Clinical trials: Tissue Grafts
Degenerative Joint Disease, Congenital Deformity
Augment® Injectable Bone Graft Compared to Autologous Bone Graft as a Bone Regeneration Device in Hindfoot Fusions
STUDY OBJECTIVES: To demonstrate equivalent clinical and radiologic outcomes as "gold standard" (Autologous Bone Graft) in a representative clinical model (hindfoot fusions) STUDY HYPOTHESIS: Augment® Injectable is an equivalent…
- Conditions
- Degenerative Joint Disease, Congenital Deformity, Arthritis, Osteoarthritis
- Trial name
- NCT01305356
- Testing
- Augment® Injectable Bone Graft, Autologous bone graft
- Where
- 25 sites in United States, Canada
- Volunteers
- 299 people
- Sponsor
- BioMimetic Therapeutics
Gingival Recession
Impact of Root Surface Conditioning With Erythritol Air Polishing and Hand Instrumentation on Recession Coverage Using the Modified Tunnel Technique and Subepithelial Connective Tissue Graft.
This study aims to evaluate whether the method of root surface preparation influences surgical outcomes. It will assess whether manual root instrumentation can be replaced by a less invasive erythritol air-polishing technique.
- Trial name
- NCT07403006
- Testing
- Erythritol Air-Polishing, Manual Root Instrumentation
- Where
- Poland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Medical University of Warsaw
Root Coverage
The Evaluation Clinical Results of Coronally Advanced Flap With Platelet Rich Fibrin
The aim of this study was to evaluate the clinical outcomes of platelet- rich fibrin and coronally advanced flap technique in the treatment of multiple gingival recessions in comparison with connective tissue graft technique.
- Trial name
- NCT04942821
- Testing
- Platelet rich fibrin and coronally advanced flap, Connective tissue graft and coronally advanced flap
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Marmara University
Gingival Recessions
Evaluation of the Clinical Efficacy of De-Epithelialized Free Gingival Graft in the Treatment of Gingival Recessions
The aim of this study is to evaluate the clinical effectiveness of three techniques used in combination with the tunnel method for the treatment of multiple gingival recessions: subepithelial connective tissue graft (SCTG Group)…
- Trial name
- NCT07100808
- Testing
- Using the tunnel technique in the treatment of gingival recession
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Yuzuncu Yil University
Diabetic Foot, Foot Ulcer; Diabetic
Study of Amniotic Membrane Graft in the Management of Diabetic Foot Ulcers
This is comparison trial comparing human amniotic membrane to standard wound care for non healing diabetic foot wounds over a 12 weeks period
- Trial name
- NCT02399826
- Testing
- Offloading, Dressing Application
- Where
- 3 sites in United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Lower Extremity Institute for Research and Therapy
Gingival Recession
Root Biomodification With Citric Acid and Tetracycline Improves the Outcomes of Root Coverage
The aim of this study is to investigate the effects of the application of a citric acid + tetracycline gel solution during 90 or 180 seconds compared to no conditioning in the outcomes of treatment of Miller's class I or II…
- Trial name
- NCT02259543
- Testing
- Root conditioning with citric acid+tetracycline solution
- Where
- Brazil
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Burn, Skin Graft
The Effects of Therapeutic Resources on Structure and Function of Normal and Burned Skin
Burning produces changes in the biomechanical properties of the skin causing limitation of movement. The increase in skin suppleness is very important in the rehabilitation process, since its increase makes therapeutic…
- Trial name
- NCT02185950
- Testing
- ultrasound, paraffin, endermotherapy
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- University of Sao Paulo
Gingival Recession, Localized, Keratinized Tissue
Effect of Modified Free Gingival Graft and Conventional Free Gingival Graft on Gingival Recession
The aim of this clinical study is to understand whether the modified free gingival graft technique is superior to the conventional free gingival graft: Will gingival recession completely close in modified free gingival grafting…
- Conditions
- Gingival Recession, Localized, Keratinized Tissue, Free Gingival Graft
- Trial name
- NCT06737120
- Testing
- Mod-fgg, Fgg
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- AYSE HUMEYRA ORUC
To Clinically Compare Post-operative Pain Between Free Gingival Grafts Stabilization Around Natural Teeth Using Titanium Tacks vs Suturing Technique
Evaluation of Post-operative Pain After Stabilization of Free Gingival Graft for Keratinized Tissue Augmentation Around Natural Teeth Using Titanium Tacks Versus Standard Suturing Technique.
The goal of this clinical trial is to learn whether titanium tacks can be used as an alternative to sutures for stabilization of free gingival grafts (FGG) around natural teeth.
- Trial name
- NCT07655349
- Testing
- Free gingival grafting (FGG) using titanium tacks for stabilization, Free gingival grafting (FGG) using sutures for stabilization.
- Where
- Egypt
- Volunteers
- 24 people
- Sponsor
- Karim Abdelrahim Mohamed Abdelsamad
Breast Cancer, Chronic Myeloproliferative Disorders
Campath-1H + FK506 and Methylprednisolone for GVHD
RATIONALE: Alemtuzumab, tacrolimus, and methylprednisolone may be an effective treatment for graft-versus-host disease caused by a donor stem cell transplant.
