Clinical trials: Tissue Grafts
Polyostotic Fibrous Dysplasia
Bone Marrow Injection to Replace Diseased Bone in Polyostotic Fibrous Dysplasia and McCune-Albright Syndrome
This study will evaluate the effectiveness of a new bone injection technique for treating bone disease in patients with polyostotic fibrous dysplasia or McCune-Albright syndrome.
- Trial name
- NCT00001851
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- National Institute of Dental and Craniofacial Research (NIDCR)
Recession, Gingival
Palatal Volumetric Change Analysis Following Connective Tissue Graft With and Without Donor Site Augmentation
The goal of this randomized clinical trial is to compare whether soft tissue augmentation placed in the donor site following a gum graft harvesting leads to volumetric changes compared to non-augmented sites in the palate.
- Trial name
- NCT05961566
- Testing
- Use of collagen matrix after subepithelial connective tissue graft harvest
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Hailey Bivens
Hypophosphatemia, Kidney Transplantation
Evaluation of Dipyridamole in Preventing Post-Transplant Hypophosphatemia in Kidney Transplant Recipients
The primary goal is to determine if Dipyridamole can improve serum phosphate levels and reduce the need for phosphate supplementation.
- Trial name
- NCT06824454
- Testing
- Dipyridamole 75 MG
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Stanford University
Epidermolysis Bullosa
Study of Cellutome System for Treatment of Individual Lesions in EB Pts
Few but persistent wounds often remain even after successful hematopoietic cell transplantation for systemic genodermatosis epidermolysis bullosa (EB).
- Trial name
- NCT02670837
- Testing
- Cellutome Epidermal Harvesting System
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Masonic Cancer Center, University of Minnesota
Gingival Recession, Localized
Effectiveness of Micro Connective Tissue Graft for Treatment of Multiple Adjacent Gingival Recession Defects
The objective of this project is to evaluate 1-year outcomes of treatment of MAGRD using a modified coronally advanced tunnel technique (MCAT) with either conventional CTG (control group) or micro-CTG (test group).
- Trial name
- NCT06030947
- Testing
- Coronally Advanced Flap combined with a Connective Tissue Graft, Coronally Advanced Flap combined with micro Connective Tissue Graft, Division of the Connective Tissue Graft into multiple micro Connective Tissue Grafts
- Where
- United Arab Emirates
- Volunteers
- 30 people
- Sponsor
- Göteborg University
Coronary Artery Disease, Myocardial Infarction (MI)
Low-dose Interleukin-2 After Myocardial Infarction to Investigate Effects on Tissue-resident Regulatory T Cells
The primary goals of this study are to compare the differences in tissue-resident Treg gene signature for activation, proliferation, and suppressive function using single-cell/-nucleus RNA sequencing in patients treated with…
- Conditions
- Coronary Artery Disease, Myocardial Infarction (MI), CABG
- Trial name
- Leuk-ALIVE (NCT07610538)
- Testing
- Interleukin-2 (Aldesleukin), Standard care
- Where
- 2 sites in United Kingdom
- Volunteers
- 24 people
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Diabetic Foot Ulcer (DFU), Chronic Foot Ulcers
Rising Tide - Amniotic Tissue(s) Treatments for Chronic Diabetic Foot Ulcers
The purpose of this clinical investigation is to evaluate the safety and efficacy of Amnion/Chorion/Amnion allograft , Amnion/Chorion allograft, and/or Amnion/Amnion allograft, plus Standard of Care (SOC) each versus SOC alone in…
- Trial name
- NCT06681428
- Testing
- Allograft
- Where
- 9 sites in United States
- Volunteers
- 240 people
- Sponsor
- Tides Medical
Chronic Myeloproliferative Disorders, Graft Versus Host Disease
Donor Peripheral Stem Cell Transplant in Treating Patients With Advanced Hematologic Cancer or Other Disorders
RATIONALE: Giving chemotherapy and total-body irradiation before a donor peripheral stem cell transplant helps stop the growth of cancer or abnormal cells.
- Conditions
- Chronic Myeloproliferative Disorders, Graft Versus Host Disease, Leukemia, Lymphoma
- Trial name
- NCT00544115
- Testing
- busulfan, cyclophosphamide, cyclosporine
- Volunteers
- 260 people
- Sponsor
- City of Hope Medical Center
Periodontitis, Periodontal Bone Loss
Non-incised Papillae Surgical Approach (NIPSA) and Connective Tissue Graft Plus Emdogain for Periodontal Defects
The present study pretends to show the results of combining a modification of the Non-incised papillae surgical approach (NIPSA) attempting to improve the outcome in the treatment of teeth with advanced periodontal support loss.
- Conditions
- Periodontitis, Periodontal Bone Loss, Periodontal; Lesion
- Trial name
- NCT03997578
- Testing
- NIPSA (Non-incised papilla surgical approach), NIPSA plus connective tissue graft
- Where
- Spain
- Volunteers
- 40 people
- Sponsor
- Universidad de Murcia
Post-COVID-19 Condition, Ulcerative Colitis
Emerging Indications for Hyperbaric Oxygen Treatment
This study will evaluate the effectiveness of hyperbaric oxygen therapy (HBOT) on treating emerging indications (i.e., conditions that have shown to potentially benefit from HBOT) using the Multicenter Registry for Hyperbaric…
- Conditions
- Post-COVID-19 Condition, Ulcerative Colitis, Crohn Disease, Calciphylaxis
- Trial name
- NCT07240649
- Testing
- Hyperbaric oxygen treatment (HBOT), 100% Oxygen
- Volunteers
- 100 people
- Sponsor
- Jay C. Buckey Jr.
