Clinical trials: Tissue Grafts
Alveolar Bone Loss
Autologous Fat Grafting Versus Subepithelial Connective Tissue Graft for Volume Augmentation
The aim of this study was to evaluate the effectiveness of autologous fat as a grafting material for soft tissue volume augmentation of localized horizontal ridge defects in humans.
- Trial name
- NCT04214041
- Testing
- Autologous fat grafting, Sub-epithelial connective tissue graft
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Nourhan M.Aly
Esophageal Stenosis
Esophageal Replacement With a Decellularized Human Esophagus Graft
The aim of the study is to analyze over a 12 month-period, the safety and the efficacy of a circumferentiel oesophageal replacement of the esophagus by a decelularized human esophagus, in 24 patient with a short esophageal…
- Trial name
- ESOGRAFT (NCT06662370)
- Testing
- Replacement of the esophagus with a decellularized human esophagus graft
- Volunteers
- 24 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Peri-implant Soft Tissue Healing
Comparison of Freeze-Dried Amniotic and Collagen Membranes for Soft Tissue Healing After Grafted Implant Surgery
The goal of this clinical trial is to learn whether Freeze-Dried Amniotic Membrane (FD-AM) or Collagen Membrane (CM) provides better soft tissue healing after Stage I dental implant surgery with particulate bone grafting in…
- Trial name
- FDAM-CM (NCT07647120)
- Testing
- Freeze-Dried Amniotic Membrane (FD-AM), Collagen Membrane (CM)
- Where
- India
- Volunteers
- 10 people
- Sponsor
- RAJAS DENTAL COLLEGE AND HOSPITAL
Gingival Recession, Gingival Recession, Localized
Free Gingival Graft Versus Connective Tissue Graft
This study wil compare FGG and CTG for recession coverage in the anterior mandibula.
- Trial name
- NCT05563428
- Testing
- Free gingival graft, Connective tissue graft
- Where
- Belgium
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Liege
Gingival Recession
OrACELL™ vs. Connective Tissue in Miller Class 3 Defects
The purpose was to compare root coverage outcomes between autogenous connective tissue graft (CTG) and decellularized human dermis (OrACELL™) in areas of facial gingival recession.
- Trial name
- NCT03226600
- Testing
- OrACELL, Connective Tissue Graft
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Texas A&M University
Psoriasis
A Study in Participants With Moderate to Severe Psoriasis
The primary purpose for this study is to help answer the following research questions The safety of ixekizumab (LY2439821) and any side effects that might be associated with it.
- Trial name
- NCT01107457
- Testing
- Ixekizumab
- Where
- 34 sites in United States, Denmark
- Volunteers
- 142 people
- Sponsor
- Eli Lilly and Company
Gingival Recession
Platelet-Rich Fibrin Prepared With Titanium in the Treatment of Multiple Gingival Recessions
The aim of this study was to treat the areas with Miller Class I bilateral multiple gingival recession in the maxillary teeth using the Titanium Platelet-Rich Fibrin (T-PRF), an autogenous biomaterial applied in combination with…
- Trial name
- NCT05270941
- Testing
- COMPARISON OF PLATELET-RICH FIBRIN PREPARED WITH TITANIUM AND SUBEPITHELIAL CONNECTIVE TISSUE GRAFT
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Necmettin Erbakan University
Gingival Recession, Non-Carious Cervical Lesions (NCCLs)
Root Coverage Performance of Restorative Materials in Class V Cavities
This prospective randomized controlled clinical trial aims to evaluate the influence of different restorative materials placed in Class V cervical lesions on the clinical outcomes of root coverage surgery using a subepithelial…
- Trial name
- NCT07687654
- Testing
- No Restoration Control Group, Glass Ionomer Cement Group, Resin Composite Group
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Zeliha Başak Çakır Erdil
Hepatic Transplantation, Rejection; Transplant, Liver
Tissue Analysis of Liver Grafts as a Predictor of Transplant Outcome.
Despite the good clinical results in terms of outcome with the application of HOPE prior to liver transplantation, very little is still known about the phenotypic and molecular changes that occur during perfusion/preservation…
- Trial name
- NCT06717542
- Testing
- histochemical and immunohistochemical analysis, RT-PCR
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Breast Cancer
Breast Reconstruction With External Pre-expansion and Autologous Fat Transfer Versus Standard Therapy
This multicentre randomized controlled trial aims to evaluate a new breast reconstruction technique- autologous fat transfer (AFT).
- Trial name
- BREAST (NCT02339779)
- Testing
- autologous fat transfer, breast implant
- Where
- 7 sites in Netherlands
- Volunteers
- 196 people
- Sponsor
- Maastricht University Medical Center
Punch Biopsy Wounds, Healing Times
Healing of Punch Graft Wounds. Comparative Study Between MariGen and Oasis: a Non-inferiority Study
The objective is to determine, if healing of punch biopsy wounds treated with the fish skin derived MariGen Wound dressing is non-inferior to healing with wounds treated with pig intestines derived Oasis Sheet wound dressing.