- Conditions
- Breast Cancer, Chronic Myeloproliferative Disorders, Gestational Trophoblastic Tumor, Graft Versus Host Disease
- Trial name
- NCT00109993
- Testing
- alemtuzumab, methylprednisolone, tacrolimus
- Where
- 6 sites in United States
- Volunteers
- 34 people
- Sponsor
- Case Comprehensive Cancer Center
Lack of Keratinized Gingiva
Titanium Tacked Soft Tissue Stabilization : A Novel Technique For Free Gingival Graft Fixation
A case series study on ten patients with lack of keratinization in the non-esthetic area .the purpose of the study is the evaluation of using the titanium tacks in free gingival graft fixation as an alternative to the…
- Trial name
- NCT05287152
- Testing
- titanium tacks or pins
- Where
- Egypt
- Volunteers
- 10 people
- Sponsor
- Egyptian Biomedical Research Network
Thin Gingiva
Clinical Evaluation of Pink Esthetic Score
Clinical evaluation of pink esthetic score in delayed implants in thin gingival biotype with and without temporization in the esthetic zone
- Trial name
- NCT03792425
- Testing
- Connective tissue graft and implant placement
- Where
- Egypt
- Volunteers
- 16 people
- Sponsor
- Cairo University
Breast Cancer, Mammaplasty
Breast Reconstruction With Autologous Tissue: Microsurgery or Fat Grafting?
Methods for breast reconstruction after mastectomy vary from rather simple techniques using expanders and implants, local flaps alone or in combination with implants, to more complex methods using autologous tissue.Transverse…
- Trial name
- NCT04273464
- Testing
- Brava-group, DIEP-group
- Where
- Norway
- Volunteers
- 57 people
- Sponsor
- Sykehuset Telemark
Psoriasis, Skin Diseases
A Phase 2b Study of Baricitinib in Participants With Moderate to Severe Psoriasis
This is a dose-ranging study designed to investigate the efficacy and safety of Baricitinib in the treatment of participants with moderate to severe, chronic plaque psoriasis as assessed by the Psoriasis Area and Severity Index…
- Conditions
- Psoriasis, Skin Diseases, Skin Diseases, Papulosquamous
- Trial name
- NCT01490632
- Testing
- Baricitinib
- Where
- 35 sites in United States, Canada and 2 more
- Volunteers
- 271 people
- Sponsor
- Eli Lilly and Company
Gingival Recessions
Guided Versus Non-Guided Harvesting Technique of Soft Tissue Graft in Cairo Recession Type I Sites
The goal of this clinical trial is to compare the healing pattern in the palate following harvesting of deepithelialized free gingival graft by two different harvesting techniques and to compare the recession coverage at the…
- Trial name
- RCT (NCT06603467)
- Testing
- non-guided de-epithelialized free gingival graft harvested, guided de-epithelialized free gingival graft harvested
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Tanta University
Hyaluronic Acid, Gingival Recession, Localized
Hyaluronic Acid and Free Gingival Graft Healing
This study aims to evaluate the impact of locally applied hyaluronic acid on free gingival graft wound bed healing and palatal donor site wound healing. Forty subjects will be randomly divided in two separate groups.
- Conditions
- Hyaluronic Acid, Gingival Recession, Localized, Pain, Postoperative
- Trial name
- NCT05990049
- Testing
- Hyadent BG
- Where
- Croatia
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Zagreb
Psoriasis, Plaque Psoriasis
Study to Evaluate Safety and Efficacy of Oral MP1032 in Psoriasis Patients
This Phase IIa study is designed to assess the safety, tolerability and pharmacokinetics of oral MP1032 in patients with moderate to severe psoriasis over a period of 6 weeks.
- Trial name
- NCT02908347
- Testing
- MP1032
- Where
- 4 sites in Germany
- Volunteers
- 46 people
- Sponsor
- MetrioPharm AG
Chronic Spontaneous Urticaria
Dose-finding Study of QGE031 as add-on Therapy to Evaluate Efficacy and Safety in Patients With CSU
This is a placebo and active-controlled phase 2b dose-finding study to evaluate efficacy and safety of QGE031 monthly subcutaneous injections as add-on therapy in patients with Chronic Spontaneous Urticaria.
- Trial name
- NCT02477332
- Testing
- QGE031, Omalizumab
- Where
- 82 sites in United States, Australia and 8 more
- Volunteers
- 382 people
- Sponsor
- Novartis Pharmaceuticals
Gingival Recession
Titanium-prepared Platelet Rich Fibrin Versus Connective Tissue Graft for Management of Type-2 Gingival Recession
The aim of the study is to evaluate the effectiveness of using titanium prepared platelet rich fibrin with coronally advanced flap in the treatment of type-2 Cairo gingival recession.
- Trial name
- NCT06621433
- Testing
- T-PRF with CAF, SECTG with CAF
- Where
- Egypt
- Volunteers
- 44 people
- Sponsor
- Rizk Beshir
Bone Cysts, Bone Atrophy
Gene-activated Bone Substitute for Maxillofacial Bone Regeneration
The purpose of this study is to evaluate the safety and efficacy of the gene-activated bone substitute consisting of octacalcium phosphate and plasmid DNA encoding vascular endothelial growth factor (VEGF) for maxillofacial bone…
- Conditions
- Bone Cysts, Bone Atrophy, Bone Deformity, Bone Fracture
- Trial name
- NCT03076138
- Testing
- Gene-activated matrix (OCP + plasmid DNA with VEGF gene)
- Where
- Russia
- Volunteers
- 20 people
- Sponsor
- Histograft Co., Ltd.