Clinical trials: Tissue Injury
Diabetic Foot Ulcers
A Clinical Study of the Safety and Efficacy of MEBO® Wound Ointment in Subjects With Diabetic Foot Ulcers (Pilot)
The objective of this study is to evaluate the safety and efficacy of MEBO in the treatment of subjects with diabetic foot ulcers (DFUs).
- Trial name
- NCT01154374
- Testing
- MEBO Wound Ointment, Standard of Care (sterile saline moistened gauze)
- Where
- 2 sites in United States
- Volunteers
- 7 people
- Sponsor
- Skingenix, Inc.
Breast Cancer, Lymphedema
Hyperbaric Oxygen Therapy Compared With Standard Therapy in Treating Chronic Arm Lymphedema in Patients Who Have Undergone Radiation Therapy for Cancer
RATIONALE: Hyperbaric oxygen therapy may be effective in repairing damaged tissue and reducing lymphedema caused by radiation therapy for cancer.
- Conditions
- Breast Cancer, Lymphedema, Perioperative/Postoperative Complications, Radiation Fibrosis
- Trial name
- NCT00077090
- Testing
- hyperbaric oxygen
- Where
- 5 sites in United Kingdom
- Volunteers
- 63 people
- Sponsor
- Institute of Cancer Research, United Kingdom
Fractures, Bone, Bone Marrow Disease
Bone Marrow Adiposity and Fragility Fractures in Postmenopausal Women
The purpose is to determine in a case-control study if an association exist between bone marrow adiposity and fragility fractures in post-menopausal women.
- Conditions
- Fractures, Bone, Bone Marrow Disease, Fat Disorder, Adiposity
- Trial name
- ADIMOS (NCT03219125)
- Testing
- Dixon Magnetic Resonance Imaging, dual-energy X-ray absorptiometry (DXA)
- Where
- France
- Volunteers
- 203 people, healthy volunteers welcome
- Sponsor
- University Hospital, Lille
Rare Disorders, Undiagnosed Disorders
Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford
The Coordination of Rare Diseases at Sanford (CoRDS) is an international patient registry that serves as a centralized resource for rare disease research.
- Conditions
- Rare Disorders, Undiagnosed Disorders, Disorders of Unknown Prevalence, Cornelia De Lange Syndrome
- Trial name
- CoRDS (NCT01793168)
- Where
- United States
- Volunteers
- 20,000 people
- Sponsor
- Sanford Health
Arthritis, Rheumatoid, Stress Disorder
Impact of Life Events and Psychological Stress in Rheumatoid Arthritis Set-up : Case-control Study Within a Multifactorial and Integrative Psychological Model
Rheumatoid Arthritis (RA) is an inflammatory rheumatic disease that can lead to structural damage and handicap. The RA physiopathology is multifactorial, including genetic and environmental risk factors.
- Trial name
- Stress-PR (NCT03550833)
- Testing
- Questionnaire, blood sample
- Where
- 5 sites in France
- Volunteers
- 152 people
- Sponsor
- University Hospital, Bordeaux
Breast Cancer, Seroma
Seroma Reduction and Drain Free Mastectomy
To prove that omitting drains after mastectomy and flap fixation does not contribute to higher incidence of seroma formation and therefore reducing patient disutility such as seroma aspirations and visits to the outpatient…
- Conditions
- Breast Cancer, Seroma, Wound Complication
- Trial name
- SARA (NCT04035590)
- Testing
- No drain, With drain
- Where
- Netherlands
- Volunteers
- 250 people
- Sponsor
- Zuyderland Medisch Centrum
Epidermolysis Bullosa Dystrophica, Epidermolysis Bullosa, Junctional
CACIPLIQ20 in Wound Healing in Subjects With Epidermolysis Bullosa
Epidermolysis bullosa (EB) is a group of inherited disorders characterized by fragility of the skin and mucous membranes within the basement membrane zone.
- Trial name
- MATHBULL (NCT06007235)
- Testing
- CACIPLIQ20
- Where
- France
- Volunteers
- 16 people
- Sponsor
- Organ, Tissue, Regeneration, Repair and Replacement
Diabetic Foot, Leg Ulcer
Obtaining and Storing Standard of Care Wound Biopsies for Immediate or Future Wound-Related Scientific Study
The objective of this study protocol is to use wound biopsies that have been obtained during standard of care management for further scientific evaluation after standard evaluation by a pathologist.
- Conditions
- Diabetic Foot, Leg Ulcer, Decubitus Ulcer
- Trial name
- NCT00759889
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Southwest Regional Wound Care Center
Chronic Skin Ulcer, Diabetic Foot Ulcer
Comparison of Platelet-Rich Plasma Dressing Versus Normal Saline Dressing for Chronic Non-Healing Ulcers
This randomized controlled trial will compare platelet rich plasma dressing with normal saline dressing for the treatment of chronic non healing cutaneous ulcers, including diabetic foot ulcers, venous leg ulcers, pressure…
- Trial name
- NCT07420868
- Testing
- Platelet Rich Plasma Dressing, Normal Saline Dressing
- Where
- Pakistan
- Volunteers
- 100 people
- Sponsor
- Multan Medical And Dental College
Hyaluronic Acid, Gingival Recession, Localized
Hyaluronic Acid and Free Gingival Graft Healing
This study aims to evaluate the impact of locally applied hyaluronic acid on free gingival graft wound bed healing and palatal donor site wound healing. Forty subjects will be randomly divided in two separate groups.
