Clinical trials: Tissue Plasminogen Activator
Endothelial Dysfunction
Autonomic Nervous System and Nitric Oxide Interactions
The investigators are interested in the role of the autonomic nervous system in the regulation of endothelial function among obese hypertensive subjects.
- Trial name
- NCT01137253
- Testing
- Trimethaphan
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University
Periodontal Diseases, Periodontal Attachment Loss
Low-level Laser Therapy as an Adjunct to Non-surgical Periodontal Treatment
The present study aimed to investigate the effects of low-level laser therapy (LLLT) as an adjunct to non-surgical periodontal treatment (NSPT) on the plasminogen-activating system in Stage 3-4, Grade C periodontitis patients.
- Conditions
- Periodontal Diseases, Periodontal Attachment Loss, Periodontal Disease, AVDC Stage 3, Periodontal Inflammation
- Trial name
- NCT05233501
- Testing
- low level laser therapy, non-surgical periodontal treatment
- Where
- Turkey (Türkiye)
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Beykent
Stroke
Thrombolytic Care During Inter-hospital Transfer
Evaluation of ischemic stroke patients receiving tissue plasminogen activator (rtPA) during air ambulance transfer
- Trial name
- NCT02752256
- Testing
- Tissue Plasminogen Activator
- Where
- United States
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Stroke, Acute
FRALYSE Trial: Comparison of the Classical Rt-PA Procedure With a Longer Procedure in Acute Ischemic Stroke
Data from the literature have suggested that a longer time of thrombolysis might be more effective in ischemic stroke. We, the investigators at Hospices Civils de Lyon, have designed a randomized protocol to test this hypothesis.
- Trial name
- NCT00132509
- Testing
- DFIL, NINDS
- Where
- France
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Sepsis and Septic Shock, Trauma
Fibrinolysis Resistance in Infection and Trauma
Blood coagulation disorders are often seen in critically ill patients e.g. with severe infection or following extensive injury, that can lead to life threatening events as a result of excessive blood clot formation leading to…
- Trial name
- FORTITUDE (NCT06680180)
- Testing
- Viscoelastometric assessment of fibrinolysis
- Where
- 4 sites in Australia
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Anders Aneman
Vascular Disease, Heart Disease
Gap Junction Potentiation of Endothelial Function With Rotigaptide
Hypothesis - Rotigaptide will improve endothelial function in the context of endothelial dysfunction. The lining of blood vessels (endothelium) can react to hormones in the blood stream causing the blood vessel muscle to relax…
- Trial name
- NCT00901563
- Testing
- Rotigaptide, Forearm vascular study
- Where
- United Kingdom
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Obesity
Renin-Angiotensin Aldosterone System and Fibrinolysis Interaction in Humans-Specific Aim 3
The purpose of the study is to determine if giving isosorbide,a drug that is used to treat chest pain, affects blood vessel release of an anti-clotting factor.
- Trial name
- NCT00685945
- Testing
- Control (bradykinin), L-NMMA + bradykinin, Isosorbide + L-NMMA + bradykinin
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University