Clinical trials: Tissue Grafts
Perianal Fistula, Adipose Tissue
Adipose Derived Mesenchymal Stem Cell Characteristics in Anal Fistulas
This study investigated the cellular and molecular characteristics of AT-MSCs obtained from autologous AT therapy in patients with high transphincteric perianal fistulas of crytoglandular origin.
- Conditions
- Perianal Fistula, Adipose Tissue, Tissue Transplantation
- Trial name
- NCT04834609
- Testing
- Injection of autologous adipose tissue in anal fistula
- Volunteers
- 27 people
- Sponsor
- University of Aarhus
Surgery, Oral
Composite Tissue Allotransplantation of the Face: Anatomical and Functional Evaluation
In hindsight, the first "face graft" raises the fundamental problem of composite tissue allotransplantation (hand, larynx, abdominal wall, etc.) with the addition of specific technical and philosophical problems.
- Trial name
- AFTC (NCT02818400)
- Testing
- composite tissue allotransplantation
- Where
- France
- Volunteers
- 5 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Dental Implant
Immediate Implants: to Graft or Not to Graft, That is the Question.
The aim was to compare two protocols for immediate implants with fixed provisional restoration, no grafting (trimodal approach=TA) versus grafting both osseous gap and peri-implant mucosa (trimodal approach with modification of…
- Trial name
- TAOM-TA (NCT05927181)
- Testing
- TAOM
- Where
- Spain
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Universidad Complutense de Madrid
Skin Transplantation, Skin Grafting
Lower Extremity Graft Study (LEGS): A Multicentre Randomised Controlled Trial of Negative Pressure Wound Therapy Versus Conventional Dressings for Split-thickness Skin Grafts After Lower Leg Skin Tumour Excision
The goal of this clinical trial is to compare the effect of negative pressure wound therapy (NPWT) versus traditional dressings on the incidence of transplant infection in adult patients undergoing split-thickness skin grafting…
- Conditions
- Skin Transplantation, Skin Grafting, Split Thickness Skin Graft, Negative-Pressure Wound Therapy
- Trial name
- LEGS (NCT07040683)
- Testing
- Negative Pressure Wound Therapy (NPWT), Traditional Dressing
- Where
- Sweden
- Volunteers
- 232 people
- Sponsor
- Region Skane
HLH - Hypoplastic Left Heart Syndrome, DORV
Two-Year Study of the Safety and Efficacy of the Second-Generation Tissue Engineered Vascular Grafts
A single arm clinical trial evaluating the safety and efficacy of the second generation TEVG as vascular conduits for extracardiac total cavopulmonary connection.
- Conditions
- HLH - Hypoplastic Left Heart Syndrome, DORV, DILV - Double Inlet Left Ventricle, Mitral Atresia
- Trial name
- TEVG-2 (NCT04467671)
- Testing
- Tissue Engineered Vascular Grafts
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Nationwide Children's Hospital
Edentulous
Implant Placement With Simultaneous Gum Grafting
This study is a comparison of implant placed and simultaneously grafted with either autogenous connective tissue or a connective tissue allograft.
- Trial name
- NCT01431144
- Testing
- connective tissue autograft, connective tissue allograft
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- University of Louisville
Recession
Modified Connective Tissue Graft Wall With Wing Technique for Posterior Teeth
The investigators reported here the application of usage modified connective tissue graft wall technique for posterior teeth. The treatment outcomes suggested the efficacy of the used technique in treating recession defects…
- Trial name
- NCT03716752
- Testing
- Modified connective tissue graft wall with wing technique
- Where
- Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Cairo University
Dental, Implant
Modified Periosteal Tissue Graft vs Collagen Matrix for Soft Tissue Augmentation Around Implants: A Comparative Study
This clinical trial aims to evaluate the effectiveness of the Modified Vascularized Interpositional Periosteal Connective Tissue Graft (mVIP-CTG) compared to Xenogeneic Collagen Matrix (XCM) around immediate implant in esthetic…
- Trial name
- NCT06808243
- Testing
- connective tissue graft, xenogenic collagen membrane
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Minia University
Soft Tissue Augmentation, Gingival Recession Localized Moderate
Evaluation of the Effect of Smoking on Palatal Donor Site Tissue Profile in the Success of Connective Tissue Grafts
This single-center prospective clinical study investigates how smoking affects palatal donor site tissue biology and, in turn, the success of connective tissue grafts used in root coverage surgery.
- Conditions
- Soft Tissue Augmentation, Gingival Recession Localized Moderate, Palatal Morphology
- Trial name
- NCT07777185
- Testing
- Coronally Advanced Flap with Subepithelial Connective Tissue Graft (CAF + CTG)
- Where
- Turkey (Türkiye)
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Ankara University
Gingival Recession
Comparative Evaluation of Buccal Fat Pad and Subepithelial Connective Tissue Graft
Compare between Buccal fat pad and subepithelial connective tissue graft in treatment of localized recession. Primary objective: to evaluate root coverage in terms of gingival thickness and esthetic.