- Conditions
- Hyaluronic Acid, Gingival Recession, Localized, Pain, Postoperative
- Trial name
- NCT05990049
- Testing
- Hyadent BG
- Where
- Croatia
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Zagreb
DFU, VLU
BIO-SEE: Bioburden Imaging Outcome Study for Equivalence Evaluation
The study aims to demonstrate the substantial equivalence of the cureVision cV system's performance in detecting moderate to high bacterial loads in direct comparison to the comparator device for fluorescence imaging in wounds…
- Conditions
- DFU, VLU, Surgical Wound, Wounds
- Trial name
- NCT07611318
- Testing
- cureVision cV
- Where
- 5 sites in United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Capsicure, LLC
Diabetic Foot Ulcers
Omeza Products in Combination With Standard of Care for the Treatment of Diabetic Foot Ulcers
This study is to evaluate the efficacy of OCM™ used in combination with off-loading devices for the treatment of diabetic foot ulcers.
- Trial name
- NCT05417425
- Testing
- Omeza collagen matrix, Omeza lidocaine lavage, Omeza skin protectant
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Omeza, LLC
Systemic Inflammatory Response Syndrome, Acute Kidney Injury
Platelets as Regulators of Inflammation in Cardiac Surgery
Platelets are increasingly recognized as a potent and ubiquitously present source of inflammatory activation. Importantly, antiplatelet therapy has been shown to significantly reduce major adverse events such as renal injury in…
- Trial name
- PRICS (NCT02568410)
- Testing
- coronary artery bypass grafting using cardiopulmonary bypass
- Where
- United States
- Volunteers
- 99 people
- Sponsor
- Duke University
Soft Tissue Sarcoma
Study Comparing Negative Pressure Dressing vs Conventional in Patients With Resected STS After Radiotherapy
This is a randomized (1:1 ratio), prospective, comparative, controlled, open-label study. The aim is to compare the efficacy of negative pressure therapy (PREVENA™) versus standard postoperative wound management on the wound…
- Trial name
- TPN-RAD (NCT05944913)
- Testing
- Prevena
- Where
- 15 sites in France
- Volunteers
- 166 people
- Sponsor
- Centre Leon Berard
Skin Ulcer, Burns
Effectiveness Comparison of Skin Micro-grafts vs Meshed Split Thickness Skin Grafts
This is a double-blind randomized controlled clinical trial, that compares the percentage of epithelialization of skin defects using the conventional meshed split thickness skin grafts vs skin micro grafts.
- Trial name
- NCT02813213
- Testing
- Skin micro Grafts, Standard skin graft
- Where
- Mexico
- Volunteers
- 30 people
- Sponsor
- Coordinación de Investigación en Salud, Mexico
Breast Cancer, Dermatologic Complications
Mometasone Furoate in Preventing Radiation Dermatitis in Patients Undergoing Radiation Therapy to the Breast or Chest Wall for Invasive Breast Cancer or Ductal Carcinoma in Situ
RATIONALE: Steroid therapy, such as mometasone furoate, may prevent radiation dermatitis caused by radiation therapy. It is not yet known whether mometasone furoate is more effective than a placebo in preventing radiation…
- Conditions
- Breast Cancer, Dermatologic Complications, Radiation Toxicity, Skin Reactions Secondary to Radiation Therapy
- Trial name
- NCT00438659
- Testing
- mometasone furoate
- Where
- 189 sites in United States
- Volunteers
- 176 people
- Sponsor
- North Central Cancer Treatment Group
Wound Healing
Comparing Two Wound Coverings for Healing and Comfort After Palatal Gum Graft Surgery in Adults
After gum-grafting surgery, the bare spot in the palate can be slow to heal and quite sore. In this study, the investigators are trying three dressing methods to see which helps most: Standard care: gelatin sponge alone, Option…
- Trial name
- NCT06950359
- Testing
- Gelatin Sponge Dressing (Cutanplast®), Cyanoacrylate Tissue Adhesive (PeriAcryl®), Polyglycolic Acid Sheet (Neoveil®)
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people
- Sponsor
- Ondokuz Mayıs University
Gingival Recession
Platelet Rich Fibrin in the Treatment of Palatal Wounds
In this study it will be investigated the usefulness of Platelet-Rich Fibrin (PRF) on in the epithelialized connective tissue graft palatal donor site healing acceleration and in the patient's morbidity reduction.
- Trial name
- NCT02438046
- Testing
- Palatal wound bandage
- Where
- Italy
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- G. d'Annunzio University
Pressure Ulcer, Bedsore
Quantification of the Pressure Threshold Related to Tissue Injury in Bedriden Paraplegics
The aim of this study is to correlate the intensity and the duration of a mechanical strain, applied over the skin of a bedridden paraplegics, with the microvascularization parameters (oxygen saturation, blood flow and blood…
- Conditions
- Pressure Ulcer, Bedsore, Spinal Cord Injury, Paraplegia
- Trial name
- NCT02412046
- Testing
- Muscle biopsy
- Where
- France
- Volunteers
- 21 people
- Sponsor
- University Hospital, Montpellier
Soft Tissue Injuries
Water Flosser vs String Floss vs Manual Toothbrush Safety
Evaluation of the Safety of a Water Flosser on Gingival and Epithelial Tissue at Different Pressure Settings
- Trial name
- NCT03049761
- Testing
- Water Flosser, String Floss, Manual Toothbrush
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- All Sum Research Center Ltd.