Clinical trials: Tissue Grafts
Primary Open Angle Glaucoma, Primary Angle Closure Glaucoma
Patch Graft Material Safety and Effectiveness in Covering Glaucoma Drainage Device Tube
The investigators hypothesize that KeraSys is a safe as Tutoplast to cover the tube of the Molteno 3 glaucoma drainage device during surgery
- Conditions
- Primary Open Angle Glaucoma, Primary Angle Closure Glaucoma, Pseudoexfoliation Glaucoma, Pigmentary Glaucoma
- Trial name
- NCT01301378
- Testing
- Molteno 3 glaucoma drainage shunt
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Wills Eye
Recession, Gingival
Clinical Evaluation of Laterally Closed Tunnel Technique Versus Coronally Advanced Flap Combined With Connective Tissue Graft for the Treatment of Isolated RT2 Gingival Recession
The aim of this study is to evaluate reduction of recession depth using lateral closed tunnel technique versus CAF technique using connective tissue graft in single RT2 gingival recession cases.
- Trial name
- NCT05823415
- Testing
- Laterally Closed Tunnel with CTG, CAF with CTG
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- British University In Egypt
Wound Healing
Healing After Connective Tissue Graft Harvesting in the Palatal Area With and Without Suture
This study evaluated the outcomes in the early healing of palatal wounds after harvesting a subepithelial connective tissue graft (SCTG) using the single incision technique with placement of a collagen haemostatic sponge (CHS)…
- Trial name
- NCT04513886
- Testing
- Subepithelial connective tissue graft (SCTG) using the single incision technique, with and without suturing the palate
- Where
- Argentina
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Mariel Viviana Gómez
Graft Rejection, Hepatocellular Carcinoma
Correlation Between Pre-transplant ICI Exposure and Post-transplant Graft Rejection
Immune checkpoint inhibitors (ICIs) have revolutionized the treatment of advanced HCC. The combination of the ICI and other treatment regimens (Anti-VEGF, locoregional therapies et al) produced superior results in patients with…
- Conditions
- Graft Rejection, Hepatocellular Carcinoma, Immunotherapy, Immune Checkpoint Inhibitor
- Trial name
- NCT05913583
- Testing
- Immune checkpoint inhibitor
- Where
- China
- Volunteers
- 160 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Neoplasm of Skin
Use of the Epidermal Micrografts for Wound Healing After Mohs or Excisional Surgery for Skin Cancer
This case series will assess the use of suction blister epidermal grafts harvested by a novel device on select patients that have wounds from Mohs or excisional surgery.
- Trial name
- NCT01536444
- Testing
- Momelan Technologies Epidermal Graft Harvesting System
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Momelan Technologies
Root Coverage, Tunneling Technique
Root Coverage With Connective Tissue Graft Associated With VISTA Versus Tunnel Technique
Several techniques were proposed in the literature to solve the problems associated with gingival recession. Root coverage was mainly indicated for esthetic concern, however, it might also be indicated for treatment of root…
- Conditions
- Root Coverage, Tunneling Technique, VISTA Technique, Sub Epithelial Connective Tissue Graft
- Trial name
- NCT03690635
- Testing
- VISTA (vestibular incision subperiosteal tunnel acess)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Cairo University
Gingival Recession
Comparison of Root Coverage of Gingival Recessions
The purpose of this study is to analyze the percentage of root coverage in Miller class I and II gingival recessions using connective tissue graft and collagen matrix with a two years follow-up.
- Trial name
- NCT02980055
- Testing
- collagen matrix, connective tissue graft
- Volunteers
- 46 people
- Sponsor
- Universidade Federal do Rio Grande do Norte
Soft Tissue Defect
Evaluation of Geistlich Fibro-Gide® in Comparison to CTG for the Treatment Around Implants
This double blind, randomized, parallel study evaluates the non-inferiority of Geistlich Fibro-Gide® in comparison to connective tissue graft for soft tissue volume augmentation around dental implants
- Trial name
- NCT04703738
- Testing
- Soft tissue flap + Connective Tissue Graft, Soft tissue flap + Geistlich Fibro-Gide®
- Where
- 5 sites in United States
- Volunteers
- 60 people
- Sponsor
- Geistlich Pharma AG
Recession, Gingival
Connective Tissue Graft Wall Technique in Management of Cairo's RT2 and RT3 With Intra-bony Defects
Recession presents a day to day challenge due to the high esthetic demand of the patients. The prevalence, extent, and severity of recession associated with intra-bony defects due to periodontitis increases with age rendering the…
- Trial name
- NCT04514055
- Testing
- De-epithelialized connective tissue graft wall
- Where
- Egypt
- Volunteers
- 10 people
- Sponsor
- Cairo University
Diabetic Foot Ulcer
Comparative Study of Amniotic Membrane Wound Graft In the Management of Diabetic Foot Ulcers
The purpose of this study is to determine whether the EpiFix human amniotic membrane is effective in the treatment of diabetic foot ulcers.
- Trial name
- NCT01552499
- Testing
- Standard of care, Applications of EpiFix
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- MiMedx Group, Inc.
Lack of Keratinized Tissue, Mucogingival Surgery
Evaluation of the Effects of Injectable Platelet-Rich Fibrin and Hyaluronic Acid Treatments, Administered in Addition to Free Gingival Graft Therapy, on Clinical Healing.
