Clinical trials: Tissue Grafts
Infection, Surgical Site
Use of Real-time Fluorescence Imaging in Diabetic Foot Ulcers: the Impact of Colonization
The study evaluates the efficacy of fluorescence-guided de-colonization in patients with non-infected diabetic foot ulcers. The efficacy will also be compared between those who used artificial dermis and split-thickness skin…
- Trial name
- NCT05873049
- Testing
- MolecuLight
- Where
- Taiwan
- Volunteers
- 210 people
- Sponsor
- Taipei Medical University Shuang Ho Hospital
Burns
Study With an Autologous Dermo-epidermal Skin Substitute for the Treatment of Burns in Adults and Adolescents
This phase IIb trial aims to evaluate the efficacy and safety of EHSG-KF (synonym denovoSkin) in comparison to meshed STSG in adults and adolescents with partial deep dermal and full thickness burns.
- Trial name
- NCT03227146
- Testing
- EHSG-KF, STSG
- Where
- 6 sites in Italy, Netherlands and 1 more
- Volunteers
- 14 people
- Sponsor
- CUTISS AG
Romberg's Disease, Craniofacial Microsomia
Role of Mesenchymal Stem Cells in Fat Grafting
Contour deformity of face causes both functional as well as aesthetic problems for the patient. Fat being an autologous tissue source is considered as an ideal soft-tissue filler because it is abundant, readily available…
- Conditions
- Romberg's Disease, Craniofacial Microsomia, Lipodystrophy, Mixed Connective Tissue Disease
- Trial name
- NCT02494752
- Testing
- Fat graft enriched with ex vivo expanded stem cells, Fat graft not enriched with ex vivo expanded stem cells
- Volunteers
- 30 people
- Sponsor
- King Edward Medical University
Peyronie's Disease
Investigation of Surgery, Collagenase, and Restorex for the Improvement of Peyronie's
The purpose of this study is to compare key clinical outcomes of collagenase clostridium histolyticum injections versus surgery for the management of Peyronie's Disease.
- Trial name
- iSCRIP (NCT04786106)
- Testing
- Collagenase Clostridium Histolyticum 0.9 MG [Xiaflex] (CCH), Penile Plication Surgery, Incision and Grafting (I&G) Surgery
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Charitable Union for the Research and Education of Peyronie's Disease
Alveolar Bone Loss
Pontic Site Development Using Soft Tissue Augmentation
in patients with vertical or horizontal defective of there ridge it is difficult to have prosthetic restoration with natural appearance emetating and simulating the adjacent abutment emergence profile so this study aims to…
- Trial name
- NCT03834649
- Testing
- partially de-epithelized connective tissue graft, Mucograft
- Where
- Egypt
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Nouran Abdulla Mater,MD
Socket Preservation
Post Extraction Alterations Following Ridge Preservation In The Esthetic Zone Using Partially Demineralized Autogenous Dentine Graft Versus Xenograft
the aim of this study is to establish if there are clinical, radio-graphical and histomorphometrical differences between using Partially Demineralized Dentin graft versus Xenograft in the esthetic zone.
- Trial name
- NCT06552793
- Testing
- autogenous partially demineralized dentin graft, Xenograft
- Where
- Egypt
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Cairo University
Gingival Recession, Connective Tissue Defect
A Novel Volume Stable Matrix for Gingival Recession Coverage at Teeth
Periodontal health and preservation of the dentition without tooth loss are important quality of life components and should be safeguarded in order to provide optimal function and esthetics.
- Trial name
- FibroGide (NCT07437417)
- Testing
- Volume stable collagen matrix, Control
- Where
- Switzerland
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Bern
Pain, Postoperative, Pain, Chronic
Pain and Impact of Chronic Pain on Function After Total Knee Replacements
After Institutional Review Board approval, adult patients scheduled for total knee arthroplasty (TKA) will be enrolled into the study after obtaining informed consent over a 24 month period.
- Conditions
- Pain, Postoperative, Pain, Chronic, Osteogenic Sarcoma, Knee Arthropathy
- Trial name
- NCT03032679
- Testing
- Non interventional study
- Where
- India
- Volunteers
- 139 people
- Sponsor
- Tata Memorial Centre
Graft Versus Host Disease, Leukemia
Busulfan, Cyclophosphamide, & Antithymocyte Globulin Followed by Stem Cell Transplant in Treating Hematologic Cancer
RATIONALE: Giving chemotherapy before a donor bone marrow transplant or peripheral stem cell transplant helps stop the growth of cancer cells and helps stop the patient's immune system from rejecting the donor's stem cells.
- Conditions
- Graft Versus Host Disease, Leukemia, Lymphoma, Multiple Myeloma and Plasma Cell Neoplasm
- Trial name
- NCT00611351
- Testing
- anti-thymocyte globulin, busulfan, cyclophosphamide
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of Nebraska
Gingival Recession, Localized
Effectiveness of Tuberosity Micro Connective Tissue Graft for Treatment of Multiple Adjacent Gingival Recession Defects
The objective of this project is to compare post-operative pain associated with palatal and tuberosity donor sites for micro-CTG, and to evaluate the outcomes in both the donor and recipient sites.
- Trial name
- NCT06650072
- Testing
- modified coronally advanced tunnel technique combined with multiple palatal micro connective tissue grafts, modified coronally advanced tunnel technique combined with multiple tuberosity micro connective tissue grafts
- Volunteers
- 30 people
- Sponsor
- Göteborg University
Free Gingival Graft, Soft Tissue Augmentation Around Dental Implants
Clinical Evaluation of a Modified Technique for Free Gingival Graft Stabilization Using Titanium Fixation Tacs Around Implants Versus Conventional Suturing Technique
The aim of this randomized, controlled, parallel-grouped, clinical trial is to evaluate the width of keratinized gingiva after free gingival graft stabilized by titanium fixation tacs compared to traditional suturing.
