Clinical trials: Tissue Injury
Breast Carcinoma, Pain
Prophylactic Topical Agents in Reducing Radiation-Induced Dermatitis in Patients With Non-inflammatory Breast Cancer
This randomized pilot phase II trial studies and compares prophylactic topical agents in reducing radiation-induced dermatitis in patients with non-inflammatory breast cancer or breast cancer in situ.
- Conditions
- Breast Carcinoma, Pain, Radiation-Induced Dermatitis, Stage 0 Breast Cancer
- Trial name
- Curcumin-II (NCT02556632)
- Testing
- Curcumin-based Gel, Dermatologic Complications Management, Laboratory Biomarker Analysis
- Where
- 6 sites in United States
- Volunteers
- 191 people
- Sponsor
- Gary Morrow
Acute Blunt Soft Tissue Injuries/Contusions
Efficacy and Safety of Diclofenac Sodium Topical Gel 1% Compared to Placebo in Subjects With Acute Blunt Trauma Injuries
This study will assess the analgesic efficacy of DSG 1% compared to placebo in the reduction of the pain associated with acute blunt trauma injuries.
- Trial name
- NCT02290821
- Where
- 10 sites in United States
- Volunteers
- 215 people
- Sponsor
- Novartis
Tendinopathy, Musculoskeletal Diseases or Conditions
Human Tendon Tissue Collection
The goal of this study is to improve understanding of tendon health and disease by using surplus tendon tissue that is routinely removed during planned orthopaedic surgeries in adults.
- Conditions
- Tendinopathy, Musculoskeletal Diseases or Conditions, ACL Surgery, Achilles Tendon Surgery
- Trial name
- NCT07606092
- Where
- 2 sites in United Kingdom
- Volunteers
- 400 people
- Sponsor
- Queen Mary University of London
Pressure Ulcer
Evaluation of Wound Dressings in the Reduction of Shear- Force
The purpose of this study is to investigate if wound dressings are capable in reducing the effects of shear- force at the skin. With our own shear- force model we are able to apply 19 Newton shear- force combined with 9 newton…
- Trial name
- NCT02348671
- Testing
- shear- force
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Wound, Wound Heal
Evaluation of V.A.C. VERAFLO CLEANSE CHOICE™ Dressing Using Normal Saline to Promote Increased Healthy Wound Bed Tissue
The study goal is to evaluate the ability of the V.A.C. ULTA™ Negative Pressure Wound Therapy System and V.A.C. VERAFLO CLEANSE CHOICE ™ (VFCC) dressing system with saline as an irrigant in increasing viable tissue in full…
- Conditions
- Wound, Wound Heal, Wounds and Injuries, Granulation Tissue
- Trial name
- NCT04026334
- Testing
- V.A.C. VERAFLO CLEANSE CHOICE™ dressing with Normal Saline
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- 3M
Achilles Tendon Rupture, Soft Tissue Injury
Platelet Concentrate in Achilles Tendon Repair
People operated for a rupture of the Achilles tendon receive a concentrate of their own platelets injected into the operated area.
- Conditions
- Achilles Tendon Rupture, Soft Tissue Injury, Tendon Injury
- Trial name
- NCT00537784
- Testing
- Autologous platelets, no injection
- Where
- Sweden
- Volunteers
- 30 people
- Sponsor
- University Hospital, Linkoeping
Post-COVID-19 Condition, Ulcerative Colitis
Emerging Indications for Hyperbaric Oxygen Treatment
This study will evaluate the effectiveness of hyperbaric oxygen therapy (HBOT) on treating emerging indications (i.e., conditions that have shown to potentially benefit from HBOT) using the Multicenter Registry for Hyperbaric…
- Conditions
- Post-COVID-19 Condition, Ulcerative Colitis, Crohn Disease, Calciphylaxis
- Trial name
- NCT07240649
- Testing
- Hyperbaric oxygen treatment (HBOT), 100% Oxygen
- Volunteers
- 100 people
- Sponsor
- Jay C. Buckey Jr.
Defect of Articular Cartilage, Osteochondral Lesion of Talus
DeNovo NT Ankle LDC Study
The purpose of this post-market clinical study is to collect long-term outcomes for DeNovo NT Graft treatment of articular cartilage lesions in the ankle in a standard clinical setting.
- Conditions
- Defect of Articular Cartilage, Osteochondral Lesion of Talus, Osteochondritis Dissecans
- Trial name
- NCT01347892
- Testing
- DeNovo NT Natural Tissue Graft
- Where
- 8 sites in United States
- Volunteers
- 205 people
- Sponsor
- Zimmer Orthobiologics, Inc.
Cardiotoxicity, Breast Cancer
Strain vs. Left Ventricular Ejection Fraction-based Cardiotoxicity Prevention in Breast Cancer
Comparing preventive effect of myocardial global longitudinal strain-based cardioprotective stragety (angiotensin receptor blocker prophylaxis) with left ventricular ejection fraction-based strategy in breast cancer patients…
- Conditions
- Cardiotoxicity, Breast Cancer, Prevention, Adjuvant
- Trial name
- NCT04429633
- Testing
- Candesartan
- Where
- South Korea
- Volunteers
- 136 people
- Sponsor
- Samsung Medical Center
Pressure Ulcers
Implanted Gluteal Stimulation System for Pressure Sore Prevention
This project will evaluate the feasibility of using a fully implanted gluteal stimulation system for the prevention of Pressure ulcers.
