Clinical trials: Tissue Grafts
Bone Resorption
Comparison of Three Transmucosal Augmentation Techniques in Immediate Implant Placement
Patients undergoing single immediate implant placement (IIP) in the premaxilla will be invited to participate in this randomized controlled trial (RCT).
- Trial name
- NCT06820489
- Testing
- Conventional connective tissue graft after immediate implant placement, Scarf connective tissue graft after immediate implant placement, Dual zone concept after immediate implant placement
- Where
- Belgium
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- University Ghent
End-stage Renal Disease, Kidney Failure, Chronic
Evaluation of the Safety and Efficacy of a Vascular Prosthesis for Hemodialysis Access in Patients With ESRD
The purpose of this study is to assess the safety and efficacy of a novel, tissue-engineered vascular prosthesis, the Human Acellular Vascular Graft, HAVG.
- Trial name
- NCT01744418
- Testing
- HAVG graft implantation
- Where
- 3 sites in Poland
- Volunteers
- 40 people
- Sponsor
- Humacyte, Inc.
Osteoporotic Fractures
Effectiveness of Adipose Tissue Derived Mesenchymal Stem Cells as Osteogenic Component in Composite Grafts
Failure rates of up to 30% are reported after proximal humeral fractures despite angular-stable devices. This may devastate not only the functional outcome but also the independence of elderly patients.
- Trial name
- ROBUST (NCT01532076)
- Testing
- Cellularized composite graft augmentation, Acellular composite graft augmentation
- Where
- Switzerland
- Volunteers
- 8 people
- Sponsor
- University Hospital, Basel, Switzerland
Alveolar Bone Loss, Partially Edentulous Jaw
Impact of Hyaluronic Acid and Bone Graft on Peri-Implant Tissue
This randomized controlled clinical trial aims to evaluate the effect of hyaluronic acid (HA) and particulate bone graft on the peri-implant tissue phenotype in patients receiving dental implants.
- Conditions
- Alveolar Bone Loss, Partially Edentulous Jaw, Dental Implant
- Trial name
- NCT07665281
- Testing
- Dental Implants with Hyaluronic Acid, Dental Implants with Hyaluronic Acid and Particulate Bone Graft, Standard Dental Implants Placement only
- Where
- 2 sites in Iraq
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Al-Mustansiriyah University
Gingival Recession, Lack of Keratinized Attached Peri-implant Mucosa
Gain of Keratinized Mucosa Around Teeth and Dental Implants Using a Combination of Strip Gingival Graft and Acellular Dermal Matrix
This study is to compare the two techniques to achieve change in the tissue quality at areas of lack of Keratinized Tissue (KT) using soft tissue grafting with autogenous graft material (Free Gingival Graft)(FGG) vs Strip…
- Conditions
- Gingival Recession, Lack of Keratinized Attached Peri-implant Mucosa, Thin Gingiva
- Trial name
- NCT04920136
- Testing
- Strip Free gingival graft (SGG) + Acellular Dermal Matrix graft (ADM), Free Gingival graft
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Systemic Sclerosis, Digital Ulcer
Autologous Adipose Tissue in the Treatment of Systemic Sclerosis Digital Ulcers
A randomized controlled trial will be performed to confirm preliminary uncontrolled data indicating that regional adipose tissue grafting is effective in inducing digital ulcer healing in patients with systemic sclerosis.
- Trial name
- ADUL-SSc (NCT03406988)
- Testing
- Autologous fat grafting
- Where
- Italy
- Volunteers
- 46 people
- Sponsor
- ASST Gaetano Pini-CTO
GVHD, Meibomian Gland Dysfunction (Disorder)
Autologous Serum Obtained by a Closed-Circuit Collection Device
Autologous serum eye drops (ASED) are an established therapy for ocular surface diseases; however, their preparation can be costly and may not be available due to the need for germ-free conditions.
- Conditions
- GVHD, Meibomian Gland Dysfunction (Disorder), Stevens-Johnson Syndrome, Limbal Keratoconjunctivitis
- Trial name
- NCT07014059
- Testing
- Autologous Serum 20%
- Where
- Brazil
- Volunteers
- 16 people
- Sponsor
- GIANCARLO FATOBENE
Mucogingival Defects, Pontic Site Development
Pontic Site Development With or Without Fixed Partial Denture
This study aims to evaluate the effectiveness of soft tissue augmentation using connective tissue graft (CTG) in pontic site defects.
- Conditions
- Mucogingival Defects, Pontic Site Development, Keratinized Tissue Deficiency, Connective Tissue Graft
- Trial name
- Pontic Site (NCT07535060)
- Testing
- Connective Tissue Graft (CTG)
- Where
- Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Cairo University
Xenograft Model
Effect of Xenogeneic Collagen Matrix on the Peri-implant Tissues of Immediate Implants.
The present clinical trial will try to demonstrate the efficacy of stable xenogeneic collagen matrix in maintaining the vestibular coronal soft tissue volume and the stabilization of mid-buccal margin position in immediate…
- Trial name
- NCT04980313
- Testing
- Xenogenic collagen matrix, Autogenous connective tissue graft
- Where
- Spain
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Universitat Internacional de Catalunya
Non-healing Wound
Effect of Lidocaine and Adrenaline Soaked Gauze Versus Normal Saline Soaked at Skin Graft Donor Site of Thigh
Investigator is studying the effects of Lidocaine and Adrenaline Soaked Gauze vs Normal Saline Soaked Gauze at Skin Graft Donor Site of Thigh.