- Trial name
- NCT01917591
- Testing
- Punch biopsies treated with MariGen Wound ECM dressing, Punch biopsies treated with Oasis ECM dressing
- Where
- Iceland
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Kerecis Ltd.
Systemic Juvenile Idiopathic Arthritis (SJIA)
ß-SPECIFIC 4 Patients: Study of Pediatric EffiCacy and Safety wIth FIrst-line Use of Canakinumab
The purpose of this study was to evaluate the efficacy observed with canakinumab dose reduction in a subgroup of patients in the extension study CACZ885G2301E1.
- Trial name
- ß-SPECIFIC 4 (NCT02296424)
- Testing
- ACZ885 150 mg (Canakinumab)
- Where
- 50 sites in United States, Austria and 14 more
- Volunteers
- 182 people
- Sponsor
- Novartis Pharmaceuticals
Dental Implantation, Peri-Implant Soft Tissue Deficiency
Volume-Stable Collagen Matrix vs. Connective Tissue Graft for Peri-Implant Soft Tissue Defects
Peri-implant soft-tissue defects will be treated with either a volume-stable collagen matrix (VCMX; test group) or an autogenous connective tissue graft (CTG; control group) following implant placement in patients with a single…
- Conditions
- Dental Implantation, Peri-Implant Soft Tissue Deficiency, Soft Tissue Augmentation
- Trial name
- NCT07782125
- Testing
- Connective tissue graft, Volume-stable collagen matrix
- Where
- Turkey (Türkiye)
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Ankara University
Gingival Recession
Gingival Recession Treatment With Concentrated Growth Factor(CGF)
Platelet concentrates(PC) are used in the field of periodontology and implantology for the content necessary key cells and growth factors to accelerate healing and to provide regeneration.
- Trial name
- NCT03020732
- Testing
- test groups, control groups
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Gazi University
Gingival Recession
Tunnel vs. CAF for the Treatment of Multiple Gingival Recessions
Many studies have compared the tunnel technique and coronally advanced flap in the treatment of single and multiple recessions. However, there is a lack of evidence that compared both techniques in combination with a connective…
- Trial name
- NCT05122468
- Testing
- Connective tissue Harvest and CAF, Connective tissue Harvest and Tunnel
- Where
- Spain
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Universidad Complutense de Madrid
Tooth Loss, Dental Diseases
Soft Tissue Changes Around Dental Implants
This study aims to characterize the healing pattern following soft tissue augmentation procedure concomitant to implant placement.
- Conditions
- Tooth Loss, Dental Diseases, Wound Heal
- Trial name
- Geistlich (NCT04265768)
- Testing
- Soft tissue augmentation surgery with CTG, Soft tissue augmentation surgery with Fibro-Gide, No soft tissue augmentation
- Where
- 2 sites in United Kingdom
- Volunteers
- 18 people
- Sponsor
- Queen Mary University of London
Gingival Recessions, Gingival Recession, Mucogingival Surgery
Histological and Clinical Evaluation of De-epithelialized Connective Tissue Grafts Obtained by Different Methods
This randomized controlled clinical study aimed to evaluate the effectiveness of two different de-epithelialization techniques-extraoral scalpel and intraoral radiofrequency (RF)-used in the preparation of de-epithelialized…
- Trial name
- DEEP-RCT (NCT07521566)
- Testing
- Extraoral de-epithelialization Group, Radiofrequency De-epithelialization
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Dokuz Eylul University
Diabetic Foot Ulcer
Comparative Study of Two Application Regimens of Amniotic Membrane Wound Graft In the Management of Diabetic Foot Ulcers
The purpose of this study is to determine whether a weekly application of EpiFix human amniotic membrane is more effective than a biweekly application (every two weeks) in the treatment of diabetic foot ulcers.
- Trial name
- NCT01657474
- Testing
- Weekly application of EpiFix plus standard of care, Biweekly application of EpiFix plus standard of care
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- MiMedx Group, Inc.
Urticaria
Efficacy Study for the Symptomatic Treatment of Chronic Idiopathic Urticaria
The objective of the study is to evaluate the efficacy and tolerability of Bilastine 20 mg Q.D., compared to Levocetirizine 5 mg Q.D. and placebo for the treatment of Chronic Idiopathic Urticaria.
- Trial name
- NCT00421109
- Testing
- Bilastine, Levocetirizine
- Where
- 50 sites in Argentina, Belgium and 5 more
- Volunteers
- 522 people
- Sponsor
- Faes Farma, S.A.
Gingival Recession
Using Inverted Periosteal Pedicle Flap in Treatment of Gingival Recession
Perioteum in the recession defect site will be used as an autogenous graft after raising a flap and the results will be compared with another group which will be treated by the gold standard ( coronally advanced flap with…
- Trial name
- IPPF (NCT03701191)
- Testing
- Inverted periosteal pedicle flap
- Where
- Egypt
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Marwa El Sayed Abbas Ahmed