Clinical trials: Tissue Grafts
Gingival Recession
Evaluation of Subepithelial Connective Tissue Graft Versus Acellular Dermal Matrix With Tunnel Technique in Treatment of Multiple Gingival Recessions
The goal of the present study is to compare the amount of root coverage resulting from subepithelial connective tissue graft and acellular dermal matrix associated with tunnel technique among patients suffering from multiple…
- Trial name
- NCT02916186
- Testing
- Acellular Dermal Matrix, Tunnel technique with the subepithelial connective tissue graft
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Cairo University
Dental Implants, Alveolar Mucosa
To Compare Free Gingival Grafts and Connective Tissue Grafts Around Implants With Lack of Keratinized Mucosa
This study will compare two commonly used soft tissue grafting techniques (free gingival graft, FGG vs. connective tissue graft, CTG) to augment the soft tissue around dental implants with a lack of keratinized mucosa.
- Trial name
- NCT03338686
- Testing
- Free Gingival Graft (FGG), Connective Tissue Graft followed by Laser Gingivoplasty
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Gingival Recession
Diode Laser for Harvesting Gingival Graft
Aims: The aim of present randomized controlled clinical study was to evaluate whether the additional use of diode laser would facilitate the donor surgery, improve the palatal wound healing and reduce post-operative morbidity…
- Trial name
- NCT02441127
- Testing
- diode laser group, scalpel control group
- Where
- Turkey (Türkiye)
- Volunteers
- 52 people
- Sponsor
- Cukurova University
Cleft Lip and Palate
Tissue Engineered Constructs for Alveolar Cleft Repair
Description of the research question In children undergoing unilateral alveolar cleft reconstruction, would stem cells carried on collagen scaffold provide bone of a good quality and quantity if compared to autogenous bone…
- Trial name
- NCT03563495
- Testing
- tissue engineered group, autogenous bone graft group
- Volunteers
- 10 people
- Sponsor
- Cairo University
Healthy Volunteers
A Study to Evaluate Pharmacokinetics of DRL_AB in Healthy Male Participants
The purpose of this study is to assess the PK comparability and compare safety and tolerability of DRL_AB administered via an auto injector (AI) or prefilled syringe (PFS) in healthy male participants.
- Trial name
- NCT07744828
- Testing
- DRL_AB
- Where
- 3 sites in New Zealand
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Dr. Reddy's Laboratories Limited
Socket Shield Technique Implant Placement, Immediate Implant Placement
Effect of Subepithelial Connective Tissue Graft With Socket Shield Technique
The goal of this clinical trial is to Evaluate of the soft tissue profile changes and labial plate of bone in the anterior esthetic area when using socket shield technique in conjunction with immediate implant and subepithelial…
- Trial name
- NCT06659081
- Testing
- socket shield technique, subepithelial connective tissue graft, implant placement
- Where
- Egypt
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Vitiligo
Promoting Repigmentation After Epidermal Cell Suspension Grafting and preVENTing the Loss of Melanocytes Using Topical Ruxolitinib for Vitiligo in Resistant Areas
Medical approaches remain the gold standard treatment for non-segmental forms of vitiligo. Topical ruxolitinib cream has demonstrated its efficacy and good tolerance for treating vitiligo.
- Trial name
- PREVENT (NCT05872477)
- Testing
- Ruxolitinib Topical
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Organ or Tissue Transplant; Complications
Pharmacokinetic Study of ENVARSUS in Adult De-novo Kidney Transplant Patients
Open-label, multicentre, randomized clinical trial to compare the pharmacokinetics of ENVARSUS® tablets and ADVAGRAF® capsules administered once daily in adult de-novo kidney transplant patients.
- Trial name
- NCT02500212
- Testing
- ENVARSUS®, ADVAGRAF®
- Where
- 7 sites in France
- Volunteers
- 75 people
- Sponsor
- Chiesi Farmaceutici S.p.A.
Myelodysplastic Syndrome, Leukemia, Myelomonocytic, Chronic
Health Outcomes of Recently Diagnosed Myelodysplastic Syndrome (MDS)/Chronic Myelomonocytic Leukemia (CMML) Patients Depending on Treatment Strategy (Wait and See, Support, Active Treatment)
Post-authorisation observational study to assess the evolution in normal clinical practice of patients recently diagnosed with myelodysplastic syndrome (MDS) or chronic myelomonocytic leukaemia (CMML), depending on the moment…
- Trial name
- NCT02085798
- Testing
- Either Wait and See, or Supportive Treatment, or Active Treatment at physician discretion
- Where
- 50 sites in Spain
- Volunteers
- 503 people
- Sponsor
- Celgene
Gingival Recession, Localized
Effect of Vestibular Depth on Predictability of Miller Class III/ RT2 Gingival Recession Coverage
Aim of this study is to assess the influence of vestibular depth on root coverage in Miller class III/ Cairo RT2 gingival recession when treated with minimally invasive technique using connective tissue graft.