- Trial name
- NCT04344483
- Testing
- 2% Lidocaine and 1:100,000 Adrenaline, Normal saline
- Where
- Pakistan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Dow University of Health Sciences
Lung Transplant Rejection
Adipose Derived Mesenchymal Cell Treatment in Lungtransplantation
To investigate safety of treatment with allogeneic adipose tissue-derived mesenchymal stromal cells (ASCs) in patients undergoing lung transplantation, to evaluate whether the treatment can reduce host immunological reaction…
- Trial name
- NCT04714801
- Testing
- adipose derived mesenchymal stromal cells, Saline
- Where
- Denmark
- Volunteers
- 30 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Graft Versus Host Disease, Leukemia
Laboratory-Treated Donor Bone Marrow in Treating Patients Who Are Undergoing a Donor Bone Marrow Transplant for Hematologic Cancer
RATIONALE: Giving chemotherapy and total-body irradiation before a donor bone marrow transplant or peripheral blood stem cell transplant helps stop the growth of cancer and abnormal cells and helps stop the patient's immune…
- Conditions
- Graft Versus Host Disease, Leukemia, Lymphoma, Multiple Myeloma and Plasma Cell Neoplasm
- Trial name
- NCT00265837
- Testing
- graft versus host disease prophylaxis/therapy, allogeneic bone marrow transplantation, in vitro-treated bone marrow transplantation
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Hopeless Tooth
Assessment of Dimensional Changes Following Grafting With Microfragmented Adipose Tissue Loaded on Allograft on Ridge Preservation
Evaluation of maxillary alveolar ridge changes (bone quantity and quality as revealed by radiographic and Histomorphometry ) utilizing microfragmented adipose tissue loaded on allograft versus allograft only for maxillary…
- Trial name
- NCT06636461
- Testing
- microfragmented adipose tissue loaded on allograft
- Where
- Egypt
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Cairo University
Chronic Myeloproliferative Disorders, Graft Versus Host Disease
Sargramostim in Reducing Graft-Versus-Host Disease in Patients Who Are Undergoing Donor Stem Cell Transplantation for Hematologic Cancer or Aplastic Anemia
RATIONALE: Colony-stimulating factors such as sargramostim may increase the number of immune cells found in bone marrow or peripheral blood and may help a person's immune system recover from the side effects of chemotherapy or…
- Conditions
- Chronic Myeloproliferative Disorders, Graft Versus Host Disease, Leukemia, Lymphoma
- Trial name
- NCT00053157
- Testing
- sargramostim
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Roswell Park Cancer Institute
Atrial Fibrillation
Impact of Left Atrial Function on Postoperative Atrial Fibrillation
We aimed to demonstrate the impact of left atrial functions which were evaluated by three different echocardiographic modalities , on postoperative atrial fibrillation.
- Trial name
- NCT00646997
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Florence Nightingale Hospital, Istanbul
Immediate Dental Implant Placement, Connective Tissue Graft
Flapless Immediate Implant Placement With Socket Shield Technique Versus Connective Tissue Graft in Anterior Maxilla
The present study aims to compare the dimensional stability of the supra-implant complex following flapless immediate implant placement using two socket management approaches: the connective tissue graft and the socket shield…
- Conditions
- Immediate Dental Implant Placement, Connective Tissue Graft, Socket Shield Technique
- Trial name
- NCT07303374
- Testing
- IIP+Socket Shield, IIP+CTG
- Where
- Egypt
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- International Dental Contiuing Education
in Vitro Activation, Dormant Follicle
In Vitro Activation of Dormant Follicles for Patients With Primary Ovarian Insufficiency
In this study, the investigators used the newly developed technique i.e. in vitro activation of dormant follicles (IVA) to promote ovarian follicle growth much more efficiently than natural, in vivo process for women with Primary…
- Conditions
- in Vitro Activation, Dormant Follicle, Primary Ovarian Insufficiency, Ovarian Resistance Syndrome
- Trial name
- IVADFPOI (NCT02322060)
- Testing
- Ovariotomy, Activate dormant follicles, Ovary tissue transplantation
- Where
- China
- Volunteers
- 35 people
- Sponsor
- The First Affiliated Hospital of Zhengzhou University
Facial Gingival Profile
The Effect of Bone Grafts on Facial Gingival Profile in Maxillary Anterior Single Tooth Replacement
The purpose of this investigator-initiated study is to evaluate the facial gingival profile following immediate implant placement and provisionalization in conjunction with connective tissue graft with or without bone graft
- Trial name
- NCT01547273
- Testing
- bone graft inside socket only, bone graft inside and outside socket, no bone graft
- Where
- 2 sites in United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Loma Linda University
Lack of Keratinized Tissue
Free Gingival Grafts (FGGs) in Mandibular Posterior Sites
In this proposed study a novel technique that utilizes bone screws as an anchorage device will be used to facilitate suturing and ensure graft tissue immobilization on full thickness recipient bed preparation sites.
- Trial name
- NCT04099680
- Testing
- Partial thickness recipient bed, Full thickness recipient bed, Bone screw (FDA approved bone screw)
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Ohio State University
Recession, Gingival
Comparison of Two Methods of Covering a Single Lower Front Tooth With Receded Gums
The primary objective of this randomized clinical trial is to compare the mean root coverage achieved with Coronally Advanced Flap (CAF) + Connective Tissue Graft (CTG) (control) to Gingival Pedicle Split Thickness flap (GPST) +…
- Trial name
- NCT06037161
- Testing
- Mandibular Incisor root coverage procedure
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Case Western Reserve University