunteers
- 108 people
- Sponsor
- University Hospital, Basel, Switzerland
Bronchopleural Fistula
ENgineered Tissue Repair of BronchopleUral FiSTula
Phase I/II Open-label Study to Assess the Safety and Efficacy of a Novel Tissue Engineered Airway Product, Consisting of Expanded Autologous Bone Marrow (BM) Derived Mesenchymal Stromal Cells (MSC) Seeded on to a Decellularised…
- Trial name
- ENTRUST (NCT04435249)
- Testing
- BPF-001
- Sponsor
- Videregen Limited