Clinical trials: Tissue Injury
Knee Osteoarthritis, Arthritis
Inflammatory Response Conventional Total Knee Replacement Versus Mako Total Knee Replacement
Total knee Arthroplasty (TKA) is a highly effective treatment for knee osteoarthritis. Mid- to long-term follow-up studies have shown good clinical outcomes following TKA; despite these results, there is a high incidence of…
- Conditions
- Knee Osteoarthritis, Arthritis, Surgery
- Trial name
- NCT04192006
- Testing
- Total Knee Arthroplasty
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- University College, London
Drug Abuse, Intravenous, Substance Dependence
A Cross-Sectional Observational Study on Retained Drug Needle Fragments in People Who Use Intravenous Drugs
In addition to the well-known toxicological harms of intravenous drug (IVD) use, there can also be local tissue complications, including infections, venous sclerosis, tissue necrosis, and drug needle fragment retentions.
- Conditions
- Drug Abuse, Intravenous, Substance Dependence, Needle Injury, Soft Tissue Injuries
- Trial name
- NCT05679284
- Testing
- Low-dose X-ray of subcutaneous tissues
- Where
- Finland
- Volunteers
- 100 people
- Sponsor
- Tampere University Hospital
Gingival Recession, Periodontal Attachment Loss
Flap Thickness Upon Root Coverage With the Use of Acellular Dermal Matrix
OrACell has been tested as a barrier in bone regenerative procedures showing promising results in new bone formation after socket preservation, but no data is available on root coverage procedures.
- Conditions
- Gingival Recession, Periodontal Attachment Loss, Periodontal Diseases, Soft Tissue Injuries
- Trial name
- NCT04802473
- Testing
- Mucogingival surgery
- Where
- Spain
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Universitat Internacional de Catalunya
Wound Heal, Wound Surgical
Early Healing of Oral Soft Tissues: a Clinical and Biomolecular Analysis. Part III
The purpose of the present study is to evaluate the effect of Hyaluronic acid application in the gene expression profile and cellular behavior in the early wound healing process -24 hours after injury- of the oral soft tissues.
- Conditions
- Wound Heal, Wound Surgical, Oral Soft Tissue Conditions, Hyaluronic Acid
- Trial name
- NCT04865952
- Testing
- periodontal surgery + 24 hr buccal attached gingiva (G) biopsy, HA application
- Where
- Italy
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- University of Roma La Sapienza
Wound, Wound Heal
Evaluation of V.A.C. VERAFLO CLEANSE CHOICE™ Dressing Using Normal Saline to Promote Increased Healthy Wound Bed Tissue
The study goal is to evaluate the ability of the V.A.C. ULTA™ Negative Pressure Wound Therapy System and V.A.C. VERAFLO CLEANSE CHOICE ™ (VFCC) dressing system with saline as an irrigant in increasing viable tissue in full…
- Conditions
- Wound, Wound Heal, Wounds and Injuries, Granulation Tissue
- Trial name
- NCT04026334
- Testing
- V.A.C. VERAFLO CLEANSE CHOICE™ dressing with Normal Saline
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- 3M
Fracture, Osteomyelitis
Treatment of Fracture Related Infection in Latin America.
Postoperative bone infection is a severe complication in the treatment of fractures and is more frequent than in elective joint replacement surgeries.
