Clinical trials: Tissue Grafts
Breast Augmentation
Improved Breast Enlargement Using the Subject's Own Fat Tissue
The goal of this clinical study is to learn if the Medical Device Under Investigation (simply "the device") is safe to use in human adults undergoing breast augmentation surgery.
- Trial name
- SWIFT (NCT07869641)
- Testing
- An injectable, biodegradable hydrogel, in reconstitution medium, Reconstitution medium
- Where
- 2 sites in Belgium
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- 4Tissue
Facial Injuries, Adipose Tissue
Effect of Concentrating Endogenous Stromal Cells in the Fat Graft
Traumatic facial injuries, especially those sustained in military combat, are characterized by destruction of bone and soft tissue.
- Trial name
- NCT01564524
- Testing
- Fat graft surgical procedure
- Where
- United States
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Cervical Cancer
Fat Grafting for Vaginal Stenosis in Gynaelogical Cancer
The GRASS study looks at performing a technique called "Fat Tissue Grafting" to assess whether it can reduce the side effects of vaginal stenosis effects and improve the sexual function of participants who wish to preserve…
- Trial name
- GRASS (NCT06015360)
- Testing
- Fat Graft
- Where
- United Kingdom
- Volunteers
- 8 people
- Sponsor
- Royal Marsden NHS Foundation Trust
Colon Ischemia, Aortic Aneurysm
Prevention of Colon Ischemia During Aortic Aneurysm (AAA) Repair
Patients undergoing surgery on their Aorta can get ischemia, a lack of blood flow, to their intestines and colon. This is very serious, as 2 out of 3 patients who have this problem die before leaving the hospital.
- Trial name
- NCT00671203
- Testing
- Reestablish colon blood flow
- Where
- 2 sites in United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Spectros Corporation
Periodontitis, Periodontitis (Stage 3)
Morphological Characteristics of Mandibular Molar Furcation Involvement and Efficacy of Regenerative Surgical Treatment
This study consists of two components evaluating furcation involvement in mandibular molars among Stage III or Stage IV periodontitis patients.
- Conditions
- Periodontitis, Periodontitis (Stage 3), Furcation Defects
- Trial name
- NCT07770256
- Testing
- Acellular Dermal Matrix + EMD + Xenograft, Autogenous Connective Tissue Graft + EMD + Xenograft
- Where
- Vietnam
- Volunteers
- 98 people
- Sponsor
- University of Medicine and Pharmacy at Ho Chi Minh City
Deep Partial or Full Thickness Wounds
Safety and Efficacy Study of FS 4 IU VH S/D (Fibrin Sealant With 4IU/mL Thrombin, Vapor Heated, Solvent/Detergent Treated) to Adhere Split Thickness Skin Grafts and Improve Wound Healing in Burn Patients
The primary objective of this study is to evaluate skin graft adherence and wound healing in burn patients to evaluate whether FS 4IU VH S/D is equivalent or superior to the current standard of care (staples).
- Trial name
- NCT00157131
- Testing
- Fibrin Sealant, ARTISS 4IU/ml VH SD, Staples
- Where
- 17 sites in United States
- Volunteers
- 150 people
- Sponsor
- Baxter Healthcare Corporation
Arrhythmias, Cardiac
Prevention of Dysrhythmias on the Cardiac Intensive Care Unit - Does Maintenance of High-normal Serum Potassium Levels Matter
The purpose of this study is to determine whether a strategy of maintaining serum potassium levels at ≥3.6 mEq/L is non-inferior to a strategy of usual treatment (≥4.5 mEq/L) on the occurrence of new onset atrial fibrillation…
- Trial name
- TIGHT-K (NCT04053816)
- Testing
- Potassium
- Where
- United Kingdom
- Volunteers
- 1,684 people
- Sponsor
- Barts & The London NHS Trust
Tooth Mobility
Assessment of Microfragmented Adipose Tissue Loaded on Bovine Graft Versus Bovine Graft Only on Ridge Preservation.
Evaluation of maxillary alveolar ridge changes (bone quantity and quality as revealed by Radiographic and Histomorphometry) utilizing microfragmented adipose tissue loaded on bovine graft versus bovine graft only for maxillary…
- Trial name
- NCT06457867
- Testing
- microfragmented adipose tissue loaded on bovine graft
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Cairo University
Penetrating Keratoplasty, Multiple Graft Failure
Subconjunctival Humira for Boston Keratoprosthesis
This trial is studying the safety and tolerability of receiving an injection of adalimumab (Humira) during the Boston Keratoprosthesis (KPro) surgery.
- Conditions
- Penetrating Keratoplasty, Multiple Graft Failure, Ocular Cicatricial Pemphigoid, Stevens-Johnson Syndrome
- Trial name
- NCT06926478
- Testing
- Adalimumab Injection
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Massachusetts Eye and Ear Infirmary
Hepatic and Hepatobiliary Disorders
Indocyanine Green Clearance Test in Liver Transplantation (LivInG)
The gap between patients awaiting and those undergoing liver transplantation (LT) continues to grow. Marginal organs carry higher risk of failure after LT however they are increasingly used to fill such gap.