The purpose of this clinical trial is to evaluate the effects of injectable platelet-rich fibrin (i-PRF) and hyaluronic acid (HA) gel on clinical healing and graft shrinkage when used in addition to Free Gingival Graft (FGG)…
- Conditions
- Lack of Keratinized Tissue, Mucogingival Surgery, Gingival Recession
- Trial name
- IPRF-HA-FGG (NCT07804888)
- Testing
- Free gingival graft, Free Gingival Graft with i-PRF, Free Gingival Graft with Hyaluronic Acid
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people
- Sponsor
- Saglik Bilimleri Universitesi
Alveolar Bone Loss, Gingival Recession
Xenogenic Collagen Matrix vs. Connective Tissue Graft for Soft Tissue Augmentation Around Early Maxillary Implants
This study compares two methods used to improve gingival tissue around dental implants placed in (the maxillary esthetic zone). After a tooth is removed and a dental implant is placed early (usually 4-8 weeks later), additional…
- Conditions
- Alveolar Bone Loss, Gingival Recession, Peri-implant Mucositis
- Trial name
- NCT07024186
- Testing
- Xenogeneic Collagen Matrix, subepithelial connective tissue graft
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Minia University
Lack of Keratinized Tissue
Fixation of Free Gingival Graft Using Tissue Tacks vs Criss-cross Sutures
Tissue tacks may improve graft stability but their effect on pain is unclear. The study compares tacks and sutures by measuring pain, stability, healing success, and patient comfort.
- Trial name
- NCT07823374
- Testing
- Criss cross sutures, Tissue tacs
- Where
- Egypt
- Volunteers
- 16 people
- Sponsor
- October University for Modern Sciences and Arts
Osteoarthritis, Osteoarthritis Thumbs
Prospective Clinical Study to Evaluate the Safety and Efficacy of Intraarticular Administration of Micro-grafts of Adipose Tissue (Adipo-micro-grafts) in the Treatment of Osteoarthritis of the Trapezium-metacarpal Joint (ADIPO_MICRO_GRAFTS_1)
The objective of this interventional study is the Change in the Michigan Hand Questionnaire (MHQ) score over time in subjects with Eaton Littler grade II and III trapeziometacarpal osteoarthritis.
- Trial name
- AMG_1 (NCT06997991)
- Testing
- adipose micro-grafts injection
- Where
- Italy
- Volunteers
- 25 people
- Sponsor
- Azienda Ospedaliero, Universitaria Ospedali Riuniti
Intrabony Periodontal Defect
Clinical, Radiographic and Volumetric Evaluation of the Entire Papilla Preservation Technique With and Without Connective Tissue Graft in the Treatment of Periodontal Intraosseous Defects.
This study is to assess the impact of implementing subepithelial connective tissue graft (SCTG) in the treatment of periodontal intrabony defects with Entire Papilla Preservation Technique (EPPT) on the clinical and radiographic…
- Trial name
- NCT07737834
- Testing
- Entire Papilla Preservation Technique (EPPT), EDTA root conditioning, Enamel Matrix Derivative (EMD)- Emdogain
- Where
- 3 sites in Poland
- Volunteers
- 30 people
- Sponsor
- Medical University of Warsaw
Gingival Recession
Platelet-rich Fibrin and Connective Tissue Graft in Recession Treatment
The aim of the trial is to evaluate the effectiveness of coronally advanced flap (CAF)+connective tissue graft(CTG)+platelet-rich fibrin(PRF) combination in Miller I and II recession treatment by comparing with CAF+CTG.
- Trial name
- NCT02397122
- Testing
- platelet-rich fibrin, connective tissue graft, coronally advanced flap
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Kırıkkale University
Dental Implants, Peri-Implant Tissues
CTG vs VCMX for Peri-implant Soft Tissue Thickness
This investigator-initiated randomized controlled clinical trial evaluated changes in peri-implant soft tissue thickness in the aesthetic zone following soft tissue augmentation.
- Conditions
- Dental Implants, Peri-Implant Tissues, Missing Tooth/Teeth
- Trial name
- NCT07324187
- Testing
- Connective Tissue Graft, Volume-Stable Collagen Matrix
- Where
- Poland
- Volunteers
- 36 people
- Sponsor
- Medical Innovation Center Wroclaw
Gingival Recession
Laterally Closed Tunnel VS Tunneling Technique in Recession Type 2
This study aims to assess the effect of tunneling technique with subepithelial connective tissue graft versus tunneling technique with laterally closed tunnel in treatment of recession type 2 defect.Few randomized clinical trial…
- Trial name
- NCT03791554
- Testing
- Group A (Lateral closed tunnel subepithelial CT graft), Group B (Tunnel procedure with subepithelial CT graft)
- Where
- Egypt
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Cairo University
Nasal Cartilage Septum Perforations
Nasal Septum Perforation Treatment Using Tissue Engineered Cartilage Graft
The purpose of this study is to investigate the safety and feasibility of implanting an engineered cartilage tissue in an interposition graft with a temporoparietal fascia (TPF) flap to repair medium size septal perforation.
- Trial name
- NSP (NCT04633928)
- Testing
- N-TEC: Autologous nasal chondrocytes and ECM proteins
- Where
- Switzerland
- Volunteers
- 5 people
- Sponsor
- University Hospital, Basel, Switzerland
Muscle Loss
Enhanced Bioscaffold for Volumetric Muscle Loss
This is a prospective, single center study conducted at the University of Pittsburgh designed to test the applicability and utility of XenMatrix™ AB Surgical Graft in the restoration of function in the setting of volumetric…
- Trial name
- MTEC-VML (NCT04051242)
- Testing
- XenMatrix™ AB Surgical Graft
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- J. Peter Rubin, MD