- Conditions
- Fracture, Osteomyelitis, Soft Tissue Injuries, Bone Loss
- Trial name
- NCT05467644
- Testing
- Treatment of Fracture Related Infection
- Where
- Brazil
- Volunteers
- 300 people
- Sponsor
- Manoel Victorino Hospital
Wound; Head, Multiple, Wound; Head, Scalp
Short Term Status of Free Dermal Fat Autografts for Complex Craniofacial Wounds
This study will evaluate the use of free autologous dermal fat grafting (also called free dermal fat autografting) to treat complex craniofacial wounds that have failed standard treatment and to understand how well these grafts…
- Conditions
- Wound; Head, Multiple, Wound; Head, Scalp, Wound; Head, Wound Infection
- Trial name
- FTFDT3 (NCT03872544)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Dufresne, Craig, MD, PC
Wounds and Injuries, Wound Infection
Long Term Status of Free Dermal Fat Autografts for Complex Craniofacial Wounds
This study will evaluate the use of free autologous dermal fat grafting (also called free dermal fat autografting) to treat complex craniofacial wounds that have failed standard treatment and to understand how well these grafts…
- Conditions
- Wounds and Injuries, Wound Infection, Facial Bones Fracture, Soft Tissue Injuries
- Trial name
- FTFDT2 (NCT03880188)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Dufresne, Craig, MD, PC
Cesarean Section Complications, Cesarean Section; Complications, Wound, Infection (Following Delivery)
The S-CARE Trial: Manual Treatment for C-sections Scars, a Pilot Study.
This study aims to examine the effects of an osteopathic treatment on adhesions related to c-sections scars.
- Trial name
- S-CARE (NCT04125498)
- Testing
- Osteopathic treatment, Self-massage
- Where
- Italy
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Studio Osteopatico Busto Arsizio
Neck Pain, Soft Tissue Injuries
Effect of Instrument-assisted Soft Tissue Mobilization Versus Myofascial Release in Treatment of Mechanical Neck Pain
Mechanical neck pain has become a major health problem recently, affecting around one-year prevalence ranging from 42 to 67% in young adults aged 20-24 years causing pain and functional deficits.
- Trial name
- NCT05213871
- Testing
- Instrument-assisted soft tissue mobilization, Myofascial release therapy, Postural correction exercises (PCE)
- Where
- Egypt
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Cairo University
Musculoskeletal Injury, Pain, Chronic
Real-World Experience of Patients Treated for Musculoskeletal Injuries With SAM in Routine Care
The purpose of this study is to evaluate continuous ultrasound treatment with diclofenac coupling patch during routine care of musculoskeletal injuries which failed conservative treatment to better understand clinical utilization…
- Conditions
- Musculoskeletal Injury, Pain, Chronic, Pain, Acute, Sport Injury
- Trial name
- NCT05254470
- Testing
- Continuous Ultrasound
- Where
- United States
- Volunteers
- 135 people
- Sponsor
- ZetrOZ, Inc.
Soft Tissue Injuries, Distal Radius Fracture
Effectiveness of a Tele-Rehabilitation Evidence-based Tablet App for Rehabilitation in Traumatic Bone and Soft Injuries of the Hand, Wrist and Fingers.
Trauma and soft injuries of the wrist, hand and fingers have a high incidence, and large social and healthcare costs are generated, mainly due to productivity loss.
- Conditions
- Soft Tissue Injuries, Distal Radius Fracture, Metacarpal Fracture, Carpal Fracture
- Trial name
- NCT04669704
- Testing
- Experimental: Tablet application, Comparator: Conventional treatment
- Where
- 2 sites in Spain
- Volunteers
- 663 people
- Sponsor
- University of Seville
Tissue Injury, Surgery
Is Regional Oxygen Saturation Effective in Predicting Perfusion Parameters and Patient Outcomes in Liver Resection
Sudden hypotension, which may develop during liver resection operations performed under general anesthesia, can affect the patient satisfaction at a high rate by causing complications during and after the operation as a result of…
- Conditions
- Tissue Injury, Surgery, Absorption; Disorder
- Trial name
- NCT05077397
- Testing
- StO2, O3
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Marmara University
Cell- and Tissue-Based Therapy, Cartilage Injury
Synovial Tissue and Fat Pad Stromal Vascular Fraction Bioengineering in Patients With Knee Articular Cartilage Injury
A phase I/II clinical trial (first in human) to assess the effectiveness and safety of the treatment of cartilage injury with a tissue engineering construct composed of stromal vascular fraction collected from the synovial…
- Conditions
- Cell- and Tissue-Based Therapy, Cartilage Injury, Knee Injuries
- Trial name
- NCT05120700
- Testing
- Synovial Tissue and Fat Pad Stromal Vascular Fraction
- Volunteers
- 10 people
- Sponsor
- University of Sao Paulo General Hospital
Acute Kidney Injury, Peritonitis
Phase 3 Study of Reltecimod vs Placebo in Patients With Sepsis-associated Acute Kidney Injury
Phase 3 multicenter study to be conducted in up to 90 qualified participating sites globally to assess the efficacy and safety of Reltecimod vs placebo in patients with sepsis-associated Stage 2/3 AKI.
