Clinical trials: Tissue Grafts
Xerostomia, Graft-versus-host-disease
Dose-Escalation Trial of Mesenchymal Stromal Cells in Patients With Medical Xerostomia
The goal of this clinical trial is to evaluate the safety and tolerability of injecting certain cells produced in bone marrow called mesenchymal stromal cells (MSCs) into salivary glands.
- Conditions
- Xerostomia, Graft-versus-host-disease, Sjogren's Disease
- Trial name
- NCT06392711
- Testing
- Mesenchymal Stromal Cells (MSC) Dose Level 0, Mesenchymal Stromal Cells (MSC) Dose Level 1
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- University of Wisconsin, Madison
Soft Tissue Infections, Gingival Recession
Clinical Effectiveness of Polymethoxy Flavones Solid Dispersion as a Dressing Material for Palatal Grafts Donor Sites
Free gingival grafting surgeries require palatal grafts harvesting from the patient own palates . The donor sites pain , infection and retarded healing by secondary intension are the complication .
- Trial name
- RCT (NCT05814003)
- Testing
- hydroxylate flavones solid dispersion application
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Assiut University
Gingival Recession
A Novel Vertical Y-shaped Tunnel Approach Versus Modified Coronally Advanced Tunnel Technique, for The Treatment of Miller Class I Gingival Recession
Recent plastic procedures have provided satisfactory results in the treatment of gingival recession but there is, presently, a greater need for procedure that cause less surgical morbidity as also provide improved results.
- Trial name
- NCT06453369
- Testing
- Y shaped Tunnel with Connective tissue graft
- Where
- Egypt
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- October 6 University
Vitiligo, Piebaldism
Evaluation of Non-cultured Epidermal Cellular Grafting vs Hyaluronic Acid for Repigmenting Vitiligo and Piebaldism
The purpose of this study is to assess the efficacy of autologous epidermal cells suspension grafting using a newly developed device named VITICELL® compared to placebo.
- Trial name
- NCT02156427
- Testing
- VITICELL
- Where
- 5 sites in Belgium, France and 1 more
- Volunteers
- 38 people
- Sponsor
- Laboratoires Genévrier
Graft vs Host Disease
Dexamethasone to Prevent Oral Chronic Graft-versus-Host Disease
This study will determine if a dexamethasone mouth rinse can reduce the risk of developing oral chronic graft-versus-host disease (cGVHD) in patients who have undergone a bone marrow (stem cell) transplant procedure.
- Trial name
- NCT00391170
- Testing
- Topical Dexamethasone
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Gingival Recession
Comparison of Root Coverage Outcomes by NORD Flap Versus Subepithelial Connective Tissue Graft in RT1 Gingival Recession
Management of GR in the initial stages (when there is no inter proximal attachment and bone loss involved) has better clinical outcomes and reduces the chances of further progression of recession.
- Trial name
- Recession type (NCT05844254)
- Testing
- novel overlapping rotated double (NORD) flap
- Where
- India
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Leukemia, Lymphoma
Peripheral Stem Cell Transplantation in Treating Patients With Hematologic Cancer
RATIONALE: Peripheral stem cell transplantation may be able to replace immune cells that were destroyed by chemotherapy or radiation therapy used to kill tumor cells.
- Conditions
- Leukemia, Lymphoma, Multiple Myeloma and Plasma Cell Neoplasm, Myelodysplastic Syndromes
- Trial name
- NCT00003396
- Testing
- anti-thymocyte globulin, graft-versus-tumor induction therapy, cyclophosphamide
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- University of Maryland, Baltimore
Gingival Recession
Tunneling Technique in Treatment of Miller's Class III Gingival Recession
Several surgical techniques have been proposed to correct recession defect and attain root coverage. Though, the majority were executed on Miller Class I and II recession defects.
- Trial name
- NCT03657706
- Testing
- group A (Tunnel procedure with subepithelial connective tissue graft (sCTG), group B (Tunnel procedure with modified free gingival graft (mFGG))
- Where
- Egypt
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Cairo University
Wound Healing
Effects of CGF and Collagen Fleece on Palatal Donor Site Healing: A Randomized Clinical Trial
This study investigated whether applying Concentrated Growth Factor (CGF) or Collagen Fleece (CF) to the palatal donor site after autogenous soft tissue graft harvesting could improve wound healing and reduce postoperative…
- Trial name
- PAL-HEAL (NCT07367165)
- Testing
- Concentrated Growth Factor (CGF), Collagen Fleece (CF), Collagen Sponge (Control)
- Where
- Turkey (Türkiye)
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Inonu University
Tooth Loss, Recession, Gingival
Soft Tissue Volume Gain and Stability Comparing Palate and Tuberosity
The goal of this study is to compare clinical and histologically the soft tissue changes in terms of volume gain and stability around dental implants in cases where a subepithelial connective tissue graft from the palate or from…
- Trial name
- NCT03090906
- Testing
- Soft tissue augmentation palate, Soft tissue augmentation tuberosity, Intraoral optical scan
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Universitat Internacional de Catalunya
Dental Implant Soft Tissue Defects in the Anterior Maxilla
A Randomized Control Trial Testing Connective Tissue Grafts vs. Allograft on Dental Implants
This randomized controlled clinical pilot trial compared the efficacy of two soft tissue grafting methods for correcting esthetic discrepancies associated with non-molar implants in the maxilla.