- Trial name
- LivInG (NCT05228587)
- Testing
- Indocyanine green
- Where
- Italy
- Volunteers
- 162 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Implantation Complication
L-PRF for Increasing Keratinised Mucosa Around Implants
The aim of this study was to evaluate the potential of L-PRF in increasing the width of the keratinsed mucosa around implants. Furthermore, it was assessed whether this surgery was associated with significantly less…
- Trial name
- NCT03190226
- Testing
- L-PRF membranes, Free Gingival Graft
- Volunteers
- 8 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Lymphedema, Breast Cancer
Use of Stem Cells in Lymphedema Post Mastectomy
The post-mastectomy lymphedema is a complication of removal of the breast and nodal plexus that causes accumulation of lymph and subsequent enlargement of the upper limb.
- Trial name
- SCL (NCT01112189)
- Testing
- Autologous transplant, Compressed sleeve treatment
- Where
- Mexico
- Volunteers
- 20 people
- Sponsor
- Hospital Universitario Dr. Jose E. Gonzalez
Air or Gas Embolism, Carbon Monoxide Poisoning
Hyperbaric Oxygen Therapy Registry
The purpose of the Hyperbaric Oxygen Therapy Registry (HBOTR) is to provide real world patient outcome and side effect information from electronic health records submitted to a specialty specific hyperbaric registry as part of…
- Conditions
- Air or Gas Embolism, Carbon Monoxide Poisoning, Clostridial Myositis and Myonecrosis (Gas Gangrene), Crush Injury, Compartment Syndrome & Other Acute Traumatic Ischemias
- Trial name
- HBOTR (NCT02483650)
- Volunteers
- 5,000 people
- Sponsor
- U.S. Wound Registry
Keratinized Tissue Deficiency
Applying of Absorbable Dressing (Reso-Pac) on the Palatal Donor Site
The periodontal dressing was applied to the donor site of the free gingival graft on the palate to protect the site, reduce postoperative pain, and improve soft tissue healing in the palatal area.
- Trial name
- NCT07898735
- Testing
- Control group : Coe-pak, Study Group: Reso-pac
- Where
- Syria
- Volunteers
- 20 people
- Sponsor
- Damascus University
Gingival Recession
Treatment of Multiple Gingival Recession Defects Using a New Xenogenic Collagen Membrane Compared to Connective Tissue Graft: a Randomized Controlled Split-mouth Clinical Study
Limitation of donor site and significant postoperative morbidity are often described in connective tissue graft. We want to show if mucogain matrix used in tunnel technique to recover RTI Cairo recessions defects could be an…
- Trial name
- Mucogreffe (NCT04800250)
- Testing
- Treatment of gingival recessions
- Where
- France
- Volunteers
- 8 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
ACL Tears
MRI Evaluation of Graft Maturation Following ACL Reconstruction
Post-surgical ACL Graft maturation will be assessed at 4.5, 6, 7.5, 9, 10.5, and 12 months with MRI.
- Trial name
- NCT07046000
- Testing
- MRI
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Skye Biologics Holdings, LLC
Gingival Recession Localized Moderate
Comparing Tunnel Technique and CAF With CTG in Mandibular Gingival Recession Treatment
The goal of this clinical trial is to evaluate the effectiveness of two different surgical techniques, the Coronally Advanced Flap (CAF) and the Tunnel Technique (TT) with Connective Tissue Grafts (CTG), in treating mandibular…
- Trial name
- NCT06135662
- Testing
- CAF + CTG, Tunnel Technique + CTG
- Where
- Spain
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Universitat Internacional de Catalunya
Chronic Myeloproliferative Disorders, Diamond-blackfan Anemia
Donor Umbilical Cord Blood Transplant in Treating Patients With Hematologic Cancer
RATIONALE: Giving chemotherapy and total-body irradiation before a donor umbilical cord blood transplant helps stop the growth of cancer and abnormal cells and helps stop the patient's immune system from rejecting the donor's…
- Conditions
- Chronic Myeloproliferative Disorders, Diamond-blackfan Anemia, Fanconi Anemia, Graft Versus Host Disease
- Trial name
- NCT00290628
- Testing
- anti-thymocyte globulin, busulfan, cyclophosphamide
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- Masonic Cancer Center, University of Minnesota
Gingival Recession Localized Moderate, Dental Implant
Free Soft Tissue Grafts FSTG) Using Autograft Palatal Donor Tissue vs. Xenograft Collagen Matrix (Zderm™)
Participant in this study are asked to participate because they have teeth or dental implants that were identified as having very little gum tissue and would benefit from gum tissue graft surgery.
- Trial name
- NCT07713199
- Testing
- Zderm
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Burn, Trauma
Trial of Zesteem (Estradiol) in Healing of Split Thickness Skin Graft Donor Sites
This trial will assess the effects of Zesteem (estradiol) on the healing of split thickness skin graft donor sites in patients aged 18-85 years.
- Conditions
- Burn, Trauma, Varicose Ulcer
- Trial name
- NCT00426972
- Testing
- estradiol (Zesteem)
- Where
- 30 sites in Germany, Latvia and 2 more
- Volunteers
- 148 people
- Sponsor
- Renovo