Clinical trials: Tissue Grafts
Gingival Recession
Comparison of Coronally Advanced Root Coverage Procedure With Collagen Matrix and Connective Tissue Graft
The present study is a human, prospective, randomised controlled clinical trial conducted to explore the outcome of a coronally advanced flap with ossix volumaxTM collagen matrix and connective tissue graft in the treatment of…
- Trial name
- NCT04195737
- Testing
- Ossix volumax collagen matrix, Connective Tissue Graft
- Where
- India
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Krishnadevaraya College of Dental Sciences & Hospital
Soft Tissue Augmentation, Pontic Site Development
Pontic Site Soft Tissue Augmentation Using De-epithelized Connective Tissue Graft Versus Partially De-epithelized Connective Tissue Graft
a comparative study to evaluate the pontic site soft tissue augmentation by partially de-epithelized connective tissue graft versus completely de-epithelized connective tissue graft (both grafts harvested from the hard palate).
- Trial name
- NCT07434297
- Testing
- Intervention, Control
- Where
- Egypt
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- October University for Modern Sciences and Arts
Gingival Recession
Cytokine and MMP Levels in Gingival Crevicular Fluid in the Treatment of Localized Gingival Recessions
The main objective of this study was to evaluate the matrix metalloproteinase (MMP)-8, and -9, tissue inhibitor of matrix metalloproteinase and interleukin-1beta levels in gingival crevicular fluid during the early and late…
- Trial name
- NCT02380872
- Testing
- Connective tissue graft, Platelet Rich Fibrin
- Where
- Turkey (Türkiye)
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Ege University
Soft Tissue Atrophy
Cyanoacrylate With Sutures for Fixation of Free Gingival Graft
fixation of FGG with sutures alone is not sufficient,we use cyanoacrylate beside sutures for fixation
- Trial name
- NCT04063475
- Testing
- cyanoacrylate tissue adhesive beside sutures
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Cairo University
Graft-Versus-Host Disease
Tissue Repair in Stem Cell Transplant Recipients
Primary Objective: 1. To determine whether rhG-CSF treatment will increase the frequency of donor-derived cells contributing to repair of damaged epithelial/endothelial or solid organ-specific tissue caused by graft-versus-host…
- Trial name
- NCT00501228
- Testing
- Filgrastim
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- M.D. Anderson Cancer Center
Accelerated Phase Chronic Myelogenous Leukemia, Acute Myeloid Leukemia With Multilineage Dysplasia Following Myelodysplastic Syndrome
A Pilot Study to Evaluate the Co-Infusion of Ex Vivo Expanded Cord Blood Cells With an Unmanipulated Cord Blood Unit in Patients Undergoing Cord Blood Transplant for Hematologic Malignancies
This phase I multicenter feasibility trial is studying the safety and potential efficacy of infusing ex vivo expanded cord blood progenitors with one unmanipulated umbilical cord blood unit for transplantation following…
- Conditions
- Accelerated Phase Chronic Myelogenous Leukemia, Acute Myeloid Leukemia With Multilineage Dysplasia Following Myelodysplastic Syndrome, Adult Acute Lymphoblastic Leukemia in Remission, Adult Acute Myeloid Leukemia in Remission
- Trial name
- NCT00343798
- Testing
- cyclophosphamide, fludarabine phosphate, cyclosporine
- Where
- 4 sites in United States
- Volunteers
- 23 people
- Sponsor
- Fred Hutchinson Cancer Center
Meningioma, Tumor, Brain
MiDura-Study (Neuro-Patch in Duraplasty)
The aim of this study is to collect systematically and proactively data regarding the performance of Neuro-Patch, like complications and handling, under daily clinical practice when used as intended by the manufacturer
- Conditions
- Meningioma, Tumor, Brain, Chiari Malformation, Vascular Malformation
- Trial name
- MiDura (NCT04189172)
- Where
- 4 sites in France, Germany
- Volunteers
- 328 people
- Sponsor
- Aesculap AG
Vascularized Composite Allotransplantation
Withdrawal of Immunosuppression in Recipients of Face and Extremity Transplants
Many patients suffer from devastating injuries to vascularized composite tissues. Vascularized composite tissues are blocs of functional tissue that can contain multiple tissue types such as bone, muscle, nerves, blood vessels…
- Trial name
- NCT01853111
- Testing
- Interleukin-2
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Brigham and Women's Hospital
Morphea (Circumscribed Scleroderma), Sclerotic Graft-versus-host Disease (GVHD)
Study on the Treatment With Water-filtered Infrared-A (wIRA) Radiation in Patients With Morphea and Sclerotic Graft-versus-host Disease
This is a prospective, intra-individual comparative study to evaluate the effectiveness of local-water filtered infrared-A (wIRA) irradiation (applied by Hydrosun® radiator 750 for radiation at the clinic, or Hydrosun® 575home…
- Trial name
- NCT04954573
- Testing
- infrared-A (wIRA)
- Where
- 2 sites in Austria
- Volunteers
- 11 people
- Sponsor
- Medical University of Graz
Cicatrization
Complications Related to Palatal Graft Harvesting
Soft tissue defects can be a problem, especially in patients with high smile lines; in these clinical scenarios, the treatment with periodontal plastic surgery in combination with the use of a connective tissue graft (CTG) is…
- Trial name
- NCT06114394
- Testing
- UPV/EHU technique (Aguirre-Zorzano et al 2017), Single incision technique (Huerzeler & Weng 1999)
- Where
- Spain
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University of the Basque Country (UPV/EHU)
Edentulous Alveolar Ridge
Edentulous Sites Augmented With Collagen Matrix or CTG
Ridge deformities can complicate prosthetic rehabilitation, especially in situations where optimal esthetic outcomes are desired.