Diabetic Wounds, Venous Stasis Wounds
The Role of Lipoaspirate Injection in the Treatment of Diabetic Lower Extremity Wounds and Venous Stasis Ulcers
A prospective, single blinded randomized clinical study will be performed to determine if the injection of lipoaspirate into diabetic or venous stasis wounds promotes wound healing or wound closure at a faster rate than…
- Trial name
- NCT00815217
- Testing
- injection of lipoaspirate, control
- Where
- United States
- Sponsor
- Washington D.C. Veterans Affairs Medical Center
Upper Central Incisor Edentulism
Central Incisors Narrow Implants in Alternative to Bone Augmentation With 4.2 mm Implants .
Horizontal bone augmentation procedures are commonly used to increase bone width to allow the placement of dental implants or to improve aesthetics in deficient areas.
- Trial name
- NCT02897193
- Testing
- ICE dental implant 4.2 mm, NICE dental implant 3.2 mm, Alpha Bio's Graft Bovine bone
- Where
- 2 sites in Chile
- Volunteers
- 42 people
- Sponsor
- Alpha - Bio Tec Ltd.
Scleroderma, Systemic, Graft Vs Host Disease
The Influence of Extracorporeal Photopheresis on Skin Sclerosis
Extracorporeal photopheresis (ECP), also known as extracorporeal photoimmunotherapy or photochemotherapy, is a leukapheresis-based therapy that has been in clinical use for over three decades after receiving FDA approval in 1988.
- Conditions
- Scleroderma, Systemic, Graft Vs Host Disease, Eosinophilic Fasciitis, Morphea
- Trial name
- NCT04752397
- Where
- Germany
- Volunteers
- 6 people
- Sponsor
- Charite University, Berlin, Germany
Connective Tissue Graft, Anterior Aesthetic Zone
Using Fascia Lata Membrane Versus Connective Tissue Graft in Immediate Implants
The aim of this study is to evaluate and compare the Vestibular Socket Therapy (VST) technique using fascia lata membrane versus connective tissue graft both with xenogenic lamina membrane in immediate implants of anterior…
- Trial name
- NCT05194826
- Testing
- Test, Control
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Hams Hamed Abdelrahman
Cholecystitis, Cholecystitis, Chronic
Shortwave Infrared Surgical Imaging Device Study
The goal of this observational study is to perform an in-human assessment of an investigational shortwave infrared (SWIR) imaging device, aimed to enhance the visualization of critical anatomical structures during surgical…
- Conditions
- Cholecystitis, Cholecystitis, Chronic, Chronic Calculous Cholecystitis, Primary Hyperparathyroidism
- Trial name
- NCT07744425
- Testing
- Observational study of SWIR imaging device in surgery
- Where
- 6 sites in United States
- Volunteers
- 50 people
- Sponsor
- Cision Vision, Inc.
Immediate Implant Placement
Alveolar Ridge and Soft Tissue Augmentation Using Graft From the Maxillary Tuberosity
In the study immediate implant is placed in the anterior region with autogenous bone grafting from the maxillary tuberosity in one group and in the other group immediate implant is placed with xenograft .IN both groups soft…
- Trial name
- NCT05670067
- Testing
- maxillary tuberosity bone graft (autogenous graft), Bone graft (xenograft)
- Where
- Egypt
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Gingival Recession, Emdogain
Gingival Recession Coverage With and Without Emdogain
Enamel matrix proteins have been shown to play a crucial role during tooth development and its supporting tissues. This is used in periodontal surgery where regeneration of lost tissues around the teeth is intended.
- Trial name
- NCT02230787
- Testing
- Recession coverage without Emdogain, Recession coverage with Emdogain
- Where
- Switzerland
- Volunteers
- 40 people
- Sponsor
- University of Bern
Alveolar Bone Loss
Localized Alveolar Ridge Augmentation With Space Maintenance Devices
The purpose of this research study is to determine whether this study treatment can improve the bone structure of the upper front part of the jaw in patients who are scheduled for surgery to have a dental implant(s) placed into…
- Trial name
- Ridge Mesh (NCT00991432)
- Testing
- INFUSE® Bone Graft
- Where
- 8 sites in United States
- Volunteers
- 10 people
- Sponsor
- Medtronic Spinal and Biologics
Hepatitis B, Chronic
A Real-world Study: Analysis of the Efficacy of Antiviral Therapy in CHB Patients Over 30 Years Old, HBV DNA Positive and ALT Normal
This is a prospective observational study of CHB patients who have not received antiviral treatment but HBV DNA are positive.Investigators aim to explore the antiviral effect and influencing factors of patients over 30 years old…
- Conditions
- Hepatitis B, Chronic, Treatment
- Trial name
- NCT07637214
- Where
- China
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Tongji Hospital
Gingival Recession
The Efficacy of De-epithelialized Free Gingival Graft on Treatment of Multiple Gingival Recessions With Tunnel Technique
The predictable treatment of multiple adjacent gingival recessions (MAGRs) represents a major challenge in periodontal plastic surgeries due to MAGRs' complicated predisposing anatomic features, such as thin gingival phenotype or…
- Trial name
- NCT04291963
- Testing
- DGG + TUN, SCTG + TUN
- Where
- Turkey (Türkiye)
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Gazi University