- Trial name
- NCT00623948
- Testing
- A fully implanted gluteal stimulation (GSTIM) system
- Where
- United States
- Sponsor
- US Department of Veterans Affairs
Pressure Injury
Prospective Case Series Evaluating the Efficacy and Safety of NeoThelium FT for Chronic Pressure Ulcers
This is a prospective case series evaluating the efficacy and safety of NeoThelium FT Amnion Skin Graft in the Mangement of Chronic Pressure Ulcers
- Trial name
- NCT07158658
- Testing
- NeoThelium FT (HCT/P 361)
- Where
- 2 sites in United States
- Volunteers
- 10 people
- Sponsor
- NuScience Medical Biologics, LLC
Hand Injuries
Cross-cultural Adaptation of the 'Cold Intolerance Severity Score' (CISS) to the Dutch Language.
To report Cold intolerance by the CISS score in medicolegal patients.
- Trial name
- Ciss-DLV (NCT05925907)
- Where
- Netherlands
- Volunteers
- 100 people
- Sponsor
- Erasmus Medical Center
Breast Cancer, Radiation Dermatitis
A Study of StrataXRT in the Prevention of Radiation Dermatitis in Breast Cancer Patients
For breast cancer patients undergoing adjuvant radiotherapy, radiation dermatitis (RD) is a common occurrence that can negatively impact patients' quality of life (QOL).
- Trial name
- NCT05594498
- Testing
- StrataXRT
- Where
- Canada
- Volunteers
- 45 people
- Sponsor
- Sunnybrook Health Sciences Centre
Diabetic Foot Ulcer, Diabetic Wound
Peer Support for Patients With Diabetic Foot Ulcers
The objective of the study is to develop a peer support program that helps improve ulcer care in patients with a diabetic foot ulcer (DFU).Diabetes, peripheral arterial disease (PAD), foot ulceration, and subsequent amputation…
- Conditions
- Diabetic Foot Ulcer, Diabetic Wound, Diabetes Mellitus, Type 2, Diabetic Foot
- Trial name
- NCT06004219
- Testing
- Peer counseling group
- Where
- 3 sites in United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Casa Colina Hospital and Centers for Healthcare
Surgical Site Infection Prevention, Episiotomy Infection
Effect of Topical Diltiazem Plus Fusidic Acid Versus Fusidic Acid Alone on Episiotomy Healing, Pain, and Resumption of Sexual Activity: A Randomized Controlled Trial in Azadi Teaching Hospital
The goal of this clinical trial is to learn if diltiazem gel combined with fucidic acid cream works better than fucidic acid cream alone to prevent surgical site infection following episiotomy repair.
- Conditions
- Surgical Site Infection Prevention, Episiotomy Infection, Episiotomy Wound, Normal Vaginal Delivery
- Trial name
- NCT07545187
- Testing
- Group 1 received sequential topical diltiazem gel 2% followed by fusidic acid cream, and Group 2 received topical fusidic acid cream alone
- Where
- Iraq
- Volunteers
- 100 people
- Sponsor
- Alaa Nadhim Hameed
Knee Injuries
Dynamic Contrast-Enhanced Fluorescence Arthroscopy of Meniscus Pilot
Single-center pilot prospective observational study to determine feasibility of assessing meniscal tissue vascularity using dynamic contrast-enhanced fluorescence arthroscopy
- Trial name
- NCT05072717
- Testing
- Perfusion with Indocyanine green
- Where
- United States
- Sponsor
- Dartmouth-Hitchcock Medical Center
Alopecia, Radiodermatitis
Exploratory Study of Norepinephrine to Prevent Alopecia in Head and Neck Cancer Patients Treated With Radiotherapy
The study will evaluate the safety of topical norepinephrine in head and neck cancer patients who are receiving treatment with intensity modulated radiotherapy (IMRT).
- Trial name
- NCT01367990
- Testing
- Norepinephrine
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- ProCertus BioPharm, Inc
Abscess of Skin and/or Subcutaneous Tissue
Loop Drainage Versus Incision and Drainage for Abscesses
This is a multicenter randomized controlled trial of loop drainage versus traditional incision and drainage in adult patients presenting to the emergency department.
- Trial name
- NCT03911518
- Testing
- Loop drainage, Incision and drainage
- Sponsor
- Gary Peksa
Pressure Injuries, Spinal Cord Injuries (SCI)
Electrical Stimulation for Clinical and Psychosocial Outcomes in Chronic Pressure Injuries
Pressure injuries are chronic wounds that frequently occur in immobilized patients and are associated with delayed healing, reduced quality of life, and significant psychological burden.
- Conditions
- Pressure Injuries, Spinal Cord Injuries (SCI), Traumatic Brain Injury
- Trial name
- NCT07493889
- Testing
- High-Voltage Monophasic Pulsed Current Electrical Stimulation, Standard Wound Care
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Gaziler Physical Medicine and Rehabilitation Education and Research Hospital
Pressure Ulcer (PU), Pressure Injury Prevention
Effect of a Risk-Based Perioperative Pressure Injury Prevention Bundle in Elective Surgery Patients
This study evaluates whether a risk-based perioperative pressure injury prevention bundle reduces the development of pressure injuries in patients undergoing elective surgery lasting 3 hours or longer.
- Conditions
- Pressure Ulcer (PU), Pressure Injury Prevention, Perioperative Care, Braden Scale
- Trial name
- RiPPB (NCT07725068)
- Testing
- Risk-Based Perioperative Pressure Injury Prevention Bundle
- Where
- Turkey (Türkiye)
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- Acibadem University
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