- Trial name
- NCT04915677
- Testing
- Soft tissue augmentation with subepithelial connective tissue graft (SCTG), Soft tissue augmentation with xenogenic volume stable collagen matrix
- Where
- Italy
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University of Turin, Italy
Gingival Recession
Clinical Evaluation of Injectable Platelet Rich Fibrin With Connective Tissue Graft for the Treatment of Deep Gingival Recession Defects.
Aim: The aim of this study was to determine whether the combined connective tissue graft (CTG) with injectable platelet rich fibrin (i-prf) with coronally advanced flap (CAF) improved root coverage of deep Miller Class I or II…
- Trial name
- NCT04032405
- Testing
- CAF+CTG+i-prf
- Where
- Turkey (Türkiye)
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Cukurova University
Gingival Recession
Mucoderm or Connective Tissue Graft for Treatment of Gingival Recessions
Coronally advanced flap plus connective tissue graft (CTG) is the gold standard therapy for root coverage. The bioabsorbable porcine collagen matrix (CM) has been widely used in periodontal and mucogingival surgery as a…
- Trial name
- NCT03675334
- Testing
- Root coverage with collagen matrix graft, Root coverage with subepithelial connective tissue graft, Basic periodontal treatment
- Where
- Brazil
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Dental Implant
Hard Tissue Augmentation With or Without Connective Tissue Graft in Immediate Esthetic Implants
This randomized controlled study is aimed to evaluate the esthetic, clinical, and radiographic outcomes following the placement of immediate single-tooth implant with hard and soft tissue augmentation.
- Trial name
- NCT07333534
- Testing
- Immediate dental implant in the esthetic zone
- Where
- Iraq
- Volunteers
- 28 people
- Sponsor
- University of Baghdad
Diabetic Foot Ulcer
Nitric Oxide Generating Gel Dressing in Patients With Diabetic Foot Ulcers
This is a 2 part study to assess the safety and efficacy of a nitric oxide (NOx) generating dressing on chronic diabetic foot ulcers (DFU). Nitric oxide has a range of effects on the body including vasodilation and angiogenesis.
- Trial name
- ProNOx1 (NCT01982565)
- Testing
- NOx dressing, Standard of Care
- Where
- 10 sites in United Kingdom
- Volunteers
- 130 people
- Sponsor
- Edixomed Ltd
Diabetic Foot, Ulcer Foot
Bioactive Split Thickness Skin Allograft Versus Standard of Care in the Treatment of Diabetic Foot Ulcers
This study is a prospective, multi-center, randomized controlled trial designed to collect patient outcome data as well as assess performance and safety of a commercially available human split thickness skin allograft with SOC…
- Trial name
- NCT04040426
- Testing
- Human split thickness skin allograft, Additional Outer Dressing Applicaiton, Offloading
- Where
- 5 sites in United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Professional Education and Research Institute
Infertility, Female
Characterizing Follicles From Auto-transplanted Ovarian Tissue
The aim of the project is to characterize the hormonal conditions in egg follicles in women who, prior to fertility treatment, have had autotransplanted frozen ovarian tissue for the purpose of fertility preservation.
- Trial name
- NCT04905771
- Where
- Denmark
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Peter Humaidan
Breast Ptosis
Hybrid Autologous Breast Augmentation in Mastopexy With Internal BRA Fixation; Using Local Breast Tissues and Fat Grafting
The breast is a very important organ for women's self-esteem and is regarded as a symbol of femininity. Deviations from normal size, shape, and symmetry are interpreted as unattractive and a sign of aging.
- Trial name
- NCT07197190
- Testing
- Autologous augmentation mastopexy with subpectoral lipofilling and upper and medial pole fat grafting.
- Where
- Egypt
- Volunteers
- 28 people
- Sponsor
- Assiut University
Dental Implants, Immediate Implant Soft Tissue Healing
Effectiveness of ALB-PRF With Two Types of Bone Grafts With Putty Form Around Immediate Dental Implants.
The goals of this clinical trial study is to evaluate the additive effect, of using ALB-PRF membrane combined with two different types of bone grafts with putty form in treatment of peri-implant bony defects around immediate…
- Conditions
- Dental Implants, Immediate Implant Soft Tissue Healing, Immediate Implant With Bone Graft
- Trial name
- ALB-PRFE-PRF (NCT06643468)
- Testing
- participants will receive immediate implant with nano-crystalline putty hydroxyapatite as bone graft and collagen membrane., participants will receive immediate implant with nano-crystalline putty hydroxyapatite as bone graft and ALB- PRF as membrane., participants will receive immediate implant with beta-tricalcium phosphate + calcium sulphate bone graft and collagen membrane.
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Graft Versus Host Disease, Systemic Scleroderma
Imatinib and Rituximab in Treating Cutaneous Sclerosis in Patients With Chronic Graft-Versus-Host Disease
This randomized phase II trial is evaluating how well imatinib mesylate works compared to rituximab in treating cutaneous sclerosis in patients with chronic graft- versus-host disease (GVHD).
- Trial name
- NCT01309997
- Testing
- imatinib mesylate, rituximab
- Where
- 10 sites in United States
- Volunteers
- 72 people
- Sponsor
- Lee, Stephanie