- Conditions
- Free Gingival Graft, Soft Tissue Augmentation Around Dental Implants, Inadequate Keratinized Tissue Around Dental Implants
- Trial name
- NCT07019428
- Testing
- Free gingival graft stabilized by Titanium fixation tacs, Free gingival graft stabilized by sutures
- Where
- Egypt
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Cairo University
Coronary Artery Disease
Study to Evaluate the Safety and Efficacy of Humacyte's Coronary Tissue Engineered Vessel (CTEV) in Patients With Coronary Artery Disease Requiring Coronary Artery Bypass Grafting (CABG)
The goal of this study is to assess safety and efficacy of Humacyte's coronary tissue engineered vessel (CTEV) used as a bypass conduit in patients requiring multi vessel coronary artery bypass grafting (CABG).
- Trial name
- NCT07730528
- Testing
- Humacyte Coronary Tissue Engineered Vessel (CTEV)
- Volunteers
- 10 people
- Sponsor
- Humacyte, Inc.
Ischemic Cardiomyopathy, Congestive Heart Failure
CABG Combined Pedicled Omentum Wrapped Autologous Atrial Tissue Patch Cardiomyoplasty for Ischemic Cardiomyopathy
The purpose of this study is in a phase I/II safety and efficacy study to evaluate the clinical effect of coronary artery bypass graft (CABG) combined pedicled omentum wrapped autologous atrial tissue patch cardiomyoplasty for…
- Conditions
- Ischemic Cardiomyopathy, Congestive Heart Failure, Coronary Artery Disease
- Trial name
- NCT00972114
- Testing
- CABG combined cardiomyoplasty, CABG combined pedicled omentum graft, CABG alone
- Where
- 2 sites in China
- Volunteers
- 70 people
- Sponsor
- China National Center for Cardiovascular Diseases
Fertility, Testicular Tissue Cryopreserved
Perceptions and Acceptance of Grafting of Cryopreserved Testicular Tissue
Cancer treatment can cause infertility. Fertility preservation is possible for many populations through, egg, sperm or ovarian tissue freezing prior to cancer treatment.
- Conditions
- Fertility, Testicular Tissue Cryopreserved, Fertility Preservation
- Trial name
- PACTT (NCT07915375)
- Testing
- No intervention
- Where
- Australia
- Volunteers
- 105 people
- Sponsor
- Murdoch Childrens Research Institute
Scleroderma, Systemic, Morphea
Patient Reported Outcomes With UVA-1 Therapy for Treatment of Sclerosing Skin Diseases
The purpose of this study is to assess the degree of improvement seen patient reported outcomes after 30 sessions of UVA-1 therapy in treating systemic scleroderma, morphea, and sclerodermatous Graft-Versus-Host Disease.
- Conditions
- Scleroderma, Systemic, Morphea, Graft Vs Host Disease
- Trial name
- NCT04922736
- Testing
- UVA-1 Phototherapy
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Utah
Gingival Recession
Clinical Evaluation of the Amount of Root Coverage Following The Use of VISTA Technique Versus Coronally Advanced Flap in Combination With Subepithelial Connective Tissue Graft for Management of Multiple Gingival Recessions
Patients with multiple recession defects will be randomly oriented into to groups. The test group will recieve a relatively new technique, the VISTA technique, combined with connective tissue graft that will be harvested from the…
- Trial name
- NCT03340987
- Testing
- vestibular incision subperiosteal tunnel access, Coronally advanced flap
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Cairo University
Modified Free Gingival Graft , Connective Tissue Graft
Efficacy of the Modified Free Gingival Graft Technique
Gingival recessions can be defined as the exposure of the root surface after an apical migration of the gingival margin in relation to the cemento-enamel junction. Gingival recessions affect both younger and older populations.
- Trial name
- FGG (NCT06580821)
- Testing
- mucogingigval surgery
- Where
- Ecuador
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Universidad de Especialidades Espiritu Santo
Gingival Recession
MCAF and EMD With and Without CTG Wall Technique for the Treatment of Class III and IV Gingival recessions-a Randomized Control Trial
Research is to compare and evaluate the clinical outcomes of the Connective tissue graft wall technique with modified coronally advanced flap to improve root coverage and clinical attachment levels in Miller's class III and IV…
- Trial name
- NCT06525285
- Testing
- Connective tissue graft wall technique
- Where
- India
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Krishnadevaraya College of Dental Sciences & Hospital
Coronary Artery Disease
A Study of Hemopure® to Enhance Tissue Preservation During Cardiopulmonary Bypass Surgery
The purpose of this study is to determine if Hemopure® will enhance tissue preservation during Cardiopulmonary Bypass surgery.
- Trial name
- NCT00301535
- Testing
- HBOC-201 (hemoglobin glutamer-250 bovine)
- Where
- 3 sites in Greece, South Africa and 1 more
- Volunteers
- 60 people
- Sponsor
- Biopure Corporation
Dry Eye Disease
Efficacy and Safety of 20% and 100% Autologous Serum Eye Drops in Patients With Severe Dry Eye Disease (AST)
A prospective, single-blinded, randomized, controlled crossover trial was conducted in patients with severe dry eye syndrome. Topical treatment with autologous serum eye drops (ASED) diluted at 20%, undiluted ASED and…
- Trial name
- AST (NCT07469865)
- Testing
- Preservative-free artificial tears, Autologous serum eyedrops 20%, Autologous serum eyedrops 100%
- Where
- Belgium
- Volunteers
- 46 people
- Sponsor
- University Hospital, Ghent