- Trial name
- RCT (NCT04849663)
- Testing
- free fat graft, subepithelial graft
- Where
- Egypt
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Diabetic; Foot Ulcers
Allogenic Dermis Versus Standard Care in the Management of Diabetic Foot Ulcers
This is comparison trial comparing human dermis to standard wound care for non healing diabetic wound
- Trial name
- NCT02331147
- Testing
- Offloading, Dressing Application
- Where
- 3 sites in United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Musculoskeletal Transplant Foundation
Gingival Recession
Treatment of Gingival Recessions with Connective Tissue or Concentrated Growth Factor Membrane Using Tunnel Technique
This randomized controlled clinical study aimed to evaluate the success of the combination of tunnel technique and concentrated growth factor membrane for root coverage in treating multiple gingival recessions and compare with…
- Trial name
- NCT04561947
- Testing
- Tunnel technique, Connective tissue graft, Concentrated growth factor membrane
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Bulent Ecevit University
Graft Versus Host Disease, Leukemia
Chemotherapy, Radiation Therapy, and Umbilical Cord Blood Transplantation in Treating Patients With Hematologic Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage cancer cells.
- Conditions
- Graft Versus Host Disease, Leukemia, Lymphoma, Multiple Myeloma and Plasma Cell Neoplasm
- Trial name
- NCT00003270
- Testing
- anti-thymocyte globulin, filgrastim, busulfan
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Roswell Park Cancer Institute
Implant Complication
Collagen Matrix + rhPDGF-BB vs Connective Tissue Graft for the Treatment of Peri-implant Soft Tissue Dehiscences
The study aims at comparing two different approaches for the treatment of implant esthetic complications (peri-implant soft tissue dehiscences): autogenous connective tissue graft vs collagen matrix + recombinant human platelet…
- Trial name
- NCT05576922
- Testing
- Prosthetic-surgical approach + autogenous graft, Prosthetic-surgical approach + graft substitute
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Harvard Medical School (HMS and HSDM)
Gingival Recession
MCAT With HA and sCTG Compared With sCTG Alone for Treatment of Multiple Gingival Recession: Clinical Trial
Microsurgical tunneling flap procedures using connective tissue grafts (CTG) are predictable for treating teeth with gingival recessions.
- Trial name
- NCT05045586
- Testing
- The tunnel technique for root coverage with CTG without Cross-linked Hyaluronic Acid, The tunnel technique for root coverage with CTG andCross-linked Hyaluronic Acid
- Where
- Poland
- Volunteers
- 15 people
- Sponsor
- Medical University of Warsaw
Keratinized Mucosa
Keratinized Tissue Gain Following Apically Positioned Flap with and Without Free Gingival Graft Strip
In non-implant edentulous patients reduction of height and width of residual alveolar ridge and reduced attached KT compromise the denture-bearing area unambiguously leading to decrease in full denture stability and retention.
- Trial name
- FGGS (NCT06694623)
- Testing
- Apically positioned flap, Apically positioned flap with FGG strip
- Where
- Serbia
- Volunteers
- 17 people
- Sponsor
- Adam Malesevic
Craniofacial Microsomia
Clinical Trial of Fat Grafts Supplemented With Adipose-derived Regenerative Cells
Although first reports of the clinical use of adipose-derived regenerative cells (ADRC) suggest that this approach may be feasible and effective for soft tissue augmentation, there is a lack of randomized, controlled clinical…
- Trial name
- NCT01674439
- Testing
- Supplementation of ADRC, Without supplementation of ADRC
- Where
- Brazil
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Immediate Implants
Subepithelial Connective Tissue Graft Versus Socket Shield Technique In Immediately Placed Implants
The purposes of study are: 1. To assess the efficacy of immediate implant placement in preserving hard and soft tissue around implants clinically and radiographically. 2.
- Trial name
- NCT06478511
- Testing
- Classic Immediate implant, Immediate implant combined with subepithelial connective tissue graft, Immediate dental implant placement using socket shield technique
- Where
- Egypt
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Soft Tissue Loss With Nerve Defect
Treatment of Soft Tissue Loss With Nerve Defect in the Finger Using the Boomerang Nerve Flap
Soft tissue loss with proper digital nerve (PDN) defect in the finger results in sensory loss of the finger pulp. Reconstruction of these complex soft tissue defects continues to be a challenge problem.
- Trial name
- NCT01629602
- Testing
- the Boomerang Nerve Flap
- Volunteers
- 49 people
- Sponsor
- The Second Hospital of Tangshan
Implant Complication
Vertical Soft Tissue Augmentation With CTG vs ADM
The study aims at comparing two different approaches for vertical soft tissue augmentation at implant sites exhibiting soft tissue dehiscences: autogenous connective tissue graft vs acellular dermal matrix + enamel matrix…
- Trial name
- NCT05729607
- Testing
- Vertical soft tissue augmentation
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Harvard Medical School (HMS and HSDM)