- Trial name
- NCT01934530
- Testing
- Soft Tissue Grafting
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Psoriasis
A One-Year Study To Evaluate The Efficacy And Safety Of CP-690,550 For Patients With Moderate To Severe Chronic Plaque Psoriasis
The main objective of this study is to compare the effects of CP-690,550 with the effects of placebo in patients being treated for moderate to severe chronic plaque psoriasis.
- Trial name
- NCT01309737
- Testing
- CP-690,550
- Where
- 94 sites in United States, Canada and 9 more
- Volunteers
- 960 people
- Sponsor
- Pfizer
Ulcer, Skin Ulcer
Epidermal Grafting in Wound Healing
Split thickness skin grafting is the normal standard of care for wound closure. However, this is an invasive procedure and associated with pain also there can be additional donor site morbidity.
- Conditions
- Ulcer, Skin Ulcer, Wounds and Injuries
- Trial name
- EPIGRAAFT (NCT02535481)
- Testing
- Epidermal grafting, Split thickness skin grafting
- Where
- United Kingdom
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University College, London
Autoimmune Diseases, Sickle Cell Disease
Microvascular and Fibrosis Imaging Study
In this study, Laser Doppler Flowmetry (LDF), Laser Doppler Imaging (LDI), Orthogonal Polarization Spectral Imaging (OPSI), Nail fold video capillaroscopy (NVC) and Optical Coherence Tomography (OCT) will be used to assess…
- Conditions
- Autoimmune Diseases, Sickle Cell Disease, Chronic Graft Versus Host Disease
- Trial name
- NCT01758250
- Testing
- Acoustic Radiation Force Impulse (ARFI), Laser Doppler Flowmetry (LDF), Laser Doppler Perfusion Imaging (LDI)
- Where
- United States
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Duke University
Varicose Ulcer
Endovenous Ablation Combined With Fat Grafting for Venous Ulcers
The aim of this trial is to determine if fat grafting may have applicability to venous ulcers by comparing healing and recurrence rates in patients who receive combined fat grafting and endovenous ablation with patients who…
- Trial name
- NCT05241704
- Testing
- Fat grafting, Endovenous ablation of superficial venous reflux
- Where
- Ireland
- Volunteers
- 20 people
- Sponsor
- National University of Ireland, Galway, Ireland
Interdental Papillae Reconstruction, Hyaluronic Acid
A Modern, Non-surgical Method for Treating Papillary Deficiencies is the Use of Hyaluronic Acid, Which Have Demonstrated Encouraging Outcome. Subperiosteal Hyaluronic Acid Injection Overlay Technique with the Idea of Merging Hyaluronic Acid Injection with Surgical Intervention to Reconstruct Idp
The interdental papilla is a crucial part of an esthetic smile, its loss results in gingival black triangles giving unpleasant appearance which directly affect patient self-esteem (Lee et al. 2016).
- Trial name
- NCT06889311
- Testing
- Subperiosteal hyaluronic acid injection overlay technique, Tunneling with connective tissue graft.
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Cairo University
Gingival Recession
Treatment Off Gingival Recession Defects Using a Xenogenic Acellular Dermal Matrix Compared to Connective Tissue Graft.
Limitation of donor site and significant postoperative morbidity are often described in connective tissue graft harvesting. We want to show if mucoderm used in tunnel technique to recover miller class I and II recessions defects…
- Trial name
- MUCODERM (NCT03162016)
- Testing
- transplants
- Where
- France
- Volunteers
- 12 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Gingival Recession
Effect of Hyaluronic Acid on Gingival Recession Treatment
Gingival marginal tissue recession is the displacement of the soft tissue margin apical to the cementoenamel junction (CEJ) with exposure of the root surface.
- Trial name
- NCT04692558
- Testing
- HYALURONIC ACID, coronally advanved flap with connective tissue harvesting
- Where
- India
- Volunteers
- 20 people
- Sponsor
- Krishnadevaraya College of Dental Sciences & Hospital
Gingival Recessions
Predetermination for Gingival Recession
Background: The aim of present clinical study was to evaluate the predictive values of baseline inter-dental papilla height (IPH), avascular exposed root surface area (AERSA) and inter-dental clinical attachment loss (CAL)…
- Trial name
- NCT02479633
- Testing
- Coronally advanced flap with connective tissue graft
- Volunteers
- 122 people
- Sponsor
- Cukurova University
Dupuytren's Disease
Efficacy of Aponeurectomy on the 2-year Recurrence Rate of Dupuytren's Disease
Dupuytren's disease is a frequent hereditary disease in Northern Europe. It is a degenerative disease affecting the palmar aponeurosis of the hand.
- Trial name
- REMEDY (NCT05067764)
- Testing
- Aponeurectomy with grafting, Aponeurectomy alone
- Where
- 2 sites in France
- Volunteers
- 172 people
- Sponsor
- Elsan