- Trial name
- NCT06000228
- Testing
- Recession coverage with CTG using minimally invasive access technique in shallow vestibule, Recession coverage with CTG using minimally invasive access technique in deep vestibule
- Where
- India
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Ischemic Heart Disease, Ischemic Cardiomyopathy
Atrial Appendage Micrograft Transplants to Assist Heart Repair After Cardiac Surgery
Ischemic heart disease (IHD) leads the global mortality statistics. Atherosclerotic plaques in coronary arteries hallmark IHD, drive hypoxia, and may rupture to result in myocardial infarction (MI) and death of contractile…
- Conditions
- Ischemic Heart Disease, Ischemic Cardiomyopathy, Heart Failure, Systolic, Heart Failure NYHA Class III
- Trial name
- AAMS2 (NCT05632432)
- Testing
- Epicardial AAMs-patch transplantation, RNA-stabilized whole blood sampling, Plasma sampling
- Where
- Finland
- Volunteers
- 50 people
- Sponsor
- Hospital District of Helsinki and Uusimaa
Breast Cancer, Breast Reconstruction
Endoscopic Nipple-Sparing Mastectomy (E-NSM) With Immediate Multistage Autologous Fat Grafting(IMAFG) for Total Breast Reconstruction Via the Axillary Incision
The goal of this clinical study is to evaluate the effectiveness and safety of a novel breast reconstruction technique combining endoscopic nipple-sparing mastectomy (E-NSM) with immediate multistage fat grafting (IMFG) in female…
- Trial name
- NCT07352137
- Testing
- endoscopic nipple-sparing mastectomy (E-NSM) with immediate implant-based reconstruction
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Guangdong Provincial Hospital of Traditional Chinese Medicine
Knee Osteoarthritis
Comparative Study Between Autologous Adipose Tissue Graft Versus Microfracture for Treatment of Articular Cartilage Defects
Knee arthroscopy using standard portals will be performed in three groups. Complete evaluation of all intra -articular structures will be performed followed by accurate localization of the cartilage defect and measurement of its…
- Trial name
- NCT05912998
- Testing
- cartilage regeneration technique
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Assiut University
Peri-Implantational Loss, Surgical Wound
Strip Graft w/ Xenogeneic Matrix vs Free Gingival Graft for the Augmentation of Peri-implant Keratinized Mucosa
The primary objective of this study is to compare changes in peri-implant keratinized mucosa (PIKM) following the application of apically repositioned flap (ARF) using a combination of a Strip graft and a Xenogeneic matrix, or…
- Conditions
- Peri-Implantational Loss, Surgical Wound, Healing Surgical Wounds, Thin-gingiva
- Trial name
- NCT06261268
- Testing
- Strip graft with Mucograft, Free gingival graft
- Where
- Spain
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Universidad Complutense de Madrid
Graft Versus Host Disease, Leukemia
A Phase II Study of Allo-HCT for B-Cell NHL Using Zevalin, Fludarabine and Melphalan
RATIONALE: Giving monoclonal antibody therapy, radioimmunotherapy, and chemotherapy before a donor stem cell transplant helps stop the growth of cancer cells and helps stop the patient's immune system from rejecting the donor's…
- Conditions
- Graft Versus Host Disease, Leukemia, Lymphoma
- Trial name
- NCT00577278
- Testing
- rituximab, fludarabine phosphate, melphalan
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- City of Hope Medical Center
Gingival Recession
Evaluation of De-epithelized Connective Tissue Grafts and Modified Combined Approach for Connective Tissue Grafts
This study aims to compare the de-epithelized gingival graft (control group) and modified combined approach for connective tissue graft (test group) in patients undergoing palatal graft harvesting for mucogingival surgery in the…
- Trial name
- NCT05717985
- Testing
- modified combined approach, de-epithelized gingival graft
- Where
- Malaysia
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- National University of Malaysia
Gingival Recession
Comparison of Cyanoacrylate Tissue Adhesive With Suture in the Treatment of Gingival Recession
The aim of this randomized controlled clinical study was to determine the effects of gingival recession closure procedures performed with tissue adhesive and suture on gingival thickness, To evaluate the effect on the amount of…
- Trial name
- NCT06499155
- Testing
- Use of periacryl in gingival recession closure procedures, Use of sutures in gingival recession closure procedures
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Necmettin Erbakan University
Facial Atrophy and Loss of Contour
Open Label, Multi-Center Study, Evaluating the Effect of Adipose Tissue Processed With the SyntrFuge™ System for Facial Fat Grafting
This is an open label multi-center study with the aim of evaluating the efficacy of adipose tissue processed with the SyntrFuge™ system in facial aesthetics and contouring.
- Trial name
- NCT05522426
- Testing
- SyntrFuge System
- Where
- 2 sites in United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Syntr Health Technologies, Inc.
Alveolar Ridge Defect
CopiOs® Pericardium Membrane for Localized Alveolar Ridge Augmentation
This is a prospective, multi-center study to evaluate the use of CopiOs Pericardium Membrane, a bovine xenograft, with use of Puros Cancellous Particulate Allograft, for the augmentation of localized alveolar ridge defects on…
- Trial name
- NCT00889265
- Testing
- CopiOs Pericardium Membrane
- Where
- 4 sites in United States
- Volunteers
- 51 people
- Sponsor
- Zimmer Biomet
Papilla Reconstruction
A Clinical Comparison of Connective Tissue Graft and Alb-PRF for Rebuilding Interdental Papilla
The interdental papilla, a small wedge of gingival tissue positioned between adjacent teeth, plays a crucial role in both dental esthetics and oral function.
- Trial name
- ALB-PRF & CTG (NCT07139392)
- Testing
- Albumin (5% serum-protein solution containing immunoglobulins), connective tissue graft
- Volunteers
- 30 people
- Sponsor
- shaimaa hamdy