- Conditions
- Acute Kidney Injury, Peritonitis, Necrotizing Soft Tissue Infection
- Trial name
- NCT03403751
- Testing
- Reltecimod 0.5 mg/kg
- Where
- 56 sites in United States, France
- Volunteers
- 58 people
- Sponsor
- Atox Bio Ltd
Burn Injury, Soft Tissue Injury
Phase I Study for Autologous Dermal Substitutes and Dermo-epidermal Skin Substitutes for Treatment of Skin Defects
The purpose of this study is the evaluation of the safety of autologous tissue-engineered dermal substitutes "denovoDerm" (first arm) and dermo-epidermal skin substitutes "denovoSkin" (second arm) transplanted onto the wound bed…
- Conditions
- Burn Injury, Soft Tissue Injury, Skin Necrosis, Scars
- Trial name
- NCT02145130
- Testing
- denovoDerm, denovoSkin
- Where
- 2 sites in Switzerland
- Volunteers
- 12 people
- Sponsor
- University of Zurich
Open Wound of Lower Limb
Comparison of Distally Based Sural Artery and Supramalleolar Flap for Coverage of Dorsum of Foot and Ankle Defects
Our main aim for this study was to evaluate the long-term outcome comparisons between sural artery and Supramalleolar flap in the reconstruction of extensive defects of non-weight bearing regions of foot and ankle.
- Trial name
- NCT05027542
- Where
- Pakistan
- Volunteers
- 53 people
- Sponsor
- Abeer Musaddiq
Tendon Injuries, Soft Tissue Injuries
Early Controlled Loading on Conservative Treated Achilles Tendon Ruptures
The purpose of this study is to measure the mechanical properties of the tendon after conservative treated Achilles tendon ruptures with or without early controlled loading.
- Conditions
- Tendon Injuries, Soft Tissue Injuries, Achilles Tendon Rupture
- Trial name
- NCT02805751
- Testing
- Early loading on a training pedal, Tendon strain exercises, Early weight bearing
- Where
- Sweden
- Volunteers
- 40 people
- Sponsor
- Linkoeping University
Rotator Cuff Injuries, Pain, Postoperative
Effect of Extracorporeal Shock Wave Therapy After Arthroscopic Rotator Cuff Repair
Although radial extracorporeal shock wave therapy (rESWT) has proven to be an effective treatment, the effectiveness of the treatment has so far been controversial.
- Conditions
- Rotator Cuff Injuries, Pain, Postoperative, Tissue Adhesion
- Trial name
- NCT04848103
- Testing
- Radial extracorporeal shockwave therapy
- Where
- South Korea
- Volunteers
- 30 people
- Sponsor
- Sahmyook University
Soft Tissue Injuries
Cost-effectiveness of Two Painkillers for Treating Pain After Limb Injuries
Background: Paracetamol and non-steroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen are commonly used oral analgesics in emergency departments (ED) not only in Hong Kong but throughout the world.
- Trial name
- NCT00528658
- Testing
- Paracetamol, Ibuprofen
- Where
- Hong Kong
- Volunteers
- 782 people
- Sponsor
- Chinese